Details for: WAPL

Gene ID: 23063

Symbol: WAPL

Ensembl ID: ENSG00000062650

Description: WAPL cohesin release factor

Associated with

Other Information

Genular Protein ID: 775723958

Symbol: WAPL_HUMAN

Name: Wings apart-like protein homolog

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15150110

Title: Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression.

PubMed ID: 15150110

DOI: 10.1158/0008-5472.can-03-3822

PubMed ID: 15383329

Title: Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2.

PubMed ID: 15383329

DOI: 10.1016/j.yexcr.2004.06.028

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17113138

Title: Wapl controls the dynamic association of cohesin with chromatin.

PubMed ID: 17113138

DOI: 10.1016/j.cell.2006.09.040

PubMed ID: 17112726

Title: Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.

PubMed ID: 17112726

DOI: 10.1016/j.cub.2006.10.061

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19696148

Title: Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1.

PubMed ID: 19696148

DOI: 10.1101/gad.1844309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19907496

Title: Cohesin acetylation speeds the replication fork.

PubMed ID: 19907496

DOI: 10.1038/nature08550

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21111234

Title: Sororin mediates sister chromatid cohesion by antagonizing wapl.

PubMed ID: 21111234

DOI: 10.1016/j.cell.2010.10.031

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26299517

Title: The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.

PubMed ID: 26299517

DOI: 10.1016/j.cub.2015.07.025

PubMed ID: 23776203

Title: Structure of the human cohesin inhibitor Wapl.

PubMed ID: 23776203

DOI: 10.1073/pnas.1304594110

PubMed ID: 30158690

Title: Clinical exome sequencing reveals locus heterogeneity and phenotypic variability of cohesinopathies.

PubMed ID: 30158690

DOI: 10.1038/s41436-018-0085-6

Sequence Information:

  • Length: 1190
  • Mass: 132946
  • Checksum: A01026E520BFAB2F
  • Sequence:
  • MTSRFGKTYS RKGGNGSSKF DEVFSNKRTT LSTKWGETTF MAKLGQKRPN FKPDIQEIPK 
    KPKVEEESTG DPFGFDSDDE SLPVSSKNLA QVKCSSYSES SEAAQLEEVT SVLEANSKIS 
    HVVVEDTVVS DKCFPLEDTL LGKEKSTNRI VEDDASISSC NKLITSDKVE NFHEEHEKNS 
    HHIHKNADDS TKKPNAETTV ASEIKETNDT WNSQFGKRPE SPSEISPIKG SVRTGLFEWD 
    NDFEDIRSED CILSLDSDPL LEMKDDDFKN RLENLNEAIE EDIVQSVLRP TNCRTYCRAN 
    KTKSSQGASN FDKLMDGTSQ ALAKANSESS KDGLNQAKKG GVSCGTSFRG TVGRTRDYTV 
    LHPSCLSVCN VTIQDTMERS MDEFTASTPA DLGEAGRLRK KADIATSKTT TRFRPSNTKS 
    KKDVKLEFFG FEDHETGGDE GGSGSSNYKI KYFGFDDLSE SEDDEDDDCQ VERKTSKKRT 
    KTAPSPSLQP PPESNDNSQD SQSGTNNAEN LDFTEDLPGV PESVKKPINK QGDKSKENTR 
    KIFSGPKRSP TKAVYNARHW NHPDSEELPG PPVVKPQSVT VRLSSKEPNQ KDDGVFKAPA 
    PPSKVIKTVT IPTQPYQDIV TALKCRREDK ELYTVVQHVK HFNDVVEFGE NQEFTDDIEY 
    LLSGLKSTQP LNTRCLSVIS LATKCAMPSF RMHLRAHGMV AMVFKTLDDS QHHQNLSLCT 
    AALMYILSRD RLNMDLDRAS LDLMIRLLEL EQDASSAKLL NEKDMNKIKE KIRRLCETVH 
    NKHLDLENIT TGHLAMETLL SLTSKRAGDW FKEELRLLGG LDHIVDKVKE CVDHLSRDED 
    EEKLVASLWG AERCLRVLES VTVHNPENQS YLIAYKDSQL IVSSAKALQH CEELIQQYNR 
    AEDSICLADS KPLPHQNVTN HVGKAVEDCM RAIIGVLLNL TNDNEWGSTK TGEQDGLIGT 
    ALNCVLQVPK YLPQEQRFDI RVLGLGLLIN LVEYSARNRH CLVNMETSCS FDSSICSGEG 
    DDSLRIGGQV HAVQALVQLF LERERAAQLA ESKTDELIKD APTTQHDKSG EWQETSGEIQ 
    WVSTEKTDGT EEKHKKEEED EELDLNKALQ HAGKHMEDCI VASYTALLLG CLCQESPINV 
    TTVREYLPEG DFSIMTEMLK KFLSFMNLTC AVGTTGQKSI SRVIEYLEHC

Genular Protein ID: 1407648480

Symbol: B2RTX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1184
  • Mass: 132226
  • Checksum: 803C394728EFD062
  • Sequence:
  • MTSRFGKTYS RKGGNGSSKF DEVFSNKRTT LSTKWGETTF MAKLGQKRPN FKPDIQEIPK 
    KPKVEEESTG DPFGFDSDDE SLPVSSKNLA QVKCSSYSES SEAAQLEEVT SVLEANSKIS 
    HVVVEDTVVS DKCFPLEDTL LGKEKSTNRI VEDDASISSC NKLITSDKVE NFHEEHEKNS 
    HHIHKNADDS TKKPNAETTV ASEIKETNDT WNSQFGKRPE SPSEISPIKG SVRTGLFEWD 
    NDFEDIRSED CILSLDSDPL LEMKDDDFKN RLENLNEAIE EDIVQSVLRP TNCRTYCRAN 
    KTKSSQGASN FDKLMDGTSQ ALAKANSESS KDGLNQAKKG GVSCGTSFRG TVGRTRDYTV 
    LHPSCLSVCN VTIQDTMERS MDEFTASTPA DLGEAGRLRK KADIATSKTT TRFRPSNTKS 
    KKDVKLEFFG FEDHETGGDE GGSGSSNYKI KYFGFDDLSE SEDDEDDDCQ VERKTSKKRT 
    KTAPSPSLQP PPESNDNSQD SQSGTNNAED LPGVPESVKK PINKQGDKSK ENTRKIFSGP 
    KRSPTKAVYN ARHWNHPDSE ELPGPPVVKP QSVTVRLSSK EPNQKDDGVF KAPAPPSKVI 
    KTVTIPTQPY QDIVTALKCR REDKELYTVV QHVKHFNDVV EFGENQEFTD DIEYLLSGLK 
    STQPLNTRCL SVISLATKCA MPSFRMHLRA HGMVAMVFKT LDDSQHHQNL SLCTAALMYI 
    LSRDRLNMDL DRASLDLMIR LLELEQDASS AKLLNEKDMN KIKEKIRRLC ETVHNKHLDL 
    ENITTGHLAM ETLLSLTSKR AGDWFKEELR LLGGLDHIVD KVKECVDHLS RDEDEEKLVA 
    SLWGAERCLR VLESVTVHNP ENQSYLIAYK DSQLIVSSAK ALQHCEELIQ QYNRAEDSIC 
    LADSKPLPHQ NVTNHVGKAV EDCMRAIIGV LLNLTNDNEW GSTKTGEQDG LIGTALNCVL 
    QVPKYLPQEQ RFDIRVLGLG LLINLVEYSA RNRHCLVNME TSCSFDSSIC SGEGDDSLRI 
    GGQVHAVQAL VQLFLERERA AQLAESKTDE LIKDAPTTQH DKSGEWQETS GEIQWVSTEK 
    TDGTEEKHKK EEEDEELDLN KALQHAGKHM EDCIVASYTA LLLGCLCQES PINVTTVREY 
    LPEGDFSIMT EMLKKFLSFM NLTCAVGTTG QKSISRVIEY LEHC

Genular Protein ID: 2253935757

Symbol: A8K273_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 762
  • Mass: 84784
  • Checksum: B2F11B6E9CC948FD
  • Sequence:
  • MTSRFGKTYS RKGGNGSSKF DEVFSNKRTT LSTKWGETTF MAKLGQKRPN FKPDIQEIPK 
    KPKVEEESTG DPFGFDSDDE SLPVSSKNLA QVKCSSYSES SEAAQLEEVT SVLEANSKIS 
    HVVVEDTVVS DKCFPLEDTL LGKEKSTNRI VEDDASISSC NKLITSDKVE NFHEEHEKNS 
    HHIHKNADDS TKKPNAETTV ASEIKETNDT WNSQFGKRPE SPSEISPIKG SVRTGLFEWD 
    NDFEDIRSED CILSLDSDPL LEMKDDDFKN RLENLNEAIE EDIVQSVLRP TNCRTYCRAN 
    KTKSSQGASN FDKLMDGTSQ ALAKANSESS KDGLNQAKKG GVSCGTSFRG TVGRTRDYTV 
    LHPSCLSVCN VTIQDTMERS MDEFTASTPA DLGEAGRLRK KADIATSKTT TRFRPSNTKS 
    KKDVKLEFFG FEDHETGGDE GGSGSSNYKI KYFGFDDLSE SEDDEGDDCQ VERKTSKKRT 
    KTAPSPSLQP PPESNDNSQD SQSGTNNAEN LDFTEDLPGV PESVKKPINK QGDKSKENTR 
    KIFSGPKRSP TKAVYNARHW NHPDSEELPG PPVVKPQSVT VRLSSKEPNQ KDDGVFKAPA 
    PPSKVIKTVT IPTQPYQDIV TALKCRREDK ELYTVVQHVK HFNDVVEFGE NQEFTDDIEY 
    LLSGLKSTQP LNTRCLSVIS LATKCAMPSF RMHLRAHGMV AMVFKTLDDS QHHQNLSLCT 
    AALMYILSRD RLNMDLDRAS LDLMIRLLEL EQDASSAKLL NE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.