Details for: AKR1B1

Gene ID: 231

Symbol: AKR1B1

Ensembl ID: ENSG00000085662

Description: aldo-keto reductase family 1 member B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.35
    Marker Score: 2838
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.24
    Marker Score: 8790
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.18
    Marker Score: 28753
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.15
    Marker Score: 1183
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.11
    Marker Score: 5733
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.07
    Marker Score: 20806
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.06
    Marker Score: 52711
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.03
    Marker Score: 2058
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.92
    Marker Score: 1918
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.92
    Marker Score: 782
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.91
    Marker Score: 472
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.89
    Marker Score: 2716
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.85
    Marker Score: 2077
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.82
    Marker Score: 1921
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.8
    Marker Score: 1695.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.77
    Marker Score: 4825
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.77
    Marker Score: 1889
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.76
    Marker Score: 2122
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.72
    Marker Score: 3594
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.71
    Marker Score: 385.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.71
    Marker Score: 7013.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.71
    Marker Score: 4317
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.67
    Marker Score: 1774
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.67
    Marker Score: 1796
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.66
    Marker Score: 1676.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.66
    Marker Score: 2825
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.65
    Marker Score: 1555.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.56
    Marker Score: 449.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.56
    Marker Score: 3168
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.56
    Marker Score: 977
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.49
    Marker Score: 1755.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.47
    Marker Score: 1572
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.47
    Marker Score: 541
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166611
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.45
    Marker Score: 9417.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.45
    Marker Score: 1655
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.41
    Marker Score: 1876.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.36
    Marker Score: 3568
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.35
    Marker Score: 5824
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.34
    Marker Score: 1679
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.33
    Marker Score: 699
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.33
    Marker Score: 3436
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.33
    Marker Score: 424
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.32
    Marker Score: 444
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.31
    Marker Score: 15265
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.31
    Marker Score: 801.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.3
    Marker Score: 743
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.28
    Marker Score: 12680
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.28
    Marker Score: 854
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.28
    Marker Score: 3534
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.28
    Marker Score: 757
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.26
    Marker Score: 797
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.26
    Marker Score: 3732
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.25
    Marker Score: 467
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.24
    Marker Score: 904
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.22
    Marker Score: 2344
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.21
    Marker Score: 12229
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.19
    Marker Score: 585
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.19
    Marker Score: 1152
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.19
    Marker Score: 863
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.19
    Marker Score: 1022
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.18
    Marker Score: 559
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.17
    Marker Score: 1800.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.17
    Marker Score: 776
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.17
    Marker Score: 330
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.16
    Marker Score: 272
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.16
    Marker Score: 7389
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 17966
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.14
    Marker Score: 1104
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.14
    Marker Score: 472
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.14
    Marker Score: 2228
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.14
    Marker Score: 1609
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.14
    Marker Score: 2069
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.13
    Marker Score: 222
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.13
    Marker Score: 9924
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.13
    Marker Score: 599
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.12
    Marker Score: 704.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.12
    Marker Score: 1206
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.11
    Marker Score: 3961
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.11
    Marker Score: 275
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.11
    Marker Score: 3493
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.11
    Marker Score: 383
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.1
    Marker Score: 223
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.1
    Marker Score: 1970
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.1
    Marker Score: 620
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.08
    Marker Score: 6587
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.08
    Marker Score: 1793
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.08
    Marker Score: 965
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.07
    Marker Score: 1254
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.06
    Marker Score: 245
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.06
    Marker Score: 350
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.06
    Marker Score: 1502
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.06
    Marker Score: 3089
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.06
    Marker Score: 1269
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.05
    Marker Score: 369
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.04
    Marker Score: 1064
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.04
    Marker Score: 496
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.04
    Marker Score: 1000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.03
    Marker Score: 1274
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.03
    Marker Score: 18296

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

## Summary The AKR1B1 gene encodes a protein called ALDR1B1, which is a member of the aldo-keto reductase family 1. This family of enzymes catalyze the reduction of various aldehydes and ketones to corresponding alcohols. ## Key characteristics * The AKR1B1 gene is located on chromosome 13q21.1. * It is a highly conserved gene, with a similar sequence found in mammals, birds, and fish. * It is expressed in a variety of cell types, including myeloid leukocytes, placental villous trophoblast, mesodermal cells, Hofbauer cells, ovarian surface epithelial cells, granulosa cells, alveolar macrophages, kidney loop of Henle thin ascending limb epithelial cells, Kupffer cells, and eurydendroid cells. * It is a key regulator of glucose metabolism, and its expression is regulated by a variety of factors, including glucose availability, insulin, and glucagon. * It is also involved in the regulation of lipid metabolism, and its expression is upregulated in conditions such as obesity and diabetes. ## Pathways and functions * The AKR1B1 protein is involved in a variety of metabolic pathways, including the metabolism of aldehydes and ketones, the metabolism of fatty acids and cholesterol, and the metabolism of steroids. * It is also involved in the regulation of inflammation, and its expression is upregulated in conditions such as sepsis and inflammation. * It is a key regulator of the immune response, and its expression is upregulated in conditions such as autoimmune diseases and cancer. ## Clinical significance * Mutations in the AKR1B1 gene have been linked to a number of human diseases, including diabetes, obesity, and cancer. * The protein is a potential target for therapeutic intervention in these diseases, and inhibitors of AKR1B1 have been shown to be effective in reducing inflammation and cell growth.

Genular Protein ID: 2630763080

Symbol: ALDR_HUMAN

Name: Aldo-keto reductase family 1 member B1

UniProtKB Accession Codes:

P15121 B2R8N3 Q5U031 Q6FGA4 Q6ICP2 Q9BS21 Q9UCI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 87 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 39 DrugCentral 1 EC 5 EMBL 19 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 2 RefSeq 1 Rhea 19 SABIO-RK 1 SASBDB 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2498333

Title: The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.

PubMed ID: 2498333

DOI: 10.1016/s0021-9258(18)60566-6

PubMed ID: 2504709

Title: Cloning and sequence determination of human placental aldose reductase gene.

PubMed ID: 2504709

DOI: 10.1016/s0021-9258(18)63766-4

PubMed ID: 2510130

Title: Nucleotide sequence of cDNA for human aldose reductase.

PubMed ID: 2510130

DOI: 10.1093/nar/17.20.8368

PubMed ID: 2111143

Title: Cloning and prokaryotic expression of a biologically active human placental aldose reductase.

PubMed ID: 2111143

DOI: 10.1089/dna.1990.9.149

PubMed ID: 2112546

Title: Cloning and expression of human aldose reductase.

PubMed ID: 2112546

DOI: 10.1016/s0021-9258(19)38740-x

PubMed ID: 1901857

Title: Structure of the human aldose reductase gene.

PubMed ID: 1901857

DOI: 10.1016/s0021-9258(20)89582-9

PubMed ID: 9195951

Title: Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene.

PubMed ID: 9195951

DOI: 10.1074/jbc.272.26.16431

PubMed ID: 14996095

Title: SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.

PubMed ID: 14996095

DOI: 10.1111/j.1365-2133.2004.05651.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8435445

Title: Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress.

PubMed ID: 8435445

DOI: 10.1016/0167-4889(93)90218-e

PubMed ID: 2492527

Title: Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine.

PubMed ID: 2492527

DOI: 10.1016/s0021-9258(19)81699-x

PubMed ID: 8343525

Title: Identification of the reactive cysteine residue in human placenta aldose reductase.

PubMed ID: 8343525

DOI: 10.1016/0167-4838(93)90258-s

PubMed ID: 8281941

Title: Sequence of pig lens aldose reductase and electrospray mass spectrometry of non-covalent and covalent complexes.

PubMed ID: 8281941

DOI: 10.1111/j.1432-1033.1993.tb18445.x

PubMed ID: 1936586

Title: Crucial role of aldose reductase activity and plasma glucose level in sorbitol accumulation in erythrocytes from diabetic patients.

PubMed ID: 1936586

DOI: 10.2337/diab.40.10.1233

PubMed ID: 8245005

Title: Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110.

PubMed ID: 8245005

DOI: 10.1016/s0021-9258(19)74444-5

PubMed ID: 10510318

Title: Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members.

PubMed ID: 10510318

DOI: 10.1042/bj3430487

PubMed ID: 12732097

Title: Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism.

PubMed ID: 12732097

DOI: 10.1042/bj20021818

PubMed ID: 17381426

Title: Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes.

PubMed ID: 17381426

DOI: 10.1042/bj20061743

PubMed ID: 19010934

Title: Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7.

PubMed ID: 19010934

DOI: 10.1093/jb/mvn152

PubMed ID: 21329684

Title: Human aldo-keto reductases 1B1 and 1B10: a comparative study on their enzyme activity toward electrophilic carbonyl compounds.

PubMed ID: 21329684

DOI: 10.1016/j.cbi.2011.02.004

PubMed ID: 21329680

Title: Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde.

PubMed ID: 21329680

DOI: 10.1016/j.cbi.2011.02.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 1621098

Title: An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.

PubMed ID: 1621098

DOI: 10.1126/science.1621098

PubMed ID: 1447221

Title: The crystal structure of the aldose reductase.NADPH binary complex.

PubMed ID: 1447221

DOI: 10.2210/pdb1abn/pdb

PubMed ID: 8234324

Title: Refined 1.8-A structure of human aldose reductase complexed with the potent inhibitor zopolrestat.

PubMed ID: 8234324

DOI: 10.1073/pnas.90.21.9847

PubMed ID: 9405046

Title: The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.

PubMed ID: 9405046

DOI: 10.1021/bi9717136

PubMed ID: 15272156

Title: The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.

PubMed ID: 15272156

DOI: 10.1107/s0907444904011370

PubMed ID: 15146478

Title: Ultrahigh resolution drug design I: details of interactions in human aldose reductase-inhibitor complex at 0.66 A.

PubMed ID: 15146478

DOI: 10.1002/prot.20015

PubMed ID: 16337231

Title: High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group.

PubMed ID: 16337231

DOI: 10.1016/j.jmb.2005.10.067

PubMed ID: 17505104

Title: The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop.

PubMed ID: 17505104

DOI: 10.1107/s0907444907011997

PubMed ID: 17418233

Title: Evidence for a novel binding site conformer of aldose reductase in ligand-bound state.

PubMed ID: 17418233

DOI: 10.1016/j.jmb.2007.03.021

PubMed ID: 17368668

Title: Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution.

PubMed ID: 17368668

DOI: 10.1016/j.jmb.2006.12.004

Sequence Information:

  • Length: 316
  • Mass: 35853
  • Checksum: 1852E8616B5DCEAE
  • Sequence:
    • MASRLLLNNG AKMPILGLGT WKSPPGQVTE AVKVAIDVGY RHIDCAHVYQ NENEVGVAIQ 
EKLREQVVKR EELFIVSKLW CTYHEKGLVK GACQKTLSDL KLDYLDLYLI HWPTGFKPGK 
EFFPLDESGN VVPSDTNILD TWAAMEELVD EGLVKAIGIS NFNHLQVEMI LNKPGLKYKP 
AVNQIECHPY LTQEKLIQYC QSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK 
HNKTTAQVLI RFPMQRNLVV IPKSVTPERI AENFKVFDFE LSSQDMTTLL SYNRNWRVCA 
LLSCTSHKDY PFHEEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.