Details for: CAND2

Gene ID: 23066

Symbol: CAND2

Ensembl ID: ENSG00000144712

Description: cullin associated and neddylation dissociated 2 (putative)

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,165
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.29
    Marker Score: 2,436
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.26
    Marker Score: 10,826
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.25
    Marker Score: 2,548
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.24
    Marker Score: 45,862
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18,791
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.2
    Marker Score: 1,848
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.17
    Marker Score: 4,523
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.17
    Marker Score: 71,801
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.16
    Marker Score: 10,900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.15
    Marker Score: 4,079
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.14
    Marker Score: 870
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.13
    Marker Score: 10,749
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.12
    Marker Score: 42,557
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.12
    Marker Score: 16,708
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.11
    Marker Score: 4,611
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.09
    Marker Score: 24,286
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.07
    Marker Score: 8,167
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.05
    Marker Score: 4,279
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.05
    Marker Score: 2,296
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.03
    Marker Score: 10,634
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,043
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.99
    Marker Score: 319
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.99
    Marker Score: 19,638
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.95
    Marker Score: 296
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.94
    Marker Score: 2,222
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.94
    Marker Score: 638
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,323
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.92
    Marker Score: 987
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.89
    Marker Score: 370
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,286
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.86
    Marker Score: 2,156
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.82
    Marker Score: 376
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.79
    Marker Score: 3,318
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 461
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.75
    Marker Score: 185
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.73
    Marker Score: 1,278
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.73
    Marker Score: 346
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.71
    Marker Score: 298
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.59
    Marker Score: 546
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.59
    Marker Score: 161
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.58
    Marker Score: 3,440
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.56
    Marker Score: 178
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 349
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.53
    Marker Score: 18,052
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.52
    Marker Score: 3,106
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.51
    Marker Score: 619
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 331
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.49
    Marker Score: 217
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.48
    Marker Score: 185
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.48
    Marker Score: 507
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.46
    Marker Score: 211
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.44
    Marker Score: 2,028
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.42
    Marker Score: 9,062
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.41
    Marker Score: 119
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 102
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.34
    Marker Score: 139
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.33
    Marker Score: 385
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.33
    Marker Score: 556
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.33
    Marker Score: 1,376
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.33
    Marker Score: 121
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.32
    Marker Score: 320
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.31
    Marker Score: 184
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.31
    Marker Score: 3,080
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.3
    Marker Score: 436
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.3
    Marker Score: 170
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.3
    Marker Score: 173
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.29
    Marker Score: 251
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.28
    Marker Score: 311
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.27
    Marker Score: 192
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.27
    Marker Score: 382
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.27
    Marker Score: 140
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.27
    Marker Score: 767
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.27
    Marker Score: 332
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.26
    Marker Score: 70
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.26
    Marker Score: 323
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.26
    Marker Score: 207
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.25
    Marker Score: 706
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 147
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.24
    Marker Score: 491
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.24
    Marker Score: 72
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.24
    Marker Score: 988
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.23
    Marker Score: 87
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.23
    Marker Score: 550

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The CAND2 gene is characterized by its involvement in several key cellular processes, including: 1. **Protein binding**: CAND2 interacts with various proteins, including the SCF complex, to regulate protein ubiquitination and degradation. 2. **Ubiquitination**: CAND2 is involved in the assembly of the SCF complex, which is responsible for the ubiquitination of target proteins. 3. **Transcription regulation**: CAND2 has been implicated in the regulation of DNA-templated transcription, suggesting its potential role in gene expression. 4. **Cell type specificity**: The CAND2 gene is significantly expressed in multiple cell types, including colon goblet cells, cardiac endothelial cells, and neurons. **Pathways and Functions** The CAND2 protein is involved in several key pathways, including: 1. **SCF complex assembly**: CAND2 interacts with the SCF complex to regulate protein ubiquitination and degradation. 2. **Positive regulation of DNA-templated transcription**: CAND2 has been implicated in the regulation of transcription, suggesting its potential role in gene expression. 3. **Protein binding**: CAND2 interacts with various proteins to regulate protein ubiquitination and degradation. 4. **Neddylation dissociation**: CAND2 is thought to play a role in the dissociation of the neddylation factor, NEDD8, from the SCF complex. The functions of the CAND2 protein are not fully understood, but it is thought to play a role in regulating protein degradation and transcriptional activity. **Clinical Significance** The CAND2 gene has been implicated in several diseases, including: 1. **Cancer**: Alterations in the CAND2 gene have been observed in various types of cancer, suggesting its potential role in tumorigenesis. 2. **Neurological disorders**: The CAND2 gene has been implicated in the regulation of neuronal function and development, suggesting its potential role in neurological disorders such as autism and schizophrenia. 3. **Cardiovascular disease**: The CAND2 gene has been shown to be involved in the regulation of cardiac endothelial cell function, suggesting its potential role in cardiovascular disease. Further research is needed to fully understand the role of the CAND2 gene in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2584794252

Symbol: CAND2_HUMAN

Name: Cullin-associated NEDD8-dissociated protein 2

UniProtKB Accession Codes:

O75155 B9EGM9 E9KL24

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 20736409

Title: Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.

PubMed ID: 20736409

DOI: 10.1074/mcp.m110.001719

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 1236
  • Mass: 135256
  • Checksum: 38F43A7C1B8322A8
  • Sequence:
    • MSTAAFHISS LLEKMTSSDK DFRFMATSDL MSELQKDSIQ LDEDSERKVV KMLLRLLEDK 
NGEVQNLAVK CLGPLVVKVK EYQVETIVDT LCTNMRSDKE QLRDIAGIGL KTVLSELPPA 
ATGSGLATNV CRKITGQLTS AIAQQEDVAV QLEALDILSD MLSRLGVPLG AFHASLLHCL 
LPQLSSPRLA VRKRAVGALG HLAAACSTDL FVELADHLLD RLPGPRVPTS PTAIRTLIQC 
LGSVGRQAGH RLGAHLDRLV PLVEDFCNLD DDELRESCLQ AFEAFLRKCP KEMGPHVPNV 
TSLCLQYIKH DPNYNYDSDE DEEQMETEDS EFSEQESEDE YSDDDDMSWK VRRAAAKCIA 
ALISSRPDLL PDFHCTLAPV LIRRFKEREE NVKADVFTAY IVLLRQTQPP KGWLEAMEEP 
TQTGSNLHML RGQVPLVVKA LQRQLKDRSV RARQGCFSLL TELAGVLPGS LAEHMPVLVS 
GIIFSLADRS SSSTIRMDAL AFLQGLLGTE PAEAFHPHLP ILLPPVMACV ADSFYKIAAE 
ALVVLQELVR ALWPLHRPRM LDPEPYVGEM SAVTLARLRA TDLDQEVKER AISCMGHLVG 
HLGDRLGDDL EPTLLLLLDR LRNEITRLPA IKALTLVAVS PLQLDLQPIL AEALHILASF 
LRKNQRALRL ATLAALDALA QSQGLSLPPS AVQAVLAELP ALVNESDMHV AQLAVDFLAT 
VTQAQPASLV EVSGPVLSEL LRLLRSPLLP AGVLAAAEGF LQALVGTRPP CVDYAKLISL 
LTAPVYEQAV DGGPGLHKQV FHSLARCVAA LSAACPQEAA STASRLVCDA RSPHSSTGVK 
VLAFLSLAEV GQVAGPGHQR ELKAVLLEAL GSPSEDVRAA ASYALGRVGA GSLPDFLPFL 
LEQIEAEPRR QYLLLHSLRE ALGAAQPDSL KPYAEDIWAL LFQRCEGAEE GTRGVVAECI 
GKLVLVNPSF LLPRLRKQLA AGRPHTRSTV ITAVKFLISD QPHPIDPLLK SFIGEFMESL 
QDPDLNVRRA TLAFFNSAVH NKPSLVRDLL DDILPLLYQE TKIRRDLIRE VEMGPFKHTV 
DDGLDVRKAA FECMYSLLES CLGQLDICEF LNHVEDGLKD HYDIRMLTFI MVARLATLCP 
APVLQRVDRL IEPLRATCTA KVKAGSVKQE FEKQDELKRS AMRAVAALLT IPEVGKSPIM 
ADFSSQIRSN PELAALFESI QKDSASAPST DSMELS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.