Details for: NMNAT2

Gene ID: 23057

Symbol: NMNAT2

Ensembl ID: ENSG00000157064

Description: nicotinamide nucleotide adenylyltransferase 2

Associated with

Other Information

Genular Protein ID: 2711551926

Symbol: NMNA2_HUMAN

Name: Nicotinamide mononucleotide adenylyltransferase 2

UniProtKB Accession Codes:

Q9BZQ4 O75067 Q5T1Q3 Q8WU99 Q96QW1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 22 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 2 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 6 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 2 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11318611

Title: Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.

PubMed ID: 11318611

DOI: 10.1006/geno.2001.6500

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12359228

Title: Identification of a novel human nicotinamide mononucleotide adenylyltransferase.

PubMed ID: 12359228

DOI: 10.1016/s0006-291x(02)02285-4

PubMed ID: 14516279

Title: Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas.

PubMed ID: 14516279

DOI: 10.1042/bj20030518

PubMed ID: 16118205

Title: Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms.

PubMed ID: 16118205

DOI: 10.1074/jbc.m508660200

PubMed ID: 17402747

Title: Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis.

PubMed ID: 17402747

DOI: 10.1021/bi6023379

PubMed ID: 29643511

Title: Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

PubMed ID: 29643511

DOI: 10.1038/s41586-018-0026-1

PubMed ID: 29997255

Title: PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2.

PubMed ID: 29997255

DOI: 10.1074/jbc.ra118.002176

PubMed ID: 34314702

Title: Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers.

PubMed ID: 34314702

DOI: 10.1016/j.cell.2021.07.005

Sequence Information:

  • Length: 307
  • Mass: 34439
  • Checksum: 702F1C74B38ECECB
  • Sequence:
    • MTETTKTHVI LLACGSFNPI TKGHIQMFER ARDYLHKTGR FIVIGGIVSP VHDSYGKQGL 
VSSRHRLIMC QLAVQNSDWI RVDPWECYQD TWQTTCSVLE HHRDLMKRVT GCILSNVNTP 
SMTPVIGQPQ NETPQPIYQN SNVATKPTAA KILGKVGESL SRICCVRPPV ERFTFVDENA 
NLGTVMRYEE IELRILLLCG SDLLESFCIP GLWNEADMEV IVGDFGIVVV PRDAADTDRI 
MNHSSILRKY KNNIMVVKDD INHPMSVVSS TKSRLALQHG DGHVVDYLSQ PVIDYILKSQ 
LYINASG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.