Details for: CLUAP1

Gene ID: 23059

Symbol: CLUAP1

Ensembl ID: ENSG00000103351

Description: clusterin associated protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.53
    Marker Score: 4,422
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.49
    Marker Score: 21,638
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.06
    Marker Score: 7,075
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.03
    Marker Score: 1,624
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.81
    Marker Score: 3,447
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.81
    Marker Score: 858
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,513
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.46
    Marker Score: 5,423
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.38
    Marker Score: 1,984
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.38
    Marker Score: 47,640
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.34
    Marker Score: 15,115
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.33
    Marker Score: 11,428
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.3
    Marker Score: 12,309
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.29
    Marker Score: 79,052
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.26
    Marker Score: 5,234
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.22
    Marker Score: 11,454
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.21
    Marker Score: 1,873
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.2
    Marker Score: 44,286
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18,666
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.18
    Marker Score: 23,480
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.13
    Marker Score: 42,821
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1
    Marker Score: 4,265
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.03
    Marker Score: 688
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.03
    Marker Score: 15,377
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.02
    Marker Score: 294
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.02
    Marker Score: 2,124
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,738
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,963
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.98
    Marker Score: 7,543
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,398
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.98
    Marker Score: 410
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.98
    Marker Score: 20,887
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.96
    Marker Score: 2,605
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.95
    Marker Score: 1,003
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,403
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.94
    Marker Score: 281
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.92
    Marker Score: 418
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,715
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.9
    Marker Score: 609
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.89
    Marker Score: 1,121
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.88
    Marker Score: 3,595
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,946
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.86
    Marker Score: 514
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.85
    Marker Score: 3,575
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.85
    Marker Score: 901
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.84
    Marker Score: 464
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.84
    Marker Score: 872
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.83
    Marker Score: 8,345
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.83
    Marker Score: 3,576
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.82
    Marker Score: 1,396
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.81
    Marker Score: 18,007
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8
    Marker Score: 8,234
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.77
    Marker Score: 833
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.77
    Marker Score: 245
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 307
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.76
    Marker Score: 1,555
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.76
    Marker Score: 824
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.76
    Marker Score: 1,436
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3,179
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.76
    Marker Score: 187
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.74
    Marker Score: 173
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.74
    Marker Score: 279
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.73
    Marker Score: 199
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.72
    Marker Score: 4,695
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.7
    Marker Score: 1,771
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.7
    Marker Score: 2,856
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.7
    Marker Score: 475
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.69
    Marker Score: 4,176
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.69
    Marker Score: 200
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.69
    Marker Score: 773
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.68
    Marker Score: 352
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.68
    Marker Score: 157
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 614
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.65
    Marker Score: 1,542
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.65
    Marker Score: 663
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.65
    Marker Score: 209
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.65
    Marker Score: 2,307
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.65
    Marker Score: 165
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 410
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.64
    Marker Score: 2,476
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.64
    Marker Score: 125
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.64
    Marker Score: 191
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.63
    Marker Score: 303
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.63
    Marker Score: 720
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.61
    Marker Score: 293
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.61
    Marker Score: 4,562
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.61
    Marker Score: 192
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6
    Marker Score: 1,722
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.6
    Marker Score: 7,950
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.6
    Marker Score: 520
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.59
    Marker Score: 2,319
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.59
    Marker Score: 1,670

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLUAP1 is a member of the clusterin family of proteins, characterized by its ability to interact with other proteins and modulate their activity. The protein is highly expressed in various cell types, including germ cells, ciliated cells, and pulmonary interstitial fibroblasts. Its expression is also observed in the central nervous system, where it may play a role in axoneme assembly and neural tube closure. **Pathways and Functions:** CLUAP1 is involved in several cellular pathways, including axoneme assembly, centrosome formation, ciliary base and tip formation, and intraflagellar transport. The protein's role in ciliary function is critical, as it helps to regulate the movement and motility of cilia, which are essential for various cellular processes, such as sensing the extracellular environment, signaling, and cell migration. CLUAP1 also interacts with other proteins involved in signaling pathways, including the Smoothened pathway, which regulates the Hedgehog signaling cascade. **Functions:** 1. **Ciliary function:** CLUAP1 regulates ciliary movement and motility, ensuring proper ciliary function and cell signaling. 2. **Cell signaling:** The protein interacts with other signaling molecules, modulating their activity and influencing various cellular processes. 3. **Organelle biogenesis and maintenance:** CLUAP1 is involved in the formation and maintenance of intracellular membrane-bounded organelles, such as the cilium and centrosome. 4. **Neural tube closure:** The protein plays a role in the formation of the neural tube, a critical structure in the development of the central nervous system. **Clinical Significance:** Dysregulation of CLUAP1 has been implicated in various human diseases, including respiratory disorders, such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Mutations in the CLUAP1 gene have also been associated with ciliopathies, a group of disorders characterized by defects in ciliary function and motility. Furthermore, CLUAP1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where ciliary dysfunction is a common feature. In conclusion, CLUAP1 is a crucial protein involved in ciliary function and cell signaling pathways. Its dysregulation has significant implications for human disease, highlighting the importance of understanding the molecular mechanisms underlying its function. Further research is necessary to elucidate the full extent of CLUAP1's role in human disease and to develop therapeutic strategies to target this protein.

Genular Protein ID: 292685572

Symbol: CLUA1_HUMAN

Name: Clusterin-associated protein 1

UniProtKB Accession Codes:

Q96AJ1 O75138 Q65ZA3 Q9H8R4 Q9H8T1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15480429

Title: Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer.

PubMed ID: 15480429

DOI: 10.1038/sj.onc.1208100

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15530380

Title: Human cilia proteome contains homolog of zebrafish polycystic kidney disease gene qilin.

PubMed ID: 15530380

DOI: 10.1016/j.cub.2004.10.011

PubMed ID: 17203229

Title: Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system.

PubMed ID: 17203229

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 26389662

Title: Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.

PubMed ID: 26389662

DOI: 10.1038/ncb3238

Sequence Information:

  • Length: 413
  • Mass: 48125
  • Checksum: 7A23D4FA2EBE5A9F
  • Sequence:
    • MSFRDLRNFT EMMRALGYPR HISMENFRTP NFGLVSEVLL WLVKRYEPQT DIPPDVDTEQ 
DRVFFIKAIA QFMATKAHIK LNTKKLYQAD GYAVKELLKI TSVLYNAMKT KGMEGSEIVE 
EDVNKFKFDL GSKIADLKAA RQLASEITSK GASLYDLLGM EVELREMRTE AIARPLEINE 
TEKVMRIAIK EILTQVQKTK DLLNNVASDE ANLEAKIEKR KLELERNRKR LETLQSVRPC 
FMDEYEKTEE ELQKQYDTYL EKFQNLTYLE QQLEDHHRME QERFEEAKNT LCLIQNKLKE 
EEKRLLKSGS NDDSDIDIQE DDESDSELEE RRLPKPQTAM EMLMQGRPGK RIVGTMQGGD 
SDDNEDSEES EIDMEDDDDE DDDLEDESIS LSPTKPNRRV RKSEPLDESD NDF

Genular Protein ID: 3428796418

Symbol: J3KNW5_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KNW5

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 RefSeq 1 SAM 2 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 432
  • Mass: 50085
  • Checksum: CEFF321BEA2B7A2C
  • Sequence:
    • MSFRDLRNFT EMMRALGYPR HISMENFRTP NFGLVSEVLL WLVKRYEPQT DIPPDVDTEQ 
DRVFFIKAIA QFMATKAHIK LNTKKLYQAD GYAVKELLKI TSVLYNAMKT KGMEGSEIVE 
EDVNKFKFDL GSKIADLKAA RQLASEITSK GASLYDLLGM EVELREMRTE AIARPLEINE 
TEKVMRIAIK EILTQVQKTK DLLNNVASDE ANLEAKIEKR KLELERNRKR LETLQSVRPC 
FMDEYEKTEE ELQKQYDTYL EKFQNLTYLE QQLEDHHRME QERFEEAKNT LCLIQNKLKE 
EEKRLLKSGS NDDSDIDIQE DDESDSELEE RRLPKPQTAM EMLMQGRPGK RIVGTMQGGD 
SDDNMEAAPA LLGKCKTSSS KKQEDSEESE IDMEDDDDED DDLEDESISL SPTKPNRRVR 
KSEPLDESDN DF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.