Details for: ATP10B

Gene ID: 23120

Symbol: ATP10B

Ensembl ID: ENSG00000118322

Description: ATPase phospholipid transporting 10B (putative)

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.89
    Marker Score: 17,188
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.1
    Marker Score: 15,123
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.54
    Marker Score: 4,351
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.88
    Marker Score: 11,141
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.56
    Marker Score: 30,126
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.36
    Marker Score: 9,583
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.2
    Marker Score: 6,628
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3
    Marker Score: 7,178
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.65
    Marker Score: 3,350
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.6
    Marker Score: 1,069
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.52
    Marker Score: 439
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.43
    Marker Score: 4,476
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.42
    Marker Score: 1,757
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.42
    Marker Score: 965
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.33
    Marker Score: 1,404
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.3
    Marker Score: 27,801
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.28
    Marker Score: 481
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.25
    Marker Score: 2,378
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.16
    Marker Score: 1,154
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.12
    Marker Score: 737
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.11
    Marker Score: 4,112
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.09
    Marker Score: 508
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.07
    Marker Score: 2,522
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.05
    Marker Score: 630
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.05
    Marker Score: 2,486
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,771
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.03
    Marker Score: 463
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,014
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.94
    Marker Score: 298
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,314
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.89
    Marker Score: 4,253
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13,795
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.87
    Marker Score: 1,414
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,278
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.86
    Marker Score: 278
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.85
    Marker Score: 421
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.85
    Marker Score: 344
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.84
    Marker Score: 1,304
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.84
    Marker Score: 728
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 334
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.8
    Marker Score: 365
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.76
    Marker Score: 729
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 665
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.72
    Marker Score: 502
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,021
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.72
    Marker Score: 661
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.7
    Marker Score: 778
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.69
    Marker Score: 281
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.68
    Marker Score: 584
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.65
    Marker Score: 544
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.64
    Marker Score: 156
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 287
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.57
    Marker Score: 2,366
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.55
    Marker Score: 244
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.53
    Marker Score: 660
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.52
    Marker Score: 940
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.51
    Marker Score: 359
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.51
    Marker Score: 852
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.51
    Marker Score: 233
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.5
    Marker Score: 158
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.49
    Marker Score: 146
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.47
    Marker Score: 860
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.47
    Marker Score: 122
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.47
    Marker Score: 6,235
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.47
    Marker Score: 124
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.47
    Marker Score: 339
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.46
    Marker Score: 133
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.45
    Marker Score: 133
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.45
    Marker Score: 3,846
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.42
    Marker Score: 1,178
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.4
    Marker Score: 276
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4
    Marker Score: 135
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.39
    Marker Score: 106
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.39
    Marker Score: 2,476
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.38
    Marker Score: 133
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.38
    Marker Score: 1,091
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.38
    Marker Score: 370
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.38
    Marker Score: 793
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.37
    Marker Score: 160
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.36
    Marker Score: 172
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.36
    Marker Score: 416
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.34
    Marker Score: 1,183
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.34
    Marker Score: 299
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.33
    Marker Score: 2,011
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.33
    Marker Score: 116
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.33
    Marker Score: 106
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 294
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.33
    Marker Score: 195
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.32
    Marker Score: 358
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.32
    Marker Score: 549

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** ATP10B is predominantly expressed in cells of the retina, including bipolar neurons, cone cells, and horizontal cells, as well as in kidney proximal convoluted tubule epithelial cells, oligodendrocytes, and immature innate lymphoid cells. Its expression in nasal mucosa goblet cells is also noteworthy, suggesting a potential role in mucosal homeostasis. 2. **Protein Structure:** The ATP10B protein is predicted to possess a characteristic phospholipid-translocating ATPase complex, enabling it to facilitate the transport of phospholipids across cellular membranes. 3. **Functional Pathways:** ATP10B is involved in various cellular processes, including: * Atpase-coupled intramembrane lipid transporter activity * Atp binding and hydrolysis activity * Glycosylceramide flippase activity * Ion channel transport and ion transport by p-type atpases * Phosphatidylcholine flippase activity * Phospholipid translocation and transport of small molecules **Pathways and Functions:** 1. **Endoplasmic Reticulum (ER) and Lysosome:** ATP10B is implicated in the regulated transport of phospholipids across the ER and lysosomal membranes, ensuring the proper functioning of these organelles. 2. **Ion Homeostasis:** The gene's involvement in ion channel transport and ion transport by p-type atpases suggests a role in maintaining cellular ion balance, which is crucial for maintaining cellular homeostasis. 3. **Phospholipid Homeostasis:** ATP10B's phospholipid-translocating ATPase complex enables the regulation of phospholipid levels in cells, which is essential for maintaining cellular membrane structure and function. 4. **Regulation of Cellular Processes:** The gene's involvement in various cellular processes, including glycosylceramide flippase activity and phosphatidylcholine flippase activity, suggests a regulatory role in cellular homeostasis. **Clinical Significance:** 1. **Retinal Diseases:** Mutations in ATP10B have been implicated in retinal diseases, such as retinitis pigmentosa, highlighting the gene's critical role in maintaining retinal function and homeostasis. 2. **Neurological Disorders:** The gene's involvement in ion homeostasis and phospholipid regulation suggests a potential link to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Kidney Function:** ATP10B's expression in kidney proximal convoluted tubule epithelial cells suggests a potential role in maintaining kidney function and homeostasis. 4. **Innate Immunity:** The gene's expression in immature innate lymphoid cells highlights its potential involvement in the regulation of innate immune responses. In conclusion, the ATP10B gene is a complex and multifaceted regulator of cellular homeostasis, with implications in various cellular processes, including ion homeostasis, phospholipid homeostasis, and regulation of cellular processes. Further research is necessary to fully elucidate the role of ATP10B in disease and to explore its therapeutic potential.

Genular Protein ID: 1148906720

Symbol: AT10B_HUMAN

Name: Phospholipid-transporting ATPase VB

UniProtKB Accession Codes:

O94823 Q9H725

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 25 ChiTaRS 1 ComplexPortal 1 DNASU 1 EC 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 4 Rhea 2 SAM 1 SFLD 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 25947375

Title: Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics.

PubMed ID: 25947375

DOI: 10.1074/jbc.m115.655191

PubMed ID: 32172343

Title: Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export.

PubMed ID: 32172343

DOI: 10.1007/s00401-020-02145-7

PubMed ID: 32892229

Title: Segregation of ATP10B variants in families with autosomal recessive parkinsonism.

PubMed ID: 32892229

DOI: 10.1007/s00401-020-02219-6

Sequence Information:

  • Length: 1461
  • Mass: 165391
  • Checksum: 2676B90416B6B541
  • Sequence:
    • MALSVDSSWH RWQWRVRDGF PHCPSETTPL LSPEKGRQSY NLTQQRVVFP NNSIFHQDWE 
EVSRRYPGNR TCTTKYTLFT FLPRNLFEQF HRWANLYFLF LVILNWMPSM EVFHREITML 
PLAIVLFVIM IKDGMEDFKR HRFDKAINCS NIRIYERKEQ TYVQKCWKDV RVGDFIQMKC 
NEIVPADILL LFSSDPNGIC HLETASLDGE TNLKQRCVVK GFSQQEVQFE PELFHNTIVC 
EKPNNHLNKF KGYMEHPDQT RTGFGCESLL LRGCTIRNTE MAVGIVIYAG HETKAMLNNS 
GPRYKRSKIE RRMNIDIFFC IGILILMCLI GAVGHSIWNG TFEEHPPFDV PDANGSFLPS 
ALGGFYMFLT MIILLQVLIP ISLYVSIELV KLGQVFFLSN DLDLYDEETD LSIQCRALNI 
AEDLGQIQYI FSDKTGTLTE NKMVFRRCTI MGSEYSHQEN AKRLETPKEL DSDGEEWTQY 
QCLSFSARWA QDPATMRSQK GAQPLRRSQS ARVPIQGHYR QRSMGHRESS QPPVAFSSSI 
EKDVTPDKNL LTKVRDAALW LETLSDSRPA KASLSTTSSI ADFFLALTIC NSVMVSTTTE 
PRQRVTIKPS SKALGTSLEK IQQLFQKLKL LSLSQSFSST APSDTDLGES LGANVATTDS 
DERDDASVCS GGDSTDDGGY RSSMWDQGDI LESGSGTSLE EALEAPATDL ARPEFCYEAE 
SPDEAALVHA AHAYSFTLVS RTPEQVTVRL PQGTCLTFSL LCTLGFDSVR KRMSVVVRHP 
LTGEIVVYTK GADSVIMDLL EDPACVPDIN MEKKLRKIRA RTQKHLDLYA RDGLRTLCIA 
KKVVSEEDFR RWASFRREAE ASLDNRDELL METAQHLENQ LTLLGATGIE DRLQEGVPDT 
IATLREAGIQ LWVLTGDKQE TAVNIAHSCR LLNQTDTVYT INTENQETCE SILNCALEEL 
KQFRELQKPD RKLFGFRLPS KTPSITSEAV VPEAGLVIDG KTLNAIFQGK LEKKFLELTQ 
YCRSVLCCRS TPLQKSMIVK LVRDKLRVMT LSIGDGANDV SMIQAADIGI GISGQEGMQA 
VMSSDFAITR FKHLKKLLLV HGHWCYSRLA RMVVYYLYKN VCYVNLLFWY QFFCGFSSST 
MIDYWQMIFF NLFFTSLPPL VFGVLDKDIS AETLLALPEL YKSGQNSECY NLSTFWISMV 
DAFYQSLICF FIPYLAYKGS DIDVFTFGTP INTISLTTIL LHQAMEMKTW TIFHGVVLLG 
SFLMYFLVSL LYNATCVICN SPTNPYWVME GQLSNPTFYL VCFLTPVVAL LPRYFFLSLQ 
GTCGKSLISK AQKIDKLPPD KRNLEIQSWR SRQRPAPVPE VARPTHHPVS SITGQDFSAS 
TPKSSNPPKR KHVEESVLHE QRCGTECMRD DSCSGDSSAQ LSSGEHLLGP NRIMAYSRGQ 
TDMCRCSKRS SHRRSQSSLT I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.