Details for: ABCF1

Gene ID: 23

Symbol: ABCF1

Ensembl ID: ENSG00000204574

Description: ATP binding cassette subfamily F member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.16
    Marker Score: 2823.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9
    Marker Score: 64727
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.76
    Marker Score: 2590
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.67
    Marker Score: 1419.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.64
    Marker Score: 6447.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6
    Marker Score: 18026
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.59
    Marker Score: 5869.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.58
    Marker Score: 3858.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.57
    Marker Score: 54370
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.55
    Marker Score: 1866
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.52
    Marker Score: 921
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.5
    Marker Score: 431
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.49
    Marker Score: 1009
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.49
    Marker Score: 7303
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.45
    Marker Score: 968
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.45
    Marker Score: 1523
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.44
    Marker Score: 1018
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.43
    Marker Score: 3259
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.4
    Marker Score: 1760.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.38
    Marker Score: 940
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.35
    Marker Score: 1406
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.35
    Marker Score: 1439
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.34
    Marker Score: 899
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.3
    Marker Score: 819
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.29
    Marker Score: 1715
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.28
    Marker Score: 853
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.28
    Marker Score: 1356
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.28
    Marker Score: 553
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.28
    Marker Score: 632
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.27
    Marker Score: 11121
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.27
    Marker Score: 998
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.25
    Marker Score: 371
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.24
    Marker Score: 364
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.24
    Marker Score: 1705
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.24
    Marker Score: 14410
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.24
    Marker Score: 5136.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.22
    Marker Score: 4997
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.22
    Marker Score: 2543
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.21
    Marker Score: 604
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.2
    Marker Score: 2252
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.18
    Marker Score: 282
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.16
    Marker Score: 562.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.16
    Marker Score: 1664
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.15
    Marker Score: 575
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.15
    Marker Score: 862
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.15
    Marker Score: 463
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.14
    Marker Score: 5493
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.14
    Marker Score: 638
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.14
    Marker Score: 421
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.14
    Marker Score: 1939
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.14
    Marker Score: 1137
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.14
    Marker Score: 7251
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.14
    Marker Score: 1143
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.13
    Marker Score: 3180
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.13
    Marker Score: 2668
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.13
    Marker Score: 4355
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.12
    Marker Score: 638
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.11
    Marker Score: 761
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.11
    Marker Score: 267
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.1
    Marker Score: 290
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.1
    Marker Score: 1185
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.1
    Marker Score: 339.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.09
    Marker Score: 1550
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.09
    Marker Score: 743
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.08
    Marker Score: 14423
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.08
    Marker Score: 2945.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.08
    Marker Score: 10715
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.07
    Marker Score: 1890
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.06
    Marker Score: 775
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.06
    Marker Score: 262.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.06
    Marker Score: 1686
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.06
    Marker Score: 1701.5
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.05
    Marker Score: 303
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.05
    Marker Score: 279
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.05
    Marker Score: 365
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.04
    Marker Score: 245
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.04
    Marker Score: 555
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.04
    Marker Score: 591
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.04
    Marker Score: 693
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.04
    Marker Score: 2073.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.04
    Marker Score: 227
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.03
    Marker Score: 505
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.03
    Marker Score: 2347
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.03
    Marker Score: 1140
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.03
    Marker Score: 2451
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.03
    Marker Score: 1793.5
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.02
    Marker Score: 526.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.02
    Marker Score: 596
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.02
    Marker Score: 5375
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.02
    Marker Score: 938
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.02
    Marker Score: 1567
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.01
    Marker Score: 1660.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.01
    Marker Score: 1184
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.01
    Marker Score: 471
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.01
    Marker Score: 578
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.01
    Marker Score: 256
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1
    Marker Score: 340
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1
    Marker Score: 231
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1
    Marker Score: 1071
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1
    Marker Score: 289

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Other Information

**Key characteristics:** * ABCF1 is a protein of approximately 130 kDa. * It is a transmembrane protein with a cytoplasmic domain and two transmembrane domains. * It is a chaperone protein that is involved in the folding and trafficking of other proteins. * ABCF1 is a highly conserved protein, with a similar sequence in mammals and humans. **Pathways and functions:** * ABCF1 is involved in the regulation of cellular energy production. * It is a key regulator of the expression of genes involved in fatty acid uptake, oxidation, and metabolism. * It also regulates the activity of mitochondrial enzymes. * ABCF1 is involved in the regulation of inflammation and cell growth. **Clinical significance:** * Mutations in ABCF1 have been linked to a number of human diseases, including breast cancer, ovarian cancer, and diabetes. * ABCF1 is a potential target for cancer therapy. * By targeting ABCF1, it may be possible to inhibit cancer growth and metastasis.

Genular Protein ID: 2322123127

Symbol: ABCF1_HUMAN

Name: ATP-binding cassette sub-family F member 1

UniProtKB Accession Codes:

Q8NE71 A2BF75 O14897 Q69YP6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEBI 2 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 EPD 1 Ensembl 14 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9790762

Title: ABC50, a novel human ATP-binding cassette protein found in tumor necrosis factor-alpha-stimulated synoviocytes.

PubMed ID: 9790762

DOI: 10.1006/geno.1998.5480

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 17894550

Title: The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2.

PubMed ID: 17894550

DOI: 10.1042/bj20070811

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19570978

Title: ABC50 promotes translation initiation in mammalian cells.

PubMed ID: 19570978

DOI: 10.1074/jbc.m109.031625

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 845
  • Mass: 95926
  • Checksum: 5C5AA662DF4C99E4
  • Sequence:
    • MPKAPKQQPP EPEWIGDGES TSPSDKVVKK GKKDKKIKKT FFEELAVEDK QAGEEEKVLK 
EKEQQQQQQQ QQQKKKRDTR KGRRKKDVDD DGEEKELMER LKKLSVPTSD EEDEVPAPKP 
RGGKKTKGGN VFAALIQDQS EEEEEEEKHP PKPAKPEKNR INKAVSEEQQ PALKGKKGKE 
EKSKGKAKPQ NKFAALDNEE EDKEEEIIKE KEPPKQGKEK AKKAEQGSEE EGEGEEEEEE 
GGESKADDPY AHLSKKEKKK LKKQMEYERQ VASLKAANAA ENDFSVSQAE MSSRQAMLEN 
ASDIKLEKFS ISAHGKELFV NADLYIVAGR RYGLVGPNGK GKTTLLKHIA NRALSIPPNI 
DVLLCEQEVV ADETPAVQAV LRADTKRLKL LEEERRLQGQ LEQGDDTAAE RLEKVYEELR 
ATGAAAAEAK ARRILAGLGF DPEMQNRPTQ KFSGGWRMRV SLARALFMEP TLLMLDEPTN 
HLDLNAVIWL NNYLQGWRKT LLIVSHDQGF LDDVCTDIIH LDAQRLHYYR GNYMTFKKMY 
QQKQKELLKQ YEKQEKKLKE LKAGGKSTKQ AEKQTKEALT RKQQKCRRKN QDEESQEAPE 
LLKRPKEYTV RFTFPDPPPL SPPVLGLHGV TFGYQGQKPL FKNLDFGIDM DSRICIVGPN 
GVGKSTLLLL LTGKLTPTHG EMRKNHRLKI GFFNQQYAEQ LRMEETPTEY LQRGFNLPYQ 
DARKCLGRFG LESHAHTIQI CKLSGGQKAR VVFAELACRE PDVLILDEPT NNLDIESIDA 
LGEAINEYKG AVIVVSHDAR LITETNCQLW VVEEQSVSQI DGDFEDYKRE VLEALGEVMV 
SRPRE

Genular Protein ID: 2196753924

Symbol: Q2L6I2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2L6I2

Database IDs:

ARBA 2 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 ExpressionAtlas 1 GO 3 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

Sequence Information:

  • Length: 807
  • Mass: 91680
  • Checksum: 1B6547EABEE7FC75
  • Sequence:
    • MPKAPKQQPP EPEWIGDGES TSPSDKVVKK GKKDKKIKKT FFEELAVEDK QAGEEEKVLK 
EKEQQQQQQQ QQQKKKRDTR KGRRKKDVDD DGEEKELMER LKKLSVPTSD EEDEVPAPKP 
RGGKKTKGGN VFAALIQDQS EEEEEEEKHP PKPAKPEKNR INKAVSEEQQ PALKGKKGKE 
EKSKGKAKPQ NKFAALDNEE EDKEEEIIKE KEPPKQGKEK AKKAEQMEYE RQVASLKAAN 
AAENDFSVSQ AEMSSRQAML ENASDIKLEK FSISAHGKEL FVNADLYIVA GRRYGLVGPN 
GKGKTTLLKH IANRALSIPP NIDVLLCEQE VVADETPAVQ AVLRADTKRL KLLEEERRLQ 
GQLEQGDDTA AERLEKVYEE LRATGAAAAE AKARRILAGL GFDPEMQNRP TQKFSGGWRM 
RVSLARALFM EPTLLMLDEP TNHLDLNAVI WLNNYLQGWR KTLLIVSHDQ GFLDDVCTDI 
IHLDAQRLHY YRGNYMTFKK MYQQKQKELL KQYEKQEKKL KELKAGGKST KQAEKQTKEA 
LTRKQQKCRR KNQDEESQEA PELLKRPKEY TVRFTFPDPP PLSPPVLGLH GVTFGYQGQK 
PLFKNLDFGI DMDSRICIVG PNGVGKSTLL LLLTGKLTPT HGEMRKNHRL KIGFFNQQYA 
EQLRMEETPT EYLQRGFNLP YQDARKCLGR FGLESHAHTI QICKLSGGQK ARVVFAELAC 
REPDVLILDE PTNNLDIESI DALGEAINEY KGAVIVVSHD ARLITETNCQ LWVVEEQSVS 
QIDGDFEDYK REVLEALGEV MVSRPRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.