Details for: TBC1D9B

Gene ID: 23061

Symbol: TBC1D9B

Ensembl ID: ENSG00000197226

Description: TBC1 domain family member 9B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.03
    Marker Score: 1,626
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2
    Marker Score: 3,490
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.64
    Marker Score: 1,098
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.46
    Marker Score: 13,861
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.44
    Marker Score: 12,382
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.37
    Marker Score: 1,477
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.33
    Marker Score: 81,939
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.28
    Marker Score: 11,994
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.26
    Marker Score: 1,944
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.24
    Marker Score: 5,050
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.12
    Marker Score: 11,613
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.12
    Marker Score: 657
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.12
    Marker Score: 4,324
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.11
    Marker Score: 754
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.07
    Marker Score: 39,599
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.07
    Marker Score: 40,653
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.03
    Marker Score: 15,390
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,687
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,911
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.99
    Marker Score: 577
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.99
    Marker Score: 399
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,388
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.97
    Marker Score: 2,217
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.96
    Marker Score: 7,383
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.96
    Marker Score: 3,304
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.96
    Marker Score: 447
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.95
    Marker Score: 988
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.94
    Marker Score: 395
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.94
    Marker Score: 990
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,390
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.92
    Marker Score: 6,849
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.92
    Marker Score: 18,226
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.91
    Marker Score: 19,445
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.91
    Marker Score: 1,341
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 430
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.91
    Marker Score: 316
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.91
    Marker Score: 7,948
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,695
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.88
    Marker Score: 970
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.87
    Marker Score: 3,617
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.87
    Marker Score: 433
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 308
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.85
    Marker Score: 3,151
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.85
    Marker Score: 1,060
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4,736
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.83
    Marker Score: 1,070
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.81
    Marker Score: 8,154
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.81
    Marker Score: 398
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.8
    Marker Score: 899
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.8
    Marker Score: 1,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 598
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.78
    Marker Score: 1,121
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.78
    Marker Score: 179
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.78
    Marker Score: 881
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.77
    Marker Score: 4,680
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.77
    Marker Score: 210
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.77
    Marker Score: 458
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.75
    Marker Score: 810
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.75
    Marker Score: 277
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.73
    Marker Score: 414
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.72
    Marker Score: 1,937
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.72
    Marker Score: 970
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 369
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.71
    Marker Score: 472
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.71
    Marker Score: 398
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.71
    Marker Score: 485
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.7
    Marker Score: 851
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,955
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.7
    Marker Score: 243
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.7
    Marker Score: 169
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.7
    Marker Score: 203
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.7
    Marker Score: 1,907
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.7
    Marker Score: 340
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.69
    Marker Score: 38,817
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.69
    Marker Score: 342
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.69
    Marker Score: 1,970
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.68
    Marker Score: 682
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.68
    Marker Score: 626
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.68
    Marker Score: 23,552
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.68
    Marker Score: 417
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 447
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.67
    Marker Score: 715
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.67
    Marker Score: 1,310
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 613
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.67
    Marker Score: 812
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.67
    Marker Score: 4,364
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.67
    Marker Score: 368
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.66
    Marker Score: 802
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.66
    Marker Score: 936
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.66
    Marker Score: 638
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.66
    Marker Score: 549
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.65
    Marker Score: 266
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.65
    Marker Score: 184
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.65
    Marker Score: 611
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.65
    Marker Score: 577

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **TBC1 domain**: The gene contains a TBC1 domain, a characteristic feature of proteins involved in the regulation of GTPase activity. 2. **GTPase activator activity**: TBC1D9B is a GTPase activator, which means it enhances the activity of GTPases, enzymes that play a crucial role in various cellular processes. 3. **Calcium ion binding**: The gene product binds to calcium ions, which is essential for various cellular functions, including signaling pathways and protein regulation. 4. **Regulation of cilium assembly**: TBC1D9B is involved in the regulation of cilium assembly, which is crucial for cellular signaling and movement. **Pathways and Functions** 1. **Activation of GTPase activity**: TBC1D9B enhances the activity of GTPases, which are involved in various cellular processes, including signaling pathways and protein regulation. 2. **Calcium ion binding**: The gene product binds to calcium ions, which is essential for various cellular functions, including signaling pathways and protein regulation. 3. **Regulation of cilium assembly**: TBC1D9B is involved in the regulation of cilium assembly, which is crucial for cellular signaling and movement. 4. **Protein binding**: The gene product binds to various proteins, which is essential for its function in cellular processes. **Clinical Significance** 1. **Pulmonary fibrosis**: TBC1D9B has been implicated in pulmonary fibrosis, a disease characterized by scarring in the lungs. 2. **Neurological disorders**: The gene has been associated with various neurological disorders, including autism spectrum disorder and schizophrenia. 3. **Cancer**: TBC1D9B has been found to be overexpressed in certain types of cancer, including breast and lung cancer. 4. **Developmental disorders**: The gene has been implicated in developmental disorders, including Down syndrome and congenital heart defects. In conclusion, TBC1D9B is a gene with multiple roles in cellular processes, including the regulation of GTPase activity, calcium ion binding, and protein binding. Its clinical significance has been implicated in various diseases, including pulmonary fibrosis, neurological disorders, cancer, and developmental disorders. Further research is necessary to fully understand the function and clinical significance of TBC1D9B.

Genular Protein ID: 2053786010

Symbol: TBC9B_HUMAN

Name: TBC1 domain family member 9B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1250
  • Mass: 140525
  • Checksum: 35D9E4914B1D8311
  • Sequence:
  • MWLSPEEVLV ANALWVTERA NPFFVLQRRR GHGRGGGLTG LLVGTLDVVL DSSARVAPYR 
    ILHQTQDSQV YWTVACGSSR KEITKHWEWL ENNLLQTLSI FDSEEDITTF VKGKIHGIIA 
    EENKNLQPQG DEDPGKFKEA ELKMRKQFGM PEGEKLVNYY SCSYWKGRVP RQGWLYLTVN 
    HLCFYSFLLG KEVSLVVQWV DITRLEKNAT LLFPESIRVD TRDQELFFSM FLNIGETFKL 
    MEQLANLAMR QLLDSEGFLE DKALPRPIRP HRNISALKRD LDARAKNECY RATFRLPRDE 
    RLDGHTSCTL WTPFNKLHIP GQMFISNNYI CFASKEEDAC HLIIPLREVT IVEKADSSSV 
    LPSPLSISTK SKMTFLFANL KDRDFLVQRI SDFLQKTPSK QPGSIGSRKA SVVDPSTESS 
    PAPQEGSEQP ASPASPLSSR QSFCAQEAPT ASQGLLKLFQ KNSPMEDLGA KGAKEKMKEE 
    SWHIHFFEYG RGVCMYRTAK TRALVLKGIP ESLRGELWLL FSGAWNEMVT HPGYYAELVE 
    KSTGKYSLAT EEIERDLHRS MPEHPAFQNE LGIAALRRVL TAYAFRNPTI GYCQAMNIVT 
    SVLLLYGSEE EAFWLLVALC ERMLPDYYNT RVVGALVDQG IFEELTRDFL PQLSEKMQDL 
    GVISSISLSW FLTLFLSVMP FESAVVIVDC FFYEGIKVIL QVALAVLDAN MEQLLGCSDE 
    GEAMTMLGRY LDNVVNKQSV SPPIPHLRAL LSSSDDPPAE VDIFELLKVS YEKFSSLRAE 
    DIEQMRFKQR LKVIQSLEDT AKRSVVRAIP VDIGFSIEEL EDLYMVFKAK HLASQYWGCS 
    RTMAGRRDPS LPYLEQYRID ASQFRELFAS LTPWACGSHT PLLAGRMFRL LDENKDSLIN 
    FKEFVTGMSG MYHGDLTEKL KVLYKLHLPP ALSPEEAESA LEAAHYFTED SSSEASPLAS 
    DLDLFLPWEA QEALPQEEQE GSGSEERGEE KGTSSPDYRH YLRMWAKEKE AQKETIKDLP 
    KMNQEQFIEL CKTLYNMFSE DPMEQDLYHA IATVASLLLR IGEVGKKFSA RTGRKPRDCA 
    TEEDEPPAPE LHQDAARELQ PPAAGDPQAK AGGDTHLGKA PQESQVVVEG GSGEGQGSPS 
    QLLSDDETKD DMSMSSYSVV STGSLQCEDL ADDTVLVGGE ACSPTARIGG TVDTDWCISF 
    EQILASILTE SVLVNFFEKR VDIGLKIKDQ KKVERQFSTA SDHEQPGVSG

Genular Protein ID: 2075296877

Symbol: Q9BW24_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 391
  • Mass: 43142
  • Checksum: F408069F5699C9DC
  • Sequence:
  • MAGRRDPSLP YLEQYRIDAS QFRELFASLT PWACGSHTPL LAGRMFRLLD ENKDSLINFK 
    EFVTGMSGMY HGYLTEKLKV LYKLHLPPAL SPEEAESALE AAHYFTEDSS SEEALPQEEQ 
    EGSGSEERGE EKGTSSPDYR HYLRMWAKEK EAQKETIKDL PKMNQEQFIE LCKTLYNMFS 
    EDPMEQDLYH AIATVASLLL RIGEVGKKFS ARTGRKPRDC ATEEDEPPAP ELHQDAAREL 
    QPPAAGDPQA KAGGDTHLGT APQESQVVVE GGSGEGQGSP SQLLSDDETK DDMSMSSYSV 
    VSTGSLQCED LADDTVLVGG EACSPTARIG GTVDTDWCIS FEQILASILT ESVLVNFFEK 
    RVDIGLKIKD QKKVERQFST ASDHEQPGVS G

Genular Protein ID: 1729571779

Symbol: B3KM54_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 449
  • Mass: 49893
  • Checksum: 2065BFEBF47B8234
  • Sequence:
  • MRFKQRLKVI QSLEDTAKRS VVRAIPVDIG FSIEELEDLY MVFKAKHLAS QYWGCSRTMA 
    GRRDPSLPYL EQYRIDASQF RELFASLTPW ACGSHTPLLA GRMFRLLDEN KDSLINFKEF 
    VTGMSGMYHG DLTEKLKVLY KLHLPPALSP EEAESALEAA HYFTEDSSSE EALPQEEQEG 
    SGSEERGEEK GTSSPDYRHY LRMWAKEKEA QKETIKDLPK MNQEQFIELC KTLYNMFSED 
    PMEQDLYHAI ATVASLLLRI GEVGKKFSAR TGRKPRDCAT EEDEPPAPEL HQDAARELQP 
    PAAGDPQAKA GGDTHLGKAP QESQVVVEGG SGEGQGSPSQ LLSDDETKDD MSMSSYSVVS 
    TGSLQCEDLA DDTVLVGGEA CSPTARIGGT VDTDWCISFE QILASILTES VLVNFFEKRV 
    DIGLKIKDQK KVERQFSTAS DHEQPGVSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.