Details for: AVL9

Gene ID: 23080

Symbol: AVL9

Ensembl ID: ENSG00000105778

Description: AVL9 cell migration associated

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.46
    Marker Score: 83,200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.4
    Marker Score: 42,576
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.31
    Marker Score: 49,196
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.22
    Marker Score: 7,446
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.21
    Marker Score: 9,249
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.2
    Marker Score: 11,803
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.12
    Marker Score: 1,831
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.09
    Marker Score: 16,054
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.08
    Marker Score: 41,460
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.06
    Marker Score: 30,794
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.02
    Marker Score: 8,414
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.01
    Marker Score: 2,706
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.01
    Marker Score: 76,330
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2
    Marker Score: 73,713
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.99
    Marker Score: 2,288
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.93
    Marker Score: 7,455
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.92
    Marker Score: 562
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.92
    Marker Score: 7,969
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.92
    Marker Score: 18,022
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.92
    Marker Score: 117,825
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.92
    Marker Score: 14,444
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.91
    Marker Score: 10,032
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.9
    Marker Score: 19,660
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.9
    Marker Score: 4,376
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.9
    Marker Score: 4,174
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.88
    Marker Score: 7,637
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.87
    Marker Score: 1,092
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.82
    Marker Score: 2,197
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.81
    Marker Score: 760
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.8
    Marker Score: 1,076
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.8
    Marker Score: 17,078
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.77
    Marker Score: 1,029
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.73
    Marker Score: 5,655
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.72
    Marker Score: 966
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.72
    Marker Score: 14,752
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.7
    Marker Score: 7,856
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.7
    Marker Score: 1,278
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.67
    Marker Score: 1,843
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.65
    Marker Score: 475
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.63
    Marker Score: 2,295
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.61
    Marker Score: 938
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.61
    Marker Score: 3,095
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.61
    Marker Score: 1,321
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.6
    Marker Score: 3,841
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.57
    Marker Score: 605
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2,374
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.51
    Marker Score: 798
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.49
    Marker Score: 23,974
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.47
    Marker Score: 1,580
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.44
    Marker Score: 1,635
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.43
    Marker Score: 742
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.43
    Marker Score: 685
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.42
    Marker Score: 708
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.41
    Marker Score: 1,252
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.41
    Marker Score: 444
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.39
    Marker Score: 963
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.38
    Marker Score: 1,066
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.38
    Marker Score: 377
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.38
    Marker Score: 2,408
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.36
    Marker Score: 1,695
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.36
    Marker Score: 449
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.34
    Marker Score: 29,865
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.27
    Marker Score: 3,636
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.27
    Marker Score: 835
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.26
    Marker Score: 704
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.26
    Marker Score: 1,090
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.24
    Marker Score: 688
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.22
    Marker Score: 1,311
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.21
    Marker Score: 384
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.2
    Marker Score: 1,502
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.18
    Marker Score: 1,974
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.17
    Marker Score: 65,505
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18,204
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.12
    Marker Score: 403
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.11
    Marker Score: 786
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.11
    Marker Score: 1,057
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.09
    Marker Score: 408
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.08
    Marker Score: 584
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.07
    Marker Score: 365
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.07
    Marker Score: 1,518
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.06
    Marker Score: 270
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.06
    Marker Score: 3,764
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.04
    Marker Score: 383
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.04
    Marker Score: 2,185
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.02
    Marker Score: 497
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.02
    Marker Score: 6,577
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.01
    Marker Score: 365
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,676
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,902
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.99
    Marker Score: 677
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,389
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.98
    Marker Score: 4,228
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.98
    Marker Score: 2,303
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.96
    Marker Score: 352
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.96
    Marker Score: 303
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.96
    Marker Score: 1,183
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.95
    Marker Score: 359
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,399
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AVL9 is a gene that exhibits significant expression in various cell types, including Purkinje cells, cortical cells of the adrenal gland, astrocytes, neuronal brush cells, and taste receptor cells. Its expression is predominantly localized to the cytoplasm and membrane, suggesting a role in regulating cell migration and membrane trafficking. The AVL9 protein is classified as a late secretory pathway protein, indicating its involvement in the final stages of protein secretion. **Pathways and Functions:** AVL9 is implicated in several key pathways, including cell migration, cytoplasm, membrane, and recycling endosome. These pathways highlight the gene's involvement in regulating cellular movement, membrane dynamics, and the sorting of proteins and lipids within the cell. Specifically, AVL9 is thought to play a role in: 1. Regulating the cytoskeleton, which is essential for cell migration and shape determination. 2. Modulating membrane trafficking, including the sorting of proteins and lipids to specific cellular compartments. 3. Involvement in the recycling endosome pathway, which is crucial for maintaining cellular homeostasis and regulating protein turnover. **Clinical Significance:** The identification of AVL9 as a key regulator of cell migration has significant implications for our understanding of various neurological disorders. Dysregulation of AVL9 has been implicated in conditions such as: 1. Neurodegenerative diseases, such as Alzheimer's and Parkinson's, where impaired cell migration and membrane trafficking contribute to disease progression. 2. Neurodevelopmental disorders, such as autism and schizophrenia, where abnormalities in AVL9 expression have been linked to impaired neuronal migration and circuit formation. 3. Neuroinflammatory conditions, such as multiple sclerosis, where AVL9 dysregulation may contribute to the disruption of the blood-brain barrier and exacerbation of disease symptoms. In conclusion, AVL9 is a critical gene that plays a pivotal role in regulating cell migration and membrane trafficking. Its dysregulation has significant implications for our understanding of various neurological disorders, highlighting the need for further research into the molecular mechanisms underlying these conditions.

Genular Protein ID: 3611006444

Symbol: AVL9_HUMAN

Name: Late secretory pathway protein AVL9 homolog

UniProtKB Accession Codes:

Q8NBF6 Q92573

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22595670

Title: Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells.

PubMed ID: 22595670

DOI: 10.1016/j.devcel.2012.04.010

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 648
  • Mass: 71947
  • Checksum: 3F59F3CA68596009
  • Sequence:
    • MEKARRGGDG VPRGPVLHIV VVGFHHKKGC QVEFSYPPLI PGDGHDSHTL PEEWKYLPFL 
ALPDGAHNYQ EDTVFFHLPP RNGNGATVFG ISCYRQIEAK ALKVRQADIT RETVQKSVCV 
LSKLPLYGLL QAKLQLITHA YFEEKDFSQI SILKELYEHM NSSLGGASLE GSQVYLGLSP 
RDLVLHFRHK VLILFKLILL EKKVLFYISP VNKLVGALMT VLSLFPGMIE HGLSDCSQYR 
PRKSMSEDGG LQESNPCADD FVSASTADVS HTNLGTIRKV MAGNHGEDAA MKTEEPLFQV 
EDSSKGQEPN DTNQYLKPPS RPSPDSSESD WETLDPSVLE DPNLKEREQL GSDQTNLFPK 
DSVPSESLPI TVQPQANTGQ VVLIPGLISG LEEDQYGMPL AIFTKGYLCL PYMALQQHHL 
LSDVTVRGFV AGATNILFRQ QKHLSDAIVE VEEALIQIHD PELRKLLNPT TADLRFADYL 
VRHVTENRDD VFLDGTGWEG GDEWIRAQFA VYIHALLAAT LQLDNEKILS DYGTTFVTAW 
KNTHNYRVWN SNKHPALAEI NPNHPFQGQY SVSDMKLRFS HSVQNSERGK KIGNVMVTTS 
RNVVQTGKAV GQSVGGAFSS AKTAMSSWLS TFTTSTSQSL TEPPDEKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.