Details for: RUFY3

Gene ID: 22902

Symbol: RUFY3

Ensembl ID: ENSG00000018189

Description: RUN and FYVE domain containing 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.94
    Marker Score: 133,227
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.12
    Marker Score: 55,365
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.05
    Marker Score: 3,692
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.96
    Marker Score: 15,528
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.95
    Marker Score: 62,894
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.86
    Marker Score: 11,965
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.84
    Marker Score: 13,141
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.83
    Marker Score: 3,980
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.76
    Marker Score: 3,172
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.72
    Marker Score: 3,652
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.65
    Marker Score: 1,396
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.62
    Marker Score: 766
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.56
    Marker Score: 1,499
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.54
    Marker Score: 6,078
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.5
    Marker Score: 1,648
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.5
    Marker Score: 49,729
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.49
    Marker Score: 13,368
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.41
    Marker Score: 91,622
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.4
    Marker Score: 8,059
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.4
    Marker Score: 10,011
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.39
    Marker Score: 18,358
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.38
    Marker Score: 35,543
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.35
    Marker Score: 2,032
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.33
    Marker Score: 9,642
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.32
    Marker Score: 17,465
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.25
    Marker Score: 83,153
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.25
    Marker Score: 4,325
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.21
    Marker Score: 4,854
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.2
    Marker Score: 923
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.2
    Marker Score: 1,150
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.17
    Marker Score: 8,401
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.17
    Marker Score: 1,673
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.16
    Marker Score: 2,428
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.15
    Marker Score: 678
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.14
    Marker Score: 4,910
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.13
    Marker Score: 1,887
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.09
    Marker Score: 19,659
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.07
    Marker Score: 2,347
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.05
    Marker Score: 612
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.04
    Marker Score: 5,813
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.03
    Marker Score: 124,795
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2
    Marker Score: 1,506
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.97
    Marker Score: 20,374
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.95
    Marker Score: 31,376
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.92
    Marker Score: 1,660
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.9
    Marker Score: 3,868
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.9
    Marker Score: 2,366
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.89
    Marker Score: 17,921
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.85
    Marker Score: 7,552
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.83
    Marker Score: 15,723
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.82
    Marker Score: 943
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.79
    Marker Score: 1,069
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.79
    Marker Score: 568
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.77
    Marker Score: 714
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.76
    Marker Score: 1,949
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.76
    Marker Score: 1,023
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.76
    Marker Score: 1,875
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.74
    Marker Score: 586
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.72
    Marker Score: 6,123
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.71
    Marker Score: 959
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.69
    Marker Score: 558
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.68
    Marker Score: 460
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.66
    Marker Score: 2,788
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.65
    Marker Score: 1,147
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.62
    Marker Score: 622
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.61
    Marker Score: 895
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.6
    Marker Score: 1,526
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2,434
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.57
    Marker Score: 916
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.57
    Marker Score: 533
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.56
    Marker Score: 1,687
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.52
    Marker Score: 1,838
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.52
    Marker Score: 1,297
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.51
    Marker Score: 559
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.51
    Marker Score: 819
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.48
    Marker Score: 1,561
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.45
    Marker Score: 1,790
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.43
    Marker Score: 363
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.42
    Marker Score: 1,714
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.42
    Marker Score: 367
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.41
    Marker Score: 1,334
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.41
    Marker Score: 790
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.38
    Marker Score: 500
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.35
    Marker Score: 636
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.34
    Marker Score: 797
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.33
    Marker Score: 45,180
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.32
    Marker Score: 1,871
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.31
    Marker Score: 636
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.31
    Marker Score: 3,730
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.3
    Marker Score: 8,469
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.29
    Marker Score: 852
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.29
    Marker Score: 466
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.29
    Marker Score: 639
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.28
    Marker Score: 3,006
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.27
    Marker Score: 3,186
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.26
    Marker Score: 399
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.24
    Marker Score: 469
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.24
    Marker Score: 1,545
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.23
    Marker Score: 283
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.23
    Marker Score: 7,899

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Domain structure:** The RUFY3 protein contains two distinct domains: a RUN domain and a FYVE domain. These domains are involved in protein-protein interactions and are essential for the regulation of cellular processes. 2. **Cellular localization:** RUFY3 is expressed in multiple cell types, including neurons, astrocytes, and inhibitory interneurons, suggesting its role in nervous system development and function. 3. **Expression patterns:** The RUFY3 gene is significantly expressed in Purkinje cells, cortical cells of the adrenal gland, lens epithelial cells, and other neural cells. **Pathways and Functions:** 1. **Actin filament organization:** RUFY3 is involved in the regulation of actin filament organization, which is essential for cell migration, axon extension, and cell polarity. 2. **Anchoring junction:** RUFY3 interacts with other proteins to regulate anchoring junctions, which are critical for maintaining cell-cell adhesion and tissue structure. 3. **Axonogenesis:** RUFY3 is involved in the regulation of axonogenesis, the process by which axons extend from neurons during development. 4. **Cell migration:** RUFY3 regulates cell migration, which is essential for tissue development and repair. 5. **Intracellular protein transport:** RUFY3 interacts with other proteins to regulate intracellular protein transport, which is critical for maintaining cellular homeostasis. 6. **Positive regulation of axon extension:** RUFY3 promotes axon extension, which is essential for neural development and function. **Clinical Significance:** 1. **Neurological disorders:** Alterations in RUFY3 expression have been implicated in various neurological disorders, including autism spectrum disorder and schizophrenia. 2. **Neurodevelopmental disorders:** RUFY3 is involved in the regulation of neural development, and alterations in its expression have been linked to neurodevelopmental disorders, such as Down syndrome and intellectual disability. 3. **Cancer:** RUFY3 has been implicated in cancer progression, particularly in the regulation of cell migration and invasion. 4. **Neurodegenerative diseases:** RUFY3 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where alterations in its expression have been linked to disease progression. In conclusion, the RUFY3 gene is a critical regulator of various cellular processes, including actin filament organization, cell migration, and axon extension. Its significant expression in multiple cell types, including neurons and astrocytes, suggests its pivotal role in nervous system development and function. Further studies are needed to elucidate the exact mechanisms of RUFY3 regulation and its clinical significance in neurological disorders.

Genular Protein ID: 2497064902

Symbol: RUFY3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7L099 B3KM25 B4DYW7 D9N163 O94948 Q9UI00

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20376209

Title: Rab5(Q79L) interacts with the carboxyl terminus of RUFY3.

PubMed ID: 20376209

DOI: 10.7150/ijbs.6.187

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25766321

Title: PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion.

PubMed ID: 25766321

DOI: 10.1038/cddis.2015.50

Sequence Information:

  • Length: 469
  • Mass: 52965
  • Checksum: E8657DF068BE4113
  • Sequence:
    • MSALTPPTDM PTPTTDKITQ AAMETIYLCK FRVSMDGEWL CLRELDDISL TPDPEPTHED 
PNYLMANERM NLMNMAKLSI KGLIESALNL GRTLDSDYAP LQQFFVVMEH CLKHGLKAKK 
TFLGQNKSFW GPLELVEKLV PEAAEITASV KDLPGLKTPV GRGRAWLRLA LMQKKLSEYM 
KALINKKELL SEFYEPNALM MEEEGAIIAG LLVGLNVIDA NFCMKGEDLD SQVGVIDFSM 
YLKDGNSSKG TEGDGQITAI LDQKNYVEEL NRHLNATVNN LQAKVDALEK SNTKLTEELA 
VANNRIITLQ EEMERVKEES SYILESNRKG PKQDRTAEGQ ALSEARKHLK EETQLRLDVE 
KELEMQISMR QEMELAMKML EKDVCEKQDA LVSLRQQLDD LRALKHELAF KLQSSDLGVK 
QKSELNSRLE EKTNQMAATI KQLEQSEKDL VKQAKTLNSA ANKLIPKHH

Genular Protein ID: 1754357071

Symbol: B4DKC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DKC2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 2 GenomeRNAi 1 InterPro 4 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 453
  • Mass: 51402
  • Checksum: 80728B74E3C6154A
  • Sequence:
    • MDGEWLCLRE LDDISLTPDP EPTHEDSWED LTDLVEQMRD DTEDPNYLMA NERMNLMNMA 
KLSIKGLIES ALNLGRTLDS DYAPLQQFFV VMEHCLKHGL KAKKTFLGQN KSFWGPLELV 
EKLVPEAAEI TASVKDLPGL KTPVGRGRAW LRLALMQKKL SEYMKALINK KELLSEFYEP 
NALMMEEEGA IIAGLLVGLN VIDANFCMKG EDLDSQVGVI DFSMYLKDGN SSKGTEGDGQ 
ITAILDQKNY VEELNRHLNA TVNNLQAKVD ALEKSNTKLT EELAVANNRI ITLQEEMERV 
KEESSYILES NRKGPKQDRT AEGQALSEAR KHLKEETQLR LDVEKELEMQ ISMRQEMELA 
MKMLEKDVCE KQDALVSLRQ QLDDLRALKH ELAFKLQSSD LGVKQKSELN SRLEEKTNQM 
AATIKQLEQS EKDLVKQAKT LNSAANKLIP KHH

Genular Protein ID: 2279326302

Symbol: B4DG59_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DG59

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 2 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 435
  • Mass: 49189
  • Checksum: 8A3E07DFFD3F9193
  • Sequence:
    • MDGEWLCLRE LDDISLTPDP EPTHEDPNYL MANERMNLMN MAKLSIKGLI ESALNLGRTL 
DSDYAPLQQF FVVMEHCLKH GLKAKKTFLG QNKSFWGPLE LVEKLVPEAA EITASVKDLP 
GLKTPVGRGR AWLRLALMQK KLSEYMKALI NKKELLSELY EPNALMMEEE GAIIAGLLVG 
LNVIDANFCM KGEDLDSQVG VIDFSMYLKD GNSSKGTEGD GQITAILDQK NYVEELNRHL 
NATVNNLQAK VDALEKSNTK LTEELAVANN RIITLQEEME RVKEESSYIL ESNRKGPKQD 
RTAEGQALSE ARKHLKEETQ LRLDVEKELE MQISMRQEME LAMKMLEKDV CEKQDALVSL 
RQQLDDLRAL KHELAFKLQS SDLGVKQKSE LNSRLEEKTN QMAATIKQLE QSEKDLVKQA 
KTLNSAANKL IPKHH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.