Details for: ARHGEF15

Gene ID: 22899

Symbol: ARHGEF15

Ensembl ID: ENSG00000198844

Description: Rho guanine nucleotide exchange factor 15

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.17
    Marker Score: 1,667
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.36
    Marker Score: 20,682
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,172
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.34
    Marker Score: 1,339
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.34
    Marker Score: 1,264
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,818
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.03
    Marker Score: 698
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.96
    Marker Score: 2,429
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.95
    Marker Score: 1,374
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,352
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.93
    Marker Score: 429
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.92
    Marker Score: 828
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.86
    Marker Score: 1,724
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.81
    Marker Score: 194
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 508
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 583
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.73
    Marker Score: 1,058
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.66
    Marker Score: 154
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.66
    Marker Score: 590
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.66
    Marker Score: 392
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.61
    Marker Score: 190
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 471
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 238
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.57
    Marker Score: 490
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.56
    Marker Score: 952
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.55
    Marker Score: 594
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.55
    Marker Score: 8,615
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.55
    Marker Score: 128
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.54
    Marker Score: 586
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.54
    Marker Score: 546
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.49
    Marker Score: 933
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.48
    Marker Score: 133
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.45
    Marker Score: 115
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 893
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.43
    Marker Score: 166
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.42
    Marker Score: 90
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.41
    Marker Score: 2,741
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.38
    Marker Score: 159
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.38
    Marker Score: 189
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 185
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.32
    Marker Score: 70
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.29
    Marker Score: 78
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.27
    Marker Score: 66
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.27
    Marker Score: 822
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.24
    Marker Score: 147
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.24
    Marker Score: 138
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.24
    Marker Score: 67
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.21
    Marker Score: 129
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.19
    Marker Score: 52
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.18
    Marker Score: 86
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.15
    Marker Score: 67
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 62
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.13
    Marker Score: 70
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.13
    Marker Score: 73
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 46
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.09
    Marker Score: 119
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.08
    Marker Score: 798
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 79
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.08
    Marker Score: 78
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.08
    Marker Score: 98
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 86
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.07
    Marker Score: 723
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 18

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Guanine nucleotide exchange factor (GEF) activity**: ARHGEF15 possesses GEF activity, enabling it to exchange GDP for GTP in small GTPases, such as Rac1 and Cdc42, thereby activating their signaling pathways. 2. **Cell death signaling**: ARHGEF15 is involved in the regulation of cell death pathways, including those mediated by the N-terminus of the Rho GTPase activating protein (N-RAGE) family. 3. **Synaptic plasticity**: ARHGEF15 regulates synaptic plasticity, particularly in the context of glutamatergic synapses, by modulating the activity of small GTPases. 4. **Tissue specificity**: ARHGEF15 is significantly expressed in hematopoietic stem cells, lung endothelial cells, and various epithelial cells, highlighting its diverse roles in different tissues. **Pathways and Functions:** 1. **Activation of GTPase activity**: ARHGEF15 stimulates the activation of Rac1 and Cdc42, leading to the regulation of various signaling pathways, including those involved in cell migration, proliferation, and differentiation. 2. **Cell death signaling**: ARHGEF15 interacts with N-RAGE, a death receptor ligand, to regulate cell death pathways, including those mediated by the JNK signaling pathway. 3. **Synaptic plasticity**: ARHGEF15 modulates the activity of small GTPases, such as Rac1 and Cdc42, to regulate synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). 4. **Regulation of small GTPase mediated signal transduction**: ARHGEF15 regulates the activity of small GTPases, such as Rac1 and Cdc42, to modulate signal transduction pathways involved in various cellular processes. **Clinical Significance:** 1. **Immune system disorders**: Dysregulation of ARHGEF15 has been implicated in various immune system disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: ARHGEF15 has been shown to regulate cell migration and invasion in various cancers, including breast cancer and lung cancer. 3. **Neurological disorders**: ARHGEF15 has been implicated in the regulation of synaptic plasticity and neuronal survival, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Epithelial disorders**: ARHGEF15 has been shown to regulate epithelial cell function, including cell migration and differentiation, making it a potential target for the treatment of epithelial disorders, such as inflammatory bowel disease. In conclusion, ARHGEF15 is a multifaceted gene involved in various cellular processes, including immune response, cell death signaling, and synaptic plasticity. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the role of ARHGEF15 in different tissues and to explore its therapeutic potential.

Genular Protein ID: 89462269

Symbol: ARHGF_HUMAN

Name: Rho guanine nucleotide exchange factor 15

UniProtKB Accession Codes:

O94989 A8K6G1 Q8N449 Q9H8B4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 CarbonylDB 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12775584

Title: EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells.

PubMed ID: 12775584

DOI: 10.1161/01.res.0000079310.81429.c8

PubMed ID: 23647072

Title: Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.

PubMed ID: 23647072

DOI: 10.1111/epi.12201

Sequence Information:

  • Length: 841
  • Mass: 91940
  • Checksum: 40D430ACF777002F
  • Sequence:
    • MSAQSLPAAT PPTQKPPRII RPRPPSRSRA AQSPGPPHNG SSPQELPRNS NDAPTPMCTP 
IFWEPPAASL KPPALLPPSA SRASLDSQTS PDSPSSTPTP SPVSRRSASP EPAPRSPVPP 
PKPSGSPCTP LLPMAGVLAQ NGSASAPGTV RRLAGRFEGG AEGRAQDADA PEPGLQARAD 
VNGEREAPLT GSGSQENGAP DAGLACPPCC PCVCHTTRPG LELRWVPVGG YEEVPRVPRR 
ASPLRTSRSR PHPPSIGHPA VVLTSYRSTA ERKLLPLLKP PKPTRVRQDA TIFGDPPQPD 
LDLLSEDGIQ TGDSPDEAPQ NTPPATVEGR EEEGLEVLKE QNWELPLQDE PLYQTYRAAV 
LSEELWGVGE DGSPSPANAG DAPTFPRPPG PRNTLWQELP AVQASGLLDT LSPQERRMQE 
SLFEVVTSEA SYLRSLRLLT DTFVLSQALR DTLTPRDHHT LFSNVQRVQG VSERFLATLL 
SRVRSSPHIS DLCDVVHAHA VGPFSVYVDY VRNQQYQEET YSRLMDTNVR FSAELRRLQS 
LPKCERLPLP SFLLLPFQRI TRLRMLLQNI LRQTEEGSSR QENAQKALGA VSKIIERCSA 
EVGRMKQTEE LIRLTQRLRF HKVKALPLVS WSRRLEFQGE LTELGCRRGG VLFASRPRFT 
PLCLLLFSDL LLITQPKSGQ RLQVLDYAHR SLVQAQQVPD PSGPPTFRLS LLSNHQGRPT 
HRLLQASSLS DMQRWLGAFP TPGPLPCSPD TIYEDCDCSQ ELCSESSAPA KTEGRSLESR 
AAPKHLHKTP EGWLKGLPGA FPAQLVCEVT GEHERRRHLR QNQRLLEAVG SSSGTPNAPP 
P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.