Details for: SMG1

Gene ID: 23049

Symbol: SMG1

Ensembl ID: ENSG00000157106

Description: SMG1 nonsense mediated mRNA decay associated PI3K related kinase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.63
    Marker Score: 9,094
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.56
    Marker Score: 135,189
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.54
    Marker Score: 56,707
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.51
    Marker Score: 7,928
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.38
    Marker Score: 80,897
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.33
    Marker Score: 130,170
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.3
    Marker Score: 8,164
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.26
    Marker Score: 48,199
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.25
    Marker Score: 1,345
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.16
    Marker Score: 81,982
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.14
    Marker Score: 2,253
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.14
    Marker Score: 2,422
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.09
    Marker Score: 2,407
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.08
    Marker Score: 2,217
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.07
    Marker Score: 15,889
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.06
    Marker Score: 40,954
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.06
    Marker Score: 30,770
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.06
    Marker Score: 75,846
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.04
    Marker Score: 8,523
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.99
    Marker Score: 1,531
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.98
    Marker Score: 1,041
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.97
    Marker Score: 2,120
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.96
    Marker Score: 8,134
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.95
    Marker Score: 2,156
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.93
    Marker Score: 4,233
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.92
    Marker Score: 934
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.91
    Marker Score: 117,554
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.91
    Marker Score: 7,389
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.89
    Marker Score: 9,274
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.88
    Marker Score: 1,425
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.88
    Marker Score: 3,611
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.87
    Marker Score: 17,629
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.87
    Marker Score: 1,252
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.86
    Marker Score: 2,499
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.86
    Marker Score: 2,312
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.84
    Marker Score: 1,028
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.81
    Marker Score: 18,383
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.81
    Marker Score: 521
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.79
    Marker Score: 17,007
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.78
    Marker Score: 1,583
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.76
    Marker Score: 557
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.75
    Marker Score: 15,048
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.74
    Marker Score: 2,565
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.74
    Marker Score: 4,881
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.72
    Marker Score: 625
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.68
    Marker Score: 6,856
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.67
    Marker Score: 2,022
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.67
    Marker Score: 824
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.64
    Marker Score: 7,602
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.64
    Marker Score: 605
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.63
    Marker Score: 2,106
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.63
    Marker Score: 1,413
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.62
    Marker Score: 4,345
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.61
    Marker Score: 696
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.61
    Marker Score: 485
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.61
    Marker Score: 16,594
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.6
    Marker Score: 1,530
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.6
    Marker Score: 963
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.59
    Marker Score: 1,372
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.58
    Marker Score: 535
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.57
    Marker Score: 5,572
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.57
    Marker Score: 2,218
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.56
    Marker Score: 582
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.56
    Marker Score: 910
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.56
    Marker Score: 1,080
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.55
    Marker Score: 901
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.52
    Marker Score: 847
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.51
    Marker Score: 749
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5
    Marker Score: 24,154
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.5
    Marker Score: 531
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.5
    Marker Score: 358
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.5
    Marker Score: 1,588
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.49
    Marker Score: 2,306
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.49
    Marker Score: 1,368
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.48
    Marker Score: 600
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.47
    Marker Score: 533
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.47
    Marker Score: 1,452
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.46
    Marker Score: 1,150
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.45
    Marker Score: 424
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.44
    Marker Score: 4,952
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.44
    Marker Score: 10,717
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.44
    Marker Score: 5,327
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.44
    Marker Score: 978
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.42
    Marker Score: 2,776
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.42
    Marker Score: 973
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.42
    Marker Score: 1,957
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.41
    Marker Score: 488
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.41
    Marker Score: 575
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.4
    Marker Score: 1,418
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.4
    Marker Score: 928
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.39
    Marker Score: 950
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.39
    Marker Score: 2,470
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.39
    Marker Score: 344
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.39
    Marker Score: 4,351
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.38
    Marker Score: 1,045
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.38
    Marker Score: 4,091
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.37
    Marker Score: 477
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.37
    Marker Score: 8,802
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.36
    Marker Score: 1,070
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.36
    Marker Score: 474

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Nonsense-mediated mRNA decay (NMD) association**: SMG1 is a key component of the NMD pathway, where it interacts with the exon junction complex (EJC) to facilitate the degradation of aberrant mRNAs. 2. **PI3K-related kinase activity**: SMG1 exhibits PI3K-related kinase activity, which is essential for its role in NMD and other cellular processes. 3. **Serine/threonine phosphorylation**: SMG1 is a serine/threonine kinase, which allows it to phosphorylate and regulate various downstream targets. 4. **Cellular expression**: SMG1 is highly expressed in various cell types, including skeletal muscle fibers, T cells, cardiac myocytes, and astrocytes. **Pathways and Functions** 1. **Nonsense-mediated mRNA decay (NMD)**: SMG1 is central to the NMD pathway, where it regulates the degradation of aberrant mRNAs containing premature stop codons. 2. **DNA damage response**: SMG1 interacts with DNA damage response pathways, facilitating the repair of DNA damage and maintaining genome stability. 3. **Telomere maintenance**: SMG1 plays a role in telomere maintenance, ensuring the integrity of telomeres and preventing telomere shortening. 4. **Protein regulation**: SMG1 regulates the phosphorylation and activity of various downstream targets, influencing cellular behavior and response to environmental stimuli. 5. **Metabolism of RNA**: SMG1 is involved in the regulation of RNA metabolism, including the degradation of aberrant mRNAs and the regulation of RNA translation. **Clinical Significance** 1. **Cancer**: Dysregulation of SMG1 has been implicated in various cancers, including breast cancer, where it is often overexpressed. 2. **Neurological disorders**: SMG1 mutations have been associated with neurological disorders, such as frontotemporal dementia and amyotrophic lateral sclerosis (ALS). 3. **Cardiovascular disease**: SMG1 is involved in the regulation of cardiac function and has been implicated in the development of cardiovascular disease. 4. **Immune system regulation**: SMG1 plays a role in regulating immune cell function, including the activity of T cells and macrophages. In conclusion, SMG1 is a multifaceted gene that plays a critical role in maintaining genome integrity, regulating protein function, and influencing cellular behavior. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms and functions. Further research on SMG1 will undoubtedly shed light on its complex role in maintaining cellular homeostasis and its potential as a therapeutic target for various diseases.

Genular Protein ID: 627862753

Symbol: SMG1_HUMAN

Name: Serine/threonine-protein kinase SMG1

UniProtKB Accession Codes:

Q96Q15 O43305 Q13284 Q8NFX2 Q96QV0 Q96RW3

Database IDs:

AGR 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 7 EMDB 18 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 10 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9566925

Title: Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.

PubMed ID: 9566925

DOI: 10.1128/mcb.18.5.3069

PubMed ID: 11544179

Title: Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.

PubMed ID: 11544179

DOI: 10.1101/gad.913001

PubMed ID: 11331269

Title: Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein.

PubMed ID: 11331269

DOI: 10.1074/jbc.c100144200

PubMed ID: 15175154

Title: The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.

PubMed ID: 15175154

DOI: 10.1016/j.molcel.2004.05.005

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 8524286

Title: Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo.

PubMed ID: 8524286

DOI: 10.1128/mcb.16.1.105

PubMed ID: 11948212

Title: Divergent origins and concerted expansion of two segmental duplications on chromosome 16.

PubMed ID: 11948212

DOI: 10.1093/jhered/92.6.462

PubMed ID: 14636577

Title: Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.

PubMed ID: 14636577

DOI: 10.1016/s1097-2765(03)00443-x

PubMed ID: 12554878

Title: Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

PubMed ID: 12554878

DOI: 10.1261/rna.2137903

PubMed ID: 16452507

Title: Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.

PubMed ID: 16452507

DOI: 10.1101/gad.1389006

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19417104

Title: SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

PubMed ID: 19417104

DOI: 10.1101/gad.1767209

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20427287

Title: Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

PubMed ID: 20427287

DOI: 10.1074/jbc.m110.121699

PubMed ID: 20810650

Title: A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

PubMed ID: 20810650

DOI: 10.1101/gad.1934210

PubMed ID: 20371770

Title: AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.

PubMed ID: 20371770

DOI: 10.1126/scisignal.2000468

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21245168

Title: The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.

PubMed ID: 21245168

DOI: 10.1101/gad.606911

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25220460

Title: The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.

PubMed ID: 25220460

DOI: 10.1016/j.celrep.2014.08.020

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26841701

Title: The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.

PubMed ID: 26841701

DOI: 10.1038/ncomms10585

PubMed ID: 33205750

Title: Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM.

PubMed ID: 33205750

DOI: 10.7554/elife.63042

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 3661
  • Mass: 410501
  • Checksum: 216A55F3121F5829
  • Sequence:
    • MSRRAPGSRL SSGGGGGGTK YPRSWNDWQP RTDSASADPD NLKYSSSRDR GGSSSYGLQP 
SNSAVVSRQR HDDTRVHADI QNDEKGGYSV NGGSGENTYG RKSLGQELRV NNVTSPEFTS 
VQHGSRALAT KDMRKSQERS MSYSDESRLS NLLRRITRED DRDRRLATVK QLKEFIQQPE 
NKLVLVKQLD NILAAVHDVL NESSKLLQEL RQEGACCLGL LCASLSYEAE KIFKWIFSKF 
SSSAKDEVKL LYLCATYKAL ETVGEKKAFS SVMQLVMTSL QSILENVDTP ELLCKCVKCI 
LLVARCYPHI FSTNFRDTVD ILVGWHIDHT QKPSLTQQVS GWLQSLEPFW VADLAFSTTL 
LGQFLEDMEA YAEDLSHVAS GESVDEDVPP PSVSLPKLAA LLRVFSTVVR SIGERFSPIR 
GPPITEAYVT DVLYRVMRCV TAANQVFFSE AVLTAANECV GVLLGSLDPS MTIHCDMVIT 
YGLDQLENCQ TCGTDYIISV LNLLTLIVEQ INTKLPSSFV EKLFIPSSKL LFLRYHKEKE 
VVAVAHAVYQ AVLSLKNIPV LETAYKLILG EMTCALNNLL HSLQLPEACS EIKHEAFKNH 
VFNVDNAKFV VIFDLSALTT IGNAKNSLIG MWALSPTVFA LLSKNLMIVH SDLAVHFPAI 
QYAVLYTLYS HCTRHDHFIS SSLSSSSPSL FDGAVISTVT TATKKHFSII LNLLGILLKK 
DNLNQDTRKL LMTWALEAAV LMKKSETYAP LFSLPSFHKF CKGLLANTLV EDVNICLQAC 
SSLHALSSSL PDDLLQRCVD VCRVQLVHSG TRIRQAFGKL LKSIPLDVVL SNNNHTEIQE 
ISLALRSHMS KAPSNTFHPQ DFSDVISFIL YGNSHRTGKD NWLERLFYSC QRLDKRDQST 
IPRNLLKTDA VLWQWAIWEA AQFTVLSKLR TPLGRAQDTF QTIEGIIRSL AAHTLNPDQD 
VSQWTTADND EGHGNNQLRL VLLLQYLENL EKLMYNAYEG CANALTSPPK VIRTFFYTNR 
QTCQDWLTRI RLSIMRVGLL AGQPAVTVRH GFDLLTEMKT TSLSQGNELE VTIMMVVEAL 
CELHCPEAIQ GIAVWSSSIV GKNLLWINSV AQQAEGRFEK ASVEYQEHLC AMTGVDCCIS 
SFDKSVLTLA NAGRNSASPK HSLNGESRKT VLSKPTDSSP EVINYLGNKA CECYISIADW 
AAVQEWQNAI HDLKKSTSST SLNLKADFNY IKSLSSFESG KFVECTEQLE LLPGENINLL 
AGGSKEKIDM KKLLPNMLSP DPRELQKSIE VQLLRSSVCL ATALNPIEQD QKWQSITENV 
VKYLKQTSRI AIGPLRLSTL TVSQSLPVLS TLQLYCSSAL ENTVSNRLST EDCLIPLFSE 
ALRSCKQHDV RPWMQALRYT MYQNQLLEKI KEQTVPIRSH LMELGLTAAK FARKRGNVSL 
ATRLLAQCSE VQLGKTTTAQ DLVQHFKKLS TQGQVDEKWG PELDIEKTKL LYTAGQSTHA 
MEMLSSCAIS FCKSVKAEYA VAKSILTLAK WIQAEWKEIS GQLKQVYRAQ HQQNFTGLST 
LSKNILTLIE LPSVNTMEEE YPRIESESTV HIGVGEPDFI LGQLYHLSSV QAPEVAKSWA 
ALASWAYRWG RKVVDNASQG EGVRLLPREK SEVQNLLPDT ITEEEKERIY GILGQAVCRP 
AGIQDEDITL QITESEDNEE DDMVDVIWRQ LISSCPWLSE LDESATEGVI KVWRKVVDRI 
FSLYKLSCSA YFTFLKLNAG QIPLDEDDPR LHLSHRVEQS TDDMIVMATL RLLRLLVKHA 
GELRQYLEHG LETTPTAPWR GIIPQLFSRL NHPEVYVRQS ICNLLCRVAQ DSPHLILYPA 
IVGTISLSSE SQASGNKFST AIPTLLGNIQ GEELLVSECE GGSPPASQDS NKDEPKSGLN 
EDQAMMQDCY SKIVDKLSSA NPTMVLQVQM LVAELRRVTV LWDELWLGVL LQQHMYVLRR 
IQQLEDEVKR VQNNNTLRKE EKIAIMREKH TALMKPIVFA LEHVRSITAA PAETPHEKWF 
QDNYGDAIEN ALEKLKTPLN PAKPGSSWIP FKEIMLSLQQ RAQKRASYIL RLEEISPWLA 
AMTNTEIALP GEVSARDTVT IHSVGGTITI LPTKTKPKKL LFLGSDGKSY PYLFKGLEDL 
HLDERIMQFL SIVNTMFATI NRQETPRFHA RHYSVTPLGT RSGLIQWVDG ATPLFGLYKR 
WQQREAALQA QKAQDSYQTP QNPGIVPRPS ELYYSKIGPA LKTVGLSLDV SRRDWPLHVM 
KAVLEELMEA TPPNLLAKEL WSSCTTPDEW WRVTQSYARS TAVMSMVGYI IGLGDRHLDN 
VLIDMTTGEV VHIDYNVCFE KGKSLRVPEK VPFRMTQNIE TALGVTGVEG VFRLSCEQVL 
HIMRRGRETL LTLLEAFVYD PLVDWTAGGE AGFAGAVYGG GGQQAESKQS KREMEREITR 
SLFSSRVAEI KVNWFKNRDE MLVVLPKLDG SLDEYLSLQE QLTDVEKLQG KLLEEIEFLE 
GAEGVDHPSH TLQHRYSEHT QLQTQQRAVQ EAIQVKLNEF EQWITHYQAA FNNLEATQLA 
SLLQEISTQM DLGPPSYVPA TAFLQNAGQA HLISQCEQLE GEVGALLQQR RSVLRGCLEQ 
LHHYATVALQ YPKAIFQKHR IEQWKTWMEE LICNTTVERC QELYRKYEMQ YAPQPPPTVC 
QFITATEMTL QRYAADINSR LIRQVERLKQ EAVTVPVCED QLKEIERCIK VFLHENGEEG 
SLSLASVIIS ALCTLTRRNL MMEGAASSAG EQLVDLTSRD GAWFLEELCS MSGNVTCLVQ 
LLKQCHLVPQ DLDIPNPMEA SETVHLANGV YTSLQELNSN FRQIIFPEAL RCLMKGEYTL 
ESMLHELDGL IEQTTDGVPL QTLVESLQAY LRNAAMGLEE ETHAHYIDVA RLLHAQYGEL 
IQPRNGSVDE TPKMSAGQML LVAFDGMFAQ VETAFSLLVE KLNKMEIPIA WRKIDIIREA 
RSTQVNFFDD DNHRQVLEEI FFLKRLQTIK EFFRLCGTFS KTLSGSSSLE DQNTVNGPVQ 
IVNVKTLFRN SCFSEDQMAK PIKAFTADFV RQLLIGLPNQ ALGLTLCSFI SALGVDIIAQ 
VEAKDFGAES KVSVDDLCKK AVEHNIQIGK FSQLVMNRAT VLASSYDTAW KKHDLVRRLE 
TSISSCKTSL QRVQLHIAMF QWQHEDLLIN RPQAMSVTPP PRSAILTSMK KKLHTLSQIE 
TSIATVQEKL AALESSIEQR LKWAGGANPA LAPVLQDFEA TIAERRNLVL KESQRASQVT 
FLCSNIIHFE SLRTRTAEAL NLDAALFELI KRCQQMCSFA SQFNSSVSEL ELRLLQRVDT 
GLEHPIGSSE WLLSAHKQLT QDMSTQRAIQ TEKEQQIETV CETIQNLVDN IKTVLTGHNR 
QLGDVKHLLK AMAKDEEAAL ADGEDVPYEN SVRQFLGEYK SWQDNIQTVL FTLVQAMGQV 
RSQEHVEMLQ EITPTLKELK TQSQSIYNNL VSFASPLVTD ATNECSSPTS SATYQPSFAA 
AVRSNTGQKT QPDVMSQNAR KLIQKNLATS ADTPPSTVPG TGKSVACSPK KAVRDPKTGK 
AVQERNSYAV SVWKRVKAKL EGRDVDPNRR MSVAEQVDYV IKEATNLDNL AQLYEGWTAW 
V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.