RAB21 | ENSG00000080371 | NCBI 23011

Details for: RAB21

Gene ID: 23011

Symbol: RAB21

Ensembl ID: ENSG00000080371

Description: RAB21, member RAS oncogene family

Associated with

Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Rab gefs exchange gtp for gdp on rabs
(R-HSA-8876198)
Rab geranylgeranylation
(R-HSA-8873719)
Rab regulation of trafficking
(R-HSA-9007101)
Vesicle-mediated transport
(R-HSA-5653656)
Anterograde axonal transport
(GO:0008089)
Axon cytoplasm
(GO:1904115)
Cleavage furrow
(GO:0032154)
Cytoplasmic side of early endosome membrane
(GO:0098559)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Early endosome membrane
(GO:0031901)
Endomembrane system
(GO:0012505)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome
(GO:0005768)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Gdp binding
(GO:0019003)
Golgi cisterna membrane
(GO:0032580)
Golgi membrane
(GO:0000139)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Intracellular protein transport
(GO:0006886)
Positive regulation of dendrite morphogenesis
(GO:0050775)
Positive regulation of early endosome to late endosome transport
(GO:2000643)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Rab protein signal transduction
(GO:0032482)
Regulation of axon extension
(GO:0030516)
Regulation of exocytosis
(GO:0017157)
Synapse
(GO:0045202)
Trans-golgi network
(GO:0005802)
Vesicle membrane
(GO:0012506)

Other Information

Proteins

Ras-related protein Rab-21

Genular Protein ID: 1868392552

Symbol: RAB21_HUMAN

Name: Ras-related protein Rab-21

UniProtKB Accession Codes:

Q9UL25 Q14466 Q569H3

Database IDs:

Citations:

PubMed ID: 10887961

Title: Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells.

PubMed ID: 10887961

DOI: 10.1078/s0171-9335(04)70034-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 15561770

Title: A role for the small GTPase Rab21 in the early endocytic pathway.

PubMed ID: 15561770

DOI: 10.1242/jcs.01560

PubMed ID: 16525121

Title: Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics.

PubMed ID: 16525121

DOI: 10.1242/jcs.02810

PubMed ID: 18477474

Title: Varp interacts with Rab38 and functions as its potential effector.

PubMed ID: 18477474

DOI: 10.1016/j.bbrc.2008.05.017

PubMed ID: 18804435

Title: Integrin trafficking regulated by Rab21 is necessary for cytokinesis.

PubMed ID: 18804435

DOI: 10.1016/j.devcel.2008.08.001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19745841

Title: Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth.

PubMed ID: 19745841

DOI: 10.1038/embor.2009.186

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25648148

Title: Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.

PubMed ID: 25648148

DOI: 10.15252/embr.201439464

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31455601

Title: RAB21 interacts with TMED10 and modulates its localization and abundance.

PubMed ID: 31455601

DOI: 10.1242/bio.045336

PubMed ID: 16034420

Title: Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.

PubMed ID: 16034420

DOI: 10.1038/nature03798

PubMed ID: 17450153

Title: Structural basis for Rab GTPase activation by VPS9 domain exchange factors.

PubMed ID: 17450153

DOI: 10.1038/nsmb1232

Sequence Information:

Length: 225
Mass: 24348
Checksum: 73CA2C127F0CBFD6
Sequence:

MAAAGGGGGG AAAAGRAYSF KVVLLGEGCV GKTSLVLRYC ENKFNDKHIT TLQASFLTKK 
LNIGGKRVNL AIWDTAGQER FHALGPIYYR DSNGAILVYD ITDEDSFQKV KNWVKELRKM 
LGNEICLCIV GNKIDLEKER HVSIQEAESY AESVGAKHYH TSAKQNKGIE ELFLDLCKRM 
IETAQVDERA KGNGSSQPGT ARRGVQIIDD EPQAQTSGGG CCSSG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RAB21

Associated with

Other Information

Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. PubMed ID: 10887961

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. PubMed ID: 7788527

A role for the small GTPase Rab21 in the early endocytic pathway. PubMed ID: 15561770

Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics. PubMed ID: 16525121

Varp interacts with Rab38 and functions as its potential effector. PubMed ID: 18477474

Integrin trafficking regulated by Rab21 is necessary for cytokinesis. PubMed ID: 18804435

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth. PubMed ID: 19745841

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion. PubMed ID: 25648148

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

RAB21 interacts with TMED10 and modulates its localization and abundance. PubMed ID: 31455601

Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. PubMed ID: 16034420

Structural basis for Rab GTPase activation by VPS9 domain exchange factors. PubMed ID: 17450153