Details for: ZHX3

Gene ID: 23051

Symbol: ZHX3

Ensembl ID: ENSG00000174306

Description: zinc fingers and homeoboxes 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 4.1
    Marker Score: 17,079
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.13
    Marker Score: 66,899
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.99
    Marker Score: 1,970
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.47
    Marker Score: 723
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.28
    Marker Score: 9,562
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.24
    Marker Score: 1,726
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.21
    Marker Score: 33,015
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.2
    Marker Score: 43,860
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.09
    Marker Score: 8,683
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.07
    Marker Score: 78,588
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.07
    Marker Score: 2,578
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.06
    Marker Score: 7,983
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.04
    Marker Score: 75,301
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.03
    Marker Score: 3,911
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.95
    Marker Score: 4,657
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.94
    Marker Score: 18,204
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.91
    Marker Score: 6,796
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9
    Marker Score: 116,935
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.85
    Marker Score: 7,517
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.84
    Marker Score: 17,436
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.83
    Marker Score: 8,484
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.8
    Marker Score: 13,814
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.78
    Marker Score: 15,256
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.77
    Marker Score: 31,484
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.76
    Marker Score: 1,527
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.73
    Marker Score: 17,864
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.7
    Marker Score: 531
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.66
    Marker Score: 1,913
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.63
    Marker Score: 904
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.57
    Marker Score: 497
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.54
    Marker Score: 1,705
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.53
    Marker Score: 9,835
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.53
    Marker Score: 8,201
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.52
    Marker Score: 2,347
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.46
    Marker Score: 961
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.45
    Marker Score: 1,557
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.43
    Marker Score: 6,183
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.42
    Marker Score: 3,337
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.42
    Marker Score: 1,750
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.4
    Marker Score: 509
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.4
    Marker Score: 3,750
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.4
    Marker Score: 758
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.39
    Marker Score: 1,863
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.38
    Marker Score: 2,324
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.38
    Marker Score: 1,475
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.37
    Marker Score: 3,899
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.35
    Marker Score: 2,956
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.32
    Marker Score: 736
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.26
    Marker Score: 291
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.25
    Marker Score: 1,192
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.24
    Marker Score: 1,262
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.23
    Marker Score: 737
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.21
    Marker Score: 18,904
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2
    Marker Score: 40,366
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.19
    Marker Score: 588
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.16
    Marker Score: 2,020
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.15
    Marker Score: 364
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.13
    Marker Score: 597
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.11
    Marker Score: 5,964
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2,219
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.06
    Marker Score: 16,988
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.05
    Marker Score: 23,441
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.04
    Marker Score: 1,263
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.04
    Marker Score: 1,125
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.02
    Marker Score: 323
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,776
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,001
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.99
    Marker Score: 1,445
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.99
    Marker Score: 5,931
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.98
    Marker Score: 357
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.98
    Marker Score: 2,242
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.97
    Marker Score: 7,313
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.96
    Marker Score: 245
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.96
    Marker Score: 403
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,408
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.94
    Marker Score: 546
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1,507
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.92
    Marker Score: 239
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,728
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.89
    Marker Score: 668
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.89
    Marker Score: 219
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,050
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.88
    Marker Score: 2,966
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.87
    Marker Score: 520
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.84
    Marker Score: 401
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.84
    Marker Score: 221
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.83
    Marker Score: 309
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.82
    Marker Score: 265
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.82
    Marker Score: 2,914
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8
    Marker Score: 910
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.8
    Marker Score: 301
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 609
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.8
    Marker Score: 219
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.79
    Marker Score: 1,998
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** ZHX3 contains a conserved zinc finger domain, which is essential for its DNA-binding activity and transcriptional regulation. 2. **Homeobox Domain:** The homeobox domain in ZHX3 is responsible for its role in cell differentiation and development. 3. **Cellular Expression:** ZHX3 is highly expressed in various cell types, including GABAergic neurons, astrocytes, and renal principal cells, highlighting its potential involvement in neurological and renal functions. 4. **Protein-Protein Interactions:** ZHX3 interacts with other proteins, such as RNA polymerase II, to regulate transcription and cell differentiation. **Pathways and Functions:** 1. **Cell Differentiation:** ZHX3 regulates cell differentiation by modulating the expression of genes involved in neuronal development and function. 2. **DNA Binding and Transcriptional Regulation:** ZHX3 binds to specific DNA sequences, influencing the transcription of target genes and regulating the expression of genes involved in various cellular processes. 3. **RNA Polymerase II-Specific Regulation:** ZHX3 interacts with RNA polymerase II to regulate transcription, which is essential for gene expression and cellular function. 4. **Chromatin Remodeling:** ZHX3 may participate in chromatin remodeling, which is critical for regulating gene expression and cellular differentiation. **Clinical Significance:** 1. **Neurological Disorders:** ZHX3's involvement in neuronal development and function suggests its potential role in neurological disorders, such as epilepsy, autism, and Alzheimer's disease. 2. **Renal Function:** ZHX3's expression in renal principal cells implies its potential involvement in renal function and disease, such as kidney cancer and nephrotic syndrome. 3. **Immunological Disorders:** ZHX3's expression in GABAergic neurons and astrocytes highlights its potential role in immune system function and disorders, such as multiple sclerosis and autoimmune diseases. 4. **Cancer:** ZHX3's involvement in cell differentiation and transcriptional regulation may contribute to its potential role in cancer development and progression. In conclusion, ZHX3 is a multifunctional gene that plays a critical role in various cellular processes, including cell differentiation, DNA binding, and regulation of transcription by RNA polymerase II. Its expression in various cell types and potential involvement in neurological, renal, and immunological disorders make it an attractive target for further research and potential therapeutic applications.

Genular Protein ID: 3673529618

Symbol: ZHX3_HUMAN

Name: Zinc fingers and homeoboxes protein 3

UniProtKB Accession Codes:

Q9H4I2 E1P5W5 F5H820 O43145 Q6NUJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 5 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12659632

Title: Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.

PubMed ID: 12659632

DOI: 10.1042/bj20021866

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14659886

Title: The mouse zinc-fingers and homeoboxes (ZHX) family: ZHX2 forms a heterodimer with ZHX3.

PubMed ID: 14659886

DOI: 10.1016/j.gene.2003.09.013

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21174497

Title: Impact of zinc fingers and homeoboxes 3 on the regulation of mesenchymal stem cell osteogenic differentiation.

PubMed ID: 21174497

DOI: 10.1089/scd.2010.0279

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 956
  • Mass: 104658
  • Checksum: B3DB35CFC1781A3A
  • Sequence:
    • MASKRKSTTP CMIPVKTVVL QDASMEAQPA ETLPEGPQQD LPPEASAASS EAAQNPSSTD 
GSTLANGHRS TLDGYLYSCK YCDFRSHDMT QFVGHMNSEH TDFNKDPTFV CSGCSFLAKT 
PEGLSLHNAT CHSGEASFVW NVAKPDNHVV VEQSIPESTS TPDLAGEPSA EGADGQAEII 
ITKTPIMKIM KGKAEAKKIH TLKENVPSQP VGEALPKLST GEMEVREGDH SFINGAVPVS 
QASASSAKNP HAANGPLIGT VPVLPAGIAQ FLSLQQQPPV HAQHHVHQPL PTAKALPKVM 
IPLSSIPTYN AAMDSNSFLK NSFHKFPYPT KAELCYLTVV TKYPEEQLKI WFTAQRLKQG 
ISWSPEEIED ARKKMFNTVI QSVPQPTITV LNTPLVASAG NVQHLIQAAL PGHVVGQPEG 
TGGGLLVTQP LMANGLQATS SPLPLTVTSV PKQPGVAPIN TVCSNTTSAV KVVNAAQSLL 
TACPSITSQA FLDASIYKNK KSHEQLSALK GSFCRNQFPG QSEVEHLTKV TGLSTREVRK 
WFSDRRYHCR NLKGSRAMIP GDHSSIIIDS VPEVSFSPSS KVPEVTCIPT TATLATHPSA 
KRQSWHQTPD FTPTKYKERA PEQLRALESS FAQNPLPLDE ELDRLRSETK MTRREIDSWF 
SERRKKVNAE ETKKAEENAS QEEEEAAEDE GGEEDLASEL RVSGENGSLE MPSSHILAER 
KVSPIKINLK NLRVTEANGR NEIPGLGACD PEDDESNKLA EQLPGKVSCK KTAQQRHLLR 
QLFVQTQWPS NQDYDSIMAQ TGLPRPEVVR WFGDSRYALK NGQLKWYEDY KRGNFPPGLL 
VIAPGNRELL QDYYMTHKML YEEDLQNLCD KTQMSSQQVK QWFAEKMGEE TRAVADTGSE 
DQGPGTGELT AVHKGMGDTY SEVSENSESW EPRVPEASSE PFDTSSPQAG RQLETD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.