Details for: ALDOC

Gene ID: 230

Symbol: ALDOC

Ensembl ID: ENSG00000109107

Description: aldolase, fructose-bisphosphate C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 119.0650
    Cell Significance Index: -18.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.0089
    Cell Significance Index: -17.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.2271
    Cell Significance Index: -18.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 35.4701
    Cell Significance Index: -14.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.3549
    Cell Significance Index: -14.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.0614
    Cell Significance Index: -18.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 9.5900
    Cell Significance Index: 604.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 8.6348
    Cell Significance Index: 453.3600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 6.6711
    Cell Significance Index: 51.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.4176
    Cell Significance Index: -16.6400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 5.3424
    Cell Significance Index: 76.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9891
    Cell Significance Index: -13.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7389
    Cell Significance Index: -18.7000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.0014
    Cell Significance Index: 17.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.5189
    Cell Significance Index: 22.4300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.3279
    Cell Significance Index: 16.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1859
    Cell Significance Index: 34.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5502
    Cell Significance Index: 496.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5078
    Cell Significance Index: 65.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4849
    Cell Significance Index: 173.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4748
    Cell Significance Index: 46.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4616
    Cell Significance Index: 27.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.3915
    Cell Significance Index: 8.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3894
    Cell Significance Index: 78.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3707
    Cell Significance Index: 40.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3161
    Cell Significance Index: 16.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3019
    Cell Significance Index: 49.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2625
    Cell Significance Index: 5.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2173
    Cell Significance Index: 15.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1768
    Cell Significance Index: 122.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1720
    Cell Significance Index: 22.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1707
    Cell Significance Index: 4.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1212
    Cell Significance Index: 23.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0995
    Cell Significance Index: 13.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0974
    Cell Significance Index: 2.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0923
    Cell Significance Index: 1.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0886
    Cell Significance Index: 2.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0829
    Cell Significance Index: 45.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0778
    Cell Significance Index: 34.4000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0746
    Cell Significance Index: 0.9300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0706
    Cell Significance Index: 1.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0523
    Cell Significance Index: 2.4400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0342
    Cell Significance Index: 0.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0342
    Cell Significance Index: 1.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0118
    Cell Significance Index: 2.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0062
    Cell Significance Index: 0.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0011
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0016
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0045
    Cell Significance Index: -2.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0046
    Cell Significance Index: -0.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0062
    Cell Significance Index: -0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0071
    Cell Significance Index: -5.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0096
    Cell Significance Index: -17.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0101
    Cell Significance Index: -18.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0114
    Cell Significance Index: -17.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0120
    Cell Significance Index: -16.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0122
    Cell Significance Index: -1.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0162
    Cell Significance Index: -9.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0179
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0183
    Cell Significance Index: -3.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0183
    Cell Significance Index: -0.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0209
    Cell Significance Index: -15.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0221
    Cell Significance Index: -2.6100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0248
    Cell Significance Index: -0.4900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0288
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0351
    Cell Significance Index: -7.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0366
    Cell Significance Index: -16.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0388
    Cell Significance Index: -3.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0507
    Cell Significance Index: -14.5900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0507
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0519
    Cell Significance Index: -5.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0535
    Cell Significance Index: -0.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0655
    Cell Significance Index: -5.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0831
    Cell Significance Index: -9.6800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0897
    Cell Significance Index: -0.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0932
    Cell Significance Index: -4.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0984
    Cell Significance Index: -2.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1099
    Cell Significance Index: -6.7400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1135
    Cell Significance Index: -0.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1148
    Cell Significance Index: -16.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1243
    Cell Significance Index: -2.9800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1359
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1390
    Cell Significance Index: -15.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1492
    Cell Significance Index: -11.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1514
    Cell Significance Index: -3.9800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1640
    Cell Significance Index: -1.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1693
    Cell Significance Index: -10.9200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1708
    Cell Significance Index: -1.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1794
    Cell Significance Index: -12.6900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1959
    Cell Significance Index: -3.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2064
    Cell Significance Index: -16.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2264
    Cell Significance Index: -7.2500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2273
    Cell Significance Index: -2.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2360
    Cell Significance Index: -12.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2411
    Cell Significance Index: -13.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2478
    Cell Significance Index: -8.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2820
    Cell Significance Index: -8.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2879
    Cell Significance Index: -10.5700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3185
    Cell Significance Index: -5.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ALDOC is a tetrameric enzyme composed of four subunits, each consisting of three domains. The enzyme is primarily localized in the cytosol of cells and exhibits a high degree of specificity for fructose-1,6-bisphosphate. ALDOC is also known for its ability to bind to various proteins, including cytoskeletal proteins, which suggests its involvement in cellular structure and organization. The enzyme's expression is widespread, with notable presence in neurons, immune cells, and epithelial cells. **Pathways and Functions:** ALDOC is integral to the glycolytic pathway, where it catalyzes the conversion of fructose-1,6-bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. This reaction is crucial for generating energy in cells, particularly during periods of high energy demand. Beyond glycolysis, ALDOC has been implicated in various cellular processes, including: 1. **Immune response:** ALDOC has been shown to play a role in the regulation of immune cell function, including the activation and degranulation of neutrophils. 2. **Cell differentiation:** ALDOC is involved in the differentiation of various cell types, including immune cells and epithelial cells. 3. **Cell survival:** The enzyme has been implicated in the regulation of cell survival pathways, including the PI3K/Akt signaling pathway. **Clinical Significance:** Dysregulation of ALDOC has been implicated in various diseases, including: 1. **Diabetes:** ALDOC has been shown to play a role in the regulation of glucose metabolism, and its dysregulation has been linked to the development of diabetes. 2. **Immune disorders:** ALDOC has been implicated in the regulation of immune cell function, and its dysregulation has been linked to the development of autoimmune diseases, such as rheumatoid arthritis. 3. **Cancer:** ALDOC has been shown to play a role in the regulation of cell growth and survival, and its dysregulation has been linked to the development of various cancers. In conclusion, ALDOC is a multifunctional enzyme that plays a critical role in cellular metabolism and immune function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying ALDOC-mediated processes.

Genular Protein ID: 153202479

Symbol: ALDOC_HUMAN

Name: Fructose-bisphosphate aldolase C

UniProtKB Accession Codes:

P09972 B2R5R3 Q3SYL3 Q6FH94 Q6P0L5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 5 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 13 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3105602

Title: The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones.

PubMed ID: 3105602

DOI: 10.1016/0300-9084(87)90246-x

PubMed ID: 3267224

Title: The complete nucleotide sequence of the gene coding for the human aldolase C.

PubMed ID: 3267224

DOI: 10.1093/nar/16.10.4733

PubMed ID: 2209624

Title: Characterization of the transcription-initiation site and of the promoter region within the 5' flanking region of the human aldolase C gene.

PubMed ID: 2209624

DOI: 10.1111/j.1432-1033.1990.tb19294.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11399750

Title: Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump.

PubMed ID: 11399750

DOI: 10.1074/jbc.m008768200

PubMed ID: 11876650

Title: Phospholipase D2 directly interacts with aldolase via its PH domain.

PubMed ID: 11876650

DOI: 10.1021/bi015700a

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15537755

Title: Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function.

PubMed ID: 15537755

DOI: 10.1110/ps.04915904

Sequence Information:

  • Length: 364
  • Mass: 39456
  • Checksum: 506A570B3E507971
  • Sequence:
    • MPHSYPALSA EQKKELSDIA LRIVAPGKGI LAADESVGSM AKRLSQIGVE NTEENRRLYR 
QVLFSADDRV KKCIGGVIFF HETLYQKDDN GVPFVRTIQD KGIVVGIKVD KGVVPLAGTD 
GETTTQGLDG LSERCAQYKK DGADFAKWRC VLKISERTPS ALAILENANV LARYASICQQ 
NGIVPIVEPE ILPDGDHDLK RCQYVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC 
PIKYTPEEIA MATVTALRRT VPPAVPGVTF LSGGQSEEEA SFNLNAINRC PLPRPWALTF 
SYGRALQASA LNAWRGQRDN AGAATEEFIK RAEVNGLAAQ GKYEGSGEDG GAAAQSLYIA 
NHAY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.