Details for: CLASP2

Gene ID: 23122

Symbol: CLASP2

Ensembl ID: ENSG00000163539

Description: cytoplasmic linker associated protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.57
    Marker Score: 188,211
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 5.36
    Marker Score: 28,123
  • Cell Name: granule cell (CL0000120)
    Fold Change: 5.12
    Marker Score: 38,585
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 5.09
    Marker Score: 17,064
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.94
    Marker Score: 26,521
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.75
    Marker Score: 11,383
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.7
    Marker Score: 10,802
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.69
    Marker Score: 6,602
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 4.26
    Marker Score: 3,206
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 4.04
    Marker Score: 5,028
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.03
    Marker Score: 18,647
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.31
    Marker Score: 1,589
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.2
    Marker Score: 4,305
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.17
    Marker Score: 1,843
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.15
    Marker Score: 13,192
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.14
    Marker Score: 3,796
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.12
    Marker Score: 6,849
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.06
    Marker Score: 970
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.94
    Marker Score: 62,744
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.89
    Marker Score: 64,572
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.84
    Marker Score: 56,440
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.79
    Marker Score: 21,424
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.76
    Marker Score: 41,214
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.73
    Marker Score: 861
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.7
    Marker Score: 102,557
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.69
    Marker Score: 7,677
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.69
    Marker Score: 1,508
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.64
    Marker Score: 1,543
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.62
    Marker Score: 767
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.6
    Marker Score: 1,711
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.56
    Marker Score: 10,594
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.55
    Marker Score: 4,289
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.54
    Marker Score: 1,413
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.51
    Marker Score: 2,893
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.5
    Marker Score: 4,814
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.47
    Marker Score: 816
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.45
    Marker Score: 1,026
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.42
    Marker Score: 89,114
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.4
    Marker Score: 1,301
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.38
    Marker Score: 914
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.33
    Marker Score: 2,015
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.32
    Marker Score: 2,874
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.31
    Marker Score: 8,925
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.28
    Marker Score: 1,330
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.2
    Marker Score: 9,162
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.19
    Marker Score: 2,734
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.16
    Marker Score: 20,363
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.14
    Marker Score: 1,280
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.11
    Marker Score: 1,628
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127,431
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.01
    Marker Score: 20,794
  • Cell Name: neuron (CL0000540)
    Fold Change: 2
    Marker Score: 8,130
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.98
    Marker Score: 2,226
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.98
    Marker Score: 2,186
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.97
    Marker Score: 2,232
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.93
    Marker Score: 1,841
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.93
    Marker Score: 34,188
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.92
    Marker Score: 3,358
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18,163
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.91
    Marker Score: 1,651
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.89
    Marker Score: 942
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.88
    Marker Score: 980
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.87
    Marker Score: 568
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.86
    Marker Score: 1,294
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15,980
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.85
    Marker Score: 913
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.84
    Marker Score: 1,631
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.82
    Marker Score: 497
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.8
    Marker Score: 6,384
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.72
    Marker Score: 1,414
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.71
    Marker Score: 617
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.67
    Marker Score: 879
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.64
    Marker Score: 850
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.64
    Marker Score: 790
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.64
    Marker Score: 1,765
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.62
    Marker Score: 6,770
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.62
    Marker Score: 545
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.6
    Marker Score: 2,468
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.56
    Marker Score: 3,906
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.56
    Marker Score: 397
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.55
    Marker Score: 1,020
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.55
    Marker Score: 1,869
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.54
    Marker Score: 913
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.53
    Marker Score: 856
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.49
    Marker Score: 703
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.48
    Marker Score: 505
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.47
    Marker Score: 23,536
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.43
    Marker Score: 370
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.4
    Marker Score: 418
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.38
    Marker Score: 398
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.37
    Marker Score: 663
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.34
    Marker Score: 843
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.34
    Marker Score: 2,722
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.32
    Marker Score: 489
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.31
    Marker Score: 489
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.29
    Marker Score: 1,828
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.25
    Marker Score: 454
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.23
    Marker Score: 427
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18,821
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 1.19
    Marker Score: 12,089

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Microtubule-binding protein:** CLASP2 interacts with microtubules, microtubule-associated proteins (MAPs), and other cellular factors to regulate microtubule dynamics. 2. **Regulation of microtubule assembly and disassembly:** CLASP2 modulates microtubule polymerization and depolymerization, influencing cellular processes such as cell division, migration, and polarity. 3. **Cell cycle regulation:** CLASP2 is involved in the regulation of cell cycle progression, particularly during mitosis, by interacting with kinetochores and microtubules. 4. **Neuronal function and development:** CLASP2 is highly expressed in neurons and is involved in axon guidance, neuronal polarity, and synaptic transmission. 5. **Negative regulation of focal adhesion assembly:** CLASP2 inhibits the formation of focal adhesions, which are critical for cell migration and wound healing. **Pathways and Functions:** 1. **Amplification of signal from kinetochores:** CLASP2 interacts with kinetochores to amplify signals that regulate microtubule attachment and separation during mitosis. 2. **Regulation of microtubule-based processes:** CLASP2 modulates microtubule polymerization and depolymerization, influencing cellular processes such as cell division, migration, and polarity. 3. **Neuronal development and function:** CLASP2 is involved in axon guidance, neuronal polarity, and synaptic transmission, highlighting its critical role in neuronal development and function. 4. **Cell cycle checkpoints:** CLASP2 regulates cell cycle progression by interacting with kinetochores and microtubules, ensuring accurate chromosome segregation. 5. **Regulation of epithelial-to-mesenchymal transition (EMT):** CLASP2 inhibits EMT, a process critical for tissue development and cancer progression. **Clinical Significance:** 1. **Neurological disorders:** CLASP2 dysfunction has been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and Parkinson's disease. 2. **Cancer:** CLASP2 expression is altered in various types of cancer, including breast, lung, and colon cancer, highlighting its potential role in cancer progression and metastasis. 3. **Neurodevelopmental disorders:** CLASP2 mutations have been identified in patients with neurodevelopmental disorders, such as intellectual disability and epilepsy. 4. **Neurodegenerative diseases:** CLASP2 dysregulation has been linked to neurodegenerative diseases, including Alzheimer's disease and amyotrophic lateral sclerosis (ALS). In conclusion, CLASP2 is a multifunctional protein that plays a critical role in regulating microtubule dynamics, cell cycle progression, and various cellular processes. Its dysregulation has been implicated in various neurological and cancer-related disorders, highlighting the importance of further research into the mechanisms of CLASP2 function and its potential therapeutic applications.

Genular Protein ID: 181634691

Symbol: CLAP2_HUMAN

Name: CLIP-associating protein 2

UniProtKB Accession Codes:

O75122 B2RTR1 F5H604 Q7L8F6 Q8N6R6 Q9BQT3 Q9BQT4 Q9H7A3 Q9NSZ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 53 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11290329

Title: Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.

PubMed ID: 11290329

DOI: 10.1016/s0092-8674(01)00288-4

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15207236

Title: The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance.

PubMed ID: 15207236

DOI: 10.1016/j.neuron.2004.05.020

PubMed ID: 15631994

Title: CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.

PubMed ID: 15631994

DOI: 10.1083/jcb.200405094

PubMed ID: 15955847

Title: Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells.

PubMed ID: 15955847

DOI: 10.1083/jcb.200412114

PubMed ID: 16824950

Title: CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.

PubMed ID: 16824950

DOI: 10.1016/j.devcel.2006.05.012

PubMed ID: 16866869

Title: Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment.

PubMed ID: 16866869

DOI: 10.1111/j.1365-2443.2006.00990.x

PubMed ID: 16914514

Title: Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.

PubMed ID: 16914514

DOI: 10.1091/mbc.e06-07-0579

PubMed ID: 17543864

Title: Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network.

PubMed ID: 17543864

DOI: 10.1016/j.devcel.2007.04.002

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19632184

Title: An EB1-binding motif acts as a microtubule tip localization signal.

PubMed ID: 19632184

DOI: 10.1016/j.cell.2009.04.065

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20937854

Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.

PubMed ID: 20937854

DOI: 10.1073/pnas.1000975107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33587225

Title: SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells.

PubMed ID: 33587225

DOI: 10.1007/s10577-021-09651-8

PubMed ID: 26003921

Title: CLASP2 has two distinct TOG domains that contribute differently to microtubule dynamics.

PubMed ID: 26003921

DOI: 10.1016/j.jmb.2015.05.012

Sequence Information:

  • Length: 1294
  • Mass: 141064
  • Checksum: EAD31F728BC63B4B
  • Sequence:
    • MAMGDDKSFD DEESVDGNRP SSAASAFKVP APKTSGNPAN SARKPGSAGG PKVGGASKEG 
GAGAVDEDDF IKAFTDVPSI QIYSSRELEE TLNKIREILS DDKHDWDQRA NALKKIRSLL 
VAGAAQYDCF FQHLRLLDGA LKLSAKDLRS QVVREACITV AHLSTVLGNK FDHGAEAIVP 
TLFNLVPNSA KVMATSGCAA IRFIIRHTHV PRLIPLITSN CTSKSVPVRR RSFEFLDLLL 
QEWQTHSLER HAAVLVETIK KGIHDADAEA RVEARKTYMG LRNHFPGEAE TLYNSLEPSY 
QKSLQTYLKS SGSVASLPQS DRSSSSSQES LNRPFSSKWS TANPSTVAGR VSAGSSKASS 
LPGSLQRSRS DIDVNAAAGA KAHHAAGQSV RSGRLGAGAL NAGSYASLED TSDKLDGTAS 
EDGRVRAKLS APLAGMGNAK ADSRGRSRTK MVSQSQPGSR SGSPGRVLTT TALSTVSSGV 
QRVLVNSASA QKRSKIPRSQ GCSREASPSR LSVARSSRIP RPSVSQGCSR EASRESSRDT 
SPVRSFQPLA SRHHSRSTGA LYAPEVYGAS GPGYGISQSS RLSSSVSAMR VLNTGSDVEE 
AVADALKKPA RRRYESYGMH SDDDANSDAS SACSERSYSS RNGSIPTYMR QTEDVAEVLN 
RCASSNWSER KEGLLGLQNL LKNQRTLSRV ELKRLCEIFT RMFADPHGKR VFSMFLETLV 
DFIQVHKDDL QDWLFVLLTQ LLKKMGADLL GSVQAKVQKA LDVTRESFPN DLQFNILMRF 
TVDQTQTPSL KVKVAILKYI ETLAKQMDPG DFINSSETRL AVSRVITWTT EPKSSDVRKA 
AQSVLISLFE LNTPEFTMLL GALPKTFQDG ATKLLHNHLR NTGNGTQSSM GSPLTRPTPR 
SPANWSSPLT SPTNTSQNTL SPSAFDYDTE NMNSEDIYSS LRGVTEAIQN FSFRSQEDMN 
EPLKRDSKKD DGDSMCGGPG MSDPRAGGDA TDSSQTALDN KASLLHSMPT HSSPRSRDYN 
PYNYSDSISP FNKSALKEAM FDDDADQFPD DLSLDHSDLV AELLKELSNH NERVEERKIA 
LYELMKLTQE ESFSVWDEHF KTILLLLLET LGDKEPTIRA LALKVLREIL RHQPARFKNY 
AELTVMKTLE AHKDPHKEVV RSAEEAASVL ATSISPEQCI KVLCPIIQTA DYPINLAAIK 
MQTKVIERVS KETLNLLLPE IMPGLIQGYD NSESSVRKAC VFCLVAVHAV IGDELKPHLS 
QLTGSKMKLL NLYIKRAQTG SGGADPTTDV SGQS

Genular Protein ID: 516499180

Symbol: E7ERI8_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ERI8

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 6 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1513
  • Mass: 165628
  • Checksum: 584449B4359CE7C0
  • Sequence:
    • MEPRSMEYFC AQVQQKDVGG RLQVGQELLL YLGAPGAISD LEEDLGRLGK TVDALTGWVG 
SSNYRVSLMG LEILSAFVDR LSTRFKSYVA MVIVALIDRM GDAKDKVRDE AQTLILKLMD 
QVAPPMYIWE QLASGFKHKN FRSREGVCLC LIETLNIFGA QPLVISKLIP HLCILFGDSN 
SQVRDAAILA IVEIYRHVGE KVRMDLYKRG IPPARLEMIF AKFDEVQSSG GMILSVCKDK 
SFDDEESVDG NRPSSAASAF KVPAPKTSGN PANSARKPGS AGGPKVGGAS KEGGAGAVDE 
DDFIKAFTDV PSIQIYSSRE LEETLNKIRE ILSDDKHDWD QRANALKKIR SLLVAGAAQY 
DCFFQHLRLL DGALKLSAKD LRSQVVREAC ITVAHLSTVL GNKFDHGAEA IVPTLFNLVP 
NSAKVMATSG CAAIRFIIRH THVPRLIPLI TSNCTSKSVP VRRRSFEFLD LLLQEWQTHS 
LERHAAVLVE TIKKGIHDAD AEARVEARKT YMGLRNHFPG EAETLYNSLE PSYQKSLQTY 
LKSSGSVASL PQSDRSSSSS QESLNRPFSS KWSTANPSTV AGRVSAGSSK ASSLPGSLQR 
SRSDIDVNAA AGAKAHHAAG QSVRSGRLGA GALNAGSYAS LEDTSDKLDG TASEDGRVRA 
KLSAPLAGMG NAKADSRGRS RTKMVSQSQP GSRSGSPGRV LTTTALSTVS SGVQRVLVNS 
ASAQKRSKIP RSQGCSREAS PSRLSVARSS RIPRPSVSQG CSREASRESS RDTSPVRSFQ 
PLGPGYGISQ SSRLSSSVSA MRVLNTGSDV EEAVADALLL GDIRTKKKPA RRRYESYGMH 
SDDDANSDAS SACSERSYSS RNGSIPTYMR QTEDVAEVLN RCASSNWSER KEGLLGLQNL 
LKNQRTLSRV ELKRLCEIFT RMFADPHGKV FSMFLETLVD FIQVHKDDLQ DWLFVLLTQL 
LKKMGADLLG SVQAKVQKAL DVTRESFPND LQFNILMRFT VDQTQTPSLK VKVAILKYIE 
TLAKQMDPGD FINSSETRLA VSRVITWTTE PKSSDVRKAA QSVLISLFEL NTPEFTMLLG 
ALPKTFQDGA TKLLHNHLRN TGNGTQSSMG SPLTRPTPRS PANWSSPLTS PTNTSQNTLS 
PSAFDYDTEN MNSEDIYSSL RGVTEAIQNF SFRSQEDMNE PLKRDSKKDD GDSMCGGPGM 
SDPRAGGDAT DSSQTALDNK ASLLHSMPTH SSPRSRDYNP YNYSDSISPF NKSALKEAMF 
DDDADQFPDD LSLDHSDLVA ELLKELSNHN ERVEERKIAL YELMKLTQEE SFSVWDEHFK 
TILLLLLETL GDKEPTIRAL ALKVLREILR HQPARFKNYA ELTVMKTLEA HKDPHKEVVR 
SAEEAASVLA TSISPEQCIK VLCPIIQTAD YPINLAAIKM QTKVIERVSK ETLNLLLPEI 
MPGLIQGYDN SESSVRKACV FCLVAVHAVI GDELKPHLSQ LTGSKMKLLN LYIKRAQTGS 
GGADPTTDVS GQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.