Details for: AKR1B1

Gene ID: 231

Symbol: AKR1B1

Ensembl ID: ENSG00000085662

Description: aldo-keto reductase family 1 member B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 208.2995
    Cell Significance Index: -32.4000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 83.2387
    Cell Significance Index: -34.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 76.4664
    Cell Significance Index: -31.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.1539
    Cell Significance Index: -18.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 72.0787
    Cell Significance Index: -34.0300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 66.7787
    Cell Significance Index: -34.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.7916
    Cell Significance Index: -31.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 28.4591
    Cell Significance Index: 759.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.5216
    Cell Significance Index: -32.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4515
    Cell Significance Index: -33.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.6644
    Cell Significance Index: 61.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2112
    Cell Significance Index: -13.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.7307
    Cell Significance Index: 73.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.6381
    Cell Significance Index: 138.5100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.0705
    Cell Significance Index: 10.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6802
    Cell Significance Index: 44.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6458
    Cell Significance Index: 57.1900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.5019
    Cell Significance Index: 11.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4335
    Cell Significance Index: 39.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.4187
    Cell Significance Index: 37.9500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.3519
    Cell Significance Index: 8.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3496
    Cell Significance Index: 28.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0469
    Cell Significance Index: 54.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0403
    Cell Significance Index: 102.9100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.0381
    Cell Significance Index: 13.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9812
    Cell Significance Index: 125.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9637
    Cell Significance Index: 20.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9264
    Cell Significance Index: 59.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8976
    Cell Significance Index: 105.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8323
    Cell Significance Index: 96.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7394
    Cell Significance Index: 667.6500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7127
    Cell Significance Index: 5.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7042
    Cell Significance Index: 96.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6517
    Cell Significance Index: 19.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5587
    Cell Significance Index: 90.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5439
    Cell Significance Index: 32.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5165
    Cell Significance Index: 93.1200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.5040
    Cell Significance Index: 4.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4778
    Cell Significance Index: 58.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4405
    Cell Significance Index: 12.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3528
    Cell Significance Index: 70.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2723
    Cell Significance Index: 148.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2268
    Cell Significance Index: 100.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2034
    Cell Significance Index: 9.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1990
    Cell Significance Index: 10.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1873
    Cell Significance Index: 12.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1518
    Cell Significance Index: 54.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0788
    Cell Significance Index: 10.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0381
    Cell Significance Index: 7.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0374
    Cell Significance Index: 6.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0332
    Cell Significance Index: 3.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0200
    Cell Significance Index: 3.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0115
    Cell Significance Index: 8.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0075
    Cell Significance Index: 0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0021
    Cell Significance Index: 3.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0070
    Cell Significance Index: -10.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0087
    Cell Significance Index: -5.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0095
    Cell Significance Index: -17.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0108
    Cell Significance Index: -14.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0285
    Cell Significance Index: -21.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0352
    Cell Significance Index: -0.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0372
    Cell Significance Index: -23.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0383
    Cell Significance Index: -0.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0400
    Cell Significance Index: -22.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0495
    Cell Significance Index: -1.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0545
    Cell Significance Index: -24.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0625
    Cell Significance Index: -1.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0703
    Cell Significance Index: -14.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0971
    Cell Significance Index: -27.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1259
    Cell Significance Index: -9.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1303
    Cell Significance Index: -14.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1509
    Cell Significance Index: -21.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1764
    Cell Significance Index: -4.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1842
    Cell Significance Index: -11.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1891
    Cell Significance Index: -21.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1952
    Cell Significance Index: -9.1000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2093
    Cell Significance Index: -1.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2151
    Cell Significance Index: -13.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2213
    Cell Significance Index: -14.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2486
    Cell Significance Index: -4.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2701
    Cell Significance Index: -8.6500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2790
    Cell Significance Index: -2.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2818
    Cell Significance Index: -19.9300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3031
    Cell Significance Index: -3.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3072
    Cell Significance Index: -24.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3143
    Cell Significance Index: -32.7300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3611
    Cell Significance Index: -8.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3620
    Cell Significance Index: -22.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3790
    Cell Significance Index: -2.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3831
    Cell Significance Index: -21.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3850
    Cell Significance Index: -17.4500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3867
    Cell Significance Index: -2.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3871
    Cell Significance Index: -28.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4353
    Cell Significance Index: -9.0300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4363
    Cell Significance Index: -6.1200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4828
    Cell Significance Index: -5.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5419
    Cell Significance Index: -23.9700
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.5923
    Cell Significance Index: -3.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6149
    Cell Significance Index: -18.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** AKR1B1 exhibits the following key characteristics: 1. **Aldo-keto reductase activity**: AKR1B1 is a member of the AKR superfamily, which is characterized by its ability to reduce aldo-keto compounds. 2. **Steroid hormone metabolism**: AKR1B1 has been implicated in the metabolism of steroid hormones, including progesterone and pregnenolone. 3. **Antioxidant activity**: AKR1B1 has been shown to have antioxidant properties, reducing oxidative stress in various cell types. 4. **Immune response regulation**: AKR1B1 has been detected in immune cells, such as myeloid leukocytes and macrophages, where it may play a role in regulating immune responses. 5. **Cellular differentiation**: AKR1B1 has been shown to be involved in the differentiation of epithelial cells, including those in the kidney and placenta. **Pathways and Functions** AKR1B1 is involved in the following pathways and functions: 1. **Alditol:NADP+ 1-oxidoreductase activity**: AKR1B1 reduces alditol to aldose, generating NADPH in the process. 2. **Allyl-alcohol dehydrogenase activity**: AKR1B1 has been shown to have a low-affinity for allyl-alcohol, a compound that is involved in the biosynthesis of steroids. 3. **C21-steroid hormone biosynthetic process**: AKR1B1 is involved in the metabolism of steroid hormones, including the conversion of pregnenolone to progesterone. 4. **Carbohydrate metabolic process**: AKR1B1 has been implicated in the metabolism of carbohydrates, including the reduction of aldoses. 5. **Electron transfer activity**: AKR1B1 has been shown to have electron transfer activity, which may contribute to its antioxidant properties. **Clinical Significance** AKR1B1 has been implicated in various diseases and disorders, including: 1. **Cancer**: AKR1B1 has been detected in various types of cancer, including ovarian cancer and prostate cancer. 2. **Atherosclerosis**: AKR1B1 has been shown to have a role in the development of atherosclerosis, a condition characterized by the buildup of fatty deposits in the arteries. 3. **Diabetes**: AKR1B1 has been implicated in the development of diabetes, a condition characterized by high blood sugar levels. 4. **Renal disease**: AKR1B1 has been detected in renal cells, where it may play a role in the development of kidney disease. In conclusion, AKR1B1 is a multifunctional enzyme that plays a critical role in various cellular processes, including metabolism, apoptosis, and immune responses. Its expression in various cell types highlights its importance in tissue development and function. Further research is needed to fully elucidate the role of AKR1B1 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2630763080

Symbol: ALDR_HUMAN

Name: Aldo-keto reductase family 1 member B1

UniProtKB Accession Codes:

P15121 B2R8N3 Q5U031 Q6FGA4 Q6ICP2 Q9BS21 Q9UCI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 87 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 40 DrugCentral 1 EC 5 EMBL 19 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 2 RefSeq 1 Rhea 19 SABIO-RK 1 SASBDB 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2498333

Title: The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.

PubMed ID: 2498333

DOI: 10.1016/s0021-9258(18)60566-6

PubMed ID: 2504709

Title: Cloning and sequence determination of human placental aldose reductase gene.

PubMed ID: 2504709

DOI: 10.1016/s0021-9258(18)63766-4

PubMed ID: 2510130

Title: Nucleotide sequence of cDNA for human aldose reductase.

PubMed ID: 2510130

DOI: 10.1093/nar/17.20.8368

PubMed ID: 2111143

Title: Cloning and prokaryotic expression of a biologically active human placental aldose reductase.

PubMed ID: 2111143

DOI: 10.1089/dna.1990.9.149

PubMed ID: 2112546

Title: Cloning and expression of human aldose reductase.

PubMed ID: 2112546

DOI: 10.1016/s0021-9258(19)38740-x

PubMed ID: 1901857

Title: Structure of the human aldose reductase gene.

PubMed ID: 1901857

DOI: 10.1016/s0021-9258(20)89582-9

PubMed ID: 9195951

Title: Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene.

PubMed ID: 9195951

DOI: 10.1074/jbc.272.26.16431

PubMed ID: 14996095

Title: SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.

PubMed ID: 14996095

DOI: 10.1111/j.1365-2133.2004.05651.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8435445

Title: Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress.

PubMed ID: 8435445

DOI: 10.1016/0167-4889(93)90218-e

PubMed ID: 2492527

Title: Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine.

PubMed ID: 2492527

DOI: 10.1016/s0021-9258(19)81699-x

PubMed ID: 8343525

Title: Identification of the reactive cysteine residue in human placenta aldose reductase.

PubMed ID: 8343525

DOI: 10.1016/0167-4838(93)90258-s

PubMed ID: 8281941

Title: Sequence of pig lens aldose reductase and electrospray mass spectrometry of non-covalent and covalent complexes.

PubMed ID: 8281941

DOI: 10.1111/j.1432-1033.1993.tb18445.x

PubMed ID: 1936586

Title: Crucial role of aldose reductase activity and plasma glucose level in sorbitol accumulation in erythrocytes from diabetic patients.

PubMed ID: 1936586

DOI: 10.2337/diab.40.10.1233

PubMed ID: 8245005

Title: Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110.

PubMed ID: 8245005

DOI: 10.1016/s0021-9258(19)74444-5

PubMed ID: 10510318

Title: Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members.

PubMed ID: 10510318

DOI: 10.1042/bj3430487

PubMed ID: 12732097

Title: Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism.

PubMed ID: 12732097

DOI: 10.1042/bj20021818

PubMed ID: 17381426

Title: Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes.

PubMed ID: 17381426

DOI: 10.1042/bj20061743

PubMed ID: 19010934

Title: Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7.

PubMed ID: 19010934

DOI: 10.1093/jb/mvn152

PubMed ID: 21329684

Title: Human aldo-keto reductases 1B1 and 1B10: a comparative study on their enzyme activity toward electrophilic carbonyl compounds.

PubMed ID: 21329684

DOI: 10.1016/j.cbi.2011.02.004

PubMed ID: 21329680

Title: Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde.

PubMed ID: 21329680

DOI: 10.1016/j.cbi.2011.02.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 1621098

Title: An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.

PubMed ID: 1621098

DOI: 10.1126/science.1621098

PubMed ID: 1447221

Title: The crystal structure of the aldose reductase.NADPH binary complex.

PubMed ID: 1447221

DOI: 10.2210/pdb1abn/pdb

PubMed ID: 8234324

Title: Refined 1.8-A structure of human aldose reductase complexed with the potent inhibitor zopolrestat.

PubMed ID: 8234324

DOI: 10.1073/pnas.90.21.9847

PubMed ID: 9405046

Title: The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.

PubMed ID: 9405046

DOI: 10.1021/bi9717136

PubMed ID: 15272156

Title: The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.

PubMed ID: 15272156

DOI: 10.1107/s0907444904011370

PubMed ID: 15146478

Title: Ultrahigh resolution drug design I: details of interactions in human aldose reductase-inhibitor complex at 0.66 A.

PubMed ID: 15146478

DOI: 10.1002/prot.20015

PubMed ID: 16337231

Title: High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group.

PubMed ID: 16337231

DOI: 10.1016/j.jmb.2005.10.067

PubMed ID: 17505104

Title: The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop.

PubMed ID: 17505104

DOI: 10.1107/s0907444907011997

PubMed ID: 17418233

Title: Evidence for a novel binding site conformer of aldose reductase in ligand-bound state.

PubMed ID: 17418233

DOI: 10.1016/j.jmb.2007.03.021

PubMed ID: 17368668

Title: Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution.

PubMed ID: 17368668

DOI: 10.1016/j.jmb.2006.12.004

Sequence Information:

  • Length: 316
  • Mass: 35853
  • Checksum: 1852E8616B5DCEAE
  • Sequence:
    • MASRLLLNNG AKMPILGLGT WKSPPGQVTE AVKVAIDVGY RHIDCAHVYQ NENEVGVAIQ 
EKLREQVVKR EELFIVSKLW CTYHEKGLVK GACQKTLSDL KLDYLDLYLI HWPTGFKPGK 
EFFPLDESGN VVPSDTNILD TWAAMEELVD EGLVKAIGIS NFNHLQVEMI LNKPGLKYKP 
AVNQIECHPY LTQEKLIQYC QSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK 
HNKTTAQVLI RFPMQRNLVV IPKSVTPERI AENFKVFDFE LSSQDMTTLL SYNRNWRVCA 
LLSCTSHKDY PFHEEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.