DKK1 | ENSG00000107984 | NCBI 22943

Details for: DKK1

Gene ID: 22943

Symbol: DKK1

Ensembl ID: ENSG00000107984

Description: dickkopf WNT signaling pathway inhibitor 1

Associated with

Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Negative regulation of tcf-dependent signaling by wnt ligand antagonists
(R-HSA-3772470)
Pou5f1 (oct4), sox2, nanog repress genes related to differentiation
(R-HSA-2892245)
Signaling by lrp5 mutants
(R-HSA-5339717)
Signaling by wnt
(R-HSA-195721)
Signaling by wnt in cancer
(R-HSA-4791275)
Signal transduction
(R-HSA-162582)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation of pluripotent stem cells
(R-HSA-452723)
Canonical wnt signaling pathway
(GO:0060070)
Cell morphogenesis
(GO:0000902)
Co-receptor binding
(GO:0039706)
Early endosome membrane
(GO:0031901)
Embryonic limb morphogenesis
(GO:0030326)
Endocardial cushion development
(GO:0003197)
Endoderm formation
(GO:0001706)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Face morphogenesis
(GO:0060325)
Forebrain development
(GO:0030900)
Growth factor activity
(GO:0008083)
Hair follicle development
(GO:0001942)
Heart induction
(GO:0003129)
Heart valve development
(GO:0003170)
Learning or memory
(GO:0007611)
Limb development
(GO:0060173)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Mesoderm formation
(GO:0001707)
Motor learning
(GO:0061743)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cardiac muscle cell differentiation
(GO:2000726)
Negative regulation of mesodermal cell fate specification
(GO:0042662)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of ossification
(GO:0030279)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of presynapse assembly
(GO:1905607)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of smad protein signal transduction
(GO:0060392)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of wnt-frizzled-lrp5/6 complex assembly
(GO:1904723)
Negative regulation of wnt signaling pathway
(GO:0030178)
Plasma membrane
(GO:0005886)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of midbrain dopaminergic neuron differentiation
(GO:1904958)
Positive regulation of wnt signaling pathway, calcium modulating pathway
(GO:0045813)
Positive regulation of wnt signaling pathway, planar cell polarity pathway
(GO:2000096)
Protein binding
(GO:0005515)
Receptor antagonist activity
(GO:0048019)
Regulation of dopaminergic neuron differentiation
(GO:1904338)
Regulation of endodermal cell fate specification
(GO:0042663)
Regulation of neuron apoptotic process
(GO:0043523)
Regulation of receptor internalization
(GO:0002090)
Regulation of synaptic transmission, glutamatergic
(GO:0051966)
Response to retinoic acid
(GO:0032526)
Synapse pruning
(GO:0098883)
Wnt signaling pathway involved in somitogenesis
(GO:0090244)

Other Information

Proteins

Dickkopf-related protein 1

Genular Protein ID: 440640454

Symbol: DKK1_HUMAN

Name: Dickkopf-related protein 1

UniProtKB Accession Codes:

O94907 B2RC19

Database IDs:

Citations:

PubMed ID: 10383463

Title: Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling.

PubMed ID: 10383463

DOI: 10.1074/jbc.274.27.19465

PubMed ID: 10570958

Title: Functional and structural diversity of the human Dickkopf gene family.

PubMed ID: 10570958

DOI: 10.1016/s0378-1119(99)00365-0

PubMed ID: 10965128

Title: The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly.

PubMed ID: 10965128

DOI: 10.1159/000015618

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11448771

Title: Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.

PubMed ID: 11448771

DOI: 10.1016/s0960-9822(01)00290-1

PubMed ID: 17143291

Title: Function and biological roles of the Dickkopf family of Wnt modulators.

PubMed ID: 17143291

DOI: 10.1038/sj.onc.1210054

PubMed ID: 17804805

Title: R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.

PubMed ID: 17804805

DOI: 10.1073/pnas.0702305104

PubMed ID: 19746449

Title: A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V).

PubMed ID: 19746449

DOI: 10.1002/jcb.22335

PubMed ID: 20093360

Title: Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

PubMed ID: 20093360

DOI: 10.1074/jbc.m109.092130

PubMed ID: 21805521

Title: Human Dickkopf-1 (huDKK1) protein: characterization of glycosylation and determination of disulfide linkages in the two cysteine-rich domains.

PubMed ID: 21805521

DOI: 10.1002/pro.705

PubMed ID: 27524201

Title: Structure of the dual-mode wnt regulator Kremen1 and insight into ternary complex formation with LRP6 and Dickkopf.

PubMed ID: 27524201

DOI: 10.1016/j.str.2016.06.020

PubMed ID: 22000856

Title: Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.

PubMed ID: 22000856

DOI: 10.1016/j.devcel.2011.09.003

Sequence Information:

Length: 266
Mass: 28672
Checksum: 5E878B2CCE4236BA
Sequence:

MMALGAAGAT RVFVAMVAAA LGGHPLLGVS ATLNSVLNSN AIKNLPPPLG GAAGHPGSAV 
SAAPGILYPG GNKYQTIDNY QPYPCAEDEE CGTDEYCASP TRGGDAGVQI CLACRKRRKR 
CMRHAMCCPG NYCKNGICVS SDQNHFRGEI EETITESFGN DHSTLDGYSR RTTLSSKMYH 
TKGQEGSVCL RSSDCASGLC CARHFWSKIC KPVLKEGQVC TKHRRKGSHG LEIFQRCYCG 
EGLSCRIQKD HHQASNSSRL HTCQRH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DKK1

Associated with

Other Information

Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. PubMed ID: 10383463

Functional and structural diversity of the human Dickkopf gene family. PubMed ID: 10570958

The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly. PubMed ID: 10965128

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. PubMed ID: 11448771

Function and biological roles of the Dickkopf family of Wnt modulators. PubMed ID: 17143291

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. PubMed ID: 17804805

A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V). PubMed ID: 19746449

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. PubMed ID: 20093360

Human Dickkopf-1 (huDKK1) protein: characterization of glycosylation and determination of disulfide linkages in the two cysteine-rich domains. PubMed ID: 21805521

Structure of the dual-mode wnt regulator Kremen1 and insight into ternary complex formation with LRP6 and Dickkopf. PubMed ID: 27524201

Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. PubMed ID: 22000856