Details for: SETX

Gene ID: 23064

Symbol: SETX

Ensembl ID: ENSG00000107290

Description: senataxin

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.02
    Marker Score: 26,508
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.54
    Marker Score: 1,477
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.32
    Marker Score: 1,152
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.1
    Marker Score: 4,031
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.07
    Marker Score: 2,378
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.06
    Marker Score: 4,531
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.95
    Marker Score: 41,682
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.89
    Marker Score: 7,918
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.89
    Marker Score: 683
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.87
    Marker Score: 37,137
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.84
    Marker Score: 1,096
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.8
    Marker Score: 7,329
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.8
    Marker Score: 68,224
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.79
    Marker Score: 109,977
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.79
    Marker Score: 26,735
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.79
    Marker Score: 1,702
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.77
    Marker Score: 1,860
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.76
    Marker Score: 1,944
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.76
    Marker Score: 1,882
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.74
    Marker Score: 608
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.74
    Marker Score: 1,872
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.73
    Marker Score: 13,279
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.73
    Marker Score: 63,876
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.72
    Marker Score: 16,336
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.72
    Marker Score: 16,170
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.7
    Marker Score: 735
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.67
    Marker Score: 880
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.66
    Marker Score: 14,224
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.65
    Marker Score: 6,379
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.63
    Marker Score: 5,607
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.61
    Marker Score: 594
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.61
    Marker Score: 6,660
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.6
    Marker Score: 469
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.59
    Marker Score: 1,064
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.58
    Marker Score: 16,304
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.53
    Marker Score: 441
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.52
    Marker Score: 84,848
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.51
    Marker Score: 3,700
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.5
    Marker Score: 1,156
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.5
    Marker Score: 17,410
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.5
    Marker Score: 2,014
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.49
    Marker Score: 1,800
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.48
    Marker Score: 720
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.47
    Marker Score: 2,137
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.46
    Marker Score: 1,822
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.46
    Marker Score: 1,264
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.46
    Marker Score: 2,146
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.45
    Marker Score: 804
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.45
    Marker Score: 1,749
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.44
    Marker Score: 1,437
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.43
    Marker Score: 2,206
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.43
    Marker Score: 3,556
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.43
    Marker Score: 578
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.42
    Marker Score: 1,829
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.41
    Marker Score: 3,365
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.39
    Marker Score: 1,971
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.39
    Marker Score: 1,276
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.38
    Marker Score: 1,045
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.37
    Marker Score: 499
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.36
    Marker Score: 347
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.36
    Marker Score: 21,886
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.36
    Marker Score: 1,208
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.36
    Marker Score: 3,816
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.35
    Marker Score: 322
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.34
    Marker Score: 751
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.34
    Marker Score: 1,520
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.33
    Marker Score: 6,171
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.33
    Marker Score: 2,428
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.33
    Marker Score: 1,194
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.32
    Marker Score: 418
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.32
    Marker Score: 492
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.31
    Marker Score: 1,393
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.31
    Marker Score: 284
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.29
    Marker Score: 2,519
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.29
    Marker Score: 756
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.28
    Marker Score: 934
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.28
    Marker Score: 1,140
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.27
    Marker Score: 441
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.26
    Marker Score: 4,678
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.26
    Marker Score: 876
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.26
    Marker Score: 1,266
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.25
    Marker Score: 1,177
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.24
    Marker Score: 278
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.24
    Marker Score: 4,399
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.24
    Marker Score: 504
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.24
    Marker Score: 383
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.23
    Marker Score: 5,321
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.23
    Marker Score: 12,395
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.23
    Marker Score: 1,248
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.23
    Marker Score: 27,441
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.23
    Marker Score: 1,060
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.23
    Marker Score: 21,747
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.22
    Marker Score: 834
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.22
    Marker Score: 293
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.21
    Marker Score: 41,219
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.21
    Marker Score: 805
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.21
    Marker Score: 298
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.21
    Marker Score: 3,237
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.2
    Marker Score: 601
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.2
    Marker Score: 409

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SETX is a mitochondrial protein, encoded by the SETX gene, which is expressed in multiple cell types, including lung endothelial cells, corneal endothelial cells, central nervous system macrophages, and kidney interstitial fibroblasts. This protein exhibits a unique structure, comprising a central catalytic domain and a C-terminal domain with a high degree of homology to other DNA helicases. SETX is also characterized by its ability to interact with various proteins, including DNA helicases, topoisomerases, and transcription factors, highlighting its multifaceted role in cellular processes. **Pathways and Functions:** SETX plays a pivotal role in maintaining genome stability through its involvement in DNA repair pathways, including double-strand break repair and telomere maintenance. It is also implicated in the regulation of transcription and RNA processing, influencing the expression of genes involved in cellular differentiation, growth, and survival. SETX has been shown to interact with other proteins in the DNA damage response pathway, including ATM and ATR, to coordinate the repair of DNA damage and maintain genome integrity. **Key Functions:** 1. **DNA repair**: SETX is involved in the repair of double-strand breaks and telomere maintenance, ensuring genome stability and preventing the accumulation of DNA damage. 2. **Transcription regulation**: SETX regulates the expression of genes involved in cellular differentiation, growth, and survival by interacting with transcription factors and RNA processing machinery. 3. **Cellular homeostasis**: SETX maintains cellular homeostasis by regulating the expression of genes involved in cellular stress response, apoptosis, and autophagy. **Clinical Significance:** Dysregulation of SETX has been implicated in various diseases, including: 1. **Amyotrophic lateral sclerosis (ALS)**: SETX mutations have been identified as a primary cause of ALS, a neurodegenerative disorder characterized by progressive motor neuron degeneration. 2. **Frontotemporal dementia (FTD)**: SETX mutations have also been linked to FTD, a group of neurodegenerative disorders characterized by cognitive decline and behavioral changes. 3. **Osteoporosis**: SETX has been implicated in the regulation of bone metabolism, and its dysregulation has been linked to osteoporosis, a condition characterized by reduced bone density and increased risk of fractures. 4. **Cancer**: SETX has been shown to play a role in the regulation of cancer-related genes, and its dysregulation has been implicated in various types of cancer, including breast, lung, and colon cancer. In conclusion, SETX is a critical protein involved in maintaining genome stability, regulating transcription, and maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of this protein in human health and disease. Further research is needed to fully elucidate the mechanisms by which SETX regulates cellular processes and to develop therapeutic strategies for the treatment of SETX-related diseases.

Genular Protein ID: 2598350977

Symbol: SETX_HUMAN

Name: Amyotrophic lateral sclerosis 4 protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14770181

Title: Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2.

PubMed ID: 14770181

DOI: 10.1038/ng1303

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17562789

Title: Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage.

PubMed ID: 17562789

DOI: 10.1083/jcb.200701042

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19515850

Title: Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation.

PubMed ID: 19515850

DOI: 10.1093/hmg/ddp278

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21576111

Title: Senataxin modulates neurite growth through fibroblast growth factor 8 signalling.

PubMed ID: 21576111

DOI: 10.1093/brain/awr084

PubMed ID: 21112256

Title: Role of senataxin in DNA damage and telomeric stability.

PubMed ID: 21112256

DOI: 10.1016/j.dnarep.2010.10.012

PubMed ID: 21700224

Title: Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.

PubMed ID: 21700224

DOI: 10.1016/j.molcel.2011.04.026

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24105744

Title: A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage.

PubMed ID: 24105744

DOI: 10.1101/gad.224923.113

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23149945

Title: Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.

PubMed ID: 23149945

DOI: 10.1128/mcb.01195-12

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 26700805

Title: SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.

PubMed ID: 26700805

DOI: 10.1038/nature16469

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15106121

Title: DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4).

PubMed ID: 15106121

DOI: 10.1086/421054

PubMed ID: 16644229

Title: Senataxin, the yeast Sen1p orthologue: characterization of a unique protein in which recessive mutations cause ataxia and dominant mutations cause motor neuron disease.

PubMed ID: 16644229

DOI: 10.1016/j.nbd.2006.02.007

PubMed ID: 16717225

Title: Autosomal recessive ataxia with peripheral neuropathy and elevated AFP: novel mutations in SETX.

PubMed ID: 16717225

DOI: 10.1212/01.wnl.0000216135.59699.9b

PubMed ID: 17096168

Title: In cis autosomal dominant mutation of Senataxin associated with tremor/ataxia syndrome.

PubMed ID: 17096168

DOI: 10.1007/s10048-006-0067-8

PubMed ID: 21190393

Title: Senataxin mutations and amyotrophic lateral sclerosis.

PubMed ID: 21190393

DOI: 10.3109/17482968.2010.545952

PubMed ID: 23566282

Title: A new SETX mutation producing AOA2 in two siblings.

PubMed ID: 23566282

DOI: 10.3109/00207454.2013.787616

PubMed ID: 23786967

Title: Exome analysis reveals a Japanese family with spinocerebellar ataxia, autosomal recessive 1.

PubMed ID: 23786967

DOI: 10.1016/j.jns.2013.05.018

PubMed ID: 23941260

Title: SETX mutations are a frequent genetic cause of juvenile and adult onset cerebellar ataxia with neuropathy and elevated serum alpha-fetoprotein.

PubMed ID: 23941260

DOI: 10.1186/1750-1172-8-123

PubMed ID: 24244371

Title: Protein interaction analysis of senataxin and the ALS4 L389S mutant yields insights into senataxin post-translational modification and uncovers mutant-specific binding with a brain cytoplasmic RNA-encoded peptide.

PubMed ID: 24244371

DOI: 10.1371/journal.pone.0078837

Sequence Information:

  • Length: 2677
  • Mass: 302880
  • Checksum: 552FFE4A23A83868
  • Sequence:
  • MSTCCWCTPG GASTIDFLKR YASNTPSGEF QTADEDLCYC LECVAEYHKA RDELPFLHEV 
    LWELETLRLI NHFEKSMKAE IGDDDELYIV DNNGEMPLFD ITGQDFENKL RVPLLEILKY 
    PYLLLHERVN ELCVEALCRM EQANCSFQVF DKHPGIYLFL VHPNEMVRRW AILTARNLGK 
    VDRDDYYDLQ EVLLCLFKVI ELGLLESPDI YTSSVLEKGK LILLPSHMYD TTNYKSYWLG 
    ICMLLTILEE QAMDSLLLGS DKQNDFMQSI LHTMEREADD DSVDPFWPAL HCFMVILDRL 
    GSKVWGQLMD PIVAFQTIIN NASYNREIRH IRNSSVRTKL EPESYLDDMV TCSQIVYNYN 
    PEKTKKDSGW RTAICPDYCP NMYEEMETLA SVLQSDIGQD MRVHNSTFLW FIPFVQSLMD 
    LKDLGVAYIA QVVNHLYSEV KEVLNQTDAV CDKVTEFFLL ILVSVIELHR NKKCLHLLWV 
    SSQQWVEAVV KCAKLPTTAF TRSSEKSSGN CSKGTAMISS LSLHSMPSNS VQLAYVQLIR 
    SLLKEGYQLG QQSLCKRFWD KLNLFLRGNL SLGWQLTSQE THELQSCLKQ IIRNIKFKAP 
    PCNTFVDLTS ACKISPASYN KEESEQMGKT SRKDMHCLEA SSPTFSKEPM KVQDSVLIKA 
    DNTIEGDNNE QNYIKDVKLE DHLLAGSCLK QSSKNIFTER AEDQIKISTR KQKSVKEISS 
    YTPKDCTSRN GPERGCDRGI IVSTRLLTDS STDALEKVST SNEDFSLKDD ALAKTSKRKT 
    KVQKDEICAK LSHVIKKQHR KSTLVDNTIN LDENLTVSNI ESFYSRKDTG VQKGDGFIHN 
    LSLDPSGVLD DKNGEQKSQN NVLPKEKQLK NEELVIFSFH ENNCKIQEFH VDGKELIPFT 
    EMTNASEKKS SPFKDLMTVP ESRDEEMSNS TSVIYSNLTR EQAPDISPKS DTLTDSQIDR 
    DLHKLSLLAQ ASVITFPSDS PQNSSQLQRK VKEDKRCFTA NQNNVGDTSR GQVIIISDSD 
    DDDDERILSL EKLTKQDKIC LEREHPEQHV STVNSKEEKN PVKEEKTETL FQFEESDSQC 
    FEFESSSEVF SVWQDHPDDN NSVQDGEKKC LAPIANTTNG QGCTDYVSEV VKKGAEGIEE 
    HTRPRSISVE EFCEIEVKKP KRKRSEKPMA EDPVRPSSSV RNEGQSDTNK RDLVGNDFKS 
    IDRRTSTPNS RIQRATTVSQ KKSSKLCTCT EPIRKVPVSK TPKKTHSDAK KGQNRSSNYL 
    SCRTTPAIVP PKKFRQCPEP TSTAEKLGLK KGPRKAYELS QRSLDYVAQL RDHGKTVGVV 
    DTRKKTKLIS PQNLSVRNNK KLLTSQELQM QRQIRPKSQK NRRRLSDCES TDVKRAGSHT 
    AQNSDIFVPE SDRSDYNCTG GTEVLANSNR KQLIKCMPSE PETIKAKHGS PATDDACPLN 
    QCDSVVLNGT VPTNEVIVST SEDPLGGGDP TARHIEMAAL KEGEPDSSSD AEEDNLFLTQ 
    NDPEDMDLCS QMENDNYKLI ELIHGKDTVE VEEDSVSRPQ LESLSGTKCK YKDCLETTKN 
    QGEYCPKHSE VKAADEDVFR KPGLPPPASK PLRPTTKIFS SKSTSRIAGL SKSLETSSAL 
    SPSLKNKSKG IQSILKVPQP VPLIAQKPVG EMKNSCNVLH PQSPNNSNRQ GCKVPFGESK 
    YFPSSSPVNI LLSSQSVSDT FVKEVLKWKY EMFLNFGQCG PPASLCQSIS RPVPVRFHNY 
    GDYFNVFFPL MVLNTFETVA QEWLNSPNRE NFYQLQVRKF PADYIKYWEF AVYLEECELA 
    KQLYPKENDL VFLAPERINE EKKDTERNDI QDLHEYHSGY VHKFRRTSVM RNGKTECYLS 
    IQTQENFPAN LNELVNCIVI SSLVTTQRKL KAMSLLGSRN QLARAVLNPN PMDFCTKDLL 
    TTTSERIIAY LRDFNEDQKK AIETAYAMVK HSPSVAKICL IHGPPGTGKS KTIVGLLYRL 
    LTENQRKGHS DENSNAKIKQ NRVLVCAPSN AAVDELMKKI ILEFKEKCKD KKNPLGNCGD 
    INLVRLGPEK SINSEVLKFS LDSQVNHRMK KELPSHVQAM HKRKEFLDYQ LDELSRQRAL 
    CRGGREIQRQ ELDENISKVS KERQELASKI KEVQGRPQKT QSIIILESHI ICCTLSTSGG 
    LLLESAFRGQ GGVPFSCVIV DEAGQSCEIE TLTPLIHRCN KLILVGDPKQ LPPTVISMKA 
    QEYGYDQSMM ARFCRLLEEN VEHNMISRLP ILQLTVQYRM HPDICLFPSN YVYNRNLKTN 
    RQTEAIRCSS DWPFQPYLVF DVGDGSERRD NDSYINVQEI KLVMEIIKLI KDKRKDVSFR 
    NIGIITHYKA QKTMIQKDLD KEFDRKGPAE VDTVDAFQGR QKDCVIVTCV RANSIQGSIG 
    FLASLQRLNV TITRAKYSLF ILGHLRTLME NQHWNQLIQD AQKRGAIIKT CDKNYRHDAV 
    KILKLKPVLQ RSLTHPPTIA PEGSRPQGGL PSSKLDSGFA KTSVAASLYH TPSDSKEITL 
    TVTSKDPERP PVHDQLQDPR LLKRMGIEVK GGIFLWDPQP SSPQHPGATP PTGEPGFPVV 
    HQDLSHIQQP AAVVAALSSH KPPVRGEPPA ASPEASTCQS KCDDPEEELC HRREARAFSE 
    GEQEKCGSET HHTRRNSRWD KRTLEQEDSS SKKRKLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.