Details for: PDXDC1
Gene ID: 23042
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PDXDC1
Ensembl ID: ENSG00000179889
Description: pyridoxal dependent decarboxylase domain containing 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 30.27rCSI 66.29%PRS 42.79
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CSI 25.55rCSI 62.1%PRS 20.56
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CSI 23.94rCSI 56.91%PRS 45.68
-
CSI 22.79rCSI 28.35%PRS 35.73
-
CSI 18.63rCSI 58.24%PRS 22.12
-
CSI 17.97rCSI 30.17%PRS 21.15
-
CSI 17.7rCSI 63.71%PRS 20.15
-
CSI 16.53rCSI 16.26%PRS 35.51
-
CSI 16.49rCSI 23.66%PRS 26.65
-
CSI 16.18rCSI 12.58%PRS 47.98
-
CSI 15.46rCSI 48.36%PRS 23.95
-
CSI 14.72rCSI 13.06%PRS 32.95
-
CSI 14.23rCSI 10.57%PRS 45.66
-
CSI 14.08rCSI 10.11%PRS 44.49
-
CSI 13.92rCSI 30.76%PRS 24.36
-
CSI 13.59rCSI 21.61%PRS 28.26
-
CSI 13.11rCSI 35.35%PRS 41.95
-
CSI 12.96rCSI 48.96%PRS 21.98
-
CSI 12.91rCSI 36.17%PRS 48.04
-
CSI 12.69rCSI 20.41%PRS 22.97
-
CSI 12.43rCSI 16.99%PRS 37.29
-
CSI 11.9rCSI 17.25%PRS 48.3
-
CSI 11.79rCSI 17.53%PRS 36.74
-
CSI 11.75rCSI 44.03%PRS 28.43
-
CSI 11.24rCSI 25.1%PRS 38.78
-
CSI 10.94rCSI 9.06%PRS 33.96
-
CSI 10.64rCSI 24.34%PRS 32.95
-
CSI 10.43rCSI 25.81%PRS 31.65
-
CSI 10.25rCSI 12.75%PRS 19.94
-
CSI 10.17rCSI 17.96%PRS 20.44
-
CSI 10.16rCSI 59.84%PRS 22.28
-
CSI 10.1rCSI 14.03%PRS 33.53
-
CSI 9.88rCSI 14.53%PRS 31
-
CSI 9.78rCSI 7.4%PRS 44.24
-
CSI 9.6rCSI 70.55%PRS 23.54
-
CSI 9.25rCSI 17.65%PRS 49.5
-
CSI 9.24rCSI 11.09%PRS 32.09
-
CSI 9.15rCSI 16.04%PRS 27
-
CSI 8.99rCSI 22.75%PRS 40.55
-
CSI 8.9rCSI 15.93%PRS 31.71
-
CSI 8.54rCSI 8.07%PRS 34.49
-
CSI 8.4rCSI 21.72%PRS 30.68
-
CSI 8.38rCSI 11.42%PRS 28.73
-
CSI 8.36rCSI 12.77%PRS 33.69
-
CSI 8.26rCSI 19.25%PRS 53.88
-
CSI 7.99rCSI 37.45%PRS 62.23
-
CSI 7.96rCSI 5.56%PRS 35.02
-
CSI 7.9rCSI 11.28%PRS 36.05
-
CSI 7.5rCSI 6.58%PRS 37.88
-
CSI 7.28rCSI 19.2%PRS 39.38
-
CSI 7.16rCSI 12.61%PRS 32.55
-
CSI 7.09rCSI 23.06%PRS 36.83
-
CSI 7.06rCSI 23.87%PRS 44.92
-
CSI 7.04rCSI 18.81%PRS 28.44
-
CSI 6.84rCSI 13.72%PRS 25.31
-
CSI 6.81rCSI 7.11%PRS 34.03
-
CSI 6.76rCSI 19.99%PRS 27.71
-
CSI 6.67rCSI 29.27%PRS 53.51
-
CSI 6.66rCSI 12.09%PRS 29.04
-
CSI 6.56rCSI 4.42%PRS 41.54
-
CSI 6.4rCSI 5.38%PRS 49.4
-
CSI 6.24rCSI 4.75%PRS 42.99
-
CSI 6.23rCSI 4.66%PRS 47.46
-
CSI 6.08rCSI 29.15%PRS 31.44
-
CSI 5.81rCSI 22.61%PRS 43.15
-
CSI 5.76rCSI 9.18%PRS 28.57
-
CSI 5.61rCSI 5.6%PRS 28.7
-
CSI 5.55rCSI 6.65%PRS 51.84
-
CSI 5.5rCSI 4.4%PRS 53.81
-
CSI 5.45rCSI 17.43%PRS 30.58
-
CSI 5.41rCSI 5.2%PRS 34.22
-
CSI 5.37rCSI 6.65%PRS 29.8
-
CSI 5.36rCSI 6.3%PRS 36.99
-
CSI 5.35rCSI 4.71%PRS 24.8
-
CSI 5.26rCSI 74.6%PRS 28
-
CSI 5.23rCSI 6.56%PRS 41.94
-
CSI 5.19rCSI 5.34%PRS 49.85
-
CSI 5.14rCSI 8.47%PRS 38.28
-
CSI 5.12rCSI 15.19%PRS 44.05
-
CSI 5.12rCSI 31.49%PRS 59.39
-
CSI 5.01rCSI 6.1%PRS 40.24
-
CSI 4.99rCSI 6.41%PRS 31.51
-
CSI 4.91rCSI 18.71%PRS 29.75
-
CSI 4.84rCSI 7.78%PRS 26.06
-
CSI 4.83rCSI 5.77%PRS 21.06
-
CSI 4.77rCSI 4.99%PRS 35.32
-
CSI 4.73rCSI 22.66%PRS 37.04
-
CSI 4.71rCSI 10.57%PRS 21.74
-
CSI 4.67rCSI 5.48%PRS 46.47
-
CSI 4.56rCSI 24.81%PRS 58.85
-
CSI 4.52rCSI 4.11%PRS 47.81
-
CSI 4.46rCSI 7.13%PRS 36.29
-
CSI 4.33rCSI 4.41%PRS 45.17
-
CSI 4.28rCSI 12.64%PRS 37.94
-
CSI 4.27rCSI 6.74%PRS 34
-
CSI 4.26rCSI 34.67%PRS 30.32
-
CSI 4.26rCSI 3.73%PRS 42.51
-
CSI 4.26rCSI 7.36%PRS 26.01
-
CSI 4.25rCSI 16.42%PRS 53.95
-
CSI 4.21rCSI 4.74%PRS 48.68
-
CSI 0.2rCSI 1.1%PRS 71.2%
-
CSI 0.2rCSI 1.2%PRS 45.5%
-
CSI 0.3rCSI 1.5%PRS 44.6%
-
CSI 0.3rCSI 0.5%PRS 42.4%
-
CSI 0.4rCSI 3.4%PRS 63.0%
-
CSI 0.4rCSI 1.6%PRS 51.0%
-
CSI 0.4rCSI 2.7%PRS 31.9%
-
CSI 0.4rCSI 1.9%PRS 32.1%
-
CSI 0.5rCSI 2.8%PRS 33.0%
-
CSI 0.5rCSI 4.9%PRS 80.6%
-
CSI 0.6rCSI 5.5%PRS 62.3%
-
CSI 0.6rCSI 2.3%PRS 38.7%
-
CSI 0.6rCSI 1.2%PRS 63.4%
-
CSI 0.6rCSI 1.7%PRS 46.6%
-
CSI 0.7rCSI 1.3%PRS 42.0%
-
CSI 0.8rCSI 2.1%PRS 56.5%
-
CSI 0.8rCSI 3.8%PRS 58.4%
-
CSI 0.8rCSI 3.0%PRS 51.4%
-
CSI 0.8rCSI 1.8%PRS 31.0%
-
CSI 0.8rCSI 1.5%PRS 48.6%
-
CSI 0.9rCSI 2.7%PRS 34.0%
-
CSI 0.9rCSI 4.0%PRS 33.4%
-
CSI 0.9rCSI 1.0%PRS 25.4%
-
CSI 0.9rCSI 0.7%PRS 31.8%
-
CSI 1.0rCSI 1.3%PRS 36.8%
-
CSI 1.0rCSI 1.5%PRS 42.8%
-
CSI 1.0rCSI 0.9%PRS 53.3%
-
CSI 1.0rCSI 0.9%PRS 36.8%
-
CSI 1.0rCSI 0.9%PRS 30.7%
-
CSI 1.1rCSI 3.1%PRS 26.8%
-
CSI 1.1rCSI 1.7%PRS 34.5%
-
CSI 1.1rCSI 2.8%PRS 26.1%
-
CSI 1.2rCSI 5.1%PRS 31.4%
-
CSI 1.2rCSI 7.4%PRS 27.6%
-
CSI 1.2rCSI 5.9%PRS 34.7%
-
CSI 1.2rCSI 3.2%PRS 39.6%
-
CSI 1.3rCSI 1.7%PRS 55.5%
-
CSI 1.3rCSI 3.3%PRS 33.7%
-
CSI 1.3rCSI 1.0%PRS 33.7%
-
CSI 1.3rCSI 4.2%PRS 25.0%
-
CSI 1.3rCSI 7.2%PRS 22.4%
-
CSI 1.3rCSI 4.5%PRS 49.8%
-
CSI 1.3rCSI 3.1%PRS 51.0%
-
CSI 1.3rCSI 3.1%PRS 44.6%
-
CSI 1.3rCSI 2.0%PRS 31.0%
-
CSI 1.3rCSI 2.1%PRS 44.0%
-
CSI 1.4rCSI 1.4%PRS 38.7%
-
CSI 1.4rCSI 3.9%PRS 51.5%
-
CSI 1.4rCSI 2.1%PRS 49.2%
-
CSI 1.4rCSI 2.8%PRS 62.2%
-
CSI 1.5rCSI 7.3%PRS 42.7%
-
CSI 1.5rCSI 2.6%PRS 41.5%
-
CSI 1.5rCSI 2.3%PRS 31.7%
-
CSI 1.5rCSI 1.6%PRS 49.2%
-
CSI 1.5rCSI 2.2%PRS 35.0%
-
CSI 1.6rCSI 6.1%PRS 14.2%
-
CSI 1.6rCSI 7.9%PRS 43.6%
-
CSI 1.6rCSI 2.5%PRS 44.2%
-
CSI 1.7rCSI 2.2%PRS 35.3%
-
CSI 1.7rCSI 4.6%PRS 31.4%
-
CSI 1.7rCSI 2.4%PRS 31.2%
-
CSI 1.7rCSI 4.3%PRS 38.2%
-
CSI 1.7rCSI 1.4%PRS 34.3%
-
CSI 1.8rCSI 3.7%PRS 48.3%
-
CSI 1.8rCSI 2.8%PRS 42.4%
-
CSI 1.8rCSI 3.5%PRS 61.9%
-
CSI 1.8rCSI 2.8%PRS 49.6%
-
CSI 1.8rCSI 9.8%PRS 40.6%
-
CSI 1.8rCSI 1.7%PRS 39.4%
-
CSI 1.8rCSI 3.4%PRS 54.5%
-
CSI 1.8rCSI 4.4%PRS 49.6%
-
CSI 1.9rCSI 2.3%PRS 39.8%
-
CSI 1.9rCSI 1.6%PRS 41.3%
-
CSI 1.9rCSI 20.6%PRS 54.7%
-
CSI 1.9rCSI 2.7%PRS 47.2%
-
CSI 1.9rCSI 4.4%PRS 33.0%
-
CSI 1.9rCSI 5.0%PRS 32.7%
-
CSI 1.9rCSI 9.9%PRS 72.1%
-
CSI 1.9rCSI 2.7%PRS 31.9%
-
CSI 2.0rCSI 2.0%PRS 52.1%
-
CSI 2.0rCSI 5.6%PRS 35.0%
-
CSI 2.0rCSI 4.8%PRS 45.2%
-
CSI 2.0rCSI 4.7%PRS 61.3%
-
CSI 2.0rCSI 6.6%PRS 24.8%
-
CSI 2.0rCSI 3.0%PRS 37.6%
-
CSI 2.0rCSI 8.2%PRS 32.4%
-
CSI 2.0rCSI 2.4%PRS 44.1%
-
CSI 2.1rCSI 3.0%PRS 41.3%
-
CSI 2.1rCSI 5.5%PRS 44.2%
-
CSI 2.1rCSI 4.6%PRS 37.2%
-
CSI 2.2rCSI 3.5%PRS 26.3%
-
CSI 2.2rCSI 1.8%PRS 38.2%
-
CSI 2.2rCSI 4.3%PRS 34.7%
-
CSI 2.2rCSI 4.5%PRS 30.8%
-
CSI 2.2rCSI 4.8%PRS 26.2%
-
CSI 2.3rCSI 12.2%PRS 50.0%
-
CSI 2.3rCSI 9.1%PRS 56.3%
-
CSI 2.3rCSI 4.6%PRS 19.9%
-
CSI 2.3rCSI 12.1%PRS 49.4%
-
CSI 2.3rCSI 9.7%PRS 36.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3192298507
Symbol: PDXD1_HUMAN
Name: Pyridoxal-dependent decarboxylase domain-containing protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9039502
Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
PubMed ID: 9039502
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 788
- Mass: 86707
- Checksum: 2BAFEDC0A1C13AD3
- Sequence:
MDASLEKIAD PTLAEMGKNL KEAVKMLEDS QRRTEEENGK KLISGDIPGP LQGSGQDMVS ILQLVQNLMH GDEDEEPQSP RIQNIGEQGH MALLGHSLGA YISTLDKEKL RKLTTRILSD TTLWLCRIFR YENGCAYFHE EEREGLAKIC RLAIHSRYED FVVDGFNVLY NKKPVIYLSA AARPGLGQYL CNQLGLPFPC LCRVPCNTVF GSQHQMDVAF LEKLIKDDIE RGRLPLLLVA NAGTAAVGHT DKIGRLKELC EQYGIWLHVE GVNLATLALG YVSSSVLAAA KCDSMTMTPG PWLGLPAVPA VTLYKHDDPA LTLVAGLTSN KPTDKLRALP LWLSLQYLGL DGFVERIKHA CQLSQRLQES LKKVNYIKIL VEDELSSPVV VFRFFQELPG SDPVFKAVPV PNMTPSGVGR ERHSCDALNR WLGEQLKQLV PASGLTVMDL EAEGTCLRFS PLMTAAVLGT RGEDVDQLVA CIESKLPVLC CTLQLREEFK QEVEATAGLL YVDDPNWSGI GVVRYEHAND DKSSLKSDPE GENIHAGLLK KLNELESDLT FKIGPEYKSM KSCLYVGMAS DNVDAAELVE TIAATAREIE ENSRLLENMT EVVRKGIQEA QVELQKASEE RLLEEGVLRQ IPVVGSVLNW FSPVQALQKG RTFNLTAGSL ESTEPIYVYK AQGAGVTLPP TPSGSRTKQR LPGQKPFKRS LRGSDALSET SSVSHIEDLE KVERLSSGPE QITLEASSTE GHPGAPSPQH TDQTEAFQKG VPHPEDDHSQ VEGPESLR
Genular Protein ID: 1091821082
Symbol: Q86XE2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
Sequence Information:
- Length: 498
- Mass: 54982
- Checksum: 84A47B0228909E0A
- Sequence:
MDASLEKIAD PTLAEMGKNL KEAVKMLEDS QRRTEEENGK KLISGDIPGP LQGSGQDMVS ILQLVQNLMH GDEDEEPQSP RIQNIGEQGH MALLGHSLGA YISTLDKEKL RKLTTRILSD TTLWLCRIFR YENGCAYFHE EEREGLAKIC RLAIHSRYED FVVDGFNVLY NKKPVIYLSA AARPGLGQYL CNQLGLPFPC LCRVPCNTVF GSQHQMDVAF LEKLIKDDIE RGRLPLLLVA NAGTAAVGHT DKIGRLKELC EQYGIWLHVE GVNLATLALG YVSSSVLAAA KCDSMTMTPG PWLGLPAVPA VTLYKHDDPA LTLVAGLTSN KPTDKLRALP LWLSLQYLGL DGFVERIKHA CQLSQRLQES LKKVNYIKIL VEDELSSPVV VFRFFQELPG SDPVFKAVPV PNMTPSGVGR ERHSCDALNR WLGEQLKQLV PASGLTVMDL EAEGTCLRFS PLMTAAGWSH CGTTTRYDCV RSRLTTRLPG STGEQAPP
Genular Protein ID: 1984778592
Symbol: Q6XYB5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
Sequence Information:
- Length: 204
- Mass: 22427
- Checksum: 10B02593FBECC97A
- Sequence:
MTMTPGPWLG LPAVPAVTLY KHDDPALTLV AGLTSNKPTD KLRALPLWLS LQYLGLDGFV ERIKHACQLS QRLQESLKKV NYIKILVEDE LSSPVVVFRF FQELPGSDPV FKAVPVPNMT PSGVGRERHS CDALNRWLGE QLKQLVPASG LTVMDLEAEG TCLRFSPLMT AAGWSHCGTT TRYDCVRSRL TTRLPGSTGE QAPP
Genular Protein ID: 2861980685
Symbol: B4DHL7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 773
- Mass: 85155
- Checksum: 881DB66D3F1A54F3
- Sequence:
MGKNLKEAVK MLEDSQRRTE EENGKKLISG DIPGPLQGSG QDMVSILQLV QNLMHGDEDE EPQSPRMQNI GEQGHMALLG HSLGAYISTL DKEKLRKLTT RILSDTTLWL CRIFRYENGC AYFHEEEREG LAKICRLAIH SRYEDFVVDG FNVLYNKKPV IYLSAAARPG LGQYLCNQLG LPFPCLCRVP CNTVFGSQHQ MDVAFLEKLI KDDIERGRLP LLLVANAGTA AVGHTDKIGR LKELCEQYGI WLHVEGVNLA TLALGYVSSS VLAAAKCDSM TMTPGLWLGL PAVPAVTLYK HDDPALTLVA GLTSNKPTDK LRALPLWLSL QYLGLDGFVE RIKHACQLSQ RLQESLKKVN YIKILVEDEL SSPVVVFRFF QELPGSDPVF KAVPVPNMTP SGVGRERHSC DALNRWLGEQ LKQLVPASGL TVMDLEAEGT CLRFSPLMTA AVLGTRGEDV DQLVACIESK LPVLCCTLQL REEFKQEVEA TAGLLYVDDP NWSGIGVVRY EHANDDKSSL KSDPEGENIH AGLLKKLNEL ESDLTFKIGP EYKSMKSCLY VGMASDNVDA AELVETIAAT AREIEENSRL LENMTEVVRK GIQEAQVELQ KASEERLLEE GVLRQIPVVG SVLNWFSPVQ ALQKGRTFNL TAGSLESTEP IYVYKAQGAG VTLPPTPSGS RTKQRLPGQK PFKRSLRGSD ALSETSSVSH IEDLEKVERL SSGPEQITLE ASSTEGHPGA PSPQHTDQTE AFQKGVPHPE DDHSQVEGPE SLR