Details for: GGA2
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.9
Marker Score: 3,897 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.59
Marker Score: 3,137 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.42
Marker Score: 5,321 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.39
Marker Score: 42,491 - Cell Name: germ cell (CL0000586)
Fold Change: 2.31
Marker Score: 4,037 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.29
Marker Score: 6,782 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.26
Marker Score: 9,466 - Cell Name: centroblast (CL0009112)
Fold Change: 2.15
Marker Score: 1,057 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.01
Marker Score: 30,099 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.01
Marker Score: 76,285 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2
Marker Score: 73,889 - Cell Name: germinal center B cell (CL0000844)
Fold Change: 2
Marker Score: 1,216 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.99
Marker Score: 8,261 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.99
Marker Score: 1,158 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.97
Marker Score: 1,153 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.95
Marker Score: 38,881 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.9
Marker Score: 17,878 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.9
Marker Score: 14,536 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.89
Marker Score: 6,989 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.89
Marker Score: 596 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.87
Marker Score: 7,215 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.81
Marker Score: 111,548 - Cell Name: neuron (CL0000540)
Fold Change: 1.79
Marker Score: 7,269 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.7
Marker Score: 16,130 - Cell Name: naive B cell (CL0000788)
Fold Change: 1.67
Marker Score: 1,489 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.66
Marker Score: 1,635 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.66
Marker Score: 14,238 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.64
Marker Score: 582 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.62
Marker Score: 16,776 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.61
Marker Score: 969 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.59
Marker Score: 33,907 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 1.55
Marker Score: 809 - Cell Name: memory B cell (CL0000787)
Fold Change: 1.55
Marker Score: 1,170 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.55
Marker Score: 39,579 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.53
Marker Score: 1,686 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.46
Marker Score: 2,249 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.44
Marker Score: 2,516 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.42
Marker Score: 594 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.4
Marker Score: 417 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.39
Marker Score: 1,576 - Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.35
Marker Score: 1,269 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.33
Marker Score: 6,141 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.32
Marker Score: 386 - Cell Name: interneuron (CL0000099)
Fold Change: 1.32
Marker Score: 602 - Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 1.3
Marker Score: 1,566 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.27
Marker Score: 1,125 - Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.22
Marker Score: 282 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.22
Marker Score: 606 - Cell Name: centrocyte (CL0009111)
Fold Change: 1.19
Marker Score: 283 - Cell Name: ependymal cell (CL0000065)
Fold Change: 1.18
Marker Score: 413 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.18
Marker Score: 651 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.18
Marker Score: 2,686 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.16
Marker Score: 367 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.15
Marker Score: 391 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.14
Marker Score: 3,257 - Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 1.14
Marker Score: 2,388 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.14
Marker Score: 3,095 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.13
Marker Score: 1,858 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.12
Marker Score: 1,179 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.12
Marker Score: 2,358 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.11
Marker Score: 448 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.1
Marker Score: 2,714 - Cell Name: basal cell (CL0000646)
Fold Change: 1.09
Marker Score: 1,408 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.06
Marker Score: 17,028 - Cell Name: oogonial cell (CL0000024)
Fold Change: 1.06
Marker Score: 1,518 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.05
Marker Score: 287 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.03
Marker Score: 540 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.02
Marker Score: 937 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.02
Marker Score: 689 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 1
Marker Score: 317 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,629 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.99
Marker Score: 594 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47,854 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.99
Marker Score: 856 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.99
Marker Score: 1,190 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.98
Marker Score: 1,057 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,381 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.98
Marker Score: 2,624 - Cell Name: Leydig cell (CL0000178)
Fold Change: 0.98
Marker Score: 1,052 - Cell Name: immature B cell (CL0000816)
Fold Change: 0.97
Marker Score: 644 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.97
Marker Score: 1,969 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.97
Marker Score: 672 - Cell Name: erythroblast (CL0000765)
Fold Change: 0.96
Marker Score: 601 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.96
Marker Score: 14,998 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.95
Marker Score: 2,249 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.95
Marker Score: 634 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.94
Marker Score: 1,333 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,387 - Cell Name: podocyte (CL0000653)
Fold Change: 0.94
Marker Score: 347 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 0.94
Marker Score: 382 - Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.93
Marker Score: 546 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.93
Marker Score: 376 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.93
Marker Score: 2,560 - Cell Name: B cell (CL0000236)
Fold Change: 0.93
Marker Score: 882 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 477 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.92
Marker Score: 1,778 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.92
Marker Score: 3,849 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.92
Marker Score: 202 - Cell Name: acinar cell (CL0000622)
Fold Change: 0.92
Marker Score: 649 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 433
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1056371582
Symbol: GGA2_HUMAN
Name: ADP-ribosylation factor-binding protein GGA2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10749927
Title: A family of ADP-ribosylation factor effectors that can alter transport through the trans-Golgi.
PubMed ID: 10749927
PubMed ID: 10747088
Title: A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome.
PubMed ID: 10747088
DOI: 10.1083/jcb.149.1.67
PubMed ID: 10702286
Title: Vear, a novel Golgi-associated protein with VHS and gamma-adaptin 'ear' domains.
PubMed ID: 10702286
PubMed ID: 10493829
Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.
PubMed ID: 10493829
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11331584
Title: The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein.
PubMed ID: 11331584
PubMed ID: 10470851
Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10470851
PubMed ID: 10814529
Title: Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin.
PubMed ID: 10814529
PubMed ID: 11301005
Title: The GGAs promote ARF-dependent recruitment of clathrin to the TGN.
PubMed ID: 11301005
PubMed ID: 11390366
Title: Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains.
PubMed ID: 11390366
PubMed ID: 11387475
Title: Sorting of mannose 6-phosphate receptors mediated by the GGAs.
PubMed ID: 11387475
PubMed ID: 11950392
Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.
PubMed ID: 11950392
DOI: 10.1042/bj20020428
PubMed ID: 11821067
Title: The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding.
PubMed ID: 11821067
PubMed ID: 11886874
Title: Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins.
PubMed ID: 11886874
PubMed ID: 12429846
Title: Clint: a novel clathrin-binding ENTH-domain protein at the Golgi.
PubMed ID: 12429846
PubMed ID: 14567678
Title: Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.
PubMed ID: 14567678
DOI: 10.1021/bi035199h
PubMed ID: 12505986
Title: Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex.
PubMed ID: 12505986
DOI: 10.1093/emboj/cdg015
PubMed ID: 12808037
Title: Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin.
PubMed ID: 12808037
PubMed ID: 14638859
Title: Mammalian GGAs act together to sort mannose 6-phosphate receptors.
PubMed ID: 14638859
PubMed ID: 14665628
Title: Definition of the consensus motif recognized by gamma-adaptin ear domains.
PubMed ID: 14665628
PubMed ID: 15039775
Title: Interactions of GGA3 with the ubiquitin sorting machinery.
PubMed ID: 15039775
DOI: 10.1038/ncb1106
PubMed ID: 15615712
Title: GGA proteins mediate the recycling pathway of memapsin 2 (BACE).
PubMed ID: 15615712
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27901063
Title: Regulation of alpha2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2.
PubMed ID: 27901063
DOI: 10.1038/srep37921
PubMed ID: 28289207
Title: Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network.
PubMed ID: 28289207
PubMed ID: 12606052
Title: Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket.
PubMed ID: 12606052
Sequence Information:
- Length: 613
- Mass: 67150
- Checksum: 4B627ABA474A069C
- Sequence:
MAATAVAAAV AGTESAQGPP GPAASLELWL NKATDPSMSE QDWSAIQNFC EQVNTDPNGP THAPWLLAHK IQSPQEKEAL YALTVLEMCM NHCGEKFHSE VAKFRFLNEL IKVLSPKYLG SWATGKVKGR VIEILFSWTV WFPEDIKIRD AYQMLKKQGI IKQDPKLPVD KILPPPSPWP KSSIFDADEE KSKLLTRLLK SNHPEDLQAA NRLIKNLVKE EQEKSEKVSK RVSAVEEVRS HVKVLQEMLS MYRRPGQAPP DQEALQVVYE RCEKLRPTLF RLASDTTDDD DALAEILQAN DLLTQGVLLY KQVMEGRVTF GNRVTSSLGD IPVSRVFQNP AGCMKTCPLI DLEVDNGPAQ MGTVVPSLLH QDLAALGISD APVTGMVSGQ NCCEEKRNPS SSTLPGGGVQ NPSADRNLLD LLSAQPAPCP LNYVSQKSVP KEVPPGTKSS PGWSWEAGPL APSPSSQNTP LAQVFVPLES VKPSSLPPLI VYDRNGFRIL LHFSQTGAPG HPEVQVLLLT MMSTAPQPVW DIMFQVAVPK SMRVKLQPAS SSKLPAFSPL MPPAVISQML LLDNPHKEPI RLRYKLTFNQ GGQPFSEVGE VKDFPDLAVL GAA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.