KANK1 | ENSG00000107104 | NCBI 23189

Details for: KANK1

Gene ID: 23189

Symbol: KANK1

Ensembl ID: ENSG00000107104

Description: KN motif and ankyrin repeat domains 1

Associated with

Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Signaling by membrane-tethered fusions of pdgfra or pdgfrb
(R-HSA-9673768)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by pdgfr in disease
(R-HSA-9671555)
Signal transduction
(R-HSA-162582)
Actin cytoskeleton organization
(GO:0030036)
Beta-catenin binding
(GO:0008013)
Cell population proliferation
(GO:0008283)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Negative regulation of actin filament polymerization
(GO:0030837)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of lamellipodium morphogenesis
(GO:2000393)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of rho protein signal transduction
(GO:0035024)
Negative regulation of ruffle assembly
(GO:1900028)
Negative regulation of substrate adhesion-dependent cell spreading
(GO:1900025)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Podocyte cell migration
(GO:0090521)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of wnt signaling pathway
(GO:0030177)
Positive regulation of wound healing
(GO:0090303)
Protein binding
(GO:0005515)
Regulation of establishment of cell polarity
(GO:2000114)
Regulation of rho protein signal transduction
(GO:0035023)
Ruffle membrane
(GO:0032587)

Other Information

Proteins

KN motif and ankyrin repeat domain-containing protein 1

Genular Protein ID: 290710683

Symbol: KANK1_HUMAN

Name: KN motif and ankyrin repeat domain-containing protein 1

UniProtKB Accession Codes:

Q14678 A2A2W8 D3DRH3 Q5W0W0 Q8IY65 Q8WX74

Database IDs:

Citations:

PubMed ID: 8724849

Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8724849

DOI: 10.1093/dnares/3.1.17

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12133830

Title: A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma.

PubMed ID: 12133830

DOI: 10.1074/jbc.m204244200

PubMed ID: 15823577

Title: Alternative splicing of the human Kank gene produces two types of Kank protein.

PubMed ID: 15823577

DOI: 10.1016/j.bbrc.2005.03.106

PubMed ID: 16301218

Title: Deletion of the ANKRD15 gene at 9p24.3 causes parent-of-origin-dependent inheritance of familial cerebral palsy.

PubMed ID: 16301218

DOI: 10.1093/hmg/ddi415

PubMed ID: 16968744

Title: Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin.

PubMed ID: 16968744

DOI: 10.1242/jcs.03169

PubMed ID: 18458160

Title: Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling.

PubMed ID: 18458160

DOI: 10.1083/jcb.200707022

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19559006

Title: A major mutation of KIF21A associated with congenital fibrosis of the extraocular muscles type 1 (CFEOM1) enhances translocation of Kank1 to the membrane.

PubMed ID: 19559006

DOI: 10.1016/j.bbrc.2009.06.109

PubMed ID: 19171758

Title: Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1.

PubMed ID: 19171758

DOI: 10.1083/jcb.200805147

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22084092

Title: Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing.

PubMed ID: 22084092

DOI: 10.1073/pnas.1117011108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25961457

Title: KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.

PubMed ID: 25961457

DOI: 10.1172/jci79504

PubMed ID: 29183992

Title: Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins.

PubMed ID: 29183992

DOI: 10.1074/jbc.m117.817494

Sequence Information:

Length: 1352
Mass: 147289
Checksum: 0C3993143391363B
Sequence:

MAHTTKVNGS ASGKAGDILS GDQDKEQKDP YFVETPYGYQ LDLDFLKYVD DIQKGNTIKR 
LNIQKRRKPS VPCPEPRTTS GQQGIWTSTE SLSSSNSDDN KQCPNFLIAR SQVTSTPISK 
PPPPLETSLP FLTIPENRQL PPPSPQLPKH NLHVTKTLME TRRRLEQERA TMQMTPGEFR 
RPRLASFGGM GTTSSLPSFV GSGNHNPAKH QLQNGYQGNG DYGSYAPAAP TTSSMGSSIR 
HSPLSSGIST PVTNVSPMHL QHIREQMAIA LKRLKELEEQ VRTIPVLQVK ISVLQEEKRQ 
LVSQLKNQRA ASQINVCGVR KRSYSAGNAS QLEQLSRARR SGGELYIDYE EEEMETVEQS 
TQRIKEFRQL TADMQALEQK IQDSSCEASS ELRENGECRS VAVGAEENMN DIVVYHRGSR 
SCKDAAVGTL VEMRNCGVSV TEAMLGVMTE ADKEIELQQQ TIESLKEKIY RLEVQLRETT 
HDREMTKLKQ ELQAAGSRKK VDKATMAQPL VFSKVVEAVV QTRDQMVGSH MDLVDTCVGT 
SVETNSVGIS CQPECKNKVV GPELPMNWWI VKERVEMHDR CAGRSVEMCD KSVSVEVSVC 
ETGSNTEESV NDLTLLKTNL NLKEVRSIGC GDCSVDVTVC SPKECASRGV NTEAVSQVEA 
AVMAVPRTAD QDTSTDLEQV HQFTNTETAT LIESCTNTCL STLDKQTSTQ TVETRTVAVG 
EGRVKDINSS TKTRSIGVGT LLSGHSGFDR PSAVKTKESG VGQININDNY LVGLKMRTIA 
CGPPQLTVGL TASRRSVGVG DDPVGESLEN PQPQAPLGMM TGLDHYIERI QKLLAEQQTL 
LAENYSELAE AFGEPHSQMG SLNSQLISTL SSINSVMKSA STEELRNPDF QKTSLGKITG 
NYLGYTCKCG GLQSGSPLSS QTSQPEQEVG TSEGKPISSL DAFPTQEGTL SPVNLTDDQI 
AAGLYACTNN ESTLKSIMKK KDGNKDSNGA KKNLQFVGIN GGYETTSSDD SSSDESSSSE 
SDDECDVIEY PLEEEEEEED EDTRGMAEGH HAVNIEGLKS ARVEDEMQVQ ECEPEKVEIR 
ERYELSEKML SACNLLKNTI NDPKALTSKD MRFCLNTLQH EWFRVSSQKS AIPAMVGDYI 
AAFEAISPDV LRYVINLADG NGNTALHYSV SHSNFEIVKL LLDADVCNVD HQNKAGYTPI 
MLAALAAVEA EKDMRIVEEL FGCGDVNAKA SQAGQTALML AVSHGRIDMV KGLLACGADV 
NIQDDEGSTA LMCASEHGHV EIVKLLLAQP GCNGHLEDND GSTALSIALE AGHKDIAVLL 
YAHVNFAKAQ SPGTPRLGRK TSPGPTHRGS FD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: KANK1

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. PubMed ID: 8724849

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma. PubMed ID: 12133830

Alternative splicing of the human Kank gene produces two types of Kank protein. PubMed ID: 15823577

Deletion of the ANKRD15 gene at 9p24.3 causes parent-of-origin-dependent inheritance of familial cerebral palsy. PubMed ID: 16301218

Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin. PubMed ID: 16968744

Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling. PubMed ID: 18458160

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

A major mutation of KIF21A associated with congenital fibrosis of the extraocular muscles type 1 (CFEOM1) enhances translocation of Kank1 to the membrane. PubMed ID: 19559006

Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1. PubMed ID: 19171758

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing. PubMed ID: 22084092

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. PubMed ID: 25961457

Structural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins. PubMed ID: 29183992