Details for: PHF8
Associated with
Other Information
Genular Protein ID: 966550397
Symbol: PHF8_HUMAN
Name: Histone lysine demethylase PHF8
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10470851
Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10470851
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16199551
Title: Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate.
PubMed ID: 16199551
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20531378
Title: PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis.
PubMed ID: 20531378
DOI: 10.1038/cr.2010.75
PubMed ID: 20548336
Title: The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation.
PubMed ID: 20548336
DOI: 10.1038/cr.2010.81
PubMed ID: 19843542
Title: PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase.
PubMed ID: 19843542
DOI: 10.1093/hmg/ddp480
PubMed ID: 20346720
Title: A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation.
PubMed ID: 20346720
PubMed ID: 20421419
Title: PHF8 targets histone methylation and RNA polymerase II to activate transcription.
PubMed ID: 20421419
DOI: 10.1128/mcb.01520-09
PubMed ID: 20208542
Title: PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.
PubMed ID: 20208542
DOI: 10.1038/nsmb.1778
PubMed ID: 20622853
Title: Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development.
PubMed ID: 20622853
DOI: 10.1038/nature09261
PubMed ID: 20622854
Title: PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.
PubMed ID: 20622854
DOI: 10.1038/nature09272
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 31691806
Title: Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.
PubMed ID: 31691806
DOI: 10.1093/hmg/ddz254
PubMed ID: 32051553
Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
PubMed ID: 32051553
PubMed ID: 20101266
Title: Structural insights into a novel histone demethylase PHF8.
PubMed ID: 20101266
DOI: 10.1038/cr.2010.8
PubMed ID: 20067792
Title: Crystal structure of the PHF8 Jumonji domain, an N(epsilon)-methyl lysine demethylase.
PubMed ID: 20067792
PubMed ID: 20023638
Title: Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.
PubMed ID: 20023638
DOI: 10.1038/nsmb.1753
PubMed ID: 17661819
Title: Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate.
PubMed ID: 17661819
PubMed ID: 23092983
Title: Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE.
PubMed ID: 23092983
DOI: 10.1038/tp.2012.102
Sequence Information:
- Length: 1060
- Mass: 117864
- Checksum: 04C83D7C5E9E56B8
- Sequence:
MNRSRAIVQR GRVLPPPAPL DTTNLAGRRT LQGRAKMASV PVYCLCRLPY DVTRFMIECD MCQDWFHGSC VGVEEEKAAD IDLYHCPNCE VLHGPSIMKK RRGSSKGHDT HKGKPVKTGS PTFVRELRSR TFDSSDEVIL KPTGNQLTVE FLEENSFSVP ILVLKKDGLG MTLPSPSFTV RDVEHYVGSD KEIDVIDVTR QADCKMKLGD FVKYYYSGKR EKVLNVISLE FSDTRLSNLV ETPKIVRKLS WVENLWPEEC VFERPNVQKY CLMSVRDSYT DFHIDFGGTS VWYHVLKGEK IFYLIRPTNA NLTLFECWSS SSNQNEMFFG DQVDKCYKCS VKQGQTLFIP TGWIHAVLTP VDCLAFGGNF LHSLNIEMQL KAYEIEKRLS TADLFRFPNF ETICWYVGKH ILDIFRGLRE NRRHPASYLV HGGKALNLAF RAWTRKEALP DHEDEIPETV RTVQLIKDLA REIRLVEDIF QQNVGKTSNI FGLQRIFPAG SIPLTRPAHS TSVSMSRLSL PSKNGSKKKG LKPKELFKKA ERKGKESSAL GPAGQLSYNL MDTYSHQALK TGSFQKAKFN ITGACLNDSD DDSPDLDLDG NESPLALLMS NGSTKRVKSL SKSRRTKIAK KVDKARLMAE QVMEDEFDLD SDDELQIDER LGKEKATLII RPKFPRKLPR AKPCSDPNRV REPGEVEFDI EEDYTTDEDM VEGVEGKLGN GSGAGGILDL LKASRQVGGP DYAALTEAPA SPSTQEAIQG MLCMANLQSS SSSPATSSLQ AWWTGGQDRS SGSSSSGLGT VSNSPASQRT PGKRPIKRPA YWRTESEEEE ENASLDEQDS LGACFKDAEY IYPSLESDDD DPALKSRPKK KKNSDDAPWS PKARVTPTLP KQDRPVREGT RVASIETGLA AAAAKLAQQE LQKAQKKKYI KKKPLLKEVE QPRPQDSNLS LTVPAPTVAA TPQLVTSSSP LPPPEPKQEA LSGSLADHEY TARPNAFGMA QANRSTTPMA PGVFLTQRRP SVGSQSNQAG QGKRPKKGLA TAKQRLGRIL KIHRNGKLLL
Genular Protein ID: 3457249708
Symbol: O95327_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 303
- Mass: 33870
- Checksum: EB3A4B15091487E1
- Sequence:
MDTYSHQALK TGSFQKAKFN ITGACLNDSD DDSPDLDLDG NESPLALLMS NGSTKRVKSL SKSRRTKIAK KVDKARLMAE QVMEDEFDLD SDDELQIDER LGKEKATLII RPKFPRKLPR ANLALTPTEF VNQEKLSLTL RRTIQQMRTW WKGLKASLGM VVALVAFLIC SRPAGRWGDL TMLPSPRPQL LPALRRPSRA CCAWPTCSPH RPHRLPLACR PGGLGDRIEA VGAPAVGWAQ CLTVLLPSAP QGSGPSSGQH TGEPRARRRR RTPVWMNRTA WERASRMQSI SILHWSLMMM TLL
Genular Protein ID: 1736906202
Symbol: H0Y3N9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15772651
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
Sequence Information:
- Length: 1049
- Mass: 116875
- Checksum: FAE401D719832302
- Sequence:
MASVPVYCLC RLPYDVTRFM IECDMCQDWF HGSCVGVEEE KAADIDLYHC PNCEVLHGPS IMKKRRGSSK GHDTHKGKPV KTGSPTFVRE LRSRTFDSSD EVILKPTGNQ LTVEFLEENS FSVPILVLKK DGLGMTLPSP SFTVRDVEHY VGSDKEIDVI DVTRQADCKM KLGDFVKYYY SGKREKVLNV ISLEFSDTRL SNLVETPKIV RKLSWVENLW PEECVFERPN VQKYCLMSVR DSYTDFHIDF GGTSVWYHVL KGEKIFYLIR PTNANLTLFE CWSSSSNQNE MFFGDQVDKC YKCSVKQGQT LFIPTGWIHA VLTPVDCLAF GGNFLHSLNI EMQLKAYEIE KRLSTADLFR FPNFETICWY VGKHILDIFR GLRENRRHPA SYLVHGGKAL NLAFRAWTRK EALPDHEDEI PETVRTVQLI KDLAREIRLV EDIFQQNVGK TSNIFGLQRI FPAGSIPLTR PAHSTSVSMS RLSLPSKNGS KKKGLKPKEL FKKAERKGKE SSALGPAGQL SYNLMDTYSH QALKTGSFQK AKFNITGACL NDSDDDSPDL DLDGNESPLA LLMSNGSTKR VKSLSKSRRT KIAKKVDKAR LMAEQVMEDE FDLDSDDELQ IDERLGKEKA TLIIRPKFPR KLPRAKPCSD PNRVREPGEV EFDIEEDYTT DEDMVEGVEG KLGNGSGAGG ILDLLKASRQ VGGPDYAALT EAPASPSTQE AIQGMLCMAN LQSSSSSPAT SSLQAWWTGG QDRSSGSSSS GLGTVSNSPA SQRTPGKRPI KRPAYWRTES EEEEENASLD EQDSLGACFK DAEYIYPSLE SDDDDPALKS RPKKKKNSDD APWSPKARVT PTLPKQDRPV REGTRVASIE TGLAAAAAKL AQQELQKAQK KKYIKKKPLL KEVEQPRPQD SNLSLTVPAP TVAATPQLVT SSSPLPPPEP KQEALSGSLA DHEYTARPNA FGMAQANRST TPMAPGVFLT QRRPSVGSQS NQAGQGKRPK KGLATAKQRL GRILKIHRNG KLLLRQVIVQ AECRQAIHEP KLKRRDAHP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.