NCBP2 | ENSG00000114503 | NCBI 22916

Details for: NCBP2

Gene ID: 22916

Symbol: NCBP2

Ensembl ID: ENSG00000114503

Description: nuclear cap binding protein subunit 2

Associated with

Abortive elongation of hiv-1 transcript in the absence of tat
(R-HSA-167242)
Axon guidance
(R-HSA-422475)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Fgfr2 alternative splicing
(R-HSA-6803529)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
Gene expression (transcription)
(R-HSA-74160)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of non-coding rna
(R-HSA-194441)
Metabolism of rna
(R-HSA-8953854)
Mrna capping
(R-HSA-72086)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Mrna splicing - minor pathway
(R-HSA-72165)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Processing of capped intronless pre-mrna
(R-HSA-75067)
Processing of intronless pre-mrnas
(R-HSA-77595)
Regulation of expression of slits and robos
(R-HSA-9010553)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription termination
(R-HSA-73856)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 iiia tm
(R-HSA-8851708)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by robo receptors
(R-HSA-376176)
Signal transduction
(R-HSA-162582)
Slbp dependent processing of replication-dependent histone pre-mrnas
(R-HSA-77588)
Slbp independent processing of histone pre-mrnas
(R-HSA-111367)
Snrnp assembly
(R-HSA-191859)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Transcription of the hiv genome
(R-HSA-167172)
Transport of mature mrna derived from an intron-containing transcript
(R-HSA-159236)
Transport of mature mrna derived from an intronless transcript
(R-HSA-159231)
Transport of mature mrnas derived from intronless transcripts
(R-HSA-159234)
Transport of mature transcript to cytoplasm
(R-HSA-72202)
Transport of the slbp dependant mature mrna
(R-HSA-159230)
Transport of the slbp independent mature mrna
(R-HSA-159227)
Viral infection pathways
(R-HSA-9824446)
Alternative mrna splicing, via spliceosome
(GO:0000380)
Cap-dependent translational initiation
(GO:0002191)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Histone mrna metabolic process
(GO:0008334)
Mirna-mediated post-transcriptional gene silencing
(GO:0035195)
Mrna 3'-end processing
(GO:0031124)
Mrna binding
(GO:0003729)
Mrna cis splicing, via spliceosome
(GO:0045292)
Mrna export from nucleus
(GO:0006406)
Mrna metabolic process
(GO:0016071)
Mrna splicing, via spliceosome
(GO:0000398)
Mrna transcription by rna polymerase ii
(GO:0042789)
Nuclear-transcribed mrna catabolic process, nonsense-mediated decay
(GO:0000184)
Nuclear cap binding complex
(GO:0005846)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of mrna 3'-end processing
(GO:0031442)
Positive regulation of rna export from nucleus
(GO:0046833)
Positive regulation of transcription elongation by rna polymerase ii
(GO:0032968)
Primary mirna processing
(GO:0031053)
Protein binding
(GO:0005515)
Regulation of translational initiation
(GO:0006446)
Regulatory ncrna-mediated post-transcriptional gene silencing
(GO:0035194)
Rna 7-methylguanosine cap binding
(GO:0000340)
Rna binding
(GO:0003723)
Rna cap binding
(GO:0000339)
Rna splicing
(GO:0008380)
Snrna binding
(GO:0017069)
Snrna export from nucleus
(GO:0006408)

Other Information

Proteins

Nuclear cap-binding protein subunit 2

Genular Protein ID: 74355826

Symbol: NCBP2_HUMAN

Name: Nuclear cap-binding protein subunit 2

UniProtKB Accession Codes:

P52298 B2RE91 B4DMK7 E9PAR5 Q14924 Q2TS50

Database IDs:

Citations:

PubMed ID: 7651522

Title: A cap-binding protein complex mediating U snRNA export.

PubMed ID: 7651522

DOI: 10.1038/376709a0

PubMed ID: 7478990

Title: Identification of the factors that interact with NCBP, an 80 kDa nuclear cap binding protein.

PubMed ID: 7478990

DOI: 10.1093/nar/23.18.3638

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8601613

Title: A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export.

PubMed ID: 8601613

DOI: 10.1083/jcb.133.1.5

PubMed ID: 9111328

Title: Interaction between the human nuclear cap-binding protein complex and hnRNP F.

PubMed ID: 9111328

DOI: 10.1128/mcb.17.5.2587

PubMed ID: 11551508

Title: Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20.

PubMed ID: 11551508

DOI: 10.1016/s0092-8674(01)00475-5

PubMed ID: 15361857

Title: eIF4G is required for the pioneer round of translation in mammalian cells.

PubMed ID: 15361857

DOI: 10.1038/nsmb824

PubMed ID: 17190602

Title: Human mRNA export machinery recruited to the 5' end of mRNA.

PubMed ID: 17190602

DOI: 10.1016/j.cell.2006.10.044

PubMed ID: 17363367

Title: The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export.

PubMed ID: 17363367

DOI: 10.1074/jbc.m700629200

PubMed ID: 17873884

Title: Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA.

PubMed ID: 17873884

DOI: 10.1038/nsmb1297

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18369367

Title: NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA.

PubMed ID: 18369367

DOI: 10.1038/embor.2008.36

PubMed ID: 19632182

Title: Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.

PubMed ID: 19632182

DOI: 10.1016/j.cell.2009.04.046

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 26382858

Title: mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3.

PubMed ID: 26382858

DOI: 10.1038/ncomms9192

PubMed ID: 34564892

Title: Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia.

PubMed ID: 34564892

DOI: 10.1002/ana.26228

PubMed ID: 11545740

Title: Crystal structure of the human nuclear cap binding complex.

PubMed ID: 11545740

DOI: 10.1016/s1097-2765(01)00299-4

PubMed ID: 12374755

Title: Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex.

PubMed ID: 12374755

DOI: 10.1093/emboj/cdf538

PubMed ID: 12434151

Title: Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.

PubMed ID: 12434151

DOI: 10.1038/nsb874

Sequence Information:

Length: 156
Mass: 18001
Checksum: B6C94F3182A2CC3D
Sequence:

MSGGLLKALR SDSYVELSQY RDQHFRGDNE EQEKLLKKSC TLYVGNLSFY TTEEQIYELF 
SKSGDIKKII MGLDKMKKTA CGFCFVEYYS RADAENAMRY INGTRLDDRI IRTDWDAGFK 
EGRQYGRGRS GGQVRDEYRQ DYDAGRGGYG KLAQNQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NCBP2

Associated with

Other Information

A cap-binding protein complex mediating U snRNA export. PubMed ID: 7651522

Identification of the factors that interact with NCBP, an 80 kDa nuclear cap binding protein. PubMed ID: 7478990

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export. PubMed ID: 8601613

Interaction between the human nuclear cap-binding protein complex and hnRNP F. PubMed ID: 9111328

Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. PubMed ID: 11551508

eIF4G is required for the pioneer round of translation in mammalian cells. PubMed ID: 15361857

Human mRNA export machinery recruited to the 5' end of mRNA. PubMed ID: 17190602

The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export. PubMed ID: 17363367

Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA. PubMed ID: 17873884

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA. PubMed ID: 18369367

Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. PubMed ID: 19632182

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. PubMed ID: 26382858

Dominant KPNA3 Mutations Cause Infantile-Onset Hereditary Spastic Paraplegia. PubMed ID: 34564892

Crystal structure of the human nuclear cap binding complex. PubMed ID: 11545740

Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex. PubMed ID: 12374755

Structural basis of m7GpppG binding to the nuclear cap-binding protein complex. PubMed ID: 12434151