Details for: ZNF609

Gene ID: 23060

Symbol: ZNF609

Ensembl ID: ENSG00000180357

Description: zinc finger protein 609

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.29
    Marker Score: 76,237
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 3.88
    Marker Score: 3,186
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.69
    Marker Score: 3,271
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.52
    Marker Score: 118,912
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.42
    Marker Score: 2,375
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.41
    Marker Score: 11,420
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.38
    Marker Score: 18,175
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.27
    Marker Score: 2,828
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.22
    Marker Score: 3,643
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 3.07
    Marker Score: 12,807
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3
    Marker Score: 2,256
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.93
    Marker Score: 5,629
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.89
    Marker Score: 15,143
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.73
    Marker Score: 5,986
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.72
    Marker Score: 6,510
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.65
    Marker Score: 1,742
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.58
    Marker Score: 54,980
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.58
    Marker Score: 1,280
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.57
    Marker Score: 930
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.56
    Marker Score: 3,445
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.5
    Marker Score: 37,453
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.47
    Marker Score: 10,318
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.46
    Marker Score: 48,897
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.45
    Marker Score: 1,328
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.41
    Marker Score: 18,191
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.36
    Marker Score: 18,113
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.35
    Marker Score: 2,933
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.35
    Marker Score: 1,370
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.31
    Marker Score: 665
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.3
    Marker Score: 2,643
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.29
    Marker Score: 10,595
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.23
    Marker Score: 9,244
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.22
    Marker Score: 3,731
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.2
    Marker Score: 83,370
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.18
    Marker Score: 7,144
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.18
    Marker Score: 3,064
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.14
    Marker Score: 79,071
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.13
    Marker Score: 1,025
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.12
    Marker Score: 6,060
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.12
    Marker Score: 1,184
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.11
    Marker Score: 33,946
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.11
    Marker Score: 548
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.11
    Marker Score: 1,182
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.1
    Marker Score: 47,012
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.1
    Marker Score: 2,542
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.07
    Marker Score: 1,149
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.06
    Marker Score: 7,957
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.04
    Marker Score: 1,218
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.01
    Marker Score: 1,165
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.98
    Marker Score: 18,640
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.98
    Marker Score: 121,657
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.95
    Marker Score: 815
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.93
    Marker Score: 611
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.92
    Marker Score: 19,833
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.91
    Marker Score: 558
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.9
    Marker Score: 1,646
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.9
    Marker Score: 483
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.89
    Marker Score: 2,089
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.88
    Marker Score: 686
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.87
    Marker Score: 1,232
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.87
    Marker Score: 17,723
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.86
    Marker Score: 1,777
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.85
    Marker Score: 1,084
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.84
    Marker Score: 680
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.83
    Marker Score: 15,677
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.82
    Marker Score: 4,566
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.81
    Marker Score: 7,369
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.77
    Marker Score: 2,579
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.77
    Marker Score: 916
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.73
    Marker Score: 1,331
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.72
    Marker Score: 660
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.71
    Marker Score: 1,848
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.71
    Marker Score: 3,924
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.69
    Marker Score: 892
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.68
    Marker Score: 1,802
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.66
    Marker Score: 527
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.64
    Marker Score: 1,976
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.63
    Marker Score: 539
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.61
    Marker Score: 797
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.59
    Marker Score: 2,453
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.53
    Marker Score: 1,601
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.49
    Marker Score: 5,290
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.48
    Marker Score: 1,046
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.47
    Marker Score: 402
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.45
    Marker Score: 9,308
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.43
    Marker Score: 519
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.41
    Marker Score: 2,870
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.4
    Marker Score: 7,544
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.38
    Marker Score: 470
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.38
    Marker Score: 520
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.38
    Marker Score: 1,947
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.37
    Marker Score: 514
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.36
    Marker Score: 5,882
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.35
    Marker Score: 1,673
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.31
    Marker Score: 4,646
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.3
    Marker Score: 1,619
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.29
    Marker Score: 3,031
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.27
    Marker Score: 458
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.27
    Marker Score: 335
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.25
    Marker Score: 593

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ZNF609 is a member of the zinc finger protein family, characterized by its unique amino acid sequence, which confers specificity towards metal ions. This property enables ZNF609 to bind to specific DNA sequences, thereby modulating gene expression. The gene's expression profile is notable for its tissue-specificity, with notable expression in cortical cells of the adrenal gland, Purkinje cells, and epithelial cells of the prostate. This specificity highlights the gene's role in regulating cellular processes within these tissues. **Pathways and Functions** ZNF609 is implicated in several key pathways, including metal ion binding, muscle organ development, and transcriptional regulation. Its involvement in metal ion binding suggests a role in modulating cellular responses to metal ions, which are essential for various cellular processes. The gene's association with muscle organ development underscores its potential role in regulating myoblast proliferation and differentiation. Furthermore, ZNF609's involvement in positive regulation of neuron migration and transcription by RNA polymerase II highlights its significance in neuronal development and function. In addition, ZNF609's expression in cells of the prostate and adrenal gland suggests a role in regulating cellular processes specific to these tissues. For instance, its presence in prostate epithelial cells may be linked to the regulation of androgen receptor signaling, which is crucial for prostate development and homeostasis. **Clinical Significance** The clinical significance of ZNF609 lies in its potential role in various diseases, particularly those affecting the nervous system and prostate. Mutations or alterations in ZNF609 expression have been implicated in several neurological disorders, including autism spectrum disorder and schizophrenia. Furthermore, the gene's expression in prostate epithelial cells suggests a potential role in prostate cancer development and progression. In addition, ZNF609's involvement in regulating myoblast proliferation and differentiation suggests a potential role in muscular dystrophy and other muscle-related disorders. Further research is necessary to elucidate the specific mechanisms by which ZNF609 contributes to these diseases, as well as to explore potential therapeutic strategies for targeting this gene. In conclusion, ZNF609 is a multifaceted gene with far-reaching implications for our understanding of cellular processes and disease. Its unique characteristics, tissue-specific expression, and involvement in key pathways underscore its importance in maintaining tissue homeostasis and regulating cellular processes. Further research is necessary to fully elucidate the clinical significance of ZNF609 and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1285376784

Symbol: ZN609_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15014 Q0D2I2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25921068

Title: Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed.

PubMed ID: 25921068

DOI: 10.1016/j.molcel.2015.03.027

PubMed ID: 28344082

Title: Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis.

PubMed ID: 28344082

DOI: 10.1016/j.molcel.2017.02.017

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1411
  • Mass: 151191
  • Checksum: 63A32348BB5C678E
  • Sequence:
    • MSLSSGASGG KGVDANPVET YDSGDEWDIG VGNLIIDLDA DLEKDQQKLE MSGSKEVGIP 
APNAVATLPD NIKFVTPVPG PQGKEGKSKS KRSKSGKDTS KPTPGTSLFT PSEGAASKKE 
VQGRSGDGAN AGGLVAAIAP KGSEKAAKAS RSVAGSKKEK ENSSSKSKKE RSEGVGTCSE 
KDPGVLQPVP LGGRGGQYDG SAGVDTGAVE PLGSIAIEPG AALNPLGTKP EPEEGENECR 
LLKKVKSEKM ESPVSTPAVL PIHLLVPVVN NDISSPCEQI MVRTRSVGVN TCDVALATEP 
ECLGPCEPGT SVNLEGIVWQ ETEDGMLVVN VTWRNKTYVG TLLDCTRHDW APPRFCDSPT 
SDLEMRNGRG RGKRMRPNSN TPVNETATAS DSKGTSNSSK TRAGANSKGR RGSQNSSEHR 
PPASSTSEDV KASPSSANKR KNKPLSDMEL NSSSEDSKGS KRVRTNSMGS ATGPLPGTKV 
EPTVLDRNCP SPVLIDCPHP NCNKKYKHIN GLKYHQAHAH TDDDSKPEAD GDSEYGEEPI 
LHADLGSCNG ASVSQKGSLS PARSATPKVR LVEPHSPSPS SKFSTKGLCK KKLSGEGDTD 
LGALSNDGSD DGPSVMDETS NDAFDSLERK CMEKEKCKKP SSLKPEKIPS KSLKSARPIA 
PAIPPQQIYT FQTATFTAAS PGSSSGLTAT VAQAMPNSPQ LKPIQPKPTV MGEPFTVNPA 
LTPAKDKKKK DKKKKESSKE LESPLTPGKV CRAEEGKSPF RESSGDGMKM EGLLNGSSDP 
HQSRLASIKA EADKIYSFTD NAPSPSIGGS SRLENTTPTQ PLTPLHVVTQ NGAEASSVKT 
NSPAYSDISD AGEDGEGKVD SVKSKDAEQL VKEGAKKTLF PPQPQSKDSP YYQGFESYYS 
PSYAQSSPGA LNPSSQAGVE SQALKTKRDE EPESIEGKVK NDICEEKKPE LSSSSQQPSV 
IQQRPNMYMQ SLYYNQYAYV PPYGYSDQSY HTHLLSTNTA YRQQYEEQQK RQSLEQQQRG 
VDKKAEMGLK EREAALKEEW KQKPSIPPTL TKAPSLTDLV KSGPGKAKEP GADPAKSVII 
PKLDDSSKLP GQAPEGLKVK LSDASHLSKE ASEAKTGAEC GRQAEMDPIL WYRQEAEPRM 
WTYVYPAKYS DIKSEDERWK EERDRKLKEE RSRSKDSVPK EDGKESTSSD CKLPTSEESR 
LGSKEPRPSV HVPVSSPLTQ HQSYIPYMHG YSYSQSYDPN HPSYRSMPAV MMQNYPGSYL 
PSSYSFSPYG SKVSGGEDAD KARASPSVTC KSSSESKALD ILQQHASHYK SKSPTISDKT 
SQERDRGGCG VVGGGGSCSS VGGASGGERS VDRPRTSPSQ RLMSTHHHHH HLGYSLLPAQ 
YNLPYAAGLS STAIVASQQG STPSLYPPPR R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.