Details for: BTBD3

Gene ID: 22903

Symbol: BTBD3

Ensembl ID: ENSG00000132640

Description: BTB domain containing 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.07
    Marker Score: 72,246
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.44
    Marker Score: 13,113
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.33
    Marker Score: 12,239
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.85
    Marker Score: 13,985
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.74
    Marker Score: 4,173
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.7
    Marker Score: 57,298
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.67
    Marker Score: 15,728
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.65
    Marker Score: 966
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.55
    Marker Score: 6,427
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.54
    Marker Score: 17,300
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.52
    Marker Score: 57,810
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.51
    Marker Score: 6,517
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.48
    Marker Score: 6,021
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.47
    Marker Score: 3,381
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.44
    Marker Score: 3,534
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.43
    Marker Score: 13,571
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.35
    Marker Score: 757
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.34
    Marker Score: 4,600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.33
    Marker Score: 2,056
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.3
    Marker Score: 3,695
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.25
    Marker Score: 2,185
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.23
    Marker Score: 75,929
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.21
    Marker Score: 488
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.19
    Marker Score: 41,207
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.18
    Marker Score: 1,023
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.18
    Marker Score: 344
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.12
    Marker Score: 11,595
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.08
    Marker Score: 561
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.07
    Marker Score: 9,171
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.05
    Marker Score: 1,474
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.05
    Marker Score: 1,407
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.04
    Marker Score: 978
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16,125
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.03
    Marker Score: 615
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.02
    Marker Score: 1,147
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.02
    Marker Score: 3,929
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1
    Marker Score: 299
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1
    Marker Score: 36,817
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,763
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1
    Marker Score: 7,641
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,987
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.99
    Marker Score: 370
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.98
    Marker Score: 8,535
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.97
    Marker Score: 796
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.96
    Marker Score: 1,610
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.96
    Marker Score: 3,204
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.95
    Marker Score: 846
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.95
    Marker Score: 662
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.94
    Marker Score: 20,011
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.92
    Marker Score: 536
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,727
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1,818
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1,445
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.89
    Marker Score: 979
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 4,994
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.87
    Marker Score: 1,841
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.87
    Marker Score: 4,026
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.86
    Marker Score: 1,636
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.85
    Marker Score: 919
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.85
    Marker Score: 419
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.84
    Marker Score: 3,500
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.83
    Marker Score: 261
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.83
    Marker Score: 939
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.81
    Marker Score: 3,007
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.79
    Marker Score: 3,312
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.79
    Marker Score: 1,163
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 603
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.78
    Marker Score: 844
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.76
    Marker Score: 1,677
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.76
    Marker Score: 4,576
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.76
    Marker Score: 15,147
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.75
    Marker Score: 928
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.74
    Marker Score: 7,485
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.74
    Marker Score: 907
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.73
    Marker Score: 696
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.73
    Marker Score: 209
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.72
    Marker Score: 901
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.72
    Marker Score: 750
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.72
    Marker Score: 228
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.72
    Marker Score: 340
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.71
    Marker Score: 759
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.71
    Marker Score: 815
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.7
    Marker Score: 365
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 635
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.69
    Marker Score: 357
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.69
    Marker Score: 534
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.69
    Marker Score: 333
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.69
    Marker Score: 10,336
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.69
    Marker Score: 1,396
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.68
    Marker Score: 588
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.68
    Marker Score: 172

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The BTBD3 gene, also known as BTB domain-containing 3, is a member of the BTB/POZ domain-containing protein family. This gene encodes a protein with a BTB domain, a structural motif that facilitates protein-protein interactions. The BTBD3 protein is highly expressed in various cell types, including cortical neurons, oligodendrocytes, and granule cells, suggesting its involvement in neural development and function. Notably, BTBD3 is also expressed in non-neuronal cells, such as adrenal gland cortical cells and ovarian stromal cells, indicating its broader tissue specificity. **Pathways and Functions:** The BTBD3 gene is involved in several cellular pathways, including: 1. **Cerebral cortex development**: BTBD3 plays a crucial role in the development of the cerebral cortex, a complex structure responsible for higher-order cognitive functions. This gene is highly expressed in cortical neurons, where it may regulate the formation and maturation of dendrites. 2. **Dendrite morphogenesis**: BTBD3 is involved in the morphogenesis of dendrites, the branching extensions of neurons that receive synaptic inputs. This gene may regulate the formation and maintenance of dendritic structures. 3. **Neurogenesis**: BTBD3 is also involved in neurogenesis, the process by which new neurons are generated in the adult brain. This gene may regulate the proliferation and differentiation of neural stem cells. 4. **Protein binding**: BTBD3 interacts with various proteins, including transcription factors and signaling molecules, which may influence its functions in cellular processes. **Clinical Significance:** Dysregulation of the BTBD3 gene has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: Mutations in BTBD3 have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Neurodegenerative diseases**: BTBD3 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it may contribute to the progression of the disease. 3. **Cancer**: BTBD3 has been found to be overexpressed in certain types of cancer, including ovarian cancer, where it may contribute to tumor progression. In conclusion, the BTBD3 gene is a complex and multifaceted gene that plays a critical role in various cellular processes, including neurodevelopment, cell differentiation, and protein interactions. Further research is needed to fully understand the functions of BTBD3 and its implications in human disease.

Genular Protein ID: 2942057320

Symbol: BTBD3_HUMAN

Name: BTB/POZ domain-containing protein 3

UniProtKB Accession Codes:

Q9Y2F9 D3DW19 Q5JY73

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 6 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 522
  • Mass: 58420
  • Checksum: A5E1359C96FF8919
  • Sequence:
    • MVDDKEKNMK CLTFFLMLPE TVKNRSKKSS KKANTSSSSS NSSKLPPVCY EIITLKTKKK 
KMAADIFPRK KPANSSSTSV QQYHQQNLSN NNLIPAPNWQ GLYPTIRERN AMMFNNDLMA 
DVHFVVGPPG GTQRLPGHKY VLAVGSSVFH AMFYGELAED KDEIRIPDVE PAAFLAMLKY 
IYCDEIDLAA DTVLATLYAA KKYIVPHLAR ACVNFLETSL SAKNACVLLS QSCLFEEPDL 
TQRCWEVIDA QAELALKSEG FCDIDFQTLE SILRRETLNA KEIVVFEAAL NWAEVECQRQ 
DLALSIENKR KVLGKALYLI RIPTMALDDF ANGAAQSGVL TLNETNDIFL WYTAAKKPEL 
QFVSKARKGL VPQRCHRFQS CAYRSNQWRY RGRCDSIQFA VDKRVFIAGF GLYGSSCGSA 
EYSAKIELKR QGVVLGQNLS KYFSDGSSNT FPVWFEYPVQ IEPDTFYTAS VILDGNELSY 
FGQEGMTEVQ CGKVTVQFQC SSDSTNGTGV QGGQIPELIF YA

Genular Protein ID: 928342248

Symbol: B4DK27_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DK27

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 8 GO 1 Gene3D 2 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 RefSeq 3 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 371
  • Mass: 41579
  • Checksum: 1762F66339BB47EA
  • Sequence:
    • MFYGELAEDK DEIRIPDVEP AAFLAMLKYI YCDEIDLAAD TVLATLYAAK KYIVPHLARA 
CVNFLETSLS AKNACVLLSQ SCLFEEPDLT QRCWEVIDAQ AELALKSEGF CDIDFQTLES 
ILRRETLNAK EIVVFEAALN WAEVECQRQD LALSIENKRK VLGKALYLIR IPTMALDDFA 
NGAAQSGVLT LNETNDIFLW YTAAKKPELQ FVSKARKGLV PQRCHRFQSC AYRSNQWRYR 
GRCDSIQFAV DKRVFIAGFG LYGSSCGSAE YSAKIELKRQ GVVLGQNLSK YFSDGSSNTF 
PVWFEYPVQI EPDTFYTASV ILDGNELSYF GQEGMTEVQC GKVTVQFQCS SDSTNGTGVQ 
GGQIPELIFY A

Genular Protein ID: 4276098288

Symbol: B4DRI6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DRI6

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 2 GenomeRNAi 1 InterPro 5 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 RefSeq 3 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 565
  • Mass: 62784
  • Checksum: 9EB07200FEF36044
  • Sequence:
    • MPLRSLPVTG HARSLPQSVP CVRVPAEPAG RWISECPGRG LRSGHRARRR TAASPEARRS 
AGETVKNRSK KSSKKANTSS SSSNSSKLPP VCYEIITLKT KKKKMAADIF PRKKPANSSS 
TSVQQYHQQN LSNNNLIPAP NWQGLYPTIR ERNAMMFNND LMADVHFVVG PPGGTQRLPG 
HKYVLAVGSS VFHAMFYGEL AEDKDEIRIP DVEPAAFLAM LKYIYCDEID LAADTVLATL 
YAAKKYIVPH LARACVNFLE TSLSAKNACV LLSQSCLFEE PDLTQRCWEV IDAQAELALK 
SEGFCDIDFQ TLESILRRET LNAKEIVVFE AALNWAEVEC QRQDLALSIE NKRKVLGKAL 
YLIRIPTMAL DDFANGAAQS GVLTLNETND IFLWYTAAKK PELQFVSKAR KGLVPQRCHR 
FQSCAYRSNQ WRYRGRCDSI QFAVDKRVFI AGFGLYGSSC GSAEYSAKIE LKRQGVVLGQ 
NLSKYFSDGS SNTFPVWFEY PVQIEPDTFY TASVILDGNE LSYFGQEGMT EVQCGKVTVQ 
FQCSSDSTNG TGVQGGQIPE LIFYA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.