Details for: SARM1

Gene ID: 23098

Symbol: SARM1

Ensembl ID: ENSG00000004139

Description: sterile alpha and TIR motif containing 1

Associated with

Other Information

Genular Protein ID: 2953843267

Symbol: SARM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6SZW1 O60277 Q7LGG3 Q9NXY5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 EMDB 17 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 25 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 57 PDBsum 38 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 6 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11386760

Title: A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans.

PubMed ID: 11386760

DOI: 10.1006/geno.2001.6548

PubMed ID: 9628581

Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9628581

DOI: 10.1093/dnares/5.1.31

PubMed ID: 15123841

Title: Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.

PubMed ID: 15123841

DOI: 10.1073/pnas.0308625101

PubMed ID: 16964262

Title: The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

PubMed ID: 16964262

DOI: 10.1038/ni1382

PubMed ID: 16985498

Title: DisSARMing Toll-like receptor signaling.

PubMed ID: 16985498

DOI: 10.1038/ni1006-1023

PubMed ID: 17724133

Title: MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival.

PubMed ID: 17724133

DOI: 10.1084/jem.20070868

PubMed ID: 18089857

Title: Studies of SARM1 uncover similarities between immune and neuronal responses to danger.

PubMed ID: 18089857

DOI: 10.1126/stke.4172007pe73

PubMed ID: 20306472

Title: SARM inhibits both TRIF- and MyD88-mediated AP-1 activation.

PubMed ID: 20306472

DOI: 10.1002/eji.200940034

PubMed ID: 22145856

Title: Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence.

PubMed ID: 22145856

DOI: 10.1042/bj20111653

PubMed ID: 25908823

Title: SARM1 activation triggers axon degeneration locally via NAD+ destruction.

PubMed ID: 25908823

DOI: 10.1126/science.1258366

PubMed ID: 27671644

Title: SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.

PubMed ID: 27671644

DOI: 10.1073/pnas.1601506113

PubMed ID: 28334607

Title: The SARM1 Toll/Interleukin-1 receptor domain possesses intrinsic NAD+ cleavage activity that promotes pathological axonal degeneration.

PubMed ID: 28334607

DOI: 10.1016/j.neuron.2017.02.022

PubMed ID: 29395922

Title: TIR domain proteins are an ancient family of NAD+-consuming enzymes.

PubMed ID: 29395922

DOI: 10.1016/j.cub.2017.12.024

PubMed ID: 30333228

Title: c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration.

PubMed ID: 30333228

DOI: 10.1074/jbc.ra118.004578

PubMed ID: 31128467

Title: A cell-permeant mimetic of NMN activates SARM1 to produce cyclic ADP-ribose and induce non-apoptotic cell death.

PubMed ID: 31128467

DOI: 10.1016/j.isci.2019.05.001

PubMed ID: 31439793

Title: TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death.

PubMed ID: 31439793

DOI: 10.1126/science.aax1771

PubMed ID: 32049506

Title: Initial kinetic characterization of sterile alpha and Toll/interleukin receptor motif-containing protein 1.

PubMed ID: 32049506

DOI: 10.1021/acs.biochem.9b01078

PubMed ID: 32828421

Title: Identification of the first noncompetitive SARM1 inhibitors.

PubMed ID: 32828421

DOI: 10.1016/j.bmc.2020.115644

PubMed ID: 31278906

Title: Structural evidence for an octameric ring arrangement of SARM1.

PubMed ID: 31278906

DOI: 10.1016/j.jmb.2019.06.030

PubMed ID: 31439792

Title: NAD+ cleavage activity by animal and plant TIR domains in cell death pathways.

PubMed ID: 31439792

DOI: 10.1126/science.aax1911

PubMed ID: 32755591

Title: Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1.

PubMed ID: 32755591

DOI: 10.1016/j.celrep.2020.107999

PubMed ID: 33053563

Title: The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative Sarm1.

PubMed ID: 33053563

DOI: 10.1038/s41586-020-2862-z

Sequence Information:

  • Length: 724
  • Mass: 79388
  • Checksum: 6391EA4C31EF6604
  • Sequence:
    • MVLTLLLSAY KLCRFFAMSG PRPGAERLAV PGPDGGGGTG PWWAAGGRGP REVSPGAGTE 
VQDALERALP ELQQALSALK QAGGARAVGA GLAEVFQLVE EAWLLPAVGR EVAQGLCDAI 
RLDGGLDLLL RLLQAPELET RVQAARLLEQ ILVAENRDRV ARIGLGVILN LAKEREPVEL 
ARSVAGILEH MFKHSEETCQ RLVAAGGLDA VLYWCRRTDP ALLRHCALAL GNCALHGGQA 
VQRRMVEKRA AEWLFPLAFS KEDELLRLHA CLAVAVLATN KEVEREVERS GTLALVEPLV 
ASLDPGRFAR CLVDASDTSQ GRGPDDLQRL VPLLDSNRLE AQCIGAFYLC AEAAIKSLQG 
KTKVFSDIGA IQSLKRLVSY STNGTKSALA KRALRLLGEE VPRPILPSVP SWKEAEVQTW 
LQQIGFSKYC ESFREQQVDG DLLLRLTEEE LQTDLGMKSG ITRKRFFREL TELKTFANYS 
TCDRSNLADW LGSLDPRFRQ YTYGLVSCGL DRSLLHRVSE QQLLEDCGIH LGVHRARILT 
AAREMLHSPL PCTGGKPSGD TPDVFISYRR NSGSQLASLL KVHLQLHGFS VFIDVEKLEA 
GKFEDKLIQS VMGARNFVLV LSPGALDKCM QDHDCKDWVH KEIVTALSCG KNIVPIIDGF 
EWPEPQVLPE DMQAVLTFNG IKWSHEYQEA TIEKIIRFLQ GRSSRDSSAG SDTSLEGAAP 
MGPT

Genular Protein ID: 2518088623

Symbol: Q0D2N8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q0D2N8

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 14 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 9 Gene3D 3 GenomeRNAi 1 IntAct 1 InterPro 7 KEGG 1 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 710
  • Mass: 77782
  • Checksum: 53A806C0108C8938
  • Sequence:
    • FFAMSGPRPG AERLAVPGPD GGGGTGPWWA AGGRGPREVS PGAGTEVQDA LERALPELQQ 
ALSALKQAGG ARAVGAGLAE VFQLVEEAWL LPAVGREVAQ GLCDAIRLDG GLDLLLRLLQ 
APELETRVQA ARLLEQILVA ENRDRVARIG LGVILNLAKE REPVELARSV AGILEHMFKH 
SEETCQRLVA AGGLDAVLYW CRRTDPALLR HCALALGNCA LHGGQAVQRR MVEKRAAEWL 
FPLAFSKEDE LLRLHACLAV AVLATNKEVE REVERSGTLA LVEPLVASLD PGRFARCLVD 
ASDTSQGRGP DDLQRLVPLL DSNRLEAQCI GAFYLCAEAA IKSLQGKTKV FSDIGAIQSL 
KRLVSYSTNG TKSALAKRAL RLLGEEVPRP ILPSVPSWKE AEVQTWLQQI GFSKYCESFR 
EQQVDGDLLL RLTEEELQTD LGMKSGITRK RFFRELTELK TFANYSTCDR SNLADWLGSL 
DPRFRQYTYG LVSCGLDRSL LHRVSEQQLL EDCGIHLGVH RARILTAARE MLHSPLPCTG 
GKPSGDTPDV FISYRRNSGS QLASLLKVHL QLHGFSVFID VEKLEAGKFE DKLIQSVMGA 
RNFVLVLSPG ALDKCMQDHD CKDWVHKEIV TALSCGKNIV PIIDGFEWPE PQVLPEDMQA 
VLTFNGIKWS HEYQEATIEK IIRFLQGRSS RDSSAGSDTS LEGAAPMGPT

Genular Protein ID: 2736530445

Symbol: Q05B42_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05B42

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 14 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 9 Gene3D 3 GenomeRNAi 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 617
  • Mass: 67941
  • Checksum: 3BCC5D1E730027FF
  • Sequence:
    • AERLAVPGPD GGGGTGPWWA AGGRGPREVS PGAGTEVQDA LEQILVAENR DRVARIGLGV 
ILNLAKEREP VELARSVAGI LEHMFKHSEE TCQRLVAAGG LDAVLYWCRR TDPALLRHCA 
LALGNCALHG GQAVQRRMVE KRAAEWLFPL AFSKEDELLR LHACLAVAVL ATNKEVEREV 
ERSGTLALVE PLVASLDPGR FARCLVDASD TSQGRGPDDL QRLVPLLDSN RLEAQCIGAF 
YLCAEAAIKS LQGKTKVFSD IGAIQSLKRL VSYSTNGTKS ALAKRALRLL GEEVPRPILP 
SVPSWKEAEV QTWLQQIGFS KYCESFREQQ VDGDLLLRLT EEELQTDLGM KSGITRKRFF 
RELTELKTFA NYSTCDRSNL ADWLGSLDPR FRQYTYGLVS CGLDRSLLHR VSEQQLLEDC 
GIHLGVHRAR ILTAAREMLH SPLPCTGGKP SGDTPDVFIS YRRNSGSQLA SLLKVHLQLH 
GFSVFIDVEK LEAGKFEDKL IQSVMGARNF VLVLSPGALD KCMQDHDCKD WVHKEIVTAL 
SCGKNIVPII DGFEWPEPQV LPEDMQAVLT FNGIKWSHEY QEATIEKIIR FLQGRSSRDS 
SAGSDTSLEG AAPMGPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.