Details for: PASK

Gene ID: 23178

Symbol: PASK

Ensembl ID: ENSG00000115687

Description: PAS domain containing serine/threonine kinase

Associated with

Other Information

Genular Protein ID: 2542424040

Symbol: PASK_HUMAN

Name: PAS domain-containing serine/threonine-protein kinase

UniProtKB Accession Codes:

Q96RG2 G5E9F1 Q05BE4 Q68DY3 Q6GSJ5 Q86XH6 Q99763 Q9UFR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 9 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 10 Rhea 6 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11459942

Title: PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase.

PubMed ID: 11459942

DOI: 10.1073/pnas.161284798

PubMed ID: 8590280

Title: Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8590280

DOI: 10.1093/dnares/2.4.167

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 16275910

Title: Control of mammalian glycogen synthase by PAS kinase.

PubMed ID: 16275910

DOI: 10.1073/pnas.0508481102

PubMed ID: 17052199

Title: Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic beta-cells.

PubMed ID: 17052199

DOI: 10.1042/bst0340791

PubMed ID: 17595531

Title: Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1.

PubMed ID: 17595531

DOI: 10.1159/000104169

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21181396

Title: Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion.

PubMed ID: 21181396

DOI: 10.1007/s00125-010-2010-7

PubMed ID: 21418524

Title: Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN.

PubMed ID: 21418524

DOI: 10.1111/j.1742-4658.2011.08100.x

PubMed ID: 19189049

Title: The PAS-domain kinase PASKIN: a new sensor in energy homeostasis.

PubMed ID: 19189049

DOI: 10.1007/s00018-009-8699-0

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12377121

Title: Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation.

PubMed ID: 12377121

DOI: 10.1016/s0969-2126(02)00857-2

PubMed ID: 20943661

Title: Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation.

PubMed ID: 20943661

DOI: 10.1074/jbc.m110.157594

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1323
  • Mass: 142929
  • Checksum: F8A3633CC6F6C8CD
  • Sequence:
    • MEDGGLTAFE EDQRCLSQSL PLPVSAEGPA AQTTAEPSRS FSSAHRHLSR RNGLSRLCQS 
RTALSEDRWS SYCLSSLAAQ NICTSKLHCP AAPEHTDPSE PRGSVSCCSL LRGLSSGWSS 
PLLPAPVCNP NKAIFTVDAK TTEILVANDK ACGLLGYSSQ DLIGQKLTQF FLRSDSDVVE 
ALSEEHMEAD GHAAVVFGTV VDIISRSGEK IPVSVWMKRM RQERRLCCVV VLEPVERVST 
WVAFQSDGTV TSCDSLFAHL HGYVSGEDVA GQHITDLIPS VQLPPSGQHI PKNLKIQRSV 
GRARDGTTFP LSLKLKSQPS SEEATTGEAA PVSGYRASVW VFCTISGLIT LLPDGTIHGI 
NHSFALTLFG YGKTELLGKN ITFLIPGFYS YMDLAYNSSL QLPDLASCLD VGNESGCGER 
TLDPWQGQDP AEGGQDPRIN VVLAGGHVVP RDEIRKLMES QDIFTGTQTE LIAGGQLLSC 
LSPQPAPGVD NVPEGSLPVH GEQALPKDQQ ITALGREEPV AIESPGQDLL GESRSEPVDV 
KPFASCEDSE APVPAEDGGS DAGMCGLCQK AQLERMGVSG PSGSDLWAGA AVAKPQAKGQ 
LAGGSLLMHC PCYGSEWGLW WRSQDLAPSP SGMAGLSFGT PTLDEPWLGV ENDREELQTC 
LIKEQLSQLS LAGALDVPHA ELVPTECQAV TAPVSSCDLG GRDLCGGCTG SSSACYALAT 
DLPGGLEAVE AQEVDVNSFS WNLKELFFSD QTDQTSSNCS CATSELRETP SSLAVGSDPD 
VGSLQEQGSC VLDDRELLLL TGTCVDLGQG RRFRESCVGH DPTEPLEVCL VSSEHYAASD 
RESPGHVPST LDAGPEDTCP SAEEPRLNVQ VTSTPVIVMR GAAGLQREIQ EGAYSGSCYH 
RDGLRLSIQF EVRRVELQGP TPLFCCWLVK DLLHSQRDSA ARTRLFLASL PGSTHSTAAE 
LTGPSLVEVL RARPWFEEPP KAVELEGLAA CEGEYSQKYS TMSPLGSGAF GFVWTAVDKE 
KNKEVVVKFI KKEKVLEDCW IEDPKLGKVT LEIAILSRVE HANIIKVLDI FENQGFFQLV 
MEKHGSGLDL FAFIDRHPRL DEPLASYIFR QLVSAVGYLR LKDIIHRDIK DENIVIAEDF 
TIKLIDFGSA AYLERGKLFY TFCGTIEYCA PEVLMGNPYR GPELEMWSLG VTLYTLVFEE 
NPFCELEETV EAAIHPPYLV SKELMSLVSG LLQPVPERRT TLEKLVTDPW VTQPVNLADY 
TWEEVFRVNK PESGVLSAAS LEMGNRSLSD VAQAQELCGG PVPGEAPNGQ GCLHPGDPRL 
LTS

Genular Protein ID: 2583953702

Symbol: B7Z7R6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z7R6

Database IDs:

ARBA 7 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 11 DNASU 1 EC 2 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 1288
  • Mass: 139464
  • Checksum: FF87EC642209A888
  • Sequence:
    • MEDGGLTAFE EDQRCLSQSL PLPVSAEGPA AQTTAEPSRS FSSAHRHLSR RNGLSRLCQS 
RTALSEDRWS SYCLSSLAAQ NICTSKLHCP AAPEHTDPSE PRGSVSCCSL LRGLSSGWSS 
PLLPAPVCNP NKAIFTVDAK TTEILVANDK ACGLLGYSSQ DLIGQKLTQF FLRSDSDVVE 
ALSEEHMEAD GHAAVVFGTV VDIISRSGEK IPVSVWMKRM RQERRLCCVV VLEPVERVST 
WVAFQSDLPP SGQHIPKNLK IQRSVGRARD GTTFPLSLKL KSQPSSEEAT TGEAAPVSGY 
RASVWVFCTI SGLITLLPDG TIHGINHSFA LTLFGYGKTE LLGKNITFLI PGFYSYMDLA 
YNSSLQLPDL ASCLDVGNES GCGERTLDPW QGQDPAEGGQ DPRINVVLAG GHVVPRDEIR 
KLMESQDIFT GTQTELIAGG QLLSCLSPQP APGVDNVPEG SLPVHGEQAL PKDQQITALG 
REEPVAIESP RQDLLGESRS EPVDVKPFAS CEDSEAPVPA EDGGSDAGMC GLCQKAQLER 
MGVSGPSGSD LWAGAAVAKP QAKGQLAGGS LLMHCPCYGS EWGLWWRSQD LAPSPSGMAG 
LSFGTPTLDE PWLGVENDRE ELQTCLIKEQ LSQLSLAEAL DVPHAELVPT ECQAVTAPVS 
SCDLGGRDLC GGCTGSSSAC YALATDLPGG LEAVEAQEVD VNSFSWNLKE LFFSDQTDQT 
SSNCSCATSE LRETPSSLAV GSDPDVGSLQ EQGSCVLDDR ELLLLTGTCV DLGQGRRFRE 
SCVGHDPTEP LEVCLVSSEH YAASDRESPG HVPSTLDAGP EDTCPSAEEP RLNVQVTSTP 
VIVMRGAAGL QREIQEGAYS GSCYHRDGLR LSIQFEVRRV ELQGPTPLFC CWLVKDLLHS 
QRDSAARTRL FLASLPGSTH STAAELTGPS LVEVLRARPW FEEPPKAVEL EGLAACEGEY 
SQKYSTMSPL GSGAFGFVWT AVDKEKNKEV VVKFIKKEKV LEDCWIEDPK LGKVTLEIAI 
LSRVEHANII KVLDIFENQG FFQLVMEKHG SGLDLFAFID RHPRLDEPLA SYIFRQLVSA 
VGYLRLKDII HRDIKDENIV IAEDFTIKLI DFGSAAYLER GKLFYTFCGT IEYCAPEVLM 
GNPYRGPELE MWSLGVTLYT LVFEENPFCE LEETVEAAIH PPYLVSKELM SLVSGLLQPV 
PERRTTLEKL VTDPWVTQPV NLADYTWEEV FRVNKPESGV LSAASLEMGN RSLSDVAQAQ 
ELCGGPVPGE APNGQGCLHP GDPRLLTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.