Details for: ABCF1

Gene ID: 23

Symbol: ABCF1

Ensembl ID: ENSG00000204574

Description: ATP binding cassette subfamily F member 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.16
    Marker Score: 2,824
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9
    Marker Score: 64,727
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.76
    Marker Score: 2,590
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.67
    Marker Score: 1,420
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.64
    Marker Score: 6,448
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6
    Marker Score: 18,026
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.59
    Marker Score: 5,870
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.58
    Marker Score: 3,859
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.57
    Marker Score: 54,370
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.55
    Marker Score: 1,866
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.52
    Marker Score: 921
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.5
    Marker Score: 431
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.49
    Marker Score: 1,009
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.49
    Marker Score: 7,303
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.45
    Marker Score: 968
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.45
    Marker Score: 1,523
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.44
    Marker Score: 1,018
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.43
    Marker Score: 3,259
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.4
    Marker Score: 1,761
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.38
    Marker Score: 940
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.35
    Marker Score: 1,406
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.35
    Marker Score: 1,439
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.34
    Marker Score: 899
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.3
    Marker Score: 819
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.29
    Marker Score: 1,715
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.28
    Marker Score: 853
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.28
    Marker Score: 1,356
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.28
    Marker Score: 553
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.28
    Marker Score: 632
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.27
    Marker Score: 11,121
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.27
    Marker Score: 998
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.25
    Marker Score: 371
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.24
    Marker Score: 364
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.24
    Marker Score: 1,705
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.24
    Marker Score: 14,410
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.24
    Marker Score: 5,137
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.22
    Marker Score: 4,997
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.22
    Marker Score: 2,543
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.21
    Marker Score: 604
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.2
    Marker Score: 2,252
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.18
    Marker Score: 282
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.16
    Marker Score: 563
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.16
    Marker Score: 1,664
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.15
    Marker Score: 575
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.15
    Marker Score: 862
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.15
    Marker Score: 463
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.14
    Marker Score: 5,493
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.14
    Marker Score: 638
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.14
    Marker Score: 421
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.14
    Marker Score: 1,939
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.14
    Marker Score: 1,137
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.14
    Marker Score: 7,251
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.14
    Marker Score: 1,143
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.13
    Marker Score: 3,180
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.13
    Marker Score: 2,668
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.13
    Marker Score: 4,355
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.12
    Marker Score: 638
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.11
    Marker Score: 761
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.11
    Marker Score: 267
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.1
    Marker Score: 290
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.1
    Marker Score: 1,185
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.1
    Marker Score: 340
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.09
    Marker Score: 1,550
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.09
    Marker Score: 743
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.08
    Marker Score: 14,423
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.08
    Marker Score: 2,946
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.08
    Marker Score: 10,715
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.07
    Marker Score: 1,890
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.06
    Marker Score: 775
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.06
    Marker Score: 263
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.06
    Marker Score: 1,686
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.06
    Marker Score: 1,702
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.05
    Marker Score: 303
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.05
    Marker Score: 279
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.05
    Marker Score: 365
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.04
    Marker Score: 245
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.04
    Marker Score: 555
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.04
    Marker Score: 591
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.04
    Marker Score: 693
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.04
    Marker Score: 2,074
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.04
    Marker Score: 227
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.03
    Marker Score: 505
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.03
    Marker Score: 2,347
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.03
    Marker Score: 1,140
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.03
    Marker Score: 2,451
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.03
    Marker Score: 1,794
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.02
    Marker Score: 527
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.02
    Marker Score: 596
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.02
    Marker Score: 5,375
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.02
    Marker Score: 938
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.02
    Marker Score: 1,567
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.01
    Marker Score: 1,661
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.01
    Marker Score: 1,184
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.01
    Marker Score: 471
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.01
    Marker Score: 578
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.01
    Marker Score: 256
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1
    Marker Score: 340
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1
    Marker Score: 231
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1
    Marker Score: 1,071
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1
    Marker Score: 289

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ABCF1 is a member of the ATP-binding cassette (ABC) family of transporters, which are known for their ability to mediate the efflux of various compounds across cellular membranes. ABCF1 exhibits a unique ability to transport a wide range of molecules, including ions, metabolites, and even proteins. Its expression is widespread, with significant presence in various cell types, including extravillous trophoblasts, fibroblasts, and immune cells such as CD8-positive T cells. **Pathways and Functions:** ABCF1 plays a crucial role in several cellular signaling pathways, including: 1. **Abc-family proteins mediated transport**: ABCF1 contributes to the efflux of molecules across the plasma membrane, influencing cellular homeostasis and signaling. 2. **ATP hydrolysis activity**: ABCF1 utilizes ATP hydrolysis to drive the transport of molecules, highlighting its connection to energy metabolism. 3. **Inflammatory response**: ABCF1 has been implicated in the regulation of inflammatory responses, with potential implications for the management of inflammatory diseases. 4. **Translation and translation factor activity**: ABCF1 modulates protein synthesis and translation, affecting cellular growth and differentiation. **Clinical Significance:** The clinical relevance of ABCF1 lies in its potential role in various immune-related disorders. Some of the potential applications of ABCF1 include: 1. **Immunotherapy**: ABCF1 may serve as a target for immunotherapeutic interventions, particularly in the context of cancer and autoimmune diseases. 2. **Inflammatory disorders**: ABCF1's involvement in inflammatory responses suggests that it may be a valuable therapeutic target for the management of inflammatory conditions. 3. **Regulation of immune cell function**: ABCF1's role in modulating immune cell function highlights its potential as a regulator of immune responses, with implications for the treatment of immune-related diseases. In conclusion, ABCF1 is a multifaceted gene that plays a critical role in various cellular processes, including transport, signaling, and translation. Its clinical significance lies in its potential applications in immunotherapy, inflammatory disorder management, and regulation of immune cell function. Further research is necessary to fully elucidate the functional significance of ABCF1 and its potential therapeutic applications.

Genular Protein ID: 2322123127

Symbol: ABCF1_HUMAN

Name: ATP-binding cassette sub-family F member 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9790762

Title: ABC50, a novel human ATP-binding cassette protein found in tumor necrosis factor-alpha-stimulated synoviocytes.

PubMed ID: 9790762

DOI: 10.1006/geno.1998.5480

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 17894550

Title: The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2.

PubMed ID: 17894550

DOI: 10.1042/bj20070811

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19570978

Title: ABC50 promotes translation initiation in mammalian cells.

PubMed ID: 19570978

DOI: 10.1074/jbc.m109.031625

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 845
  • Mass: 95926
  • Checksum: 5C5AA662DF4C99E4
  • Sequence:
  • MPKAPKQQPP EPEWIGDGES TSPSDKVVKK GKKDKKIKKT FFEELAVEDK QAGEEEKVLK 
    EKEQQQQQQQ QQQKKKRDTR KGRRKKDVDD DGEEKELMER LKKLSVPTSD EEDEVPAPKP 
    RGGKKTKGGN VFAALIQDQS EEEEEEEKHP PKPAKPEKNR INKAVSEEQQ PALKGKKGKE 
    EKSKGKAKPQ NKFAALDNEE EDKEEEIIKE KEPPKQGKEK AKKAEQGSEE EGEGEEEEEE 
    GGESKADDPY AHLSKKEKKK LKKQMEYERQ VASLKAANAA ENDFSVSQAE MSSRQAMLEN 
    ASDIKLEKFS ISAHGKELFV NADLYIVAGR RYGLVGPNGK GKTTLLKHIA NRALSIPPNI 
    DVLLCEQEVV ADETPAVQAV LRADTKRLKL LEEERRLQGQ LEQGDDTAAE RLEKVYEELR 
    ATGAAAAEAK ARRILAGLGF DPEMQNRPTQ KFSGGWRMRV SLARALFMEP TLLMLDEPTN 
    HLDLNAVIWL NNYLQGWRKT LLIVSHDQGF LDDVCTDIIH LDAQRLHYYR GNYMTFKKMY 
    QQKQKELLKQ YEKQEKKLKE LKAGGKSTKQ AEKQTKEALT RKQQKCRRKN QDEESQEAPE 
    LLKRPKEYTV RFTFPDPPPL SPPVLGLHGV TFGYQGQKPL FKNLDFGIDM DSRICIVGPN 
    GVGKSTLLLL LTGKLTPTHG EMRKNHRLKI GFFNQQYAEQ LRMEETPTEY LQRGFNLPYQ 
    DARKCLGRFG LESHAHTIQI CKLSGGQKAR VVFAELACRE PDVLILDEPT NNLDIESIDA 
    LGEAINEYKG AVIVVSHDAR LITETNCQLW VVEEQSVSQI DGDFEDYKRE VLEALGEVMV 
    SRPRE

Genular Protein ID: 2196753924

Symbol: Q2L6I2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

Sequence Information:

  • Length: 807
  • Mass: 91680
  • Checksum: 1B6547EABEE7FC75
  • Sequence:
  • MPKAPKQQPP EPEWIGDGES TSPSDKVVKK GKKDKKIKKT FFEELAVEDK QAGEEEKVLK 
    EKEQQQQQQQ QQQKKKRDTR KGRRKKDVDD DGEEKELMER LKKLSVPTSD EEDEVPAPKP 
    RGGKKTKGGN VFAALIQDQS EEEEEEEKHP PKPAKPEKNR INKAVSEEQQ PALKGKKGKE 
    EKSKGKAKPQ NKFAALDNEE EDKEEEIIKE KEPPKQGKEK AKKAEQMEYE RQVASLKAAN 
    AAENDFSVSQ AEMSSRQAML ENASDIKLEK FSISAHGKEL FVNADLYIVA GRRYGLVGPN 
    GKGKTTLLKH IANRALSIPP NIDVLLCEQE VVADETPAVQ AVLRADTKRL KLLEEERRLQ 
    GQLEQGDDTA AERLEKVYEE LRATGAAAAE AKARRILAGL GFDPEMQNRP TQKFSGGWRM 
    RVSLARALFM EPTLLMLDEP TNHLDLNAVI WLNNYLQGWR KTLLIVSHDQ GFLDDVCTDI 
    IHLDAQRLHY YRGNYMTFKK MYQQKQKELL KQYEKQEKKL KELKAGGKST KQAEKQTKEA 
    LTRKQQKCRR KNQDEESQEA PELLKRPKEY TVRFTFPDPP PLSPPVLGLH GVTFGYQGQK 
    PLFKNLDFGI DMDSRICIVG PNGVGKSTLL LLLTGKLTPT HGEMRKNHRL KIGFFNQQYA 
    EQLRMEETPT EYLQRGFNLP YQDARKCLGR FGLESHAHTI QICKLSGGQK ARVVFAELAC 
    REPDVLILDE PTNNLDIESI DALGEAINEY KGAVIVVSHD ARLITETNCQ LWVVEEQSVS 
    QIDGDFEDYK REVLEALGEV MVSRPRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.