PAXIP1 | ENSG00000157212 | NCBI 22976

Details for: PAXIP1

Gene ID: 22976

Symbol: PAXIP1

Ensembl ID: ENSG00000157212

Description: PAX interacting protein 1

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Developmental biology
(R-HSA-1266738)
Dna double-strand break repair
(R-HSA-5693532)
Epigenetic regulation of gene expression
(R-HSA-212165)
Formation of wdr5-containing histone-modifying complexes
(R-HSA-9772755)
Gene expression (transcription)
(R-HSA-74160)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Adipose tissue development
(GO:0060612)
Chorion development
(GO:0060717)
Chromatin remodeling
(GO:0006338)
Chromosome
(GO:0005694)
Dna damage response, signal transduction by p53 class mediator
(GO:0030330)
Dna recombination
(GO:0006310)
Dna repair
(GO:0006281)
Endothelial cell migration
(GO:0043542)
Histone methyltransferase complex
(GO:0035097)
Mll3/4 complex
(GO:0044666)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Nuclear matrix
(GO:0016363)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of isotype switching
(GO:0045830)
Positive regulation of isotype switching to igg isotypes
(GO:0048304)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Protein binding
(GO:0005515)
Regulation of cell cycle g2/m phase transition
(GO:1902749)
Response to ionizing radiation
(GO:0010212)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

PAX-interacting protein 1

Genular Protein ID: 1925017984

Symbol: PAXI1_HUMAN

Name: PAX-interacting protein 1

UniProtKB Accession Codes:

Q6ZW49 O15404 Q6N099 Q6ZWH9 Q7Z315 Q86UN0 Q8N4P9 Q96HP2

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 9225980

Title: cDNAs with long CAG trinucleotide repeats from human brain.

PubMed ID: 9225980

DOI: 10.1007/s004390050476

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11940591

Title: The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter.

PubMed ID: 11940591

DOI: 10.1074/jbc.m201657200

PubMed ID: 14576432

Title: BRCT repeats as phosphopeptide-binding modules involved in protein targeting.

PubMed ID: 14576432

DOI: 10.1126/science.1088877

PubMed ID: 15456759

Title: Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation.

PubMed ID: 15456759

DOI: 10.1074/jbc.m411021200

PubMed ID: 17925232

Title: The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

PubMed ID: 17925232

DOI: 10.1016/j.devcel.2007.09.004

PubMed ID: 17500065

Title: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

PubMed ID: 17500065

DOI: 10.1074/jbc.m701574200

PubMed ID: 17178841

Title: Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.

PubMed ID: 17178841

DOI: 10.1128/mcb.01506-06

PubMed ID: 17690115

Title: Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage.

PubMed ID: 17690115

DOI: 10.1093/nar/gkm493

PubMed ID: 17761849

Title: Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

PubMed ID: 17761849

DOI: 10.1126/science.1149042

PubMed ID: 18353733

Title: PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage.

PubMed ID: 18353733

DOI: 10.1016/j.dnarep.2008.02.001

PubMed ID: 19723507

Title: Biochemical characterisation of the SWI/SNF family member HLTF.

PubMed ID: 19723507

DOI: 10.1016/j.bbrc.2009.08.151

PubMed ID: 20088963

Title: PTIP promotes DNA double-strand break repair through homologous recombination.

PubMed ID: 20088963

DOI: 10.1111/j.1365-2443.2009.01379.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23727112

Title: 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

PubMed ID: 23727112

DOI: 10.1016/j.cell.2013.05.023

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 1069
Mass: 121341
Checksum: 78CD535A150E1FC1
Sequence:

MSDQAPKVPE EMFREVKYYA VGDIDPQVIQ LLKAGKAKEV SYNALASHII SEDGDNPEVG 
EAREVFDLPV VKPSWVILSV QCGTLLPVNG FSPESCQIFF GITACLSQVS SEDRSALWAL 
VTFYGGDCQL TLNKKCTHLI VPEPKGEKYE CALKRASIKI VTPDWVLDCV SEKTKKDEAF 
YHPRLIIYEE EEEEEEEEEE VENEEQDSQN EGSTDEKSSP ASSQEGSPSG DQQFSPKSNT 
EKSKGELMFD DSSDSSPEKQ ERNLNWTPAE VPQLAAAKRR LPQGKEPGLI NLCANVPPVP 
GNILPPEVRG NLMAAGQNLQ SSERSEMIAT WSPAVRTLRN ITNNADIQQM NRPSNVAHIL 
QTLSAPTKNL EQQVNHSQQG HTNANAVLFS QVKVTPETHM LQQQQQAQQQ QQQHPVLHLQ 
PQQIMQLQQQ QQQQISQQPY PQQPPHPFSQ QQQQQQQAHP HQFSQQQLQF PQQQLHPPQQ 
LHRPQQQLQP FQQQHALQQQ FHQLQQHQLQ QQQLAQLQQQ HSLLQQQQQQ QIQQQQLQRM 
HQQQQQQQMQ SQTAPHLSQT SQALQHQVPP QQPPQQQQQQ QPPPSPQQHQ LFGHDPAVEI 
PEEGFLLGCV FAIADYPEQM SDKQLLATWK RIIQAHGGTV DPTFTSRCTH LLCESQVSSA 
YAQAIRERKR CVTAHWLNTV LKKKKMVPPH RALHFPVAFP PGGKPCSQHI ISVTGFVDSD 
RDDLKLMAYL AGAKYTGYLC RSNTVLICKE PTGLKYEKAK EWRIPCVNAQ WLGDILLGNF 
EALRQIQYSR YTAFSLQDPF APTQHLVLNL LDAWRVPLKV SAELLMSIRL PPKLKQNEVA 
NVQPSSKRAR IEDVPPPTKK LTPELTPFVL FTGFEPVQVQ QYIKKLYILG GEVAESAQKC 
THLIASKVTR TVKFLTAISV VKHIVTPEWL EECFRCQKFI DEQNYILRDA EAEVLFSFSL 
EESLKRAHVS PLFKAKYFYI TPGICPSLST MKAIVECAGG KVLSKQPSFR KLMEHKQNSS 
LSEIILISCE NDLHLCREYF ARGIDVHNAE FVLTGVLTQT LDYESYKFN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PAXIP1

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence of human chromosome 7. PubMed ID: 12853948

cDNAs with long CAG trinucleotide repeats from human brain. PubMed ID: 9225980

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter. PubMed ID: 11940591

BRCT repeats as phosphopeptide-binding modules involved in protein targeting. PubMed ID: 14576432

Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PubMed ID: 15456759

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. PubMed ID: 17925232

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. PubMed ID: 17500065

Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. PubMed ID: 17178841

Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage. PubMed ID: 17690115

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. PubMed ID: 17761849

PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage. PubMed ID: 18353733

Biochemical characterisation of the SWI/SNF family member HLTF. PubMed ID: 19723507

PTIP promotes DNA double-strand break repair through homologous recombination. PubMed ID: 20088963

Initial characterization of the human central proteome. PubMed ID: 21269460

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. PubMed ID: 23727112

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163