Details for: ATF6
Associated with
Other Information
Genular Protein ID: 1663499513
Symbol: ATF6A_HUMAN
Name: Cyclic AMP-dependent transcription factor ATF-6 alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9271374
PubMed ID: 9837962
Title: Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins; involvement of basic-leucine zipper transcription factors.
PubMed ID: 9837962
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2516827
Title: Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.
PubMed ID: 2516827
PubMed ID: 10564271
Title: Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress.
PubMed ID: 10564271
PubMed ID: 11163209
Title: ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.
PubMed ID: 11163209
PubMed ID: 11779464
Title: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.
PubMed ID: 11779464
PubMed ID: 11158310
Title: Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response.
PubMed ID: 11158310
PubMed ID: 11483355
Title: The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis.
PubMed ID: 11483355
PubMed ID: 12782636
Title: A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.
PubMed ID: 12782636
PubMed ID: 14699159
Title: Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response.
PubMed ID: 14699159
PubMed ID: 17765680
Title: Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.
PubMed ID: 17765680
PubMed ID: 22682248
Title: A thrombospondin-dependent pathway for a protective ER stress response.
PubMed ID: 22682248
PubMed ID: 26063662
Title: Mutation of ATF6 causes autosomal recessive achromatopsia.
PubMed ID: 26063662
PubMed ID: 26029869
Title: Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia.
PubMed ID: 26029869
DOI: 10.1038/ng.3319
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 31875558
Title: LACC1 required for NOD2-induced, ER stress-mediated innate immune outcomes in human macrophages and LACC1 risk variants modulate these outcomes.
PubMed ID: 31875558
PubMed ID: 34623328
Title: Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.
PubMed ID: 34623328
DOI: 10.1172/jci145472
Sequence Information:
- Length: 670
- Mass: 74585
- Checksum: 5EBD08CF4121D41A
- Sequence:
MGEPAGVAGT MESPFSPGLF HRLDEDWDSA LFAELGYFTD TDELQLEAAN ETYENNFDNL DFDLDLMPWE SDIWDINNQI CTVKDIKAEP QPLSPASSSY SVSSPRSVDS YSSTQHVPEE LDLSSSSQMS PLSLYGENSN SLSSAEPLKE DKPVTGPRNK TENGLTPKKK IQVNSKPSIQ PKPLLLPAAP KTQTNSSVPA KTIIIQTVPT LMPLAKQQPI ISLQPAPTKG QTVLLSQPTV VQLQAPGVLP SAQPVLAVAG GVTQLPNHVV NVVPAPSANS PVNGKLSVTK PVLQSTMRNV GSDIAVLRRQ QRMIKNRESA CQSRKKKKEY MLGLEARLKA ALSENEQLKK ENGTLKRQLD EVVSENQRLK VPSPKRRVVC VMIVLAFIIL NYGPMSMLEQ DSRRMNPSVS PANQRRHLLG FSAKEAQDTS DGIIQKNSYR YDHSVSNDKA LMVLTEEPLL YIPPPPCQPL INTTESLRLN HELRGWVHRH EVERTKSRRM TNNQQKTRIL QGALEQGSNS QLMAVQYTET TSSISRNSGS ELQVYYASPR SYQDFFEAIR RRGDTFYVVS FRRDHLLLPA TTHNKTTRPK MSIVLPAINI NENVINGQDY EVMMQIDCQV MDTRILHIKS SSVPPYLRDQ QRNQTNTFFG SPPAATEATH VVSTIPESLQ
Genular Protein ID: 4245291856
Symbol: A0A7P0Z421_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
Sequence Information:
- Length: 689
- Mass: 76932
- Checksum: 200EDD246F30A1E4
- Sequence:
MGEPAGVAGT MESPFSPGLF HRLDEDWDSA LFAELGYFTD TDELQLEAAN ETYENNFDNL DFDLDLMPWE SDIWDINNQI CTVKDIKAEP QPLSPASSSY SVSSPRSVDS YSSTQHVPEE LDLSSSSQMS PLSLYGENSN SLSSAEPLKE DKPVTGPRNK TENGLTPKKK IQVNSKPSIQ PKPLLLPAAP KTQTNSSVPA KTIIIQTVPT LMPLAKQQPI ISLQPAPTKG QTVLLSQPTV VQLQAPGVLP SAQPVLAVAG GVTQLPNHVV NVVPAPSANS PVNGKLSVTK PVLQSTMRNV GSDIAVLRRQ QRMIKNRESA CQSRKKKKEY MLGLEARLKA ALSENEQLKK ENGTLKRQLD EVVSENQRLK VPSPKRRVVC VMIVLAFIIL NYGPMSMLEQ DSRRMNPSVS PANQRRHLLG FSAKEAQDTS DGIIQKNSYS KLLRNLRYKE TNFVHPCFRY DHSVSNDKAL MVLTEEPLLY IPPPPCQPLI NTTESLRLNH ELRGWVHRHE VERTKSRRMT NNQQKTRILQ GALEQGSNSQ LMAVQYTETT SSISRNSGSE LQVYYASPRS YQDFFEAIRR RGDTFYVVSF RRDHLLLPAT THNKTTRPKM SIVLPAININ ENVINGQDYE VMMQIDCQVM DTRILHIKSS SVPPYLRDQQ RNQTNTFFGS PPAATEATHV VSTIPESLQ
Genular Protein ID: 1841980815
Symbol: A8K383_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 670
- Mass: 74594
- Checksum: 315A33EC6670857A
- Sequence:
MGEPAGVAGT MESPFSPGLF HRLDEDWDSA LFAELGYFTD TDELQLEAAN ETYENNFDNL DFDLDLMPWE SDIWDINNQI CTVKDIKAEP QPLSPASSSY SVSSPRSVDS YSSTQHVPEE LDLSSSSQMS PLSLYGENSN SLSSPEPLKE DKPVTGSRNK TENGLTPKKK IQVNSKPPIQ PKPLLLPAAP KTQTNSSVPA KTIIIRTVPT LMPLAKQQPI ISLQPAPTKG QTVLLSQPTV VQPQAPGVLP SAQPVLAVAG GVTQLPNHVV NVVPAPSANS PVNGKLSVTK PVLQSTMRNV GSDIAVLRRQ QRMIKNRESA CQSRKKKKEY MLGLEARLKA ALSENEQLKK ENGTLKRQLD EVVSENQRLK VPSPKRRVVC VMIVLAFIIL NYGPMSMLEQ DSRRMNPSVS PANQRRHLLG FSAKEAQDTS DGIIQKNSYR YDHSVSNDKA LMVLTEEPLL YIPPPPCQPL INTTESLRLN HELRGWVHRH EVERTKSRRM TNNQQKARIL QGALEQGSNS QLMAVQYTET TSSISRDSGS ELQVYYASPR SYQDFFEAIR RRGDTFYVVS FRRDHLLLPA TTHNKTTRPK MSIVLPAINI NENVINGQDY EVMMQIDCQV MDTRILHIKS SSVPPYLRDQ QRNQTNTFFG SPPAATEATH VVSTIPESLQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.