Details for: PCNX1

Gene ID: 22990

Symbol: PCNX1

Ensembl ID: ENSG00000100731

Description: pecanex 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 6.11
    Marker Score: 81,238
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.81
    Marker Score: 5,128
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 3.6
    Marker Score: 1,747
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.02
    Marker Score: 3,659
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.84
    Marker Score: 11,879
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.56
    Marker Score: 1,422
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.53
    Marker Score: 5,559
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.49
    Marker Score: 53,170
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.41
    Marker Score: 47,884
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.37
    Marker Score: 18,166
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.33
    Marker Score: 88,558
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.32
    Marker Score: 34,638
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.25
    Marker Score: 1,314
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.2
    Marker Score: 1,281
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.2
    Marker Score: 81,045
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.17
    Marker Score: 2,495
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.17
    Marker Score: 8,985
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.11
    Marker Score: 4,056
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.09
    Marker Score: 8,070
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.04
    Marker Score: 2,258
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.04
    Marker Score: 45,558
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.03
    Marker Score: 19,129
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.01
    Marker Score: 9,311
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2
    Marker Score: 122,853
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.95
    Marker Score: 1,167
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.91
    Marker Score: 1,005
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.89
    Marker Score: 5,385
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.89
    Marker Score: 551
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.88
    Marker Score: 17,872
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.87
    Marker Score: 591
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.81
    Marker Score: 18,717
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.79
    Marker Score: 15,378
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.79
    Marker Score: 1,378
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.76
    Marker Score: 737
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.73
    Marker Score: 4,134
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.7
    Marker Score: 1,562
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.68
    Marker Score: 2,815
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.66
    Marker Score: 6,757
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.65
    Marker Score: 923
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.65
    Marker Score: 2,880
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.64
    Marker Score: 5,828
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.58
    Marker Score: 1,342
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.57
    Marker Score: 2,425
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.55
    Marker Score: 6,453
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.51
    Marker Score: 478
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.49
    Marker Score: 1,837
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.48
    Marker Score: 1,409
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.47
    Marker Score: 1,585
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.47
    Marker Score: 455
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.46
    Marker Score: 539
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.42
    Marker Score: 708
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.41
    Marker Score: 511
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.4
    Marker Score: 383
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.39
    Marker Score: 472
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.38
    Marker Score: 1,725
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.38
    Marker Score: 829
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.35
    Marker Score: 584
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.33
    Marker Score: 674
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.3
    Marker Score: 332
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.3
    Marker Score: 491
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.29
    Marker Score: 1,605
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.28
    Marker Score: 19,953
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.26
    Marker Score: 629
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.26
    Marker Score: 326
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.24
    Marker Score: 2,910
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.21
    Marker Score: 627
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.21
    Marker Score: 806
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2
    Marker Score: 40,886
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.2
    Marker Score: 1,061
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.19
    Marker Score: 780
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.17
    Marker Score: 1,095
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.16
    Marker Score: 1,315
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.16
    Marker Score: 1,637
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.15
    Marker Score: 2,342
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.12
    Marker Score: 2,803
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.11
    Marker Score: 2,014
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.09
    Marker Score: 5,370
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.09
    Marker Score: 758
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.08
    Marker Score: 3,840
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.08
    Marker Score: 934
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.07
    Marker Score: 340
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.06
    Marker Score: 335
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.06
    Marker Score: 367
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.05
    Marker Score: 571
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.05
    Marker Score: 276
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.04
    Marker Score: 381
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.04
    Marker Score: 315
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.03
    Marker Score: 358
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.02
    Marker Score: 319
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.01
    Marker Score: 366
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1
    Marker Score: 684
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1
    Marker Score: 2,803
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,643
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,868
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.99
    Marker Score: 1,052
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.99
    Marker Score: 1,066
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.99
    Marker Score: 602
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.98
    Marker Score: 5,814
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,383
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.98
    Marker Score: 395

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCNX1 exhibits a unique expression profile, with significant levels detected in cells that line the epithelium of the eye, lung, and brain. Its association with membrane-related pathways suggests a role in cellular adhesion, migration, and signaling. The gene's expression in cardiac muscle cells and lens epithelial cells further hints at its involvement in tissue-specific functions, such as cardiac development and lens transparency. Notably, PCNX1's expression is also observed in astrocytes, a type of glial cell in the brain, which may indicate a broader role in maintaining neural homeostasis. **Pathways and Functions:** PCNX1's involvement in membrane-related pathways suggests a role in regulating cellular adhesion and migration. This could involve interactions with cell surface receptors, such as integrins or cadherins, to modulate cell-cell and cell-extracellular matrix interactions. Additionally, PCNX1 may be involved in signaling pathways, such as the PI3K/AKT or MAPK/ERK pathways, which are critical for regulating cellular growth, differentiation, and survival. The gene's expression in lens epithelial cells and ciliary muscle cells suggests a role in maintaining lens transparency and regulating intraocular pressure. **Clinical Significance:** While PCNX1's clinical significance remains unclear, its expression in various cell types suggests potential applications in disease modeling and therapy. For instance, understanding PCNX1's role in cardiac development and function may provide insights into the pathogenesis of cardiovascular diseases, such as heart failure or arrhythmias. Similarly, PCNX1's expression in lens epithelial cells and ciliary muscle cells may shed light on the molecular mechanisms underlying glaucoma and other ocular disorders. Furthermore, PCNX1's involvement in membrane-related pathways suggests potential therapeutic applications in cancer, where disruptions in cell adhesion and migration are a hallmark of tumorigenesis. In conclusion, PCNX1 is a novel gene with a complex expression profile and potential roles in maintaining cellular homeostasis. Further research is needed to elucidate the functional significance of PCNX1 and its potential applications in disease modeling and therapy. As our understanding of this enigmatic gene continues to evolve, it is likely to reveal new insights into the intricate mechanisms governing cellular behavior and disease.

Genular Protein ID: 708195841

Symbol: PCX1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96RV3 B2RTR6 O94897 Q96AI7 Q9Y2J9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 2 SAM 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 2341
  • Mass: 258676
  • Checksum: 3C38BD853B2F59D1
  • Sequence:
    • MGSQTLQILR QGVWAALSGG WYYDPHQATF VNALHLYLWL FLLGLPFTLY MALPSTMIIV 
AVYCPVIAAV FIVLKMVNYR LHRALDAGEV VDRTANEFTD QRTKAEQGNC STRRKDSNGP 
SDPGGGIEMS EFIREATPPV GCSSRNSYAG LDPSNQIGSG SSRLGTAATI KGDTDTAKTS 
DDISLSLGQS SSLCKEGSEE QDLAADRKLF RLVSNDSFIS IQPSLSSCGQ DLPRDFSDKV 
NLPSHNHHHH VDQSLSSACD TEVASLVPLH SHSYRKDHRP RGVPRTSSSA VAFPDTSLND 
FPLYQQRRGL DPVSELESSK PLSGSKESLV ENSGLSGEFQ LAGDLKINTS QPPTKSGKSK 
PLKAEKSMDS LRSLSTRSSG STESYCSGTD RDTNSTVSSY KSEQTSSTHI ESILSEHEES 
PKAGTKSGRK KECCAGPEEK NSCASDKRTS SEKIAMEAST NSGVHEAKDP TPSDEMHNQR 
GLSTSASEEA NKNPHANEFT SQGDRPPGNT AENKEEKSDK SAVSVDSKVR KDVGGKQKEG 
DVRPKSSSVI HRTASAHKSG RRRTGKKRAS SFDSSRHRDY VCFRGVSGTK PHSAIFCHDE 
DSSDQSDLSR ASSVQSAHQF SSDSSSSTTS HSCQSPEGRY SALKTKHTHK ERGTDSEHTH 
KAHLVPEGTS KKRATRRTSS TNSAKTRARV LSLDSGTVAC LNDSNRLMAP ESIKPLTTSK 
SDLEAKEGEV LDELSLLGRA SQLETVTRSR NSLPNQVAFP EGEEQDAVSG AAQASEEAVS 
FRRERSTFRR QAVRRRHNAG SNPTPPTLLI GSPLSLQDGQ QGQQSTAQVK VQSRPPSQAA 
VLSASASLLV RNGSVHLEAS HDNASAVGGS SLHDELGKFS STLYETGGCD MSLVNFEPAA 
RRASNICDTD SHVSSSTSVR FYPHDVLSLP QIRLNRLLTI DTDLLEQQDI DLSPDLAATY 
GPTEEAAQKV KHYYRFWILP QLWIGINFDR LTLLALFDRN REILENVLAV ILAILVAFLG 
SILLIQGFFR DIWVFQFCLV IASCQYSLLK SVQPDSSSPR HGHNRIIAYS RPVYFCICCG 
LIWLLDYGSR NLTATKFKLY GITFTNPLVF ISARDLVIVF TLCFPIVFFI GLLPQVNTFV 
MYLCEQLDIH IFGGNATTSL LAALYSFICS IVAVALLYGL CYGALKDSWD GQHIPVLFSI 
FCGLLVAVSY HLSRQSSDPS VLFSLVQSKI FPKTEEKNPE DPLSEVKDPL PEKLRNSVSE 
RLQSDLVVCI VIGVLYFAIH VSTVFTVLQP ALKYVLYTLV GFVGFVTHYV LPQVRKQLPW 
HCFSHPLLKT LEYNQYEVRN AATMMWFEKL HVWLLFVEKN IIYPLIVLNE LSSSAETIAS 
PKKLNTELGA LMITVAGLKL LRSSFSSPTY QYVTVIFTVL FFKFDYEAFS ETMLLDLFFM 
SILFNKLWEL LYKLQFVYTY IAPWQITWGS AFHAFAQPFA VPHSAMLFIQ AAVSAFFSTP 
LNPFLGSAIF ITSYVRPVKF WERDYNTKRV DHSNTRLASQ LDRNPGSDDN NLNSIFYEHL 
TRSLQHSLCG DLLLGRWGNY STGDCFILAS DYLNALVHLI EIGNGLVTFQ LRGLEFRGTY 
CQQREVEAIT EGVEEDEGFC CCEPGHIPHM LSFNAAFSQR WLAWEVIVTK YILEGYSITD 
NSAASMLQVF DLRKVLTTYY VKGIIYYVTT SSKLEEWLAN ETMQEGLRLC ADRNYVDVDP 
TFNPNIDEDY DHRLAGISRE SFCVIYLNWI EYCSSRRAKP VDVDKDSSLV TLCYGLCVLG 
RRALGTASHH MSSNLESFLY GLHALFKGDF RISSIRDEWI FADMELLRKV VVPGIRMSIK 
LHQDHFTSPD EYDDPTVLYE AIVSHEKNLV IAHEGDPAWR SAVLANSPSL LALRHVMDDG 
TNEYKIIMLN RRYLSFRVIK VNKECVRGLW AGQQQELVFL RNRNPERGSI QNAKQALRNM 
INSSCDQPIG YPIFVSPLTT SYSDSHEQLK DILGGPISLG NIRNFIVSTW HRLRKGCGAG 
CNSGGNIEDS DTGGGTSCTG NNATTANNPH SNVTQGSIGN PGQGSGTGLH PPVTSYPPTL 
GTSHSSHSVQ SGLVRQSPAR ASVASQSSYC YSSRHSSLRM STTGFVPCRR SSTSQISLRN 
LPSSIQSRLS MVNQMEPSGQ SGLACVQHGL PSSSSSSQSI PACKHHTLVG FLATEGGQSS 
ATDAQPGNTL SPANNSHSRK AEVIYRVQIV DPSQILEGIN LSKRKELQWP DEGIRLKAGR 
NSWKDWSPQE GMEGHVIHRW VPCSRDPGTR SHIDKAVLLV QIDDKYVTVI ETGVLELGAE 
V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.