Details for: SV2C
Associated with
Other Information
Genular Protein ID: 3592972075
Symbol: SV2C_HUMAN
Name: Synaptic vesicle glycoprotein 2C
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10470851
Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10470851
PubMed ID: 21483489
Title: Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors.
PubMed ID: 21483489
PubMed ID: 27313224
Title: Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1.
PubMed ID: 27313224
DOI: 10.1042/bcj20160439
PubMed ID: 24240280
Title: Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A.
PubMed ID: 24240280
DOI: 10.1038/nature12732
PubMed ID: 27294781
Title: N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.
PubMed ID: 27294781
DOI: 10.1038/nsmb.3245
PubMed ID: 28252640
Title: Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C.
PubMed ID: 28252640
DOI: 10.1038/srep43588
PubMed ID: 29649119
Title: Crystal structure of botulinum neurotoxin A2 in complex with the human protein receptor SV2C reveals plasticity in receptor binding.
PubMed ID: 29649119
Sequence Information:
- Length: 727
- Mass: 82342
- Checksum: 0411B47057B3279C
- Sequence:
MEDSYKDRTS LMKGAKDIAR EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ DEEDDDDYYP AGETYNGEAN DDEGSSEATE GHDEDDEIYE GEYQGIPSMN QAKDSIVSVG QPKGDEYKDR RELESERRAD EEELAQQYEL IIQECGHGRF QWALFFVLGM ALMADGVEVF VVGFVLPSAE TDLCIPNSGS GWLGSIVYLG MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG YGFFLFCRLL SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV GKHDEAWMIL KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG TWYRRCFVRI RTELYGIWLT FMRCFNYPVR DNTIKLTIVW FTLSFGYYGL SVWFPDVIKP LQSDEYALLT RNVERDKYAN FTINFTMENQ IHTGMEYDNG RFIGVKFKSV TFKDSVFKSC TFEDVTSVNT YFKNCTFIDT VFDNTDFEPY KFIDSEFKNC SFFHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA WNSLDVVTVE LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKSIP ILLASTVLVC GGLVGLCLPD TRTQVLM
Genular Protein ID: 1531710860
Symbol: B3KT41_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
Sequence Information:
- Length: 676
- Mass: 77279
- Checksum: 1F34D410819D521F
- Sequence:
MEDSYKDRTS LMKGAKDIAR EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ DEEDDDDYYP AGETYNGEAN DDEGSSEATE GHDEDDEIYE GEYQGIPSMN QAKDSIVSVG QPKGDEYKDR RELESERRAD EEELAQQYEL IIQECGHGRF QWALFFVLGM ALMADGVEVF VVGFVLPSAE TDLCIPNSGS GWLGSIVYLG MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG YGFFLFCRLL SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV GKHDEAWMIL KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG TWYRRCFVRI RTELYGIWLT FMRCFNYPVR DNTIKLTIVW FTLSFGYYGL SVWFPDVIKP LQSDEYALLT RNVERDKYAN FTINFTMENQ IHTGMEYDNG RFIGVKFKSV TFKDSVFKSC TFEDVTSVNT YFKNCTFIDT VFDNTDFEPY KFIDSEFKNC SFFHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA WNSLDVVTVE LYPTDRRRRV LPCCPG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.