Details for: CARD8
Associated with
Other Information
Genular Protein ID: 649389543
Symbol: CARD8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10231032
Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10231032
PubMed ID: 11821383
Title: CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.
PubMed ID: 11821383
PubMed ID: 11956601
Title: NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation.
PubMed ID: 11956601
PubMed ID: 11551959
Title: CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways.
PubMed ID: 11551959
PubMed ID: 18212821
Title: Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation.
PubMed ID: 18212821
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 22087307
Title: CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain.
PubMed ID: 22087307
PubMed ID: 11408476
Title: TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer.
PubMed ID: 11408476
PubMed ID: 12067710
Title: TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation.
PubMed ID: 12067710
PubMed ID: 15030775
Title: NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
PubMed ID: 15030775
PubMed ID: 24517500
Title: CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction.
PubMed ID: 24517500
DOI: 10.1186/ar4483
PubMed ID: 29967349
Title: DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
PubMed ID: 29967349
PubMed ID: 31525884
Title: DPP9's enzymatic activity and not its binding to CARD8 inhibits inflammasome activation.
PubMed ID: 31525884
PubMed ID: 32796818
Title: DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes.
PubMed ID: 32796818
PubMed ID: 33053349
Title: Activation of the CARD8 inflammasome requires a disordered region.
PubMed ID: 33053349
PubMed ID: 32840892
Title: CARD8 inflammasome activation triggers pyroptosis in human T cells.
PubMed ID: 32840892
PubMed ID: 32558991
PubMed ID: 32051255
Title: Caspase-1 interdomain linker cleavage is required for pyroptosis.
PubMed ID: 32051255
PubMed ID: 33154409
Title: Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells.
PubMed ID: 33154409
PubMed ID: 33731929
Title: Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
PubMed ID: 33731929
PubMed ID: 33542150
Title: CARD8 is an inflammasome sensor for HIV-1 protease activity.
PubMed ID: 33542150
PubMed ID: 35165443
Title: M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.
PubMed ID: 35165443
PubMed ID: 36357533
Title: Chemical inhibition of DPP9 sensitizes the CARD8 inflammasome in HIV-1-infected cells.
PubMed ID: 36357533
PubMed ID: 23695559
Title: The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces.
PubMed ID: 23695559
PubMed ID: 34019797
Title: Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.
PubMed ID: 34019797
PubMed ID: 33420028
Title: Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
PubMed ID: 33420028
PubMed ID: 33420033
Title: Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
PubMed ID: 33420033
PubMed ID: 17030188
Title: TUCAN (CARD8) genetic variants and inflammatory bowel disease.
PubMed ID: 17030188
PubMed ID: 19319132
Title: Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.
PubMed ID: 19319132
DOI: 10.1038/ajg.2009.29
PubMed ID: 23506543
Title: The CARD8 p.C10X mutation associates with a low anti-glycans antibody response in patients with Crohn's disease.
PubMed ID: 23506543
PubMed ID: 26462578
Title: Is the CARD8 rs2043211 polymorphism associated with susceptibility to Crohn's disease? A meta-analysis.
PubMed ID: 26462578
PubMed ID: 29408806
Title: Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease.
PubMed ID: 29408806
DOI: 10.1172/jci98642
Sequence Information:
- Length: 537
- Mass: 60652
- Checksum: 55775D025C5461BE
- Sequence:
MEKKECPEKS SSSEEELPRR DSGSSRNIDA SKLIRLQGSR KLLVDNSIRE LQYTKTGIFF QAEACVTNDT VYRELPCVSE TLCDISHFFQ EDDETEAEPL LFRAVPECQL SGGDIPSVSE EQESSEGQDS GDICSEENQI VSSYASKVCF EIEEDYKNRQ FLGPEGNVDV ELIDKSTNRY SVWFPTAGWY LWSATGLGFL VRDEVTVTIA FGSWSQHLAL DLQHHEQWLV GGPLFDVTAE PEEAVAEIHL PHFISLQAGE VDVSWFLVAH FKNEGMVLEH PARVEPFYAV LESPSFSLMG ILLRIASGTR LSIPITSNTL IYYHPHPEDI KFHLYLVPSD ALLTKAIDDE EDRFHGVRLQ TSPPMEPLNF GSSYIVSNSA NLKVMPKELK LSYRSPGEIQ HFSKFYAGQM KEPIQLEITE KRHGTLVWDT EVKPVDLQLV AASAPPPFSG AAFVKENHRQ LQARMGDLKG VLDDLQDNEV LTENEKELVE QEKTRQSKNE ALLSMVEKKG DLALDVLFRS ISERDPYLVS YLRQQNL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.