TAB2 | ENSG00000055208 | NCBI 23118

Details for: TAB2

Gene ID: 23118

Symbol: TAB2

Ensembl ID: ENSG00000055208

Description: TGF-beta activated kinase 1 (MAP3K7) binding protein 2

Associated with

Activated tak1 mediates p38 mapk activation
(R-HSA-450302)
Adaptive immune system
(R-HSA-1280218)
Alpha-protein kinase 1 signaling pathway
(R-HSA-9645460)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Disease
(R-HSA-1643685)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-17 signaling
(R-HSA-448424)
Irak2 mediated activation of tak1 complex
(R-HSA-937042)
Irak2 mediated activation of tak1 complex upon tlr7/8 or 9 stimulation
(R-HSA-975163)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-HSA-450321)
Map kinase activation
(R-HSA-450294)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Nod1/2 signaling pathway
(R-HSA-168638)
Nuclear signaling by erbb4
(R-HSA-1251985)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by erbb4
(R-HSA-1236394)
Signaling by interleukins
(R-HSA-449147)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Tcr signaling
(R-HSA-202403)
Ticam1,traf6-dependent induction of tak1 complex
(R-HSA-9014325)
Tnfr1-induced nf-kappa-b signaling pathway
(R-HSA-5357956)
Tnf signaling
(R-HSA-75893)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6-mediated induction of tak1 complex within tlr4 complex
(R-HSA-937072)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Endosome membrane
(GO:0010008)
Heart development
(GO:0007507)
Inflammatory response
(GO:0006954)
K63-linked polyubiquitin modification-dependent protein binding
(GO:0070530)
Lysosomal membrane
(GO:0005765)
Molecular adaptor activity
(GO:0060090)
Negative regulation of autophagy
(GO:0010507)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of protein kinase activity
(GO:0045860)
Protein binding
(GO:0005515)
Response to lipopolysaccharide
(GO:0032496)
Ubiquitin binding
(GO:0043130)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Mitogen-activated protein kinase kinase kinase 7-interacting protein 2
B4DIR9_HUMAN

Genular Protein ID: 2025107464

Symbol: TAB2_HUMAN

Name: Mitogen-activated protein kinase kinase kinase 7-interacting protein 2

UniProtKB Accession Codes:

Q9NYJ8 B2RCC4 E1P5A0 O94838 Q6I9W8 Q76N06 Q9UFP7

Database IDs:

Citations:

PubMed ID: 10882101

Title: TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.

PubMed ID: 10882101

DOI: 10.1016/s1097-2765(00)80244-0

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11460167

Title: TAK1 is a ubiquitin-dependent kinase of MKK and IKK.

PubMed ID: 11460167

DOI: 10.1038/35085597

PubMed ID: 14633987

Title: Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.

PubMed ID: 14633987

DOI: 10.1093/emboj/cdg605

PubMed ID: 15327770

Title: TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.

PubMed ID: 15327770

DOI: 10.1016/j.molcel.2004.08.008

PubMed ID: 17449468

Title: RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.

PubMed ID: 17449468

DOI: 10.1074/jbc.m701913200

PubMed ID: 18299187

Title: NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation.

PubMed ID: 18299187

DOI: 10.1016/j.cellsig.2008.01.015

PubMed ID: 18079694

Title: A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.

PubMed ID: 18079694

DOI: 10.1038/sj.emboj.7601962

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19521662

Title: WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway.

PubMed ID: 19521662

DOI: 10.1007/s00018-009-0059-6

PubMed ID: 19675569

Title: Direct activation of protein kinases by unanchored polyubiquitin chains.

PubMed ID: 19675569

DOI: 10.1038/nature08247

PubMed ID: 20493459

Title: Haploinsufficiency of TAB2 causes congenital heart defects in humans.

PubMed ID: 20493459

DOI: 10.1016/j.ajhg.2010.04.011

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22158122

Title: Cysteine methylation disrupts ubiquitin-chain sensing in NF-kappaB activation.

PubMed ID: 22158122

DOI: 10.1038/nature10690

PubMed ID: 21512573

Title: TRIM5 is an innate immune sensor for the retrovirus capsid lattice.

PubMed ID: 21512573

DOI: 10.1038/nature09976

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25412445

Title: Structure and specificity of the bacterial cysteine methyltransferase effector NleE suggests a novel substrate in human DNA repair pathway.

PubMed ID: 25412445

DOI: 10.1371/journal.ppat.1004522

PubMed ID: 24434549

Title: TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3.

PubMed ID: 24434549

DOI: 10.1073/pnas.1318227111

PubMed ID: 27445336

Title: Identification of a distinct substrate-binding domain in the bacterial cysteine methyltransferase effectors NleE and OspZ.

PubMed ID: 27445336

DOI: 10.1074/jbc.m116.734079

PubMed ID: 33184450

Title: The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-kappaB activation and the innate immune response.

PubMed ID: 33184450

DOI: 10.1038/s41423-020-00564-w

PubMed ID: 36681779

Title: E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2.

PubMed ID: 36681779

DOI: 10.1038/s41418-023-01115-2

PubMed ID: 19935683

Title: Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.

PubMed ID: 19935683

DOI: 10.1038/nsmb.1731

PubMed ID: 27426733

Title: Mutations in MAP3K7 that alter the activity of the TAK1 signaling complex cause frontometaphyseal dysplasia.

PubMed ID: 27426733

DOI: 10.1016/j.ajhg.2016.05.024

Sequence Information:

Length: 693
Mass: 76494
Checksum: 47BB8709320084D7
Sequence:

MAQGSHQIDF QVLHDLRQKF PEVPEVVVSR CMLQNNNNLD ACCAVLSQES TRYLYGEGDL 
NFSDDSGISG LRNHMTSLNL DLQSQNIYHH GREGSRMNGS RTLTHSISDG QLQGGQSNSE 
LFQQEPQTAP AQVPQGFNVF GMSSSSGASN SAPHLGFHLG SKGTSSLSQQ TPRFNPIMVT 
LAPNIQTGRN TPTSLHIHGV PPPVLNSPQG NSIYIRPYIT TPGGTTRQTQ QHSGWVSQFN 
PMNPQQVYQP SQPGPWTTCP ASNPLSHTSS QQPNQQGHQT SHVYMPISSP TTSQPPTIHS 
SGSSQSSAHS QYNIQNISTG PRKNQIEIKL EPPQRNNSSK LRSSGPRTSS TSSSVNSQTL 
NRNQPTVYIA ASPPNTDELM SRSQPKVYIS ANAATGDEQV MRNQPTLFIS TNSGASAASR 
NMSGQVSMGP AFIHHHPPKS RAIGNNSATS PRVVVTQPNT KYTFKITVSP NKPPAVSPGV 
VSPTFELTNL LNHPDHYVET ENIQHLTDPT LAHVDRISET RKLSMGSDDA AYTQALLVHQ 
KARMERLQRE LEIQKKKLDK LKSEVNEMEN NLTRRRLKRS NSISQIPSLE EMQQLRSCNR 
QLQIDIDCLT KEIDLFQARG PHFNPSAIHN FYDNIGFVGP VPPKPKDQRS IIKTPKTQDT 
EDDEGAQWNC TACTFLNHPA LIRCEQCEMP RHF

Genular Protein ID: 4012752288

Symbol: B4DIR9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DIR9

Database IDs:

Sequence Information:

Length: 661
Mass: 72805
Checksum: 015F78EA415E266C
Sequence:

MQNNNNLDAC CAVLSQESTR YLYGEGDLNF SDDSGISGLR NHMTSLNLDL QSQNIYHHGR 
EGSRMNGSRT LTHSISDGQL QGGQSNSELF QQEPQTAPAQ VPQGFNVFGM SSSSGASNSA 
PHLGFHLGSK GTSSLSQQTP RFNPIMVTLA PNIQTGRNTP TSLHIHGVPP PVLNSPQGNS 
IYIRPYITTP GGTTRQTQQH SGWVSQFNPM NPQQVYQPSQ PGPWTTCPAS NPLSHTSSQQ 
PNQQGHQTSH VYMPISSPTT SQPPTIHSSG SSQSSAHSQY NIQNISTGPR KNQIEIKLEP 
PQRNNSSKLR SSGPRTSSTS SSVNSQTLNR NQPTVYIAAS PPNTDELMSR SQPKVYISAN 
AATGDEQVMR NQPTLFISTN SGASAASRNM SGQVSMGPAF IHHHPPKSRA IGNNSATSPR 
VVVTQPNTKY TFKITVSPNK PPAVSPGVVS PTFELTNLLN HPDHYVETEN IQHLTDPTLA 
HVDRISETRK LSMGSDDAAY TQALLVHQKA RMERLQRELE IQKKKLDKLK SEVNEMENNL 
TRRRLKRSNS ISQIPSLEEM QQLRSCNRQL QIDIDCLTKE IDLFQARGPH FNPSAIHNFY 
DNIGFVGPVP PKPKDQRSII KTPKTQDTED DEGAQWNCTA CTFLNHPALI RCEQCEMPRH 
F

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TAB2

Associated with

Other Information

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. PubMed ID: 10882101

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9872452

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

TAK1 is a ubiquitin-dependent kinase of MKK and IKK. PubMed ID: 11460167

Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. PubMed ID: 14633987

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. PubMed ID: 15327770

RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. PubMed ID: 17449468

NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation. PubMed ID: 18299187

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. PubMed ID: 18079694

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway. PubMed ID: 19521662

Direct activation of protein kinases by unanchored polyubiquitin chains. PubMed ID: 19675569

Haploinsufficiency of TAB2 causes congenital heart defects in humans. PubMed ID: 20493459

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Cysteine methylation disrupts ubiquitin-chain sensing in NF-kappaB activation. PubMed ID: 22158122

TRIM5 is an innate immune sensor for the retrovirus capsid lattice. PubMed ID: 21512573

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Structure and specificity of the bacterial cysteine methyltransferase effector NleE suggests a novel substrate in human DNA repair pathway. PubMed ID: 25412445

TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3. PubMed ID: 24434549

Identification of a distinct substrate-binding domain in the bacterial cysteine methyltransferase effectors NleE and OspZ. PubMed ID: 27445336

The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-kappaB activation and the innate immune response. PubMed ID: 33184450

E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2. PubMed ID: 36681779

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain. PubMed ID: 19935683

Mutations in MAP3K7 that alter the activity of the TAK1 signaling complex cause frontometaphyseal dysplasia. PubMed ID: 27426733