Details for: KDM1A

Gene ID: 23028

Symbol: KDM1A

Ensembl ID: ENSG00000004487

Description: lysine demethylase 1A

Associated with

Other Information

Genular Protein ID: 2859732461

Symbol: KDM1A_HUMAN

Name: BRAF35-HDAC complex protein BHC110

UniProtKB Accession Codes:

O60341 A8MWP9 Q5TH94 Q5TH95 Q86VT7 Q8IXK4 Q8NDP6 Q8TAZ3 Q96AW4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 4 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 7 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 57 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 92 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 Rhea 3 SABIO-RK 1 SAM 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12032298

Title: A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.

PubMed ID: 12032298

DOI: 10.1073/pnas.112008599

PubMed ID: 11102443

Title: Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.

PubMed ID: 11102443

DOI: 10.1074/jbc.m007372200

PubMed ID: 12493763

Title: A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.

PubMed ID: 12493763

DOI: 10.1074/jbc.m208992200

PubMed ID: 15620353

Title: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.

PubMed ID: 15620353

DOI: 10.1016/j.cell.2004.12.012

PubMed ID: 15811342

Title: Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process.

PubMed ID: 15811342

DOI: 10.1016/j.febslet.2005.03.015

PubMed ID: 16140033

Title: Regulation of LSD1 histone demethylase activity by its associated factors.

PubMed ID: 16140033

DOI: 10.1016/j.molcel.2005.08.027

PubMed ID: 16079794

Title: An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation.

PubMed ID: 16079794

DOI: 10.1038/nature04021

PubMed ID: 16079795

Title: LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription.

PubMed ID: 16079795

DOI: 10.1038/nature04020

PubMed ID: 16223729

Title: Human histone demethylase LSD1 reads the histone code.

PubMed ID: 16223729

DOI: 10.1074/jbc.m509549200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17805299

Title: p53 is regulated by the lysine demethylase LSD1.

PubMed ID: 17805299

DOI: 10.1038/nature06092

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20389281

Title: The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1.

PubMed ID: 20389281

DOI: 10.1038/emboj.2010.63

PubMed ID: 19880879

Title: ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1.

PubMed ID: 19880879

DOI: 10.1074/jbc.m109.065862

PubMed ID: 25750265

Title: Retraction: 'ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1'.

PubMed ID: 25750265

DOI: 10.1074/jbc.a109.065862

PubMed ID: 20228790

Title: Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.

PubMed ID: 20228790

DOI: 10.1038/nature08839

PubMed ID: 20562920

Title: Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition.

PubMed ID: 20562920

DOI: 10.1038/onc.2010.234

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25018020

Title: Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development.

PubMed ID: 25018020

DOI: 10.1016/j.molcel.2014.06.006

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 29030483

Title: RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.

PubMed ID: 29030483

DOI: 10.15252/embj.201796525

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30497519

Title: The deubiquitinase USP38 affects cellular functions through interacting with LSD1.

PubMed ID: 30497519

DOI: 10.1186/s40659-018-0201-8

PubMed ID: 29358331

Title: LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase-dependent proteolysis of the stem-cell protein SOX2.

PubMed ID: 29358331

DOI: 10.1074/jbc.ra117.000342

PubMed ID: 29691401

Title: Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4-DCAF5 ubiquitin ligase.

PubMed ID: 29691401

DOI: 10.1038/s41467-018-04019-9

PubMed ID: 33980486

Title: The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.

PubMed ID: 33980486

DOI: 10.1126/sciadv.abf2229

PubMed ID: 16885027

Title: Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase.

PubMed ID: 16885027

DOI: 10.1016/j.molcel.2006.07.012

PubMed ID: 16956976

Title: Crystal structure of human histone lysine-specific demethylase 1 (LSD1).

PubMed ID: 16956976

DOI: 10.1073/pnas.0606381103

PubMed ID: 16531230

Title: Solution structure of the SWIRM domain of human histone demethylase LSD1.

PubMed ID: 16531230

DOI: 10.1016/j.str.2005.12.004

PubMed ID: 21300290

Title: Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex.

PubMed ID: 21300290

DOI: 10.1016/j.str.2011.01.001

PubMed ID: 23721412

Title: Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase.

PubMed ID: 23721412

DOI: 10.1021/cb4001926

PubMed ID: 23020937

Title: Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study.

PubMed ID: 23020937

DOI: 10.1016/s0140-6736(12)61480-9

PubMed ID: 24838796

Title: De novo ANKRD11 and KDM1A gene mutations in a male with features of KBG syndrome and Kabuki syndrome.

PubMed ID: 24838796

DOI: 10.1002/ajmg.a.36450

PubMed ID: 26656649

Title: Gene discovery for Mendelian conditions via social networking: de novo variants in KDM1A cause developmental delay and distinctive facial features.

PubMed ID: 26656649

DOI: 10.1038/gim.2015.161

Sequence Information:

  • Length: 852
  • Mass: 92903
  • Checksum: A61CEDE51E4E0C1D
  • Sequence:
    • MLSGKKAAAA AAAAAAAATG TEAGPGTAGG SENGSEVAAQ PAGLSGPAEV GPGAVGERTP 
RKKEPPRASP PGGLAEPPGS AGPQAGPTVV PGSATPMETG IAETPEGRRT SRRKRAKVEY 
REMDESLANL SEDEYYSEEE RNAKAEKEKK LPPPPPQAPP EEENESEPEE PSGVEGAAFQ 
SRLPHDRMTS QEAACFPDII SGPQQTQKVF LFIRNRTLQL WLDNPKIQLT FEATLQQLEA 
PYNSDTVLVH RVHSYLERHG LINFGIYKRI KPLPTKKTGK VIIIGSGVSG LAAARQLQSF 
GMDVTLLEAR DRVGGRVATF RKGNYVADLG AMVVTGLGGN PMAVVSKQVN MELAKIKQKC 
PLYEANGQAV PKEKDEMVEQ EFNRLLEATS YLSHQLDFNV LNNKPVSLGQ ALEVVIQLQE 
KHVKDEQIEH WKKIVKTQEE LKELLNKMVN LKEKIKELHQ QYKEASEVKP PRDITAEFLV 
KSKHRDLTAL CKEYDELAET QGKLEEKLQE LEANPPSDVY LSSRDRQILD WHFANLEFAN 
ATPLSTLSLK HWDQDDDFEF TGSHLTVRNG YSCVPVALAE GLDIKLNTAV RQVRYTASGC 
EVIAVNTRST SQTFIYKCDA VLCTLPLGVL KQQPPAVQFV PPLPEWKTSA VQRMGFGNLN 
KVVLCFDRVF WDPSVNLFGH VGSTTASRGE LFLFWNLYKA PILLALVAGE AAGIMENISD 
DVIVGRCLAI LKGIFGSSAV PQPKETVVSR WRADPWARGS YSYVAAGSSG NDYDLMAQPI 
TPGPSIPGAP QPIPRLFFAG EHTIRNYPAT VHGALLSGLR EAGRIADQFL GAMYTLPRQA 
TPGVPAQQSP SM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.