ALDOB | ENSG00000136872 | NCBI 229

Details for: ALDOB

Gene ID: 229

Symbol: ALDOB

Ensembl ID: ENSG00000136872

Description: aldolase, fructose-bisphosphate B

Associated with

Disease
(R-HSA-1643685)
Diseases of carbohydrate metabolism
(R-HSA-5663084)
Diseases of metabolism
(R-HSA-5668914)
Fructose catabolism
(R-HSA-70350)
Fructose metabolism
(R-HSA-5652084)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Hereditary fructose intolerance
(R-HSA-5657560)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Atpase binding
(GO:0051117)
Centriolar satellite
(GO:0034451)
Cytoskeletal protein binding
(GO:0008092)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Fructose-1-phosphate aldolase activity
(GO:0061609)
Fructose-bisphosphate aldolase activity
(GO:0004332)
Fructose 1,6-bisphosphate metabolic process
(GO:0030388)
Fructose binding
(GO:0070061)
Fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
(GO:0061624)
Fructose metabolic process
(GO:0006000)
Gluconeogenesis
(GO:0006094)
Glycolytic process
(GO:0006096)
Identical protein binding
(GO:0042802)
Microtubule organizing center
(GO:0005815)
Molecular adaptor activity
(GO:0060090)
Nadh oxidation
(GO:0006116)
Negative regulation of pentose-phosphate shunt
(GO:1905856)
Positive regulation of atp-dependent activity
(GO:0032781)
Protein binding
(GO:0005515)
Vacuolar proton-transporting v-type atpase complex assembly
(GO:0070072)

Other Information

Proteins

Fructose-bisphosphate aldolase B

Genular Protein ID: 3655984182

Symbol: ALDOB_HUMAN

Name: Fructose-bisphosphate aldolase B

UniProtKB Accession Codes:

P05062 Q13741 Q13742 Q5T7D6

Database IDs:

Citations:

PubMed ID: 6548561

Title: Isolation and nucleotide sequence of a full-length cDNA coding for aldolase B from human liver.

PubMed ID: 6548561

DOI: 10.1093/nar/12.19.7401

PubMed ID: 2410860

Title: Human aldolase isozyme gene: the structure of multispecies aldolase B mRNAs.

PubMed ID: 2410860

DOI: 10.1093/nar/13.14.5055

PubMed ID: 6585824

Title: Complete amino acid sequence for human aldolase B derived from cDNA and genomic clones.

PubMed ID: 6585824

DOI: 10.1073/pnas.81.9.2738

PubMed ID: 2830249

Title: Human aldolase B gene: characterization of the genomic aldolase B gene and analysis of sequences required for multiple polyadenylations.

PubMed ID: 2830249

DOI: 10.1093/oxfordjournals.jbchem.a122142

PubMed ID: 3016456

Title: Characterization of the human aldolase B gene.

PubMed ID: 3016456

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 2649152

Title: Construction and expression of human aldolase A and B expression plasmids in Escherichia coli host.

PubMed ID: 2649152

DOI: 10.1016/0167-4781(89)90156-5

PubMed ID: 6689266

Title: Nucleotide sequence of a cDNA clone for human aldolase B.

PubMed ID: 6689266

DOI: 10.1016/0006-291x(83)91243-3

PubMed ID: 18000879

Title: Novel interaction partners of Bardet-Biedl syndrome proteins.

PubMed ID: 18000879

DOI: 10.1002/cm.20250

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 35122041

Title: Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways.

PubMed ID: 35122041

DOI: 10.1038/s43018-020-0086-7

PubMed ID: 11679716

Title: The structure of human liver fructose-1,6-bisphosphate aldolase.

PubMed ID: 11679716

DOI: 10.1107/s0907444901012719

PubMed ID: 8535439

Title: Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene.

PubMed ID: 8535439

DOI: 10.1002/humu.1380060303

PubMed ID: 3383242

Title: Catalytic deficiency of human aldolase B in hereditary fructose intolerance caused by a common missense mutation.

PubMed ID: 3383242

DOI: 10.1016/s0092-8674(88)90349-2

PubMed ID: 1967768

Title: Molecular analysis of aldolase B genes in hereditary fructose intolerance.

PubMed ID: 1967768

DOI: 10.1016/0140-6736(90)90603-3

PubMed ID: 8299883

Title: A partially active mutant aldolase B from a patient with hereditary fructose intolerance.

PubMed ID: 8299883

DOI: 10.1096/fasebj.8.1.8299883

PubMed ID: 7717389

Title: Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance.

PubMed ID: 7717389

PubMed ID: 8162030

Title: Identification of a novel mutation (Leu 256-->Pro) in the human aldolase B gene associated with hereditary fructose intolerance.

PubMed ID: 8162030

DOI: 10.1093/hmg/3.1.203

PubMed ID: 2336380

Title: A new aldolase B variant, N334K, is a common cause of hereditary fructose intolerance in Yugoslavia.

PubMed ID: 2336380

DOI: 10.1093/nar/18.7.1925

PubMed ID: 10024431

Title: Screening for hereditary fructose intolerance mutations by reverse dot-blot.

PubMed ID: 10024431

DOI: 10.1006/mcpr.1998.0208

PubMed ID: 10970798

Title: Functional and molecular modelling studies of two hereditary fructose intolerance-causing mutations at arginine 303 in human liver aldolase.

PubMed ID: 10970798

DOI: 10.1042/bj3500823

PubMed ID: 12205126

Title: Molecular analysis of the aldolase B gene in patients with hereditary fructose intolerance from Spain.

PubMed ID: 12205126

DOI: 10.1136/jmg.39.9.e56

PubMed ID: 15532022

Title: Six novel alleles identified in Italian hereditary fructose intolerance patients enlarge the mutation spectrum of the aldolase B gene.

PubMed ID: 15532022

DOI: 10.1002/humu.9290

PubMed ID: 15880727

Title: The spectrum of aldolase B (ALDOB) mutations and the prevalence of hereditary fructose intolerance in Central Europe.

PubMed ID: 15880727

DOI: 10.1002/humu.9343

PubMed ID: 20848650

Title: Hereditary fructose intolerance: functional study of two novel ALDOB natural variants and characterization of a partial gene deletion.

PubMed ID: 20848650

DOI: 10.1002/humu.21359

Sequence Information:

Length: 364
Mass: 39473
Checksum: DCE314E7AC5586CA
Sequence:

MAHRFPALTQ EQKKELSEIA QSIVANGKGI LAADESVGTM GNRLQRIKVE NTEENRRQFR 
EILFSVDSSI NQSIGGVILF HETLYQKDSQ GKLFRNILKE KGIVVGIKLD QGGAPLAGTN 
KETTIQGLDG LSERCAQYKK DGVDFGKWRA VLRIADQCPS SLAIQENANA LARYASICQQ 
NGLVPIVEPE VIPDGDHDLE HCQYVTEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHAC 
TKKYTPEQVA MATVTALHRT VPAAVPGICF LSGGMSEEDA TLNLNAINLC PLPKPWKLSF 
SYGRALQASA LAAWGGKAAN KEATQEAFMK RAMANCQAAK GQYVHTGSSG AASTQSLFTA 
CYTY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ALDOB

Associated with

Other Information

Isolation and nucleotide sequence of a full-length cDNA coding for aldolase B from human liver. PubMed ID: 6548561

Human aldolase isozyme gene: the structure of multispecies aldolase B mRNAs. PubMed ID: 2410860

Complete amino acid sequence for human aldolase B derived from cDNA and genomic clones. PubMed ID: 6585824

Human aldolase B gene: characterization of the genomic aldolase B gene and analysis of sequences required for multiple polyadenylations. PubMed ID: 2830249

Characterization of the human aldolase B gene. PubMed ID: 3016456

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

Construction and expression of human aldolase A and B expression plasmids in Escherichia coli host. PubMed ID: 2649152

Nucleotide sequence of a cDNA clone for human aldolase B. PubMed ID: 6689266

Novel interaction partners of Bardet-Biedl syndrome proteins. PubMed ID: 18000879

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways. PubMed ID: 35122041

The structure of human liver fructose-1,6-bisphosphate aldolase. PubMed ID: 11679716

Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene. PubMed ID: 8535439

Catalytic deficiency of human aldolase B in hereditary fructose intolerance caused by a common missense mutation. PubMed ID: 3383242

Molecular analysis of aldolase B genes in hereditary fructose intolerance. PubMed ID: 1967768

A partially active mutant aldolase B from a patient with hereditary fructose intolerance. PubMed ID: 8299883

Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance. PubMed ID: 7717389

Identification of a novel mutation (Leu 256--&gt;Pro) in the human aldolase B gene associated with hereditary fructose intolerance. PubMed ID: 8162030

A new aldolase B variant, N334K, is a common cause of hereditary fructose intolerance in Yugoslavia. PubMed ID: 2336380

Screening for hereditary fructose intolerance mutations by reverse dot-blot. PubMed ID: 10024431

Functional and molecular modelling studies of two hereditary fructose intolerance-causing mutations at arginine 303 in human liver aldolase. PubMed ID: 10970798

Molecular analysis of the aldolase B gene in patients with hereditary fructose intolerance from Spain. PubMed ID: 12205126

Six novel alleles identified in Italian hereditary fructose intolerance patients enlarge the mutation spectrum of the aldolase B gene. PubMed ID: 15532022

The spectrum of aldolase B (ALDOB) mutations and the prevalence of hereditary fructose intolerance in Central Europe. PubMed ID: 15880727

Hereditary fructose intolerance: functional study of two novel ALDOB natural variants and characterization of a partial gene deletion. PubMed ID: 20848650