Details for: P2RX2

Gene ID: 22953

Symbol: P2RX2

Ensembl ID: ENSG00000187848

Description: purinergic receptor P2X 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.03
    Marker Score: 2617
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48061
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5357
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.93
    Marker Score: 744
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 476
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.44
    Marker Score: 243
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.41
    Marker Score: 776
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.41
    Marker Score: 117
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.33
    Marker Score: 506
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.31
    Marker Score: 1873
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.3
    Marker Score: 350
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.26
    Marker Score: 327.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.24
    Marker Score: 3734.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.23
    Marker Score: 383
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.23
    Marker Score: 239.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.22
    Marker Score: 186
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.22
    Marker Score: 114
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.21
    Marker Score: 210.5
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.21
    Marker Score: 85
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.21
    Marker Score: 437
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.18
    Marker Score: 359
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.15
    Marker Score: 59
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.15
    Marker Score: 71
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.15
    Marker Score: 420
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.14
    Marker Score: 140
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.12
    Marker Score: 51
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1
    Marker Score: 59
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.09
    Marker Score: 161
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.09
    Marker Score: 144
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.09
    Marker Score: 369
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.08
    Marker Score: 63
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.08
    Marker Score: 197
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 76
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.07
    Marker Score: 169.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.06
    Marker Score: 12.5
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 67
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.05
    Marker Score: 92
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.05
    Marker Score: 84
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.04
    Marker Score: 141
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.04
    Marker Score: 84
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.04
    Marker Score: 277
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.04
    Marker Score: 61
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: follicular dendritic cell (CL0000442)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.04
    Marker Score: 56
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.04
    Marker Score: 146
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.03
    Marker Score: 61.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.03
    Marker Score: 43
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.03
    Marker Score: 70
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.03
    Marker Score: 40
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.03
    Marker Score: 56
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.03
    Marker Score: 11

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Other Information

**Key Characteristics:** 1. **Structure:** The P2RX2 receptor is a ligand-gated ion channel that binds to extracellular ATP, leading to the influx of cations, including calcium, into the cell. 2. **Expression:** The P2RX2 gene is widely expressed in various tissues, including the brain, heart, lungs, and gastrointestinal tract. 3. **Function:** The P2RX2 receptor is involved in the regulation of calcium ion transport, neurotransmission, and cellular signaling pathways. 4. **Signaling pathways:** The P2RX2 receptor is involved in multiple signaling pathways, including those related to pain, inflammation, and cellular development. **Pathways and Functions:** 1. **Calcium ion transport:** The P2RX2 receptor regulates calcium ion transport into the cell, which is essential for various cellular processes, including muscle contraction, neurotransmission, and cell signaling. 2. **Neurotransmission:** The P2RX2 receptor is involved in the regulation of neurotransmission, particularly in the central nervous system, where it plays a role in pain perception and synaptic transmission. 3. **Immune response:** The P2RX2 receptor is expressed on immune cells, including macrophages and T cells, where it regulates the production of cytokines and the activation of immune responses. 4. **Cellular development:** The P2RX2 receptor is involved in the regulation of cellular development, particularly in the development of the nervous system and the gastrointestinal tract. **Clinical Significance:** 1. **Pain management:** The P2RX2 receptor has been implicated in the regulation of pain perception, making it a potential target for pain management therapies. 2. **Neurological disorders:** The P2RX2 receptor has been associated with various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Inflammatory diseases:** The P2RX2 receptor has been implicated in the regulation of inflammatory responses, making it a potential target for therapies aimed at reducing inflammation. 4. **Cancer:** The P2RX2 receptor has been associated with various types of cancer, including colon cancer and lung cancer, where it plays a role in tumor progression and metastasis. In conclusion, the P2RX2 gene encodes for a purinergic receptor that plays a critical role in various physiological and pathological processes, including immune response, cellular development, and neurotransmission. Further research is needed to fully understand the role of the P2RX2 receptor in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 357454935

Symbol: P2RX2_HUMAN

Name: P2X purinoceptor 2

UniProtKB Accession Codes:

Q9UBL9 A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 13 Ensembl 7 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 RNAct 1 Reactome 2 RefSeq 8 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10570044

Title: Molecular and functional characterization of human P2X(2) receptors.

PubMed ID: 10570044

DOI: 10.1124/mol.56.6.1171

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 23345450

Title: Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise.

PubMed ID: 23345450

DOI: 10.1073/pnas.1222285110

PubMed ID: 24211385

Title: A novel P2RX2 mutation in an Italian family affected by autosomal dominant nonsyndromic hearing loss.

PubMed ID: 24211385

DOI: 10.1016/j.gene.2013.10.052

Sequence Information:

  • Length: 471
  • Mass: 51754
  • Checksum: 84CD61DA136EF420
  • Sequence:
    • MAAAQPKYPA GATARRLARG CWSALWDYET PKVIVVRNRR LGVLYRAVQL LILLYFVWYV 
FIVQKSYQES ETGPESSIIT KVKGITTSEH KVWDVEEYVK PPEGGSVFSI ITRVEATHSQ 
TQGTCPESIR VHNATCLSDA DCVAGELDML GNGLRTGRCV PYYQGPSKTC EVFGWCPVED 
GASVSQFLGT MAPNFTILIK NSIHYPKFHF SKGNIADRTD GYLKRCTFHE ASDLYCPIFK 
LGFIVEKAGE SFTELAHKGG VIGVIINWDC DLDLPASECN PKYSFRRLDP KHVPASSGYN 
FRFAKYYKIN GTTTRTLIKA YGIRIDVIVH GQAGKFSLIP TIINLATALT SVGVGSFLCD 
WILLTFMNKN KVYSHKKFDK VCTPSHPSGS WPVTLARVLG QAPPEPGHRS EDQHPSPPSG 
QEGQQGAECG PAFPPLRPCP ISAPSEQMVD TPASEPAQAS TPTDPKGLAQ L

Genular Protein ID: 574443517

Symbol: Q32MC3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q32MC3 H0YGR7

Database IDs:

ARBA 12 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 DNASU 1 EMBL 3 Ensembl 2 GO 6 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 KEGG 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 8 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 349
  • Mass: 38918
  • Checksum: 45DBE19E5A6295FE
  • Sequence:
    • MAAAQPKYPA GATARRLARG CWSALWDYET PKVIVVRNRR LGVLYRAVQL LILLYFVWYV 
FIVQKSYQES ETGPESSIIT KVKGITTSEH KVWDVEEYVK PPEGGSVFSI ITRVEATHSQ 
TQGTCPESIR VHNATCLSDA DCVAGELDML GNGLRTGRCV PYYQGPSKTC EVFGWCPVED 
GASVSQFLGT MAPNFTILIK NSIHYPKFHF SKGNIADRTD GYLKRCTFHE ASDLYCPIFK 
LGFIVEKAGE SFTELAHKGG VIGVIINWDC DLDLPASECN PKYSFRRLDP KHVPASSGYN 
FRFAKYYKIN GTTTRTLIKA YGIRIDVIVH GQVPAPAGGR EVQPDSHHY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.