Details for: ZSWIM8

Gene ID: 23053

Symbol: ZSWIM8

Ensembl ID: ENSG00000214655

Description: zinc finger SWIM-type containing 8

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.26
    Marker Score: 77,478
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.25
    Marker Score: 11,892
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.25
    Marker Score: 26,682
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.24
    Marker Score: 1,911
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.24
    Marker Score: 10,614
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.11
    Marker Score: 10,442
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.09
    Marker Score: 11,273
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.07
    Marker Score: 624
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.05
    Marker Score: 38,653
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1
    Marker Score: 3,873
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1
    Marker Score: 1,105
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,721
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,945
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.99
    Marker Score: 37,746
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.99
    Marker Score: 416
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.99
    Marker Score: 4,035
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,396
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,399
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.94
    Marker Score: 546
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.92
    Marker Score: 8,085
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.91
    Marker Score: 2,006
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.91
    Marker Score: 416
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,709
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.9
    Marker Score: 17,977
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.9
    Marker Score: 3,773
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.89
    Marker Score: 13,365
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.89
    Marker Score: 6,846
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.89
    Marker Score: 597
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13,549
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.84
    Marker Score: 885
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.84
    Marker Score: 964
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.83
    Marker Score: 3,461
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.83
    Marker Score: 1,902
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.83
    Marker Score: 722
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.82
    Marker Score: 225
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.81
    Marker Score: 536
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8
    Marker Score: 394
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8
    Marker Score: 5,115
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.79
    Marker Score: 1,866
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.79
    Marker Score: 231
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.78
    Marker Score: 3,370
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.77
    Marker Score: 244
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.76
    Marker Score: 1,125
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 305
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 581
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.76
    Marker Score: 423
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.75
    Marker Score: 1,013
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.74
    Marker Score: 1,295
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.73
    Marker Score: 355
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.73
    Marker Score: 3,926
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,061
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.72
    Marker Score: 603
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.72
    Marker Score: 871
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.71
    Marker Score: 1,375
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.71
    Marker Score: 737
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.71
    Marker Score: 852
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.7
    Marker Score: 222
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.69
    Marker Score: 1,164
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.69
    Marker Score: 747
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.69
    Marker Score: 469
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.68
    Marker Score: 3,165
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.68
    Marker Score: 735
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.68
    Marker Score: 212
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.67
    Marker Score: 4,001
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.67
    Marker Score: 1,595
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 607
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.66
    Marker Score: 328
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.66
    Marker Score: 308
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.66
    Marker Score: 666
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.65
    Marker Score: 323
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.64
    Marker Score: 147
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.64
    Marker Score: 606
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.63
    Marker Score: 1,701
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.63
    Marker Score: 161
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.63
    Marker Score: 21,432
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.62
    Marker Score: 665
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.62
    Marker Score: 370
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.62
    Marker Score: 745
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.62
    Marker Score: 2,190
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.62
    Marker Score: 230
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.61
    Marker Score: 357
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.61
    Marker Score: 10,858
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.61
    Marker Score: 226
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.61
    Marker Score: 759
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.61
    Marker Score: 558
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.6
    Marker Score: 348
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.59
    Marker Score: 1,053
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.59
    Marker Score: 191
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 390
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.58
    Marker Score: 618
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.58
    Marker Score: 397
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.58
    Marker Score: 4,966

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ZSWIM8 gene is a member of the SWIM (SWI-like with 8 zinc fingers) family of genes, characterized by the presence of eight zinc fingers. These zinc fingers are responsible for binding to specific DNA sequences, allowing for the regulation of gene expression. The ZSWIM8 gene is specifically expressed in neural cells, including L2/3-6 intratelencephalic projecting glutamatergic neurons, corticothalamic-projecting glutamatergic cortical neurons, astrocytes of the cerebral cortex, and GABAergic cortical interneurons. **Pathways and Functions:** The ZSWIM8 gene is implicated in several key pathways, including: 1. **Axon Guidance:** ZSWIM8 is involved in the regulation of axon guidance, a critical process for the development and connectivity of neural circuits. 2. **Cul2-ring ubiquitin ligase complex:** ZSWIM8 is a component of the Cul2-ring ubiquitin ligase complex, which is responsible for the ubiquitination and degradation of target proteins. 3. **Cul3-ring ubiquitin ligase complex:** ZSWIM8 is also a component of the Cul3-ring ubiquitin ligase complex, which is involved in the regulation of protein ubiquitination. 4. **Mirna catabolic process:** ZSWIM8 is involved in the regulation of mirna catabolic process, which is critical for the maintenance of genome stability. 5. **Protein ubiquitination:** ZSWIM8 is a ubiquitin ligase-substrate adaptor, which is involved in the regulation of protein ubiquitination. **Clinical Significance:** The clinical significance of the ZSWIM8 gene is still emerging, but it is clear that ZSWIM8 plays a crucial role in maintaining neural circuitry and function. Mutations in the ZSWIM8 gene have been implicated in various neurological disorders, including autism spectrum disorder and schizophrenia. Further research is needed to fully understand the role of ZSWIM8 in human disease and to explore potential therapeutic strategies. In conclusion, the ZSWIM8 gene is a critical component of neural development and function, and its dysregulation has been implicated in various neurological disorders. Further research is needed to fully understand the role of ZSWIM8 in human disease and to explore potential therapeutic strategies.

Genular Protein ID: 2579266867

Symbol: ZSWM8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A7E2V4 B2RP37 O94987 Q17RS8 Q2TAB8 Q6P439 Q8IW81 Q8NB34 Q9H8F3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 11 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24012004

Title: The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons.

PubMed ID: 24012004

DOI: 10.1016/j.neuron.2013.06.035

PubMed ID: 33184234

Title: A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming.

PubMed ID: 33184234

DOI: 10.1126/science.abc9546

PubMed ID: 33184237

Title: The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation.

PubMed ID: 33184237

DOI: 10.1126/science.abc9359

Sequence Information:

  • Length: 1837
  • Mass: 197297
  • Checksum: 391CF6AE25E4F8C6
  • Sequence:
    • MELMFAEWED GERFSFEDSD RFEEDSLCSF ISEAESLCQN WRGWRKQSAG PNSPTGGGGG 
GGSGGTRMRD GLVIPLVELS AKQVAFHIPF EVVEKVYPPV PEQLQLRIAF WSFPENEEDI 
RLYSCLANGS ADEFQRGDQL FRMRAVKDPL QIGFHLSATV VPPQMVPPKG AYNVAVMFDR 
CRVTSCSCTC GAGAKWCTHV VALCLFRIHN ASAVCLRAPV SESLSRLQRD QLQKFAQYLI 
SELPQQILPT AQRLLDELLS SQSTAINTVC GAPDPTAGPS ASDQSTWYLD ESTLTDNIKK 
TLHKFCGPSP VVFSDVNSMY LSSTEPPAAA EWACLLRPLR GREPEGVWNL LSIVREMFKR 
RDSNAAPLLE ILTDQCLTYE QITGWWYSVR TSASHSSASG HTGRSNGQSE VAAHACASMC 
DEMVTLWRLA VLDPALSPQR RRELCTQLRQ WQLKVIENVK RGQHKKTLER LFPGFRPAVE 
ACYFNWEEAY PLPGVTYSGT DRKLALCWAR ALPSRPGASR SGGLEESRDR PRPLPTEPAV 
RPKEPGTKRK GLGEGVPSSQ RGPRRLSAEG GDKALHKMGP GGGKAKALGG AGSGSKGSAG 
GGSKRRLSSE DSSLEPDLAE MSLDDSSLAL GAEASTFGGF PESPPPCPLH GGSRGPSTFL 
PEPPDTYEED GGVYFSEGPE PPTASVGPPG LLPGDVCTQD DLPSTDESGN GLPKTKEAAP 
AVGEEDDDYQ AYYLNAQDGA GGEEEKAEGG AGEEHDLFAG LKPLEQESRM EVLFACAEAL 
HAHGYSSEAS RLTVELAQDL LANPPDLKVE PPPAKGKKNK VSTSRQTWVA TNTLSKAAFL 
LTVLSERPEH HNLAFRVGMF ALELQRPPAS TKALEVKLAY QESEVAALLK KIPLGPSEMS 
TMRCRAEELR EGTLCDYRPV LPLMLASFIF DVLCAPGSRP PSRNWNSETP GDEELGFEAA 
VAALGMKTTV SEAEHPLLCE GTRREKGDLA LALMITYKDD QAKLKKILDK LLDRESQTHK 
PQTLSSFYSS SRPTTASQRS PSKHGGPSAP GALQPLTSGS AGPAQPGSVA GAGPGPTEGF 
TEKNVPESSP HSPCEGLPSE AALTPRPEGK VPSRLALGSR GGYNGRGWGS PGRPKKKHTG 
MASIDSSAPE TTSDSSPTLS RRPLRGGWAP TSWGRGQDSD SISSSSSDSL GSSSSSGSRR 
ASASGGARAK TVEVGRYKGR RPESHAPHVP NQPSEAAAHF YFELAKTVLI KAGGNSSTSI 
FTHPSSSGGH QGPHRNLHLC AFEIGLYALG LHNFVSPNWL SRTYSSHVSW ITGQAMEIGS 
AALTILVECW DGHLTPPEVA SLADRASRAR DSNMVRAAAE LALSCLPHAH ALNPNEIQRA 
LVQCKEQDNL MLEKACMAVE EAAKGGGVYP EVLFEVAHQW FWLYEQTAGG SSTAREGATS 
CSASGIRAGG EAGRGMPEGR GGPGTEPVTV AAAAVTAAAT VVPVISVGSS LYPGPGLGHG 
HSPGLHPYTA LQPHLPCSPQ YLTHPAHPAH PMPHMPRPAV FPVPSSAYPQ GVHPAFLGAQ 
YPYSVTPPSL AATAVSFPVP SMAPITVHPY HTEPGLPLPT SVACELWGQG TVSSVHPAST 
FPAIQGASLP ALTTQPSPLV SGGFPPPEEE THSQPVNPHS LHHLHAAYRV GMLALEMLGR 
RAHNDHPNNF SRSPPYTDDV KWLLGLAAKL GVNYVHQFCV GAAKGVLSPF VLQEIVMETL 
QRLSPAHAHN HLRAPAFHQL VQRCQQAYMQ YIHHRLIHLT PADYDDFVNA IRSARSAFCL 
TPMGMMQFND ILQNLKRSKQ TKELWQRVSL EMATFSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.