LPIN1 | ENSG00000134324 | NCBI 23175

Details for: LPIN1

Gene ID: 23175

Symbol: LPIN1

Ensembl ID: ENSG00000134324

Description: lipin 1

Associated with

Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Depolymerization of the nuclear lamina
(R-HSA-4419969)
Glycerophospholipid biosynthesis
(R-HSA-1483206)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Nuclear envelope breakdown
(R-HSA-2980766)
Phospholipid metabolism
(R-HSA-1483257)
Synthesis of pc
(R-HSA-1483191)
Synthesis of pe
(R-HSA-1483213)
Triglyceride biosynthesis
(R-HSA-75109)
Triglyceride metabolism
(R-HSA-8979227)
Animal organ regeneration
(GO:0031100)
Cellular response to insulin stimulus
(GO:0032869)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Fatty acid catabolic process
(GO:0009062)
Mitochondrial outer membrane
(GO:0005741)
Mitotic nuclear membrane disassembly
(GO:0007077)
Negative regulation of myelination
(GO:0031642)
Nuclear envelope
(GO:0005635)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatidate phosphatase activity
(GO:0008195)
Phosphatidic acid biosynthetic process
(GO:0006654)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of dna replication
(GO:0045740)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Transcription coactivator activity
(GO:0003713)
Triglyceride biosynthetic process
(GO:0019432)
Triglyceride mobilization
(GO:0006642)

Other Information

Proteins

LPIN1_HUMAN

Genular Protein ID: 2268879461

Symbol: LPIN1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14693 A8MU38 B4DET9 B4DGS4 B4DGZ6 B5MC18 B7Z858 D6W506 E7ESE7 F5GY24 Q53T25

Database IDs:

Citations:

PubMed ID: 8724849

Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8724849

DOI: 10.1093/dnares/3.1.17

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17158099

Title: Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.

PubMed ID: 17158099

DOI: 10.1074/jbc.m610745200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20231281

Title: Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms.

PubMed ID: 20231281

DOI: 10.1074/jbc.m110.117747

PubMed ID: 22134922

Title: Nuclear envelope phosphatase-regulatory subunit 1 (formerly TMEM188) is the metazoan SPO7 ortholog and functions in the lipin activation pathway.

PubMed ID: 22134922

DOI: 10.1074/jbc.m111.324350

PubMed ID: 29765047

Title: Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate.

PubMed ID: 29765047

DOI: 10.1038/s41467-018-04363-w

PubMed ID: 12111372

Title: Identification of single-nucleotide polymorphisms in the human LPIN1 gene.

PubMed ID: 12111372

DOI: 10.1007/s100380200052

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18817903

Title: Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood.

PubMed ID: 18817903

DOI: 10.1016/j.ajhg.2008.09.002

Sequence Information:

Length: 890
Mass: 98664
Checksum: 781761FC47E9CEE7
Sequence:

MNYVGQLAGQ VFVTVKELYK GLNPATLSGC IDIIVIRQPN GNLQCSPFHV RFGKMGVLRS 
REKVVDIEIN GESVDLHMKL GDNGEAFFVQ ETDNDQEVIP MHLATSPILS EGASRMECQL 
KRGSVDRMRG LDPSTPAQVI APSETPSSSS VVKKRRKRRR KSQLDSLKRD DNMNTSEDED 
MFPIEMSSDE AMELLESSRT LPNDIPPFQD DIPEENLSLA VIYPQSASYP NSDREWSPTP 
SPSGSRPSTP KSDSELVSKS TERTGQKNPE MLWLWGELPQ AAKSSSPHKM KESSPLSSRK 
ICDKSHFQAI HSESSDTFSD QSPTLVGGAL LDQNKPQTEM QFVNEEDLET LGAAAPLLPM 
IEELKPPSAS VVQTANKTDS PSRKRDKRSR HLGADGVYLD DLTDMDPEVA ALYFPKNGDP 
SGLAKHASDN GARSANQSPQ SVGSSGVDSG VESTSDGLRD LPSIAISLCG GLSDHREITK 
DAFLEQAVSY QQFVDNPAII DDPNLVVKIG SKYYNWTTAA PLLLAMQAFQ KPLPKATVES 
IMRDKMPKKG GRWWFSWRGR NTTIKEESKP EQCLAGKAHS TGEQPPQLSL ATRVKHESSS 
SDEERAAAKP SNAGHLPLLP NVSYKKTLRL TSEQLKSLKL KNGPNDVVFS VTTQYQGTCR 
CEGTIYLWNW DDKVIISDID GTITRSDTLG HILPTLGKDW THQGIAKLYH KVSQNGYKFL 
YCSARAIGMA DMTRGYLHWV NERGTVLPQG PLLLSPSSLF SALHREVIEK KPEKFKVQCL 
TDIKNLFFPN TEPFYAAFGN RPADVYSYKQ VGVSLNRIFT VNPKGELVQE HAKTNISSYV 
RLCEVVDHVF PLLKRSHSSD FPCSDTFSNF TFWREPLPPF ENQDIHSASA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: LPIN1

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. PubMed ID: 8724849

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. PubMed ID: 17158099

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms. PubMed ID: 20231281

Nuclear envelope phosphatase-regulatory subunit 1 (formerly TMEM188) is the metazoan SPO7 ortholog and functions in the lipin activation pathway. PubMed ID: 22134922

Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. PubMed ID: 29765047

Identification of single-nucleotide polymorphisms in the human LPIN1 gene. PubMed ID: 12111372

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood. PubMed ID: 18817903