RCOR1 | ENSG00000089902 | NCBI 23186

Details for: RCOR1

Gene ID: 23186

Symbol: RCOR1

Ensembl ID: ENSG00000089902

Description: REST corepressor 1

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Disease
(R-HSA-1643685)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Hdacs deacetylate histones
(R-HSA-3214815)
Hemostasis
(R-HSA-109582)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Pip3 activates akt signaling
(R-HSA-1257604)
Potential therapeutics for sars
(R-HSA-9679191)
Pten regulation
(R-HSA-6807070)
Regulation of pten gene transcription
(R-HSA-8943724)
Sars-cov infections
(R-HSA-9679506)
Signal transduction
(R-HSA-162582)
Viral infection pathways
(R-HSA-9824446)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Dna repair complex
(GO:1990391)
Enzyme binding
(GO:0019899)
Erythrocyte differentiation
(GO:0030218)
Histone deacetylase complex
(GO:0000118)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of megakaryocyte differentiation
(GO:0045654)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Transcription corepressor activity
(GO:0003714)
Transcription regulator complex
(GO:0005667)
Transcription repressor complex
(GO:0017053)

Other Information

Proteins

REST corepressor 1

Genular Protein ID: 2337907267

Symbol: RCOR1_HUMAN

Name: REST corepressor 1

UniProtKB Accession Codes:

Q9UKL0 J3KN32 Q15044 Q6P2I9 Q86VG5

Database IDs:

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10449787

Title: CoREST: a functional corepressor required for regulation of neural-specific gene expression.

PubMed ID: 10449787

DOI: 10.1073/pnas.96.17.9873

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 10734093

Title: The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.

PubMed ID: 10734093

DOI: 10.1074/jbc.275.13.9461

PubMed ID: 11516394

Title: Regulation of neuronal traits by a novel transcriptional complex.

PubMed ID: 11516394

DOI: 10.1016/s0896-6273(01)00371-3

PubMed ID: 11102443

Title: Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.

PubMed ID: 11102443

DOI: 10.1074/jbc.m007372200

PubMed ID: 11171972

Title: CoREST is an integral component of the CoREST-human histone deacetylase complex.

PubMed ID: 11171972

DOI: 10.1073/pnas.98.4.1454

PubMed ID: 12192000

Title: REST repression of neuronal genes requires components of the hSWI.SNF complex.

PubMed ID: 12192000

DOI: 10.1074/jbc.m205691200

PubMed ID: 12032298

Title: A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.

PubMed ID: 12032298

DOI: 10.1073/pnas.112008599

PubMed ID: 12399542

Title: Corepressor-dependent silencing of chromosomal regions encoding neuronal genes.

PubMed ID: 12399542

DOI: 10.1126/science.1076469

PubMed ID: 12493763

Title: A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.

PubMed ID: 12493763

DOI: 10.1074/jbc.m208992200

PubMed ID: 16140033

Title: Regulation of LSD1 histone demethylase activity by its associated factors.

PubMed ID: 16140033

DOI: 10.1016/j.molcel.2005.08.027

PubMed ID: 16079794

Title: An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation.

PubMed ID: 16079794

DOI: 10.1038/nature04021

PubMed ID: 15897453

Title: Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells.

PubMed ID: 15897453

DOI: 10.1073/pnas.0502658102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16885027

Title: Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase.

PubMed ID: 16885027

DOI: 10.1016/j.molcel.2006.07.012

Sequence Information:

Length: 485
Mass: 53327
Checksum: 77E90FB0EFD514B2
Sequence:

MPAMVEKGPE VSGKRRGRNN AAASASAAAA SAAASAACAS PAATAASGAA ASSASAAAAS 
AAAAPNNGQN KSLAAAAPNG NSSSNSWEEG SSGSSSDEEH GGGGMRVGPQ YQAVVPDFDP 
AKLARRSQER DNLGMLVWSP NQNLSEAKLD EYIAIAKEKH GYNMEQALGM LFWHKHNIEK 
SLADLPNFTP FPDEWTVEDK VLFEQAFSFH GKTFHRIQQM LPDKSIASLV KFYYSWKKTR 
TKTSVMDRHA RKQKREREES EDELEEANGN NPIDIEVDQN KESKKEVPPT ETVPQVKKEK 
HSTQAKNRAK RKPPKGMFLS QEDVEAVSAN ATAATTVLRQ LDMELVSVKR QIQNIKQTNS 
ALKEKLDGGI EPYRLPEVIQ KCNARWTTEE QLLAVQAIRK YGRDFQAISD VIGNKSVVQV 
KNFFVNYRRR FNIDEVLQEW EAEHGKEETN GPSNQKPVKS PDNSIKMPEE EDEAPVLDVR 
YASAS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RCOR1

Associated with

Other Information

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

CoREST: a functional corepressor required for regulation of neural-specific gene expression. PubMed ID: 10449787

Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. PubMed ID: 7584044

The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. PubMed ID: 10734093

Regulation of neuronal traits by a novel transcriptional complex. PubMed ID: 11516394

Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. PubMed ID: 11102443

CoREST is an integral component of the CoREST-human histone deacetylase complex. PubMed ID: 11171972

REST repression of neuronal genes requires components of the hSWI.SNF complex. PubMed ID: 12192000

A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. PubMed ID: 12032298

Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. PubMed ID: 12399542

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. PubMed ID: 12493763

Regulation of LSD1 histone demethylase activity by its associated factors. PubMed ID: 16140033

An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. PubMed ID: 16079794

Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells. PubMed ID: 15897453

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. PubMed ID: 16885027