Details for: CARD8
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.69
Marker Score: 1,549 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.34
Marker Score: 664 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.33
Marker Score: 794 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.29
Marker Score: 314 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.27
Marker Score: 70,889 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.25
Marker Score: 539 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.21
Marker Score: 1,138 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.2
Marker Score: 12,136 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.18
Marker Score: 1,702 - Cell Name: blood cell (CL0000081)
Fold Change: 1.16
Marker Score: 13,462 - Cell Name: endothelial cell (CL0000115)
Fold Change: 1.16
Marker Score: 1,036 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.15
Marker Score: 3,237 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.14
Marker Score: 1,226 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.14
Marker Score: 273 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.13
Marker Score: 2,200 - Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.1
Marker Score: 993 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.1
Marker Score: 1,107 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.08
Marker Score: 1,160 - Cell Name: mature T cell (CL0002419)
Fold Change: 1.08
Marker Score: 10,723 - Cell Name: ependymal cell (CL0000065)
Fold Change: 1.08
Marker Score: 377 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.07
Marker Score: 2,144 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.07
Marker Score: 1,558 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.06
Marker Score: 2,630 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.05
Marker Score: 524 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.05
Marker Score: 715 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.05
Marker Score: 325 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,640 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47,863 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.99
Marker Score: 356 - Cell Name: erythroblast (CL0000765)
Fold Change: 0.98
Marker Score: 614 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,382 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.98
Marker Score: 1,784 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.98
Marker Score: 3,079 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.96
Marker Score: 961 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.95
Marker Score: 6,055 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.94
Marker Score: 1,687 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.94
Marker Score: 497 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,385 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.93
Marker Score: 2,249 - Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 0.93
Marker Score: 325 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.93
Marker Score: 49,020 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.92
Marker Score: 377 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.92
Marker Score: 473 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.92
Marker Score: 2,493 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.91
Marker Score: 2,706 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.91
Marker Score: 430 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.91
Marker Score: 2,508 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.9
Marker Score: 192 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2,688 - Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.9
Marker Score: 1,058 - Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.89
Marker Score: 208 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.89
Marker Score: 835 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.89
Marker Score: 491 - Cell Name: PP cell (CL0000696)
Fold Change: 0.88
Marker Score: 198 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.88
Marker Score: 515 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,292 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.87
Marker Score: 2,214 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.86
Marker Score: 198 - Cell Name: memory B cell (CL0000787)
Fold Change: 0.86
Marker Score: 653 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 310 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.86
Marker Score: 831 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.86
Marker Score: 3,516 - Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.85
Marker Score: 212 - Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.84
Marker Score: 212 - Cell Name: lung macrophage (CL1001603)
Fold Change: 0.84
Marker Score: 964 - Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.84
Marker Score: 183 - Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.84
Marker Score: 187 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.83
Marker Score: 199 - Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.83
Marker Score: 205 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.83
Marker Score: 408 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.83
Marker Score: 630 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.83
Marker Score: 1,450 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 0.83
Marker Score: 2,416 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.82
Marker Score: 333 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.82
Marker Score: 4,689 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.82
Marker Score: 329 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.82
Marker Score: 520 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.82
Marker Score: 367 - Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.81
Marker Score: 886 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.81
Marker Score: 254 - Cell Name: tendon cell (CL0000388)
Fold Change: 0.81
Marker Score: 199 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.81
Marker Score: 20,702 - Cell Name: smooth muscle cell of small intestine (CL1000275)
Fold Change: 0.81
Marker Score: 211 - Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.8
Marker Score: 199 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.8
Marker Score: 479 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.8
Marker Score: 275 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.8
Marker Score: 3,412 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.78
Marker Score: 207 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.78
Marker Score: 403 - Cell Name: oocyte (CL0000023)
Fold Change: 0.78
Marker Score: 193 - Cell Name: naive B cell (CL0000788)
Fold Change: 0.78
Marker Score: 696 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.78
Marker Score: 486 - Cell Name: promyelocyte (CL0000836)
Fold Change: 0.78
Marker Score: 384 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.78
Marker Score: 750 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.77
Marker Score: 652 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.77
Marker Score: 249 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1,250 - Cell Name: neutrophil (CL0000775)
Fold Change: 0.77
Marker Score: 469 - Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.77
Marker Score: 505 - Cell Name: muscle precursor cell (CL0000680)
Fold Change: 0.77
Marker Score: 199
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 649389543
Symbol: CARD8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10231032
Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10231032
PubMed ID: 11821383
Title: CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.
PubMed ID: 11821383
PubMed ID: 11956601
Title: NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation.
PubMed ID: 11956601
PubMed ID: 11551959
Title: CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways.
PubMed ID: 11551959
PubMed ID: 18212821
Title: Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation.
PubMed ID: 18212821
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 22087307
Title: CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain.
PubMed ID: 22087307
PubMed ID: 11408476
Title: TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer.
PubMed ID: 11408476
PubMed ID: 12067710
Title: TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation.
PubMed ID: 12067710
PubMed ID: 15030775
Title: NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
PubMed ID: 15030775
PubMed ID: 24517500
Title: CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction.
PubMed ID: 24517500
DOI: 10.1186/ar4483
PubMed ID: 29967349
Title: DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
PubMed ID: 29967349
PubMed ID: 31525884
Title: DPP9's enzymatic activity and not its binding to CARD8 inhibits inflammasome activation.
PubMed ID: 31525884
PubMed ID: 32796818
Title: DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes.
PubMed ID: 32796818
PubMed ID: 33053349
Title: Activation of the CARD8 inflammasome requires a disordered region.
PubMed ID: 33053349
PubMed ID: 32840892
Title: CARD8 inflammasome activation triggers pyroptosis in human T cells.
PubMed ID: 32840892
PubMed ID: 32558991
PubMed ID: 32051255
Title: Caspase-1 interdomain linker cleavage is required for pyroptosis.
PubMed ID: 32051255
PubMed ID: 33154409
Title: Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells.
PubMed ID: 33154409
PubMed ID: 33731929
Title: Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
PubMed ID: 33731929
PubMed ID: 33542150
Title: CARD8 is an inflammasome sensor for HIV-1 protease activity.
PubMed ID: 33542150
PubMed ID: 35165443
Title: M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.
PubMed ID: 35165443
PubMed ID: 36357533
Title: Chemical inhibition of DPP9 sensitizes the CARD8 inflammasome in HIV-1-infected cells.
PubMed ID: 36357533
PubMed ID: 23695559
Title: The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces.
PubMed ID: 23695559
PubMed ID: 34019797
Title: Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.
PubMed ID: 34019797
PubMed ID: 33420028
Title: Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
PubMed ID: 33420028
PubMed ID: 33420033
Title: Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
PubMed ID: 33420033
PubMed ID: 17030188
Title: TUCAN (CARD8) genetic variants and inflammatory bowel disease.
PubMed ID: 17030188
PubMed ID: 19319132
Title: Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.
PubMed ID: 19319132
DOI: 10.1038/ajg.2009.29
PubMed ID: 23506543
Title: The CARD8 p.C10X mutation associates with a low anti-glycans antibody response in patients with Crohn's disease.
PubMed ID: 23506543
PubMed ID: 26462578
Title: Is the CARD8 rs2043211 polymorphism associated with susceptibility to Crohn's disease? A meta-analysis.
PubMed ID: 26462578
PubMed ID: 29408806
Title: Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease.
PubMed ID: 29408806
DOI: 10.1172/jci98642
Sequence Information:
- Length: 537
- Mass: 60652
- Checksum: 55775D025C5461BE
- Sequence:
MEKKECPEKS SSSEEELPRR DSGSSRNIDA SKLIRLQGSR KLLVDNSIRE LQYTKTGIFF QAEACVTNDT VYRELPCVSE TLCDISHFFQ EDDETEAEPL LFRAVPECQL SGGDIPSVSE EQESSEGQDS GDICSEENQI VSSYASKVCF EIEEDYKNRQ FLGPEGNVDV ELIDKSTNRY SVWFPTAGWY LWSATGLGFL VRDEVTVTIA FGSWSQHLAL DLQHHEQWLV GGPLFDVTAE PEEAVAEIHL PHFISLQAGE VDVSWFLVAH FKNEGMVLEH PARVEPFYAV LESPSFSLMG ILLRIASGTR LSIPITSNTL IYYHPHPEDI KFHLYLVPSD ALLTKAIDDE EDRFHGVRLQ TSPPMEPLNF GSSYIVSNSA NLKVMPKELK LSYRSPGEIQ HFSKFYAGQM KEPIQLEITE KRHGTLVWDT EVKPVDLQLV AASAPPPFSG AAFVKENHRQ LQARMGDLKG VLDDLQDNEV LTENEKELVE QEKTRQSKNE ALLSMVEKKG DLALDVLFRS ISERDPYLVS YLRQQNL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.