Details for: HECW1

Gene ID: 23072

Symbol: HECW1

Ensembl ID: ENSG00000002746

Description: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.68
    Marker Score: 158,089
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.61
    Marker Score: 24,739
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.14
    Marker Score: 21,702
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 4.01
    Marker Score: 13,451
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.95
    Marker Score: 29,781
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.62
    Marker Score: 8,319
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.87
    Marker Score: 1,667
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.76
    Marker Score: 1,236
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.56
    Marker Score: 19,626
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.39
    Marker Score: 90,845
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.39
    Marker Score: 11,037
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.36
    Marker Score: 1,132
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.34
    Marker Score: 86,272
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.29
    Marker Score: 9,505
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.28
    Marker Score: 2,817
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.22
    Marker Score: 8,566
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20,556
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.16
    Marker Score: 4,092
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.15
    Marker Score: 827
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127,901
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.03
    Marker Score: 30,360
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2
    Marker Score: 20,633
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.94
    Marker Score: 1,284
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,306
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.88
    Marker Score: 37,384
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,133
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.87
    Marker Score: 7,618
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.78
    Marker Score: 2,153
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.71
    Marker Score: 2,879
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2,555
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.66
    Marker Score: 968
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,168
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.57
    Marker Score: 5,588
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.52
    Marker Score: 637
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.48
    Marker Score: 3,018
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.47
    Marker Score: 3,466
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,393
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.34
    Marker Score: 1,892
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.32
    Marker Score: 740
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.2
    Marker Score: 1,499
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.19
    Marker Score: 1,365
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18,158
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.14
    Marker Score: 347
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.08
    Marker Score: 1,184
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.08
    Marker Score: 1,138
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.07
    Marker Score: 644
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,806
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,031
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.97
    Marker Score: 1,304
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,331
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.93
    Marker Score: 254
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 425
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.86
    Marker Score: 3,591
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.84
    Marker Score: 270
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.82
    Marker Score: 258
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.74
    Marker Score: 15,840
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.74
    Marker Score: 252
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.71
    Marker Score: 338
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.71
    Marker Score: 369
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.68
    Marker Score: 2,846
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.66
    Marker Score: 327
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.65
    Marker Score: 627
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.65
    Marker Score: 388
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.62
    Marker Score: 6,243
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.59
    Marker Score: 154
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 452
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.56
    Marker Score: 146
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.55
    Marker Score: 243
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.55
    Marker Score: 154
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.53
    Marker Score: 134
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.52
    Marker Score: 890
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.5
    Marker Score: 326
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.48
    Marker Score: 872
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.48
    Marker Score: 414
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.47
    Marker Score: 1,337
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.46
    Marker Score: 882
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.44
    Marker Score: 529
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.43
    Marker Score: 159
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.42
    Marker Score: 169
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.42
    Marker Score: 276
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4
    Marker Score: 1,657
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.38
    Marker Score: 112
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.38
    Marker Score: 127
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.37
    Marker Score: 214

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HECW1 is a member of the HECT family of E3 ubiquitin ligases, characterized by the presence of three distinct domains: HECT (Heme E3 C-terminal), C2 (calcium-binding), and WW (tryptophan-rich). These domains enable HECW1 to recognize and bind to specific protein substrates, facilitating their ubiquitination and subsequent degradation. HECW1's ability to interact with a wide range of proteins makes it a versatile regulator of cellular processes. **Pathways and Functions:** HECW1 is involved in various signaling pathways, including: 1. **Negative regulation of canonical Wnt signaling pathway**: HECW1 has been shown to inhibit the Wnt/β-catenin pathway, which is crucial for cell proliferation, differentiation, and survival. 2. **Regulation of dendrite morphogenesis**: HECW1 influences the development and maintenance of dendritic structures in neurons, which is essential for synaptic plasticity and learning. 3. **Protein binding and ubiquitination**: HECW1 interacts with a range of proteins, including those involved in transcriptional regulation, protein degradation, and signaling. 4. **Signal transduction**: HECW1 modulates signaling pathways involved in immune cell function, including those involved in T cell activation and cytokine production. **Clinical Significance:** The dysregulation of HECW1 has been implicated in various neurological and immune disorders, including: 1. **Neurodegenerative diseases**: HECW1's role in regulating synaptic plasticity and dendrite morphogenesis makes it a potential target for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Immune disorders**: HECW1's involvement in immune cell function and signaling pathways makes it a potential target for the treatment of immune disorders, such as autoimmune diseases and cancer. 3. **Cancer**: HECW1's role in regulating protein degradation and signaling pathways makes it a potential target for the development of cancer therapies. In conclusion, HECW1 is a multifaceted protein with a wide range of functions in cellular regulation. Its dysregulation has been implicated in various neurological and immune disorders, making it a potential target for the development of novel therapies. Further research is needed to fully elucidate the mechanisms by which HECW1 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 1143139464

Symbol: HECW1_HUMAN

Name: E3 ubiquitin-protein ligase HECW1

UniProtKB Accession Codes:

Q76N89 A7E2X0 A8MYS3 B4DH42 O15036 Q9HCC7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 6 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14684739

Title: NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.

PubMed ID: 14684739

DOI: 10.1074/jbc.m312389200

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 1606
  • Mass: 179554
  • Checksum: 22AE698F16276E98
  • Sequence:
    • MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN MDLRGGPHDG 
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIDEV 
LSENFLDYKN RGVNGSHRGQ IIWKIDASSY FVEPETKICF KYYHGVSGAL RATTPSVTVK 
NSAAPIFKSI GADETVQGQG SRRLISFSLS DFQAMGLKKG MFFNPDPYLK ISIQPGKHSI 
FPALPHHGQE RRSKIIGNTV NPIWQAEQFS FVSLPTDVLE IEVKDKFAKS RPIIKRFLGK 
LSMPVQRLLE RHAIGDRVVS YTLGRRLPTD HVSGQLQFRF EITSSIHPDD EEISLSTEPE 
SAQIQDSPMN NLMESGSGEP RSEAPESSES WKPEQLGEGS VPDGPGNQSI ELSRPAEEAA 
VITEAGDQGM VSVGPEGAGE LLAQVQKDIQ PAPSAEELAE QLDLGEEASA LLLEDGEAPA 
STKEEPLEEE ATTQSRAGRE EEEKEQEEEG DVSTLEQGEG RLQLRASVKR KSRPCSLPVS 
ELETVIASAC GDPETPRTHY IRIHTLLHSM PSAQGGSAAE EEDGAEEEST LKDSSEKDGL 
SEVDTVAADP SALEEDREEP EGATPGTAHP GHSGGHFPSL ANGAAQDGDT HPSTGSESDS 
SPRQGGDHSC EGCDASCCSP SCYSSSCYST SCYSSSCYSA SCYSPSCYNG NRFASHTRFS 
SVDSAKISES TVFSSQDDEE EENSAFESVP DSMQSPELDP ESTNGAGPWQ DELAAPSGHV 
ERSPEGLESP VAGPSNRREG ECPILHNSQP VSQLPSLRPE HHHYPTIDEP LPPNWEARID 
SHGRVFYVDH VNRTTTWQRP TAAATPDGMR RSGSIQQMEQ LNRRYQNIQR TIATERSEED 
SGSQSCEQAP AGGGGGGGSD SEAESSQSSL DLRREGSLSP VNSQKITLLL QSPAVKFITN 
PEFFTVLHAN YSAYRVFTSS TCLKHMILKV RRDARNFERY QHNRDLVNFI NMFADTRLEL 
PRGWEIKTDQ QGKSFFVDHN SRATTFIDPR IPLQNGRLPN HLTHRQHLQR LRSYSAGEAS 
EVSRNRGASL LARPGHSLVA AIRSQHQHES LPLAYNDKIV AFLRQPNIFE MLQERQPSLA 
RNHTLREKIH YIRTEGNHGL EKLSCDADLV ILLSLFEEEI MSYVPLQAAF HPGYSFSPRC 
SPCSSPQNSP GLQRASARAP SPYRRDFEAK LRNFYRKLEA KGFGQGPGKI KLIIRRDHLL 
EGTFNQVMAY SRKELQRNKL YVTFVGEEGL DYSGPSREFF FLLSQELFNP YYGLFEYSAN 
DTYTVQISPM SAFVENHLEW FRFSGRILGL ALIHQYLLDA FFTRPFYKAL LRLPCDLSDL 
EYLDEEFHQS LQWMKDNNIT DILDLTFTVN EEVFGQVTER ELKSGGANTQ VTEKNKKEYI 
ERMVKWRVER GVVQQTEALV RGFYEVVDSR LVSVFDAREL ELVIAGTAEI DLNDWRNNTE 
YRGGYHDGHL VIRWFWAAVE RFNNEQRLRL LQFVTGTSSV PYEGFAALRG SNGLRRFCIE 
KWGKITSLPR AHTCFNRLDL PPYPSYSMLY EKLLTAVEET STFGLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.