Details for: ATG2A

Gene ID: 23130

Symbol: ATG2A

Ensembl ID: ENSG00000110046

Description: autophagy related 2A

Associated with

Other Information

Genular Protein ID: 246275352

Symbol: ATG2A_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21887408

Title: Human hAtg2A protein expressed in yeast is recruited to preautophagosomal structure but does not complement autophagy defects of atg2Delta strain.

PubMed ID: 21887408

PubMed ID: 22219374

Title: Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets.

PubMed ID: 22219374

DOI: 10.1091/mbc.e11-09-0785

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28820312

Title: Architecture of the ATG2B-WDR45 complex and an aromatic Y/HF motif crucial for complex formation.

PubMed ID: 28820312

DOI: 10.1080/15548627.2017.1359381

PubMed ID: 28561066

Title: WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.

PubMed ID: 28561066

DOI: 10.1038/ncomms15637

PubMed ID: 31271352

Title: The autophagic membrane tether ATG2A transfers lipids between membranes.

PubMed ID: 31271352

DOI: 10.7554/elife.45777

PubMed ID: 30952800

Title: ATG2 transports lipids to promote autophagosome biogenesis.

PubMed ID: 30952800

DOI: 10.1083/jcb.201811139

PubMed ID: 32610138

Title: Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery.

PubMed ID: 32610138

DOI: 10.1016/j.celrep.2020.107837

PubMed ID: 33106659

Title: Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.

PubMed ID: 33106659

DOI: 10.1038/s41594-020-00520-2

PubMed ID: 33850023

Title: A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis.

PubMed ID: 33850023

DOI: 10.1073/pnas.2101562118

PubMed ID: 32483132

Title: Multi-site-mediated entwining of the linear WIR-motif around WIPI beta-propellers for autophagy.

PubMed ID: 32483132

DOI: 10.1038/s41467-020-16523-y

Sequence Information:

  • Length: 1938
  • Mass: 212860
  • Checksum: B0072E075E305A33
  • Sequence:
  • MSRWLWPWSN CVKERVCRYL LHHYLGHFFQ EHLSLDQLSL DLYKGSVALR DIHLEIWSVN 
    EVLESMESPL ELVEGFVGSI EVAVPWAALL TDHCTVRVSG LQLTLQPRRG PAPGAADSQS 
    WASCMTTSLQ LAQECLRDGL PEPSEPPQPL EGLEMFAQTI ETVLRRIKVT FLDTVVRVEH 
    SPGDGERGVA VEVRVQRLEY CDEAVRDPSQ APPVDVHQPP AFLHKLLQLA GVRLHYEELP 
    AQEEPPEPPL QIGSCSGYME LMVKLKQNEA FPGPKLEVAG QLGSLHLLLT PRQLQQLQEL 
    LSAVSLTDHE GLADKLNKSR PLGAEDLWLI EQDLNQQLQA GAVAEPLSPD PLTNPLLNLD 
    NTDLFFSMAG LTSSVASALS ELSLSDVDLA SSVRSDMASR RLSAQAHPAG KMAPNPLLDT 
    MRPDSLLKMT LGGVTLTLLQ TSAPSSGPPD LATHFFTEFD ATKDGPFGSR DFHHLRPRFQ 
    RACPCSHVRL TGTAVQLSWE LRTGSRGRRT TSMEVHFGQL EVLECLWPRG TSEPEYTEIL 
    TFPGTLGSQA SARPCAHLRH TQILRRVPKS RPRRSVACHC HSELALDLAN FQADVELGAL 
    DRLAALLRLA TVPAEPPAGL LTEPLPAMEQ QTVFRLSAPR ATLRLRFPIA DLRPEPDPWA 
    GQAVRAEQLR LELSEPQFRS ELSSGPGPPV PTHLELTCSD LHGIYEDGGK PPVPCLRVSK 
    ALDPKSTGRK YFLPQVVVTV NPQSSSTQWE VAPEKGEELE LSVESPCELR EPEPSPFSSK 
    RTMYETEEMV IPGDPEEMRT FQSRTLALSR CSLEVILPSV HIFLPSKEVY ESIYNRINND 
    LLMWEPADLL PTPDPAAQPS GFPGPSGFWH DSFKMCKSAF KLANCFDLTP DSDSDDEDAH 
    FFSVGASGGP QAAAPEAPSL HLQSTFSTLV TVLKGRITAL CETKDEGGKR LEAVHGELVL 
    DMEHGTLFSV SQYCGQPGLG YFCLEAEKAT LYHRAAVDDY PLPSHLDLPS FAPPAQLAPT 
    IYPSEEGVTE RGASGRKGQG RGPHMLSTAV RIHLDPHKNV KEFLVTLRLH KATLRHYMAL 
    PEQSWHSQLL EFLDVLDDPV LGYLPPTVIT ILHTHLFSCS VDYRPLYLPV RVLITAETFT 
    LSSNIIMDTS TFLLRFILDD SALYLSDKCE VETLDLRRDY VCVLDVDLLE LVIKTWKGST 
    EGKLSQPLFE LRCSNNVVHV HSCADSCALL VNLLQYVMST GDLHPPPRPP SPTEIAGQKL 
    SESPASLPSC PPVETALINQ RDLADALLDT ERSLRELAQP SGGHLPQASP ISVYLFPGER 
    SGAPPPSPPV GGPAGSLGSC SEEKEDEREE EGDGDTLDSD EFCILDAPGL GIPPRDGEPV 
    VTQLHPGPIV VRDGYFSRPI GSTDLLRAPA HFPVPSTRVV LREVSLVWHL YGGRDFGPHP 
    GHRARTGLSG PRSSPSRCSG PNRPQNSWRT QGGSGRQHHV LMEIQLSKVS FQHEVYPAEP 
    ATGPAAPSQE LEERPLSRQV FIVQELEVRD RLASSQINKF LYLHTSERMP RRAHSNMLTI 
    KALHVAPTTN LGGPECCLRV SLMPLRLNVD QDALFFLKDF FTSLVAGINP VVPGETSAEA 
    RPETRAQPSS PLEGQAEGVE TTGSQEAPGG GHSPSPPDQQ PIYFREFRFT SEVPIWLDYH 
    GKHVTMDQVG TFAGLLIGLA QLNCSELKLK RLCCRHGLLG VDKVLGYALN EWLQDIRKNQ 
    LPGLLGGVGP MHSVVQLFQG FRDLLWLPIE QYRKDGRLMR GLQRGAASFG SSTASAALEL 
    SNRLVQAIQA TAETVYDILS PAAPVSRSLQ DKRSARRLRR GQQPADLREG VAKAYDTVRE 
    GILDTAQTIC DVASRGHEQK GLTGAVGGVI RQLPPTVVKP LILATEATSS LLGGMRNQIV 
    PDAHKDHALK WRSDSAQD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.