Details for: DDN

Gene ID: 23109

Symbol: DDN

Ensembl ID: ENSG00000181418

Description: dendrin

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1,178
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,687
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 508
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 803
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 704
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.04
    Marker Score: 430
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,840
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,065
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 467
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.95
    Marker Score: 242
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,355
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13,781
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1,381
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,980
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 497
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.55
    Marker Score: 204
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.55
    Marker Score: 1,120
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.51
    Marker Score: 4,421
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.48
    Marker Score: 188
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.45
    Marker Score: 692
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 217
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 172
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.34
    Marker Score: 109
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.34
    Marker Score: 3,225
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 203
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.33
    Marker Score: 20,447
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.32
    Marker Score: 104
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.3
    Marker Score: 228
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.27
    Marker Score: 125
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.24
    Marker Score: 232
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.24
    Marker Score: 74
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.23
    Marker Score: 932
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.23
    Marker Score: 112
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.23
    Marker Score: 175
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.22
    Marker Score: 517
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.21
    Marker Score: 2,007
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.21
    Marker Score: 56
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.21
    Marker Score: 121
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.18
    Marker Score: 112
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.18
    Marker Score: 6,720
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.18
    Marker Score: 1,351
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.18
    Marker Score: 177
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.15
    Marker Score: 716
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 66
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.15
    Marker Score: 2,965
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.15
    Marker Score: 49
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.14
    Marker Score: 5,308
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.14
    Marker Score: 93
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.13
    Marker Score: 382
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.13
    Marker Score: 213
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.12
    Marker Score: 1,777
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.09
    Marker Score: 145
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.09
    Marker Score: 340
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.08
    Marker Score: 811
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.07
    Marker Score: 297
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 81
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.06
    Marker Score: 260
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.06
    Marker Score: 147
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.06
    Marker Score: 47
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 50
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.05
    Marker Score: 10
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.05
    Marker Score: 66

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Dendrin is a single-celled, protein-encoding gene that belongs to the Dendrin family. It is significantly expressed in cells of the gastrointestinal tract, including goblet cells, transit amplifying cells, and intestinal epithelial cells. Additionally, dendrin is also expressed in the brain, where it is found in GABAergic interneurons and radial glial cells. The gene's expression patterns suggest a role in cellular differentiation, development, and maintenance. **Pathways and Functions:** Dendrin's protein product is involved in various cellular processes, including: 1. **Cell signaling**: Dendrin interacts with RNA polymerase II, a key enzyme in gene transcription, to regulate the expression of specific genes. 2. **Cell differentiation**: Dendrin is required for the development and maintenance of specific cell types, such as goblet cells and intestinal epithelial cells. 3. **Cell adhesion**: Dendrin may play a role in cell adhesion, particularly in the context of the intestinal epithelium. 4. **Neurological development**: Dendrin is expressed in the brain, where it may contribute to the development and function of GABAergic interneurons. **Clinical Significance:** Dendrin's expression in various cell types and its involvement in cellular processes suggest potential implications in human health and disease. Some possible clinical applications of dendrin research include: 1. **Gastrointestinal disorders**: Dysregulation of dendrin expression may contribute to gastrointestinal disorders, such as inflammatory bowel disease (IBD) or cancer. 2. **Neurological disorders**: Dendrin's role in neurological development and function may be relevant to the pathogenesis of neurodegenerative diseases, such as Alzheimer's or Parkinson's disease. 3. **Cancer research**: Dendrin's expression in cancer cells may provide insights into the development and progression of certain types of cancer. In conclusion, dendrin is a gene with a complex and multifaceted role in cellular and immunological processes. Further research into the functions and clinical significance of dendrin is necessary to fully understand its implications in human health and disease.

Genular Protein ID: 3245887315

Symbol: DEND_HUMAN

Name: Dendrin

UniProtKB Accession Codes:

O94850

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 10 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12559952

Title: Characterization of KIBRA, a novel WW domain-containing protein.

PubMed ID: 12559952

DOI: 10.1016/s0006-291x(02)02945-5

PubMed ID: 16751601

Title: CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin.

PubMed ID: 16751601

DOI: 10.1093/jb/mvj105

PubMed ID: 16464232

Title: Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring.

PubMed ID: 16464232

DOI: 10.1111/j.1471-4159.2006.03679.x

PubMed ID: 17251388

Title: Expression and subcellular distribution of novel glomerulus-associated proteins Dendrin, Ehd3, Sh2d4a, Plekhh2, and 2310066E14Rik.

PubMed ID: 17251388

DOI: 10.1681/asn.2006060675

PubMed ID: 18356187

Title: Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome.

PubMed ID: 18356187

DOI: 10.1093/ndt/gfn100

Sequence Information:

  • Length: 711
  • Mass: 75996
  • Checksum: D55B3CBE792519D4
  • Sequence:
    • MLDGPLFSEG PDSPRELQDE ESGSCLWVQK SKLLVIEVKT ISCHYSRRAP SRQPMDFQAS 
HWARGFQNRT CGPRPGSPQP PPRRPWASRV LQEATNWRAG PLAEVRAREQ EKRKAASQER 
EAKETERKRR KAGGARRSPP GRPRPEPRNA PRVAQLAGLP APLRPERLAP VGRAPRPSAQ 
PQSDPGSAWA GPWGGRRPGP PSYEAHLLLR GSAGTAPRRR WDRPPPYVAP PSYEGPHRTL 
GTKRGPGNSQ VPTSSAPAAT PARTDGGRTK KRLDPRIYRD VLGAWGLRQG QGLLGGSPGC 
GAARARPEPG KGVVEKSLGL AAADLNSGSD SHPQAKATGS AGTEIAPAGS ATAAPCAPHP 
APRSRHHLKG SREGKEGEQI WFPKCWIPSP KKQPPRHSQT LPRPWAPGGT GWRESLGLGE 
GAGPETLEGW KATRRAHTLP RSSQGLSRGE GVFVIDATCV VIRSQYVPTP RTQQVQLLPS 
GVTRVVGDSP SQSKPGKEEG EGATVFPSPC QKRLSSSRLL HQPGGGRGGE AEGGRPGDST 
LEERTFRILG LPAPEVNLRD APTQPGSPEH QALGPAASGA QGRAEGSEVA VVQRRAGRGW 
ARTPGPYAGA LREAVSRIRR HTAPDSDTDE AEELSVHSGS SDGSDTEAPG ASWRNERTLP 
EVGNSSPEED GKTAELSDSV GEILDVISQT EEVLFGVRDI RGTQQGNRKR Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.