NT5C2 | ENSG00000076685 | NCBI 22978

Details for: NT5C2

Gene ID: 22978

Symbol: NT5C2

Ensembl ID: ENSG00000076685

Description: 5'-nucleotidase, cytosolic II

Associated with

Abacavir adme
(R-HSA-2161522)
Abacavir metabolism
(R-HSA-2161541)
Drug adme
(R-HSA-9748784)
Metabolism
(R-HSA-1430728)
Metabolism of nucleotides
(R-HSA-15869)
Nucleotide catabolism
(R-HSA-8956319)
Purine catabolism
(R-HSA-74259)
Ribavirin adme
(R-HSA-9755088)
5'-nucleotidase activity
(GO:0008253)
Adenosine metabolic process
(GO:0046085)
Allantoin metabolic process
(GO:0000255)
Atp binding
(GO:0005524)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dgmp metabolic process
(GO:0046054)
Gmp 5'-nucleotidase activity
(GO:0050484)
Gmp metabolic process
(GO:0046037)
Identical protein binding
(GO:0042802)
Imp 5'-nucleotidase activity
(GO:0050483)
Imp catabolic process
(GO:0006204)
Imp metabolic process
(GO:0046040)
Metal ion binding
(GO:0046872)
Negative regulation of defense response to virus by host
(GO:0050689)
Nucleoside phosphotransferase activity
(GO:0050146)
Protein binding
(GO:0005515)
Protein k48-linked ubiquitination
(GO:0070936)
Ubiquitin protein ligase activity
(GO:0061630)
Xmp 5'-nucleosidase activity
(GO:0106411)

Other Information

Proteins

5NTC_HUMAN
A8K6K2_HUMAN

Genular Protein ID: 2006589829

Symbol: 5NTC_HUMAN

Name: N/A

UniProtKB Accession Codes:

P49902 B7Z382 D3DR91 Q5JUV5

Database IDs:

Citations:

PubMed ID: 7999131

Title: Molecular cloning of human cytosolic purine 5'-nucleotidase.

PubMed ID: 7999131

DOI: 10.1006/bbrc.1994.2752

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1659319

Title: Nucleoside phosphotransferase activity of human colon carcinoma cytosolic 5'-nucleotidase.

PubMed ID: 1659319

DOI: 10.1016/0003-9861(91)90125-3

PubMed ID: 9371705

Title: Bovine cytosolic IMP/GMP-specific 5'-nucleotidase: cloning and expression of active enzyme in Escherichia coli.

PubMed ID: 9371705

DOI: 10.1042/bj3280483

PubMed ID: 10092873

Title: ATP and phosphate reciprocally affect subunit association of human recombinant High Km 5'-nucleotidase. Role for the C-terminal polyglutamic acid tract in subunit association and catalytic activity.

PubMed ID: 10092873

DOI: 10.1046/j.1432-1327.1999.00099.x

PubMed ID: 12907246

Title: Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy.

PubMed ID: 12907246

DOI: 10.1016/s0006-2952(03)00290-9

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24482476

Title: Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.

PubMed ID: 24482476

DOI: 10.1126/science.1247363

PubMed ID: 17405878

Title: Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition.

PubMed ID: 17405878

DOI: 10.1074/jbc.m700917200

PubMed ID: 21396942

Title: Structural basis for the allosteric regulation and substrate recognition of human cytosolic 5'-nucleotidase II.

PubMed ID: 21396942

DOI: 10.1016/j.jmb.2011.02.059

PubMed ID: 28884889

Title: Novel homozygous missense mutation in NT5C2 underlying hereditary spastic paraplegia SPG45.

PubMed ID: 28884889

DOI: 10.1002/ajmg.a.38414

Sequence Information:

Length: 561
Mass: 64970
Checksum: 4C27D762575E0EA2
Sequence:

MSTSWSDRLQ NAADMPANMD KHALKKYRRE AYHRVFVNRS LAMEKIKCFG FDMDYTLAVY 
KSPEYESLGF ELTVERLVSI GYPQELLSFA YDSTFPTRGL VFDTLYGNLL KVDAYGNLLV 
CAHGFNFIRG PETREQYPNK FIQRDDTERF YILNTLFNLP ETYLLACLVD FFTNCPRYTS 
CETGFKDGDL FMSYRSMFQD VRDAVDWVHY KGSLKEKTVE NLEKYVVKDG KLPLLLSRMK 
EVGKVFLATN SDYKYTDKIM TYLFDFPHGP KPGSSHRPWQ SYFDLILVDA RKPLFFGEGT 
VLRQVDTKTG KLKIGTYTGP LQHGIVYSGG SSDTICDLLG AKGKDILYIG DHIFGDILKS 
KKRQGWRTFL VIPELAQELH VWTDKSSLFE ELQSLDIFLA ELYKHLDSSS NERPDISSIQ 
RRIKKVTHDM DMCYGMMGSL FRSGSRQTLF ASQVMRYADL YAASFINLLY YPFSYLFRAA 
HVLMPHESTV EHTHVDINEM ESPLATRNRT SVDFKDTDYK RHQLTRSISE IKPPNLFPLA 
PQEITHCHDE DDDEEEEEEE E

Genular Protein ID: 210214622

Symbol: A8K6K2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K6K2

Database IDs:

Sequence Information:

Length: 561
Mass: 64960
Checksum: 4C27D76255339EA2
Sequence:

MSTSWSDRLQ NAADMPANMD KHALKKYRRE AYHRVFVNRS LAMEKIKCFG FDMDYTLAVY 
KSPEYESLGF ELTVERLVSI GYPQELLSFA YDSTFPTRGL VFDTLYGNLL KVDAYGNLLV 
CAHGFNFIRG PETREQYPNK FIQRDDTERF YILNTLFNLP ETYLLACLVD FFTNCPRYTS 
CETGFKDGDL FMSYRSMFQD VRDAVDWVHY KGSLKEKTVE NLEKYVVKDG KLPLLLSRMK 
EVGKVFLATN SDYKYTDKIM TYLFDFPHGP KPGSSHRPWQ SYFDLILVDA RKPLFFGEGT 
VLRQVDTKTG KLKIGTYTGP LQHGIVYSGG SSDTICDLLG AKGKDILYIG DHIFGDILKS 
KKRQGWRTFL VIPELAQELH VWTDKSSLFE ELQSLDIFLA ELYKHLDSSS NERPDISSIQ 
RRIKKVTHDM DMCYGMMGSL FRSGSRQTLF ASQVMRYADL YAASFINLLY YPFSYLFRAA 
HVLMPHESTV EHTHVDINEM ESPLATRNRT SVDFKDTDYK RHQLTRSISE IKPPNLFPLA 
SQEITHCHDE DDDEEEEEEE E

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NT5C2

Associated with

Other Information

Molecular cloning of human cytosolic purine 5'-nucleotidase. PubMed ID: 7999131

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nucleoside phosphotransferase activity of human colon carcinoma cytosolic 5'-nucleotidase. PubMed ID: 1659319

Bovine cytosolic IMP/GMP-specific 5'-nucleotidase: cloning and expression of active enzyme in Escherichia coli. PubMed ID: 9371705

ATP and phosphate reciprocally affect subunit association of human recombinant High Km 5'-nucleotidase. Role for the C-terminal polyglutamic acid tract in subunit association and catalytic activity. PubMed ID: 10092873

Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy. PubMed ID: 12907246

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. PubMed ID: 24482476

Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition. PubMed ID: 17405878

Structural basis for the allosteric regulation and substrate recognition of human cytosolic 5'-nucleotidase II. PubMed ID: 21396942

Novel homozygous missense mutation in NT5C2 underlying hereditary spastic paraplegia SPG45. PubMed ID: 28884889