Details for: ALDOC

Gene ID: 230

Symbol: ALDOC

Ensembl ID: ENSG00000109107

Description: aldolase, fructose-bisphosphate C

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.34
    Marker Score: 5247
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.35
    Marker Score: 9554
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.32
    Marker Score: 6738
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.29
    Marker Score: 3100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.74
    Marker Score: 3938
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.7
    Marker Score: 805
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.69
    Marker Score: 494
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 1.62
    Marker Score: 1998
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.35
    Marker Score: 28850
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.34
    Marker Score: 304
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.33
    Marker Score: 1111.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.31
    Marker Score: 1131
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.19
    Marker Score: 4588
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.18
    Marker Score: 12211.5
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.18
    Marker Score: 614
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.13
    Marker Score: 475
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.06
    Marker Score: 6754.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.03
    Marker Score: 1595
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71768
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47992
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.94
    Marker Score: 3905
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5231
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.91
    Marker Score: 34609
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.91
    Marker Score: 1402
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.89
    Marker Score: 242
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.88
    Marker Score: 435
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.86
    Marker Score: 1079
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.85
    Marker Score: 1514
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13084
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.81
    Marker Score: 3117
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.81
    Marker Score: 6939
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.8
    Marker Score: 6117
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.77
    Marker Score: 28557.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.76
    Marker Score: 1049
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.73
    Marker Score: 10941
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.73
    Marker Score: 416
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 288.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 650
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.71
    Marker Score: 877
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.71
    Marker Score: 14095
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.69
    Marker Score: 239
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2897
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.68
    Marker Score: 378
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.68
    Marker Score: 150
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.67
    Marker Score: 2786
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.67
    Marker Score: 41311
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.66
    Marker Score: 632
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.63
    Marker Score: 675
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.6
    Marker Score: 2899
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.6
    Marker Score: 196
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.58
    Marker Score: 4529.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.58
    Marker Score: 2358
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.57
    Marker Score: 458
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.56
    Marker Score: 5625
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.56
    Marker Score: 5256
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.54
    Marker Score: 226
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.54
    Marker Score: 300.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.53
    Marker Score: 4572
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.53
    Marker Score: 1950.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.51
    Marker Score: 728
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.48
    Marker Score: 1311
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.48
    Marker Score: 468.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.47
    Marker Score: 419
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.46
    Marker Score: 128
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.46
    Marker Score: 967
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.45
    Marker Score: 386
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.45
    Marker Score: 4306
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.45
    Marker Score: 781
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.45
    Marker Score: 302
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.44
    Marker Score: 158
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.43
    Marker Score: 638
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.42
    Marker Score: 191
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.42
    Marker Score: 172
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.42
    Marker Score: 717
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.42
    Marker Score: 174
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.41
    Marker Score: 2632
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4
    Marker Score: 398
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4
    Marker Score: 264.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.4
    Marker Score: 482
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.4
    Marker Score: 78
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.4
    Marker Score: 117
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.4
    Marker Score: 2578
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.39
    Marker Score: 625
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.39
    Marker Score: 110
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.39
    Marker Score: 109
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 102
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.38
    Marker Score: 919

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Other Information

**Key characteristics:** - It is a glycoprotein with a molecular weight of approximately 120 kDa. - It is found in both soluble and membrane-bound forms. - It is expressed in high levels in certain cell types, including retinal rod cells, immune cells, and epithelial cells. - It is involved in the regulation of glucose metabolism, glycolysis, and the immune response. **Pathways and functions:** - ALDOC is involved in the cytoskeletal protein binding pathway, where it helps to maintain the structure and integrity of cell membranes. - It is also involved in the epithelial cell differentiation pathway, where it is expressed in epithelial cells and is required for the formation of the epithelial cell layer. - In the immune system, ALDOC is expressed in immune cells, where it plays a role in the regulation of inflammation and immune responses. - It is involved in the regulation of glucose metabolism, where it helps to convert glucose into glycogen. - It is also involved in the regulation of gluconeogenesis, the process by which the body converts non-carbohydrate substrates into glucose. **Clinical significance:** ALDOC gene mutations have been linked to several human diseases, including retinitis pigmentosa, a genetic eye disorder that affects the function of retinal rod cells. Mutations in the ALDOC gene can also lead to the development of certain types of cancer. **Additional information:** - ALDOC is a key regulator of the cellular response to injury and inflammation. - It is also involved in the regulation of cell migration and differentiation. - It is a promising target for the treatment of eye diseases and cancer.

Genular Protein ID: 153202479

Symbol: ALDOC_HUMAN

Name: Fructose-bisphosphate aldolase C

UniProtKB Accession Codes:

P09972 B2R5R3 Q3SYL3 Q6FH94 Q6P0L5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 5 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 13 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3105602

Title: The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones.

PubMed ID: 3105602

DOI: 10.1016/0300-9084(87)90246-x

PubMed ID: 3267224

Title: The complete nucleotide sequence of the gene coding for the human aldolase C.

PubMed ID: 3267224

DOI: 10.1093/nar/16.10.4733

PubMed ID: 2209624

Title: Characterization of the transcription-initiation site and of the promoter region within the 5' flanking region of the human aldolase C gene.

PubMed ID: 2209624

DOI: 10.1111/j.1432-1033.1990.tb19294.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11399750

Title: Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump.

PubMed ID: 11399750

DOI: 10.1074/jbc.m008768200

PubMed ID: 11876650

Title: Phospholipase D2 directly interacts with aldolase via its PH domain.

PubMed ID: 11876650

DOI: 10.1021/bi015700a

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15537755

Title: Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function.

PubMed ID: 15537755

DOI: 10.1110/ps.04915904

Sequence Information:

  • Length: 364
  • Mass: 39456
  • Checksum: 506A570B3E507971
  • Sequence:
    • MPHSYPALSA EQKKELSDIA LRIVAPGKGI LAADESVGSM AKRLSQIGVE NTEENRRLYR 
QVLFSADDRV KKCIGGVIFF HETLYQKDDN GVPFVRTIQD KGIVVGIKVD KGVVPLAGTD 
GETTTQGLDG LSERCAQYKK DGADFAKWRC VLKISERTPS ALAILENANV LARYASICQQ 
NGIVPIVEPE ILPDGDHDLK RCQYVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC 
PIKYTPEEIA MATVTALRRT VPPAVPGVTF LSGGQSEEEA SFNLNAINRC PLPRPWALTF 
SYGRALQASA LNAWRGQRDN AGAATEEFIK RAEVNGLAAQ GKYEGSGEDG GAAAQSLYIA 
NHAY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.