Details for: GGA2
Associated with
Other Information
Genular Protein ID: 1056371582
Symbol: GGA2_HUMAN
Name: ADP-ribosylation factor-binding protein GGA2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10749927
Title: A family of ADP-ribosylation factor effectors that can alter transport through the trans-Golgi.
PubMed ID: 10749927
PubMed ID: 10747088
Title: A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome.
PubMed ID: 10747088
DOI: 10.1083/jcb.149.1.67
PubMed ID: 10702286
Title: Vear, a novel Golgi-associated protein with VHS and gamma-adaptin 'ear' domains.
PubMed ID: 10702286
PubMed ID: 10493829
Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.
PubMed ID: 10493829
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11331584
Title: The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein.
PubMed ID: 11331584
PubMed ID: 10470851
Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10470851
PubMed ID: 10814529
Title: Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin.
PubMed ID: 10814529
PubMed ID: 11301005
Title: The GGAs promote ARF-dependent recruitment of clathrin to the TGN.
PubMed ID: 11301005
PubMed ID: 11390366
Title: Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains.
PubMed ID: 11390366
PubMed ID: 11387475
Title: Sorting of mannose 6-phosphate receptors mediated by the GGAs.
PubMed ID: 11387475
PubMed ID: 11950392
Title: GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors.
PubMed ID: 11950392
DOI: 10.1042/bj20020428
PubMed ID: 11821067
Title: The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding.
PubMed ID: 11821067
PubMed ID: 11886874
Title: Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins.
PubMed ID: 11886874
PubMed ID: 12429846
Title: Clint: a novel clathrin-binding ENTH-domain protein at the Golgi.
PubMed ID: 12429846
PubMed ID: 14567678
Title: Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.
PubMed ID: 14567678
DOI: 10.1021/bi035199h
PubMed ID: 12505986
Title: Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex.
PubMed ID: 12505986
DOI: 10.1093/emboj/cdg015
PubMed ID: 12808037
Title: Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin.
PubMed ID: 12808037
PubMed ID: 14638859
Title: Mammalian GGAs act together to sort mannose 6-phosphate receptors.
PubMed ID: 14638859
PubMed ID: 14665628
Title: Definition of the consensus motif recognized by gamma-adaptin ear domains.
PubMed ID: 14665628
PubMed ID: 15039775
Title: Interactions of GGA3 with the ubiquitin sorting machinery.
PubMed ID: 15039775
DOI: 10.1038/ncb1106
PubMed ID: 15615712
Title: GGA proteins mediate the recycling pathway of memapsin 2 (BACE).
PubMed ID: 15615712
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27901063
Title: Regulation of alpha2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2.
PubMed ID: 27901063
DOI: 10.1038/srep37921
PubMed ID: 28289207
Title: Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network.
PubMed ID: 28289207
PubMed ID: 12606052
Title: Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket.
PubMed ID: 12606052
Sequence Information:
- Length: 613
- Mass: 67150
- Checksum: 4B627ABA474A069C
- Sequence:
MAATAVAAAV AGTESAQGPP GPAASLELWL NKATDPSMSE QDWSAIQNFC EQVNTDPNGP THAPWLLAHK IQSPQEKEAL YALTVLEMCM NHCGEKFHSE VAKFRFLNEL IKVLSPKYLG SWATGKVKGR VIEILFSWTV WFPEDIKIRD AYQMLKKQGI IKQDPKLPVD KILPPPSPWP KSSIFDADEE KSKLLTRLLK SNHPEDLQAA NRLIKNLVKE EQEKSEKVSK RVSAVEEVRS HVKVLQEMLS MYRRPGQAPP DQEALQVVYE RCEKLRPTLF RLASDTTDDD DALAEILQAN DLLTQGVLLY KQVMEGRVTF GNRVTSSLGD IPVSRVFQNP AGCMKTCPLI DLEVDNGPAQ MGTVVPSLLH QDLAALGISD APVTGMVSGQ NCCEEKRNPS SSTLPGGGVQ NPSADRNLLD LLSAQPAPCP LNYVSQKSVP KEVPPGTKSS PGWSWEAGPL APSPSSQNTP LAQVFVPLES VKPSSLPPLI VYDRNGFRIL LHFSQTGAPG HPEVQVLLLT MMSTAPQPVW DIMFQVAVPK SMRVKLQPAS SSKLPAFSPL MPPAVISQML LLDNPHKEPI RLRYKLTFNQ GGQPFSEVGE VKDFPDLAVL GAA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.