Details for: TNIK
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: neuronal brush cell (CL0000555)
Fold Change: 5.69
Marker Score: 19,069 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 5.49
Marker Score: 3,611 - Cell Name: granule cell (CL0000120)
Fold Change: 5.12
Marker Score: 38,576 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 4.96
Marker Score: 29,835 - Cell Name: stellate neuron (CL0000122)
Fold Change: 4.55
Marker Score: 24,434 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 4.47
Marker Score: 23,455 - Cell Name: macroglial cell (CL0000126)
Fold Change: 4.45
Marker Score: 10,230 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 4.25
Marker Score: 143,412 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 3.72
Marker Score: 1,786 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 3.61
Marker Score: 80,608 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.5
Marker Score: 62,195 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.5
Marker Score: 14,637 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 3.24
Marker Score: 69,187 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.22
Marker Score: 7,059 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 3.04
Marker Score: 14,082 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 2.83
Marker Score: 1,641 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.83
Marker Score: 56,194 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 2.75
Marker Score: 871 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.64
Marker Score: 20,227 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.63
Marker Score: 99,746 - Cell Name: astrocyte (CL0000127)
Fold Change: 2.62
Marker Score: 2,274 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.61
Marker Score: 7,459 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.6
Marker Score: 759 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.54
Marker Score: 10,526 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.47
Marker Score: 1,033 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.44
Marker Score: 1,358 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.41
Marker Score: 88,879 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.4
Marker Score: 921 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.37
Marker Score: 5,681 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 2.32
Marker Score: 2,897 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.26
Marker Score: 713 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.22
Marker Score: 2,688 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 2.2
Marker Score: 1,759 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 2.18
Marker Score: 1,657 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.15
Marker Score: 3,605 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.15
Marker Score: 20,178 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.13
Marker Score: 8,219 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 2.06
Marker Score: 2,551 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.04
Marker Score: 125,631 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.01
Marker Score: 7,144 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.97
Marker Score: 1,104 - Cell Name: neuron (CL0000540)
Fold Change: 1.95
Marker Score: 7,951 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.91
Marker Score: 18,113 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.88
Marker Score: 4,708 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.87
Marker Score: 16,033 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.86
Marker Score: 29,884 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.83
Marker Score: 500 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.66
Marker Score: 24,868 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.61
Marker Score: 1,394 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.61
Marker Score: 2,486 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.6
Marker Score: 3,767 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.59
Marker Score: 576 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.54
Marker Score: 898 - Cell Name: ganglion interneuron (CL0000397)
Fold Change: 1.49
Marker Score: 451 - Cell Name: podocyte (CL0000653)
Fold Change: 1.47
Marker Score: 543 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.46
Marker Score: 1,571 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,141 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.44
Marker Score: 415 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.4
Marker Score: 475 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.34
Marker Score: 806 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.33
Marker Score: 20,845 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.27
Marker Score: 4,525 - Cell Name: lymphocyte (CL0000542)
Fold Change: 1.24
Marker Score: 624 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.23
Marker Score: 5,142 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.18
Marker Score: 510 - Cell Name: endocrine cell (CL0000163)
Fold Change: 1.18
Marker Score: 609 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.15
Marker Score: 293 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.13
Marker Score: 7,368 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.13
Marker Score: 422 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.12
Marker Score: 1,293 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.12
Marker Score: 59,400 - Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 1.11
Marker Score: 743 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.1
Marker Score: 1,480 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.09
Marker Score: 3,452 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.08
Marker Score: 440 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.08
Marker Score: 347 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.05
Marker Score: 1,273 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.03
Marker Score: 268 - Cell Name: basophil (CL0000767)
Fold Change: 1.03
Marker Score: 490 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.01
Marker Score: 954 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.01
Marker Score: 2,048 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1
Marker Score: 660 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,715 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,942 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.99
Marker Score: 811 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,396 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.98
Marker Score: 1,878 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.98
Marker Score: 395 - Cell Name: Mueller cell (CL0000636)
Fold Change: 0.96
Marker Score: 1,325 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.96
Marker Score: 4,123 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 491 - Cell Name: acinar cell (CL0000622)
Fold Change: 0.95
Marker Score: 668 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,406 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 446 - Cell Name: Unknown (CL0000548)
Fold Change: 0.93
Marker Score: 678 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.93
Marker Score: 1,509 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.91
Marker Score: 1,260 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,717 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.9
Marker Score: 847 - Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.9
Marker Score: 994
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2560511556
Symbol: TNIK_HUMAN
Name: TRAF2 and NCK-interacting protein kinase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10521462
Title: TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton.
PubMed ID: 10521462
PubMed ID: 9628581
Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9628581
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 15342639
Title: The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton.
PubMed ID: 15342639
PubMed ID: 18930710
Title: MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1.
PubMed ID: 18930710
PubMed ID: 18088087
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19061864
Title: Rap2 function requires palmitoylation and recycling endosome localization.
PubMed ID: 19061864
PubMed ID: 19816403
Title: The kinase TNIK is an essential activator of Wnt target genes.
PubMed ID: 19816403
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20159449
Title: Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.
PubMed ID: 20159449
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21690388
Title: Smad inhibition by the Ste20 kinase Misshapen.
PubMed ID: 21690388
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27106596
Title: A null mutation in TNIK defines a novel locus for intellectual disability.
PubMed ID: 27106596
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 1360
- Mass: 154943
- Checksum: 3590BC2905A72C3D
- Sequence:
MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE REQRRHYEEQ MRREEERRRA EHEQEYIRRQ LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL EEQRQAERLQ RQLKQERDYL VSLQHQRQEQ RPVEKKPLYH YKEGMSPSEK PAWAKEVEER SRLNRQSSPA MPHKVANRIS DPNLPPRSES FSISGVQPAR TPPMLRPVDP QIPHLVAVKS QGPALTASQS VHEQPTKGLS GFQEALNVTS HRVEMPRQNS DPTSENPPLP TRIEKFDRSS WLRQEEDIPP KVPQRTTSIS PALARKNSPG NGSALGPRLG SQPIRASNPD LRRTEPILES PLQRTSSGSS SSSSTPSSQP SSQGGSQPGS QAGSSERTRV RANSKSEGSP VLPHEPAKVK PEESRDITRP SRPASYKKAI DEDLTALAKE LRELRIEETN RPMKKVTDYS SSSEESESSE EEEEDGESET HDGTVAVSDI PRLIPTGAPG SNEQYNVGMV GTHGLETSHA DSFSGSISRE GTLMIRETSG EKKRSGHSDS NGFAGHINLP DLVQQSHSPA GTPTEGLGRV STHSQEMDSG TEYGMGSSTK ASFTPFVDPR VYQTSPTDED EEDEESSAAA LFTSELLRQE QAKLNEARKI SVVNVNPTNI RPHSDTPEIR KYKKRFNSEI LCAALWGVNL LVGTENGLML LDRSGQGKVY NLINRRRFQQ MDVLEGLNVL VTISGKKNKL RVYYLSWLRN RILHNDPEVE KKQGWITVGD LEGCIHYKVV KYERIKFLVI ALKNAVEIYA WAPKPYHKFM AFKSFADLQH KPLLVDLTVE EGQRLKVIFG SHTGFHVIDV DSGNSYDIYI PSHIQGNITP HAIVILPKTD GMEMLVCYED EGVYVNTYGR ITKDVVLQWG EMPTSVAYIH SNQIMGWGEK AIEIRSVETG HLDGVFMHKR AQRLKFLCER NDKVFFASVR SGGSSQVFFM TLNRNSMMNW
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.