Details for: ERP44

Gene ID: 23071

Symbol: ERP44

Ensembl ID: ENSG00000023318

Description: endoplasmic reticulum protein 44

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.11
    Marker Score: 9,100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.08
    Marker Score: 2,508
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.92
    Marker Score: 49,102
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.88
    Marker Score: 4,281
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.86
    Marker Score: 7,318
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.8
    Marker Score: 15,470
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.75
    Marker Score: 7,139
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.73
    Marker Score: 2,306
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.7
    Marker Score: 19,749
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.69
    Marker Score: 4,677
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.69
    Marker Score: 2,999
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.69
    Marker Score: 62,395
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.68
    Marker Score: 103,287
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.65
    Marker Score: 15,510
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.64
    Marker Score: 62,417
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.63
    Marker Score: 2,408
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.62
    Marker Score: 15,370
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.61
    Marker Score: 1,610
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.6
    Marker Score: 883
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.58
    Marker Score: 88,497
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.58
    Marker Score: 6,114
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.58
    Marker Score: 16,323
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.57
    Marker Score: 13,526
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.57
    Marker Score: 375
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.57
    Marker Score: 3,049
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.56
    Marker Score: 976
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.55
    Marker Score: 3,740
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.54
    Marker Score: 437
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.54
    Marker Score: 30,668
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.52
    Marker Score: 51,782
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.52
    Marker Score: 7,295
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.51
    Marker Score: 22,596
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.5
    Marker Score: 6,234
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.49
    Marker Score: 602
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.49
    Marker Score: 1,369
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.47
    Marker Score: 616
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.46
    Marker Score: 1,676
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.46
    Marker Score: 597
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.46
    Marker Score: 2,664
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.46
    Marker Score: 509
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.46
    Marker Score: 726
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.46
    Marker Score: 1,302
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.46
    Marker Score: 3,629
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.46
    Marker Score: 11,168
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.45
    Marker Score: 1,870
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.45
    Marker Score: 16,311
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.44
    Marker Score: 357
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.43
    Marker Score: 3,741
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.43
    Marker Score: 2,272
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.42
    Marker Score: 2,282
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.41
    Marker Score: 2,577
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.41
    Marker Score: 492
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.41
    Marker Score: 2,172
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.41
    Marker Score: 1,647
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.4
    Marker Score: 1,414
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.39
    Marker Score: 3,051
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.39
    Marker Score: 48,113
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.39
    Marker Score: 513
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.38
    Marker Score: 1,179
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.38
    Marker Score: 3,281
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.38
    Marker Score: 942
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.38
    Marker Score: 29,405
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.37
    Marker Score: 912
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.37
    Marker Score: 1,437
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.36
    Marker Score: 906
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.35
    Marker Score: 390
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.35
    Marker Score: 4,000
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.35
    Marker Score: 982
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.34
    Marker Score: 1,144
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.34
    Marker Score: 1,566
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.34
    Marker Score: 2,334
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.33
    Marker Score: 539
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.33
    Marker Score: 501
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 1.33
    Marker Score: 855
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.32
    Marker Score: 290
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.32
    Marker Score: 552
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.32
    Marker Score: 371
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.32
    Marker Score: 695
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.32
    Marker Score: 1,177
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.31
    Marker Score: 746
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.3
    Marker Score: 701
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.3
    Marker Score: 6,028
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.3
    Marker Score: 532
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.3
    Marker Score: 822
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.3
    Marker Score: 10,161
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.3
    Marker Score: 892
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.3
    Marker Score: 449
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.3
    Marker Score: 1,372
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.3
    Marker Score: 1,556
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.29
    Marker Score: 13,118
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.28
    Marker Score: 2,669
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.28
    Marker Score: 510
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.28
    Marker Score: 1,232
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.28
    Marker Score: 1,409
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.27
    Marker Score: 4,002
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.27
    Marker Score: 582
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.27
    Marker Score: 1,103
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.27
    Marker Score: 901
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.26
    Marker Score: 335
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.26
    Marker Score: 3,190

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ERP44 is a small, approximately 12-kDa protein that resides in the ER lumen. It is highly conserved across species, suggesting its essential role in maintaining ER function. ERP44 is a member of the protein disulfide isomerase (PDI) family, which plays a critical role in protein folding and ER stress response. Its unique structure and localization allow it to interact with various proteins, influencing ER homeostasis and immune response. **Pathways and Functions:** ERP44 is involved in several key pathways, including: 1. **Cell surface protein glycosylation**: ERP44 assists in the proper glycosylation of cell surface proteins, ensuring their correct folding and presentation. 2. **Protein folding**: ERP44 helps to maintain protein homeostasis by facilitating the folding of misfolded proteins, thereby preventing ER stress. 3. **ER stress response**: ERP44 is activated in response to ER stress, where it helps to restore ER homeostasis by promoting protein folding and degradation of misfolded proteins. 4. **Immune response**: ERP44 is significantly expressed in immune cells, where it plays a crucial role in neutrophil degranulation, innate immune response, and adaptive immune response. 5. **Exosome-mediated protein transport**: ERP44 is involved in the transport of proteins to the exosome, a membrane-bound organelle responsible for protein degradation and secretion. **Clinical Significance:** Dysregulation of ERP44 has been implicated in various diseases, including: 1. **Autoimmune disorders**: ERP44 dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where ER stress and immune dysregulation play a key role. 2. **Cancer**: ERP44 overexpression has been observed in several types of cancer, where it may contribute to tumorigenesis and metastasis. 3. **Neurodegenerative diseases**: ERP44 dysfunction has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where ER stress and protein misfolding play a key role. 4. **Infectious diseases**: ERP44 may play a role in the innate immune response to infections, such as influenza and tuberculosis. In conclusion, ERP44 is a multifunctional protein that plays a critical role in maintaining ER homeostasis, immune response, and cell surface function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of ERP44 and its potential therapeutic applications.

Genular Protein ID: 2128498279

Symbol: ERP44_HUMAN

Name: Endoplasmic reticulum resident protein 44

UniProtKB Accession Codes:

Q9BS26 O60319 Q4VXC1 Q5VWZ7 Q6UW14 Q8WX67

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 5 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11847130

Title: ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family.

PubMed ID: 11847130

DOI: 10.1093/emboj/21.4.835

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14517240

Title: Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44.

PubMed ID: 14517240

DOI: 10.1093/emboj/cdg491

PubMed ID: 11921445

Title: Towards complete analysis of the platelet proteome.

PubMed ID: 11921445

DOI: 10.1002/1615-9861(200203)2:3<288::aid-prot288>3.0.co;2-0

PubMed ID: 15652484

Title: Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44.

PubMed ID: 15652484

DOI: 10.1016/j.cell.2004.11.048

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29858230

Title: Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1alpha.

PubMed ID: 29858230

DOI: 10.15252/embj.201798699

PubMed ID: 18552768

Title: Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail.

PubMed ID: 18552768

DOI: 10.1038/embor.2008.88

Sequence Information:

  • Length: 406
  • Mass: 46971
  • Checksum: 3865DCF3811BC263
  • Sequence:
    • MHPAVFLSLP DLRCSLLLLV TWVFTPVTTE ITSLDTENID EILNNADVAL VNFYADWCRF 
SQMLHPIFEE ASDVIKEEFP NENQVVFARV DCDQHSDIAQ RYRISKYPTL KLFRNGMMMK 
REYRGQRSVK ALADYIRQQK SDPIQEIRDL AEITTLDRSK RNIIGYFEQK DSDNYRVFER 
VANILHDDCA FLSAFGDVSK PERYSGDNII YKPPGHSAPD MVYLGAMTNF DVTYNWIQDK 
CVPLVREITF ENGEELTEEG LPFLILFHMK EDTESLEIFQ NEVARQLISE KGTINFLHAD 
CDKFRHPLLH IQKTPADCPV IAIDSFRHMY VFGDFKDVLI PGKLKQFVFD LHSGKLHREF 
HHGPDPTDTA PGEQAQDVAS SPPESSFQKL APSEYRYTLL RDRDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.