TRIM32 | ENSG00000119401 | NCBI 22954

Details for: TRIM32

Gene ID: 22954

Symbol: TRIM32

Ensembl ID: ENSG00000119401

Description: tripartite motif containing 32

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cytosolic sensors of pathogen-associated dna
(R-HSA-1834949)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Regulation of innate immune responses to cytosolic dna
(R-HSA-3134975)
Actin ubiquitination
(GO:0007014)
Axon development
(GO:0061564)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Fat cell differentiation
(GO:0045444)
Free ubiquitin chain polymerization
(GO:0010994)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Muscle cell cellular homeostasis
(GO:0046716)
Myosin binding
(GO:0017022)
Negative regulation of cilium assembly
(GO:1902018)
Negative regulation of fibroblast proliferation
(GO:0048147)
Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902230)
Negative regulation of toll-like receptor 4 signaling pathway
(GO:0034144)
Negative regulation of viral transcription
(GO:0032897)
Nucleus
(GO:0005634)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell motility
(GO:2000147)
Positive regulation of chemokine (c-c motif) ligand 20 production
(GO:1903886)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of interleukin-17-mediated signaling pathway
(GO:1903883)
Positive regulation of neurogenesis
(GO:0050769)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of proteolysis
(GO:0045862)
Positive regulation of striated muscle cell differentiation
(GO:0051155)
Positive regulation of tumor necrosis factor-mediated signaling pathway
(GO:1903265)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein k48-linked ubiquitination
(GO:0070936)
Protein polyubiquitination
(GO:0000209)
Protein self-association
(GO:0043621)
Protein ubiquitination
(GO:0016567)
Response to tumor necrosis factor
(GO:0034612)
Response to uv
(GO:0009411)
Rna binding
(GO:0003723)
Striated muscle myosin thick filament
(GO:0005863)
Suppression of viral release by host
(GO:0044790)
Tat protein binding
(GO:0030957)
Tissue homeostasis
(GO:0001894)
Transcription coactivator activity
(GO:0003713)
Translation initiation factor binding
(GO:0031369)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin binding
(GO:0043130)
Ubiquitin protein ligase activity
(GO:0061630)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

E3 ubiquitin-protein ligase TRIM32

Genular Protein ID: 3968206249

Symbol: TRI32_HUMAN

Name: E3 ubiquitin-protein ligase TRIM32

UniProtKB Accession Codes:

Q13049 Q9NQP8

Database IDs:

Citations:

PubMed ID: 7778269

Title: Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins.

PubMed ID: 7778269

DOI: 10.1006/viro.1995.1266

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19349376

Title: TRIM32 is an E3 ubiquitin ligase for dysbindin.

PubMed ID: 19349376

DOI: 10.1093/hmg/ddp167

PubMed ID: 22500027

Title: Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable Bardet-Biedl syndrome protein complex, the BBSome.

PubMed ID: 22500027

DOI: 10.1074/jbc.m112.341487

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26394407

Title: SseK3 is a Salmonella effector that binds TRIM32 and modulates the host's NF-kappaB signalling activity.

PubMed ID: 26394407

DOI: 10.1371/journal.pone.0138529

PubMed ID: 31123703

Title: Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains.

PubMed ID: 31123703

DOI: 10.1126/sciadv.aau8857

PubMed ID: 11822024

Title: Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene.

PubMed ID: 11822024

DOI: 10.1086/339083

PubMed ID: 16606853

Title: Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11).

PubMed ID: 16606853

DOI: 10.1073/pnas.0600158103

PubMed ID: 17994549

Title: Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H.

PubMed ID: 17994549

DOI: 10.1002/humu.20633

PubMed ID: 21344540

Title: BBS genotype-phenotype assessment of a multiethnic patient cohort calls for a revision of the disease definition.

PubMed ID: 21344540

DOI: 10.1002/humu.21480

Sequence Information:

Length: 653
Mass: 71989
Checksum: D83B1595CA8378FD
Sequence:

MAAAAASHLN LDALREVLEC PICMESFTEE QLRPKLLHCG HTICRQCLEK LLASSINGVR 
CPFCSKITRI TSLTQLTDNL TVLKIIDTAG LSEAVGLLMC RSCGRRLPRQ FCRSCGLVLC 
EPCREADHQP PGHCTLPVKE AAEERRRDFG EKLTRLRELM GELQRRKAAL EGVSKDLQAR 
YKAVLQEYGH EERRVQDELA RSRKFFTGSL AEVEKSNSQV VEEQSYLLNI AEVQAVSRCD 
YFLAKIKQAD VALLEETADE EEPELTASLP RELTLQDVEL LKVGHVGPLQ IGQAVKKPRT 
VNVEDSWAME ATASAASTSV TFREMDMSPE EVVASPRASP AKQRGPEAAS NIQQCLFLKK 
MGAKGSTPGM FNLPVSLYVT SQGEVLVADR GNYRIQVFTR KGFLKEIRRS PSGIDSFVLS 
FLGADLPNLT PLSVAMNCQG LIGVTDSYDN SLKVYTLDGH CVACHRSQLS KPWGITALPS 
GQFVVTDVEG GKLWCFTVDR GSGVVKYSCL CSAVRPKFVT CDAEGTVYFT QGLGLNLENR 
QNEHHLEGGF SIGSVGPDGQ LGRQISHFFS ENEDFRCIAG MCVDARGDLI VADSSRKEIL 
HFPKGGGYSV LIREGLTCPV GIALTPKGQL LVLDCWDHCI KIYSYHLRRY STP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TRIM32

Associated with

Other Information

Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins. PubMed ID: 7778269

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

TRIM32 is an E3 ubiquitin ligase for dysbindin. PubMed ID: 19349376

Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable Bardet-Biedl syndrome protein complex, the BBSome. PubMed ID: 22500027

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

SseK3 is a Salmonella effector that binds TRIM32 and modulates the host's NF-kappaB signalling activity. PubMed ID: 26394407

Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains. PubMed ID: 31123703

Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene. PubMed ID: 11822024

Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11). PubMed ID: 16606853

Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H. PubMed ID: 17994549

BBS genotype-phenotype assessment of a multiethnic patient cohort calls for a revision of the disease definition. PubMed ID: 21344540