Details for: WAPL

Gene ID: 23063

Symbol: WAPL

Ensembl ID: ENSG00000062650

Description: WAPL cohesin release factor

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.25
    Marker Score: 43,214
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.2
    Marker Score: 1,068
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.03
    Marker Score: 1,231
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.99
    Marker Score: 5,679
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.92
    Marker Score: 8,026
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.85
    Marker Score: 2,041
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.81
    Marker Score: 1,660
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.73
    Marker Score: 3,802
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.73
    Marker Score: 1,820
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.64
    Marker Score: 1,462
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.63
    Marker Score: 1,382
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.63
    Marker Score: 6,750
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.6
    Marker Score: 505
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.58
    Marker Score: 2,269
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.53
    Marker Score: 32,572
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.52
    Marker Score: 93,363
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.51
    Marker Score: 1,611
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.51
    Marker Score: 3,184
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.51
    Marker Score: 14,304
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.5
    Marker Score: 1,730
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.48
    Marker Score: 1,857
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.48
    Marker Score: 432
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.48
    Marker Score: 12,676
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.47
    Marker Score: 54,342
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.47
    Marker Score: 731
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.45
    Marker Score: 55,226
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.43
    Marker Score: 1,540
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.42
    Marker Score: 849
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.42
    Marker Score: 5,493
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.42
    Marker Score: 409
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.39
    Marker Score: 20,779
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.38
    Marker Score: 1,066
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.36
    Marker Score: 12,815
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.35
    Marker Score: 914
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.33
    Marker Score: 777
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.33
    Marker Score: 778
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.32
    Marker Score: 26,318
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.32
    Marker Score: 2,545
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.32
    Marker Score: 2,035
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.32
    Marker Score: 694
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.3
    Marker Score: 13,446
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.3
    Marker Score: 9,979
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.29
    Marker Score: 5,348
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.29
    Marker Score: 2,348
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.29
    Marker Score: 861
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.28
    Marker Score: 671
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.28
    Marker Score: 445
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.28
    Marker Score: 472
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19,939
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.27
    Marker Score: 1,534
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.27
    Marker Score: 3,041
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.26
    Marker Score: 302
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.26
    Marker Score: 1,692
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.26
    Marker Score: 474
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.25
    Marker Score: 885
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.25
    Marker Score: 1,516
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.24
    Marker Score: 463
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.24
    Marker Score: 823
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.23
    Marker Score: 1,174
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.22
    Marker Score: 528
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.21
    Marker Score: 673
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.21
    Marker Score: 308
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.2
    Marker Score: 1,704
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.2
    Marker Score: 487
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.2
    Marker Score: 875
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2
    Marker Score: 357
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.19
    Marker Score: 939
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.19
    Marker Score: 40,527
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.18
    Marker Score: 7,591
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.17
    Marker Score: 1,220
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.17
    Marker Score: 3,464
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.16
    Marker Score: 305
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.16
    Marker Score: 1,702
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.15
    Marker Score: 330
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.14
    Marker Score: 251
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.14
    Marker Score: 464
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.14
    Marker Score: 360
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.14
    Marker Score: 1,206
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.14
    Marker Score: 396
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.14
    Marker Score: 775
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.13
    Marker Score: 253
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.13
    Marker Score: 277
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.11
    Marker Score: 4,811
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.11
    Marker Score: 403
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.11
    Marker Score: 466
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.1
    Marker Score: 2,600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.1
    Marker Score: 624
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.09
    Marker Score: 1,144
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.09
    Marker Score: 321
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.09
    Marker Score: 2,715
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.09
    Marker Score: 607
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.08
    Marker Score: 9,522
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.08
    Marker Score: 1,100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.08
    Marker Score: 649
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.08
    Marker Score: 10,865
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.07
    Marker Score: 267
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.07
    Marker Score: 3,804
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.07
    Marker Score: 23,900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.07
    Marker Score: 245
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.07
    Marker Score: 293

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cohesin Release Function:** WAPL is characterized by its ability to release cohesin from chromatin, facilitating the separation of sister chromatids during mitosis. 2. **Cell Cycle Regulation:** WAPL's expression is tightly regulated throughout the cell cycle, ensuring timely release of cohesin and proper chromosome segregation. 3. **Tissue-Specific Expression:** WAPL is specifically expressed in various cell types, including cardiac muscle cells, myeloid dendritic cells, and retinal rod cells, suggesting a role in tissue-specific functions. 4. **Protein Localization:** WAPL localizes to the nucleus and cytoplasm, where it interacts with cohesin and other chromatin-associated proteins. **Pathways and Functions:** 1. **Cohesin Loading and Resolution:** WAPL regulates cohesin loading and resolution by interacting with cohesin and chromatin-associated proteins, ensuring proper sister chromatid cohesion and chromosome segregation. 2. **Mitotic Spindle Assembly:** WAPL's release of cohesin contributes to the assembly of the mitotic spindle, facilitating proper chromosome segregation during mitosis. 3. **Cell Cycle Progression:** WAPL's expression is tightly regulated throughout the cell cycle, ensuring timely release of cohesin and proper chromosome segregation. 4. **Chromatin Dynamics:** WAPL's interaction with chromatin-associated proteins regulates chromatin dynamics, influencing gene expression and cellular processes. **Clinical Significance:** Dysregulation of WAPL has been implicated in various diseases, including cancer and developmental disorders. For example: 1. **Cancer:** Altered WAPL expression has been observed in various cancers, including breast cancer and leukemia, suggesting a role in tumorigenesis and cancer progression. 2. **Developmental Disorders:** WAPL mutations have been linked to developmental disorders, such as congenital heart defects and neurological disorders, highlighting the importance of WAPL in tissue development and function. In conclusion, WAPL is a critical gene involved in the regulation of cohesin release and chromosome segregation. Its dysregulation has significant implications for disease, highlighting the need for further research into the mechanisms and clinical significance of WAPL.

Genular Protein ID: 775723958

Symbol: WAPL_HUMAN

Name: Wings apart-like protein homolog

UniProtKB Accession Codes:

Q7Z5K2 A7E2B5 Q5VSK5 Q8IX10 Q92549

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15150110

Title: Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression.

PubMed ID: 15150110

DOI: 10.1158/0008-5472.can-03-3822

PubMed ID: 15383329

Title: Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2.

PubMed ID: 15383329

DOI: 10.1016/j.yexcr.2004.06.028

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17113138

Title: Wapl controls the dynamic association of cohesin with chromatin.

PubMed ID: 17113138

DOI: 10.1016/j.cell.2006.09.040

PubMed ID: 17112726

Title: Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.

PubMed ID: 17112726

DOI: 10.1016/j.cub.2006.10.061

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19696148

Title: Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1.

PubMed ID: 19696148

DOI: 10.1101/gad.1844309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19907496

Title: Cohesin acetylation speeds the replication fork.

PubMed ID: 19907496

DOI: 10.1038/nature08550

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21111234

Title: Sororin mediates sister chromatid cohesion by antagonizing wapl.

PubMed ID: 21111234

DOI: 10.1016/j.cell.2010.10.031

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26299517

Title: The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.

PubMed ID: 26299517

DOI: 10.1016/j.cub.2015.07.025

PubMed ID: 23776203

Title: Structure of the human cohesin inhibitor Wapl.

PubMed ID: 23776203

DOI: 10.1073/pnas.1304594110

PubMed ID: 30158690

Title: Clinical exome sequencing reveals locus heterogeneity and phenotypic variability of cohesinopathies.

PubMed ID: 30158690

DOI: 10.1038/s41436-018-0085-6

Sequence Information:

  • Length: 1190
  • Mass: 132946
  • Checksum: A01026E520BFAB2F
  • Sequence:
    • MTSRFGKTYS RKGGNGSSKF DEVFSNKRTT LSTKWGETTF MAKLGQKRPN FKPDIQEIPK 
KPKVEEESTG DPFGFDSDDE SLPVSSKNLA QVKCSSYSES SEAAQLEEVT SVLEANSKIS 
HVVVEDTVVS DKCFPLEDTL LGKEKSTNRI VEDDASISSC NKLITSDKVE NFHEEHEKNS 
HHIHKNADDS TKKPNAETTV ASEIKETNDT WNSQFGKRPE SPSEISPIKG SVRTGLFEWD 
NDFEDIRSED CILSLDSDPL LEMKDDDFKN RLENLNEAIE EDIVQSVLRP TNCRTYCRAN 
KTKSSQGASN FDKLMDGTSQ ALAKANSESS KDGLNQAKKG GVSCGTSFRG TVGRTRDYTV 
LHPSCLSVCN VTIQDTMERS MDEFTASTPA DLGEAGRLRK KADIATSKTT TRFRPSNTKS 
KKDVKLEFFG FEDHETGGDE GGSGSSNYKI KYFGFDDLSE SEDDEDDDCQ VERKTSKKRT 
KTAPSPSLQP PPESNDNSQD SQSGTNNAEN LDFTEDLPGV PESVKKPINK QGDKSKENTR 
KIFSGPKRSP TKAVYNARHW NHPDSEELPG PPVVKPQSVT VRLSSKEPNQ KDDGVFKAPA 
PPSKVIKTVT IPTQPYQDIV TALKCRREDK ELYTVVQHVK HFNDVVEFGE NQEFTDDIEY 
LLSGLKSTQP LNTRCLSVIS LATKCAMPSF RMHLRAHGMV AMVFKTLDDS QHHQNLSLCT 
AALMYILSRD RLNMDLDRAS LDLMIRLLEL EQDASSAKLL NEKDMNKIKE KIRRLCETVH 
NKHLDLENIT TGHLAMETLL SLTSKRAGDW FKEELRLLGG LDHIVDKVKE CVDHLSRDED 
EEKLVASLWG AERCLRVLES VTVHNPENQS YLIAYKDSQL IVSSAKALQH CEELIQQYNR 
AEDSICLADS KPLPHQNVTN HVGKAVEDCM RAIIGVLLNL TNDNEWGSTK TGEQDGLIGT 
ALNCVLQVPK YLPQEQRFDI RVLGLGLLIN LVEYSARNRH CLVNMETSCS FDSSICSGEG 
DDSLRIGGQV HAVQALVQLF LERERAAQLA ESKTDELIKD APTTQHDKSG EWQETSGEIQ 
WVSTEKTDGT EEKHKKEEED EELDLNKALQ HAGKHMEDCI VASYTALLLG CLCQESPINV 
TTVREYLPEG DFSIMTEMLK KFLSFMNLTC AVGTTGQKSI SRVIEYLEHC

Genular Protein ID: 1407648480

Symbol: B2RTX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RTX8

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1184
  • Mass: 132226
  • Checksum: 803C394728EFD062
  • Sequence:
    • MTSRFGKTYS RKGGNGSSKF DEVFSNKRTT LSTKWGETTF MAKLGQKRPN FKPDIQEIPK 
KPKVEEESTG DPFGFDSDDE SLPVSSKNLA QVKCSSYSES SEAAQLEEVT SVLEANSKIS 
HVVVEDTVVS DKCFPLEDTL LGKEKSTNRI VEDDASISSC NKLITSDKVE NFHEEHEKNS 
HHIHKNADDS TKKPNAETTV ASEIKETNDT WNSQFGKRPE SPSEISPIKG SVRTGLFEWD 
NDFEDIRSED CILSLDSDPL LEMKDDDFKN RLENLNEAIE EDIVQSVLRP TNCRTYCRAN 
KTKSSQGASN FDKLMDGTSQ ALAKANSESS KDGLNQAKKG GVSCGTSFRG TVGRTRDYTV 
LHPSCLSVCN VTIQDTMERS MDEFTASTPA DLGEAGRLRK KADIATSKTT TRFRPSNTKS 
KKDVKLEFFG FEDHETGGDE GGSGSSNYKI KYFGFDDLSE SEDDEDDDCQ VERKTSKKRT 
KTAPSPSLQP PPESNDNSQD SQSGTNNAED LPGVPESVKK PINKQGDKSK ENTRKIFSGP 
KRSPTKAVYN ARHWNHPDSE ELPGPPVVKP QSVTVRLSSK EPNQKDDGVF KAPAPPSKVI 
KTVTIPTQPY QDIVTALKCR REDKELYTVV QHVKHFNDVV EFGENQEFTD DIEYLLSGLK 
STQPLNTRCL SVISLATKCA MPSFRMHLRA HGMVAMVFKT LDDSQHHQNL SLCTAALMYI 
LSRDRLNMDL DRASLDLMIR LLELEQDASS AKLLNEKDMN KIKEKIRRLC ETVHNKHLDL 
ENITTGHLAM ETLLSLTSKR AGDWFKEELR LLGGLDHIVD KVKECVDHLS RDEDEEKLVA 
SLWGAERCLR VLESVTVHNP ENQSYLIAYK DSQLIVSSAK ALQHCEELIQ QYNRAEDSIC 
LADSKPLPHQ NVTNHVGKAV EDCMRAIIGV LLNLTNDNEW GSTKTGEQDG LIGTALNCVL 
QVPKYLPQEQ RFDIRVLGLG LLINLVEYSA RNRHCLVNME TSCSFDSSIC SGEGDDSLRI 
GGQVHAVQAL VQLFLERERA AQLAESKTDE LIKDAPTTQH DKSGEWQETS GEIQWVSTEK 
TDGTEEKHKK EEEDEELDLN KALQHAGKHM EDCIVASYTA LLLGCLCQES PINVTTVREY 
LPEGDFSIMT EMLKKFLSFM NLTCAVGTTG QKSISRVIEY LEHC

Genular Protein ID: 2253935757

Symbol: A8K273_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K273

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 1

Sequence Information:

  • Length: 762
  • Mass: 84784
  • Checksum: B2F11B6E9CC948FD
  • Sequence:
    • MTSRFGKTYS RKGGNGSSKF DEVFSNKRTT LSTKWGETTF MAKLGQKRPN FKPDIQEIPK 
KPKVEEESTG DPFGFDSDDE SLPVSSKNLA QVKCSSYSES SEAAQLEEVT SVLEANSKIS 
HVVVEDTVVS DKCFPLEDTL LGKEKSTNRI VEDDASISSC NKLITSDKVE NFHEEHEKNS 
HHIHKNADDS TKKPNAETTV ASEIKETNDT WNSQFGKRPE SPSEISPIKG SVRTGLFEWD 
NDFEDIRSED CILSLDSDPL LEMKDDDFKN RLENLNEAIE EDIVQSVLRP TNCRTYCRAN 
KTKSSQGASN FDKLMDGTSQ ALAKANSESS KDGLNQAKKG GVSCGTSFRG TVGRTRDYTV 
LHPSCLSVCN VTIQDTMERS MDEFTASTPA DLGEAGRLRK KADIATSKTT TRFRPSNTKS 
KKDVKLEFFG FEDHETGGDE GGSGSSNYKI KYFGFDDLSE SEDDEGDDCQ VERKTSKKRT 
KTAPSPSLQP PPESNDNSQD SQSGTNNAEN LDFTEDLPGV PESVKKPINK QGDKSKENTR 
KIFSGPKRSP TKAVYNARHW NHPDSEELPG PPVVKPQSVT VRLSSKEPNQ KDDGVFKAPA 
PPSKVIKTVT IPTQPYQDIV TALKCRREDK ELYTVVQHVK HFNDVVEFGE NQEFTDDIEY 
LLSGLKSTQP LNTRCLSVIS LATKCAMPSF RMHLRAHGMV AMVFKTLDDS QHHQNLSLCT 
AALMYILSRD RLNMDLDRAS LDLMIRLLEL EQDASSAKLL NE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.