Details for: FAN1

Gene ID: 22909

Symbol: FAN1

Ensembl ID: ENSG00000198690

Description: FANCD2 and FANCI associated nuclease 1

Associated with

Other Information

Genular Protein ID: 2657961482

Symbol: FAN1_HUMAN

Name: Myotubularin-related protein 15

UniProtKB Accession Codes:

Q9Y2M0 A8K4M2 Q86WU8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 EPD 1 Ensembl 9 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 10 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 7 SAM 1 SMART 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20603015

Title: Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.

PubMed ID: 20603015

DOI: 10.1016/j.cell.2010.06.021

PubMed ID: 20603016

Title: Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.

PubMed ID: 20603016

DOI: 10.1016/j.cell.2010.06.022

PubMed ID: 20935496

Title: Human KIAA1018/FAN1 localizes to stalled replication forks via its ubiquitin-binding domain.

PubMed ID: 20935496

DOI: 10.4161/cc.9.19.13207

PubMed ID: 20603073

Title: A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

PubMed ID: 20603073

DOI: 10.1016/j.molcel.2010.06.023

PubMed ID: 20671156

Title: FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair.

PubMed ID: 20671156

DOI: 10.1126/science.1192656

PubMed ID: 21115814

Title: KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents.

PubMed ID: 21115814

DOI: 10.1073/pnas.1011081107

PubMed ID: 22854063

Title: Human KIAA1018/FAN1 nuclease is a new mitotic substrate of APC/C(Cdh1).

PubMed ID: 22854063

DOI: 10.5732/cjc.012.10144

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24981866

Title: FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain.

PubMed ID: 24981866

DOI: 10.1016/j.celrep.2014.06.001

PubMed ID: 25135477

Title: FANCD2-controlled chromatin access of the Fanconi-associated nuclease FAN1 is crucial for the recovery of stalled replication forks.

PubMed ID: 25135477

DOI: 10.1128/mcb.00457-14

PubMed ID: 24344280

Title: Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism.

PubMed ID: 24344280

DOI: 10.1073/pnas.1309475110

PubMed ID: 25430771

Title: DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.

PubMed ID: 25430771

DOI: 10.1126/science.1258973

PubMed ID: 22772369

Title: FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair.

PubMed ID: 22772369

DOI: 10.1038/ng.2347

Sequence Information:

  • Length: 1017
  • Mass: 114225
  • Checksum: 5E4E0A8A1A158F50
  • Sequence:
    • MMSEGKPPDK KRPRRSLSIS KNKKKASNSI ISCFNNAPPA KLACPVCSKM VPRYDLNRHL 
DEMCANNDFV QVDPGQVGLI NSNVSMVDLT SVTLEDVTPK KSPPPKTNLT PGQSDSAKRE 
VKQKISPYFK SNDVVCKNQD ELRNRSVKVI CLGSLASKLS RKYVKAKKSI DKDEEFAGSS 
PQSSKSTVVK SLIDNSSEIE DEDQILENSS QKENVFKCDS LKEECIPEHM VRGSKIMEAE 
SQKATRECEK SALTPGFSDN AIMLFSPDFT LRNTLKSTSE DSLVKQECIK EVVEKREACH 
CEEVKMTVAS EAKIQLSDSE AKSHSSADDA SAWSNIQEAP LQDDSCLNND IPHSIPLEQG 
SSCNGPGQTT GHPYYLRSFL VVLKTVLENE DDMLLFDEQE KGIVTKFYQL SATGQKLYVR 
LFQRKLSWIK MTKLEYEEIA LDLTPVIEEL TNAGFLQTES ELQELSEVLE LLSAPELKSL 
AKTFHLVNPN GQKQQLVDAF LKLAKQRSVC TWGKNKPGIG AVILKRAKAL AGQSVRICKG 
PRAVFSRILL LFSLTDSMED EDAACGGQGQ LSTVLLVNLG RMEFPSYTIN RKTHIFQDRD 
DLIRYAAATH MLSDISSAMA NGNWEEAKEL AQCAKRDWNR LKNHPSLRCH EDLPLFLRCF 
TVGWIYTRIL SRFVEILQRL HMYEEAVREL ESLLSQRIYC PDSRGRWWDR LALNLHQHLK 
RLEPTIKCIT EGLADPEVRT GHRLSLYQRA VRLRESPSCK KFKHLFQQLP EMAVQDVKHV 
TITGRLCPQR GMCKSVFVME AGEAADPTTV LCSVEELALA HYRRSGFDQG IHGEGSTFST 
LYGLLLWDII FMDGIPDVFR NACQAFPLDL CTDSFFTSRR PALEARLQLI HDAPEESLRA 
WVAATWHEQE GRVASLVSWD RFTSLQQAQD LVSCLGGPVL SGVCRHLAAD FRHCRGGLPD 
LVVWNSQSRH FKLVEVKGPN DRLSHKQMIW LAELQKLGAE VEVCHVVAVG AKSQSLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.