ARSG | ENSG00000141337 | NCBI 22901

Details for: ARSG

Gene ID: 22901

Symbol: ARSG

Ensembl ID: ENSG00000141337

Description: arylsulfatase G

Associated with

Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-HSA-163841)
Glycosphingolipid catabolism
(R-HSA-9840310)
Glycosphingolipid metabolism
(R-HSA-1660662)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Sphingolipid metabolism
(R-HSA-428157)
The activation of arylsulfatases
(R-HSA-1663150)
Arylsulfatase activity
(GO:0004065)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular space
(GO:0005615)
Lysosome
(GO:0005764)
Metal ion binding
(GO:0046872)
N-sulfoglucosamine-3-sulfatase activity
(GO:0033889)
Sulfur compound metabolic process
(GO:0006790)

Other Information

Proteins

Arylsulfatase G

Genular Protein ID: 2084845442

Symbol: ARSG_HUMAN

Name: Arylsulfatase G

UniProtKB Accession Codes:

Q96EG1 Q6UXF2 Q9Y2K4

Database IDs:

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12461688

Title: Molecular and biochemical characterisation of a novel sulphatase gene: arylsulfatase G (ARSG).

PubMed ID: 12461688

DOI: 10.1038/sj.ejhg.5200887

PubMed ID: 18283100

Title: Arylsulfatase G, a novel lysosomal sulfatase.

PubMed ID: 18283100

DOI: 10.1074/jbc.m709917200

PubMed ID: 22689975

Title: Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice.

PubMed ID: 22689975

DOI: 10.1073/pnas.1202071109

PubMed ID: 25135642

Title: Molecular characterization of arylsulfatase G: expression, processing, glycosylation, transport, and activity.

PubMed ID: 25135642

DOI: 10.1074/jbc.m114.584144

PubMed ID: 29300381

Title: A homozygous founder missense variant in arylsulfatase G abolishes its enzymatic activity causing atypical Usher syndrome in humans.

PubMed ID: 29300381

DOI: 10.1038/gim.2017.227

PubMed ID: 25825126

Title: Accumulation of rare variants in the arylsulfatase G (ARSG) gene in task-specific dystonia.

PubMed ID: 25825126

DOI: 10.1007/s00415-015-7718-3

Sequence Information:

Length: 525
Mass: 57061
Checksum: ADAB673A02B25754
Sequence:

MGWLFLKVLL AGVSFSGFLY PLVDFCISGK TRGQKPNFVI ILADDMGWGD LGANWAETKD 
TANLDKMASE GMRFVDFHAA ASTCSPSRAS LLTGRLGLRN GVTRNFAVTS VGGLPLNETT 
LAEVLQQAGY VTGIIGKWHL GHHGSYHPNF RGFDYYFGIP YSHDMGCTDT PGYNHPPCPA 
CPQGDGPSRN LQRDCYTDVA LPLYENLNIV EQPVNLSSLA QKYAEKATQF IQRASTSGRP 
FLLYVALAHM HVPLPVTQLP AAPRGRSLYG AGLWEMDSLV GQIKDKVDHT VKENTFLWFT 
GDNGPWAQKC ELAGSVGPFT GFWQTRQGGS PAKQTTWEGG HRVPALAYWP GRVPVNVTST 
ALLSVLDIFP TVVALAQASL PQGRRFDGVD VSEVLFGRSQ PGHRVLFHPN SGAAGEFGAL 
QTVRLERYKA FYITGGARAC DGSTGPELQH KFPLIFNLED DTAEAVPLER GGAEYQAVLP 
EVRKVLADVL QDIANDNISS ADYTQDPSVT PCCNPYQIAC RCQAA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ARSG

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10231032

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular and biochemical characterisation of a novel sulphatase gene: arylsulfatase G (ARSG). PubMed ID: 12461688

Arylsulfatase G, a novel lysosomal sulfatase. PubMed ID: 18283100

Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice. PubMed ID: 22689975

Molecular characterization of arylsulfatase G: expression, processing, glycosylation, transport, and activity. PubMed ID: 25135642

A homozygous founder missense variant in arylsulfatase G abolishes its enzymatic activity causing atypical Usher syndrome in humans. PubMed ID: 29300381

Accumulation of rare variants in the arylsulfatase G (ARSG) gene in task-specific dystonia. PubMed ID: 25825126