Details for: TNRC6B
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: cardiac neuron (CL0010022)
Fold Change: 4.74
Marker Score: 5,902 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 4.69
Marker Score: 11,736 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 4.11
Marker Score: 3,646 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 4.04
Marker Score: 18,707 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 3.92
Marker Score: 5,271 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 3.86
Marker Score: 86,173 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 3.81
Marker Score: 12,774 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 3.78
Marker Score: 127,751 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.76
Marker Score: 4,546 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 3.75
Marker Score: 3,239 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 3.7
Marker Score: 2,569 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 3.7
Marker Score: 2,433 - Cell Name: stellate neuron (CL0000122)
Fold Change: 3.65
Marker Score: 19,622 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 3.61
Marker Score: 15,036 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: 3.57
Marker Score: 2,690 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.48
Marker Score: 61,728 - Cell Name: hepatoblast (CL0005026)
Fold Change: 3.46
Marker Score: 11,341 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 3.46
Marker Score: 18,132 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.34
Marker Score: 13,971 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 3.3
Marker Score: 4,640 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 3.29
Marker Score: 1,830 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 3.29
Marker Score: 7,876 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 3.28
Marker Score: 6,320 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.18
Marker Score: 6,985 - Cell Name: contractile cell (CL0000183)
Fold Change: 3.17
Marker Score: 1,719 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 3.15
Marker Score: 2,073 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.12
Marker Score: 3,539 - Cell Name: renal principal cell (CL0005009)
Fold Change: 3.11
Marker Score: 2,400 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 3.09
Marker Score: 65,994 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 3.08
Marker Score: 1,532 - Cell Name: mesangial cell (CL0000650)
Fold Change: 3.06
Marker Score: 3,694 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 3.04
Marker Score: 1,772 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 3.04
Marker Score: 3,499 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.03
Marker Score: 169,196 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 3.02
Marker Score: 2,876 - Cell Name: endocrine cell (CL0000163)
Fold Change: 3.01
Marker Score: 1,557 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 3.01
Marker Score: 766 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 3.01
Marker Score: 879 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 2.96
Marker Score: 3,188 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 2.92
Marker Score: 1,528 - Cell Name: acinar cell (CL0000622)
Fold Change: 2.92
Marker Score: 2,059 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.92
Marker Score: 1,536 - Cell Name: astrocyte (CL0000127)
Fold Change: 2.88
Marker Score: 2,494 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.86
Marker Score: 1,033 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 2.85
Marker Score: 904 - Cell Name: macroglial cell (CL0000126)
Fold Change: 2.81
Marker Score: 6,459 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.81
Marker Score: 55,806 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.79
Marker Score: 147,770 - Cell Name: granule cell (CL0000120)
Fold Change: 2.79
Marker Score: 21,032 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.78
Marker Score: 41,498 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.75
Marker Score: 21,077 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 2.75
Marker Score: 792 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.69
Marker Score: 102,140 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 2.65
Marker Score: 1,274 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.63
Marker Score: 7,490 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.61
Marker Score: 676 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.58
Marker Score: 1,508 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.56
Marker Score: 808 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.54
Marker Score: 2,503 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 2.51
Marker Score: 1,457 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.5
Marker Score: 4,194 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.49
Marker Score: 10,326 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 2.47
Marker Score: 898 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.47
Marker Score: 7,781 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 2.46
Marker Score: 921 - Cell Name: podocyte (CL0000653)
Fold Change: 2.46
Marker Score: 910 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.42
Marker Score: 1,836 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 2.42
Marker Score: 2,995 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.42
Marker Score: 89,305 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.42
Marker Score: 8,606 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.41
Marker Score: 1,441 - Cell Name: melanocyte (CL0000148)
Fold Change: 2.41
Marker Score: 977 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 2.4
Marker Score: 1,344 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.39
Marker Score: 2,552 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.36
Marker Score: 564 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.36
Marker Score: 988 - Cell Name: sympathetic neuron (CL0011103)
Fold Change: 2.36
Marker Score: 779 - Cell Name: thymocyte (CL0000893)
Fold Change: 2.36
Marker Score: 2,467 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.34
Marker Score: 1,167 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 2.33
Marker Score: 839 - Cell Name: microglial cell (CL0000129)
Fold Change: 2.32
Marker Score: 4,223 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.29
Marker Score: 1,133 - Cell Name: erythroblast (CL0000765)
Fold Change: 2.29
Marker Score: 1,430 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.29
Marker Score: 6,136 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.28
Marker Score: 2,524 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.28
Marker Score: 3,226 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.27
Marker Score: 6,487 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.27
Marker Score: 979 - Cell Name: fat cell (CL0000136)
Fold Change: 2.27
Marker Score: 1,266 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 2.26
Marker Score: 769 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.25
Marker Score: 36,177 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.25
Marker Score: 2,381 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.24
Marker Score: 8,668 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.23
Marker Score: 2,261 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.21
Marker Score: 659 - Cell Name: basal cell (CL0000646)
Fold Change: 2.18
Marker Score: 2,817 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 2.16
Marker Score: 496 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 2.15
Marker Score: 634 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.15
Marker Score: 7,622 - Cell Name: fast muscle cell (CL0000190)
Fold Change: 2.14
Marker Score: 646
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3985831285
Symbol: TNR6B_HUMAN
Name: Trinucleotide repeat-containing gene 6B protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10470851
Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10470851
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16289642
Title: Identification of novel argonaute-associated proteins.
PubMed ID: 16289642
PubMed ID: 18690212
Title: Prolyl 4-hydroxylation regulates Argonaute 2 stability.
PubMed ID: 18690212
DOI: 10.1038/nature07186
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19167051
Title: Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.
PubMed ID: 19167051
PubMed ID: 19304925
Title: Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.
PubMed ID: 19304925
DOI: 10.1261/rna.1448009
PubMed ID: 19383768
Title: The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.
PubMed ID: 19383768
DOI: 10.1261/rna.1606309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21981923
Title: GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.
PubMed ID: 21981923
PubMed ID: 21984185
Title: miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.
PubMed ID: 21984185
DOI: 10.1038/nsmb.2149
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24726324
Title: MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
PubMed ID: 24726324
PubMed ID: 32354837
Title: 4E-T-bound mRNAs are stored in a silenced and deadenylated form.
PubMed ID: 32354837
PubMed ID: 29463886
Title: A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development.
PubMed ID: 29463886
PubMed ID: 32152250
Title: Pathogenic variants in TNRC6B cause a genetic disorder characterised by developmental delay/intellectual disability and a spectrum of neurobehavioural phenotypes including autism and ADHD.
PubMed ID: 32152250
Sequence Information:
- Length: 1833
- Mass: 194002
- Checksum: E982B786C97C75D0
- Sequence:
MREKEQEREE QLMEDKKRKK EDKKKKEATQ KVTEQKTKVP EVTKPSLSQP TAASPIGSSP SPPVNGGNNA KRVAVPNGQP PSAARYMPRE VPPRFRCQQD HKVLLKRGQP PPPSCMLLGG GAGPPPCTAP GANPNNAQVT GALLQSESGT APDSTLGGAA ASNYANSTWG SGASSNNGTS PNPIHIWDKV IVDGSDMEEW PCIASKDTES SSENTTDNNS ASNPGSEKST LPGSTTSNKG KGSQCQSASS GNECNLGVWK SDPKAKSVQS SNSTTENNNG LGNWRNVSGQ DRIGPGSGFS NFNPNSNPSA WPALVQEGTS RKGALETDNS NSSAQVSTVG QTSREQQSKM ENAGVNFVVS GREQAQIHNT DGPKNGNTNS LNLSSPNPME NKGMPFGMGL GNTSRSTDAP SQSTGDRKTG SVGSWGAARG PSGTDTVSGQ SNSGNNGNNG KEREDSWKGA SVQKSTGSKN DSWDNNNRST GGSWNFGPQD SNDNKWGEGN KMTSGVSQGE WKQPTGSDEL KIGEWSGPNQ PNSSTGAWDN QKGHPLPENQ GNAQAPCWGR SSSSTGSEVG GQSTGSNHKA GSSDSHNSGR RSYRPTHPDC QAVLQTLLSR TDLDPRVLSN TGWGQTQIKQ DTVWDIEEVP RPEGKSDKGT EGWESAATQT KNSGGWGDAP SQSNQMKSGW GELSASTEWK DPKNTGGWND YKNNNSSNWG GGRPDEKTPS SWNENPSKDQ GWGGGRQPNQ GWSSGKNGWG EEVDQTKNSN WESSASKPVS GWGEGGQNEI GTWGNGGNAS LASKGGWEDC KRSPAWNETG RQPNSWNKQH QQQQPPQQPP PPQPEASGSW GGPPPPPPGN VRPSNSSWSS GPQPATPKDE EPSGWEEPSP QSISRKMDID DGTSAWGDPN SYNYKNVNLW DKNSQGGPAP REPNLPTPMT SKSASVWSKS TPPAPDNGTS AWGEPNESSP GWGEMDDTGA STTGWGNTPA NAPNAMKPNS KSMQDGWGES DGPVTGARHP SWEEEEDGGV WNTTGSQGSA SSHNSASWGQ GGKKQMKCSL KGGNNDSWMN PLAKQFSNMG LLSQTEDNPS SKMDLSVGSL SDKKFDVDKR AMNLGDFNDI MRKDRSGFRP PNSKDMGTTD SGPYFEKLTL PFSNQDGCLG DEAPCSPFSP SPSYKLSPSG STLPNVSLGA IGTGLNPQNF AARQGGSHGL FGNSTAQSRG LHTPVQPLNS SPSLRAQVPP QFISPQVSAS MLKQFPNSGL SPGLFNVGPQ LSPQQIAMLS QLPQIPQFQL ACQLLLQQQQ QQQLLQNQRK ISQAVRQQQE QQLARMVSAL QQQQQQQQRQ PGMKHSPSHP VGPKPHLDNM VPNALNVGLP DLQTKGPIPG YGSGFSSGGM DYGMVGGKEA GTESRFKQWT SMMEGLPSVA TQEANMHKNG AIVAPGKTRG GSPYNQFDII PGDTLGGHTG PAGDSWLPAK SPPTNKIGSK SSNASWPPEF QPGVPWKGIQ NIDPESDPYV TPGSVLGGTA TSPIVDTDHQ LLRDNTTGSN SSLNTSLPSP GAWPYSASDN SFTNVHSTSA KFPDYKSTWS PDPIGHNPTH LSNKMWKNHI SSRNTTPLPR PPPGLTNPKP SSPWSSTAPR SVRGWGTQDS RLASASTWSD GGSVRPSYWL VLHNLTPQID GSTLRTICMQ HGPLLTFHLN LTQGTALIRY STKQEAAKAQ TALHMCVLGN TTILAEFATD DEVSRFLAQA QPPTPAATPS APAAGWQSLE TGQNQSDPVG PALNLFGGST GLGQWSSSAG GSSGADLAGA SLWGPPNYSS SLWGVPTVED PHRMGSPAPL LPGDLLGGGS DSI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.