Details for: ENDOD1

Gene ID: 23052

Symbol: ENDOD1

Ensembl ID: ENSG00000149218

Description: endonuclease domain containing 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,682
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.46
    Marker Score: 1,684
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.28
    Marker Score: 7,607
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.25
    Marker Score: 953
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.21
    Marker Score: 2,892
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.17
    Marker Score: 2,040
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.15
    Marker Score: 3,608
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.08
    Marker Score: 39,747
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.08
    Marker Score: 10,820
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.08
    Marker Score: 22,945
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.07
    Marker Score: 1,332
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1
    Marker Score: 956
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,750
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,974
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.99
    Marker Score: 237
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.98
    Marker Score: 19,582
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.98
    Marker Score: 306
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.98
    Marker Score: 9,181
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.96
    Marker Score: 403
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.95
    Marker Score: 58,420
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.95
    Marker Score: 1,461
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.95
    Marker Score: 8,990
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.92
    Marker Score: 7,945
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,714
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,129
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.89
    Marker Score: 262
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 356
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.87
    Marker Score: 619
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,252
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.86
    Marker Score: 928
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.84
    Marker Score: 394
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.84
    Marker Score: 1,906
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.83
    Marker Score: 456
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.81
    Marker Score: 2,212
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.79
    Marker Score: 3,069
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.79
    Marker Score: 380
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.77
    Marker Score: 1,815
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.76
    Marker Score: 761
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.76
    Marker Score: 754
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.74
    Marker Score: 6,409
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.74
    Marker Score: 28,015
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.73
    Marker Score: 438
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.73
    Marker Score: 612
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11,428
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.72
    Marker Score: 208
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.71
    Marker Score: 10,641
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.71
    Marker Score: 1,411
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.71
    Marker Score: 1,326
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 449
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.7
    Marker Score: 148
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,898
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.69
    Marker Score: 5,107
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 620
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.68
    Marker Score: 383
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.68
    Marker Score: 1,377
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.66
    Marker Score: 440
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.66
    Marker Score: 951
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.65
    Marker Score: 590
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.65
    Marker Score: 1,249
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.64
    Marker Score: 1,637
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.64
    Marker Score: 4,187
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.64
    Marker Score: 804
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.63
    Marker Score: 395
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.63
    Marker Score: 3,038
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.63
    Marker Score: 368
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.63
    Marker Score: 641
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.63
    Marker Score: 3,298
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.62
    Marker Score: 424
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.62
    Marker Score: 150
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.61
    Marker Score: 10,854
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.61
    Marker Score: 300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.61
    Marker Score: 1,626
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1,140
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.59
    Marker Score: 191
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.59
    Marker Score: 861
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.58
    Marker Score: 4,551
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 383
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.58
    Marker Score: 2,356
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.58
    Marker Score: 3,458
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.57
    Marker Score: 946
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.57
    Marker Score: 252
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.57
    Marker Score: 270
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.57
    Marker Score: 372
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.56
    Marker Score: 130
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 337
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.56
    Marker Score: 2,304
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.54
    Marker Score: 246
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.54
    Marker Score: 575
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.53
    Marker Score: 136
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.53
    Marker Score: 1,212

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Domain structure:** The ENDOD1 protein contains multiple domains, including an endonuclease domain, which is involved in DNA cleavage and repair, and protein-binding domains that facilitate interactions with other proteins. 2. **Expression pattern:** ENDOD1 is expressed in a variety of cell types, including mural cells, vascular leptomeningeal cells, Sertoli cells, and granulosa cells, suggesting its role in maintaining tissue homeostasis and cellular differentiation. 3. **Signaling pathways:** ENDOD1 is involved in several signaling pathways, including platelet activation, signaling and aggregation, and response to elevated platelet cytosolic Ca2+, highlighting its role in regulating cellular responses to stimuli. **Pathways and Functions:** 1. **Innate immune response:** ENDOD1 is involved in the innate immune response, particularly in the regulation of inflammatory responses and the production of pro-inflammatory cytokines. 2. **Hemostasis:** ENDOD1 plays a critical role in hemostasis, particularly in the regulation of platelet activation, aggregation, and degranulation, ensuring blood clotting and preventing excessive bleeding. 3. **Cellular differentiation:** ENDOD1 is involved in the regulation of cellular differentiation, particularly in the development of granulosa cells and oligodendrocytes, highlighting its role in maintaining tissue homeostasis. 4. **Extracellular regulation:** ENDOD1 is also involved in the regulation of extracellular processes, including the formation of exosomes and the regulation of metal ion binding, underscoring its role in maintaining cellular homeostasis. **Clinical Significance:** 1. **Hemostatic disorders:** Dysregulation of ENDOD1 has been implicated in various hemostatic disorders, including thrombocytopenia and bleeding disorders, highlighting its importance in maintaining blood clotting. 2. **Inflammatory diseases:** ENDOD1 has been implicated in the regulation of inflammatory responses, particularly in diseases such as atherosclerosis and rheumatoid arthritis, underscoring its role in maintaining tissue homeostasis. 3. **Cancer:** ENDOD1 has been implicated in the regulation of cellular differentiation and proliferation, particularly in the development of certain types of cancer, highlighting its potential as a therapeutic target. 4. **Neurological disorders:** ENDOD1 has been implicated in the regulation of cellular differentiation and function, particularly in the development of neurological disorders such as multiple sclerosis and Parkinson's disease, underscoring its potential as a therapeutic target. In conclusion, ENDOD1 is a multifaceted gene that plays a critical role in various biological processes, including innate immunity, hemostasis, and cellular differentiation. Further research is needed to fully elucidate the mechanisms by which ENDOD1 regulates these processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 427578127

Symbol: ENDD1_HUMAN

Name: Endonuclease domain-containing 1 protein

UniProtKB Accession Codes:

O94919 A8K6K8 Q6GQY5 Q8TAQ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 EPD 1 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11921445

Title: Towards complete analysis of the platelet proteome.

PubMed ID: 11921445

DOI: 10.1002/1615-9861(200203)2:3<288::aid-prot288>3.0.co;2-0

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 32614325

Title: Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.

PubMed ID: 32614325

DOI: 10.7554/elife.57306

Sequence Information:

  • Length: 500
  • Mass: 55017
  • Checksum: 5B62754FE2E9AD9C
  • Sequence:
    • MGTARWLALG SLFALAGLLE GRLVGEEEAG FGECDKFFYA GTPPAGLAAD SHVKICQRAE 
GAERFATLYS TRDRIPVYSA FRAPRPAPGG AEQRWLVEPQ IDDPNSNLEE AINEAEAITS 
VNSLGSKQAL NTDYLDSDYQ RGQLYPFSLS SDVQVATFTL TNSAPMTQSF QERWYVNLHS 
LMDRALTPQC GSGEDLYILT GTVPSDYRVK DKVAVPEFVW LAACCAVPGG GWAMGFVKHT 
RDSDIIEDVM VKDLQKLLPF NPQLFQNNCG ETEQDTEKMK KILEVVNQIQ DEERMVQSQK 
SSSPLSSTRS KRSTLLPPEA SEGSSSFLGK LMGFIATPFI KLFQLIYYLV VAILKNIVYF 
LWCVTKQVIN GIESCLYRLG SATISYFMAI GEELVSIPWK VLKVVAKVIR ALLRILCCLL 
KAICRVLSIP VRVLVDVATF PVYTMGAIPI VCKDIALGLG GTVSLLFDTA FGTLGGLFQV 
VFSVCKRIGY KVTFDNSGEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.